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304896-28-4,MFCD01909444
Catalog No.:AA00309C

304896-28-4 | AGK2

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$15.00   $11.00
- +
5mg
98%
in stock  
$37.00   $26.00
- +
10mg
98%
in stock  
$62.00   $43.00
- +
25mg
98%
in stock  
$103.00   $72.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00309C
Chemical Name:
AGK2
CAS Number:
304896-28-4
Molecular Formula:
C23H13Cl2N3O2
Molecular Weight:
434.2742
MDL Number:
MFCD01909444
SMILES:
N#CC(=Cc1ccc(o1)c1cc(Cl)ccc1Cl)C(=O)Nc1cccc2c1cccn2
Properties
Computed Properties
 
Complexity:
706  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
5.9  

Literature

Title: 5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors.

Journal: Journal of medicinal chemistry 20160414

Title: Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach.

Journal: Journal of medicinal chemistry 20141023

Title: Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.

Journal: Journal of medicinal chemistry 20120628

Title: Substrates for efficient fluorometric screening employing the NAD-dependent sirtuin 5 lysine deacylase (KDAC) enzyme.

Journal: Journal of medicinal chemistry 20120614

Title: After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders.

Journal: Bioorganic & medicinal chemistry 20110615

Title: Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.

Journal: Journal of medicinal chemistry 20100211

Title: Chemical probes for histone-modifying enzymes.

Journal: Nature chemical biology 20081001

Title: Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.

Journal: Science (New York, N.Y.) 20070727

Title: The Sir2 family of protein deacetylases.

Journal: Annual review of biochemistry 20040101

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Yeast hexokinase A. Succinylation and properties of the active subunit.

Journal: European journal of biochemistry 19751115

Title: Tatum PR, et al. Identification of novel SIRT2-selective inhibitors using a click chemistry approach. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1871-4.

Title: Kim HW, et al. Sirtuin inhibitors, EX527 and AGK2, suppress cell migration by inhibiting HSF1 protein stability. Oncol Rep. 2016 Jan;35(1):235-42.

Title: Li Y, et al. Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells. Neurosci Lett. 2013 Jun 7;544:36-40.

Title: Zhao T, et al. Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic Model. Curr Mol Med. 2015;15(7):634-41.

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