[1]Daugey;DeRycke;Brotin;Buffeteau[Chirality,2018,vol.30,#4,p.342-350]
[2]Robbins,MichaelA.;Devine,PaulN.;Oh,Taeboem;Renard,Marc;Ghosez,Léon[OrganicSyntheses,1999,vol.76,p.101-101]
[3]FEIT[Journalofmedicinalchemistry,1964,vol.7,p.14-17]
[4]Devine,PaulN.;Oh,Taeboem[TetrahedronLetters,1991,vol.32,#7,p.883-886]
[5]Park,Soobong;Anderson,Christopher;Loeber,Rachel;Seetharaman,Mahadevan;Jones,Roger;Tretyakova,Natalia[JournaloftheAmericanChemicalSociety,2005,vol.127,#41,p.14355-14365]
[1]Feit,P.W.[TetrahedronLetters,1961,p.716-717]
[1]Journalofmedicinalchemistry,1964,vol.7,p.14-17
[2]TetrahedronLetters,1961,p.716-717
Title: Allo-SCT for AML and MDS with treosulfan compared with BU-based regimens: reduced toxicity vs reduced intensity.
Journal: Bone marrow transplantation 20121001
Title: Allogeneic hematopoietic SCT in patients with AML following treosulfan/fludarabine conditioning.
Journal: Bone marrow transplantation 20120901
Title: Phase II prospective study of treosulfan-based reduced-intensity conditioning in allogeneic HSCT for hematological malignancies from 10/10 HLA-identical unrelated donor.
Journal: Annals of hematology 20120801
Title: A prospective multicenter study of treosulfan in elderly patients with recurrent ovarian cancer: results of a planned safety analysis.
Journal: Journal of cancer research and clinical oncology 20120801
Title: Nonmyeloablative conditioning generates autoantigen-encoding bone marrow that prevents and cures an experimental autoimmune disease.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20120801
Title: Allogeneic hematopoietic stem cell transplantation in thalassemia major: results of a reduced-toxicity conditioning regimen based on the use of treosulfan.
Journal: Blood 20120712
Title: HPLC method for determination of biologically active epoxy-transformers of treosulfan in human plasma: pharmacokinetic application.
Journal: Journal of pharmaceutical and biomedical analysis 20120325
Title: Treosulfan-based conditioning before hematopoietic SCT: more than a BU look-alike.
Journal: Bone marrow transplantation 20120101
Title: Intermediate intensity conditioning regimen containing FLAMSA, treosulfan, cyclophosphamide, and ATG for allogeneic stem cell transplantation in elderly patients with relapsed or high-risk acute myeloid leukemia.
Journal: Annals of hematology 20120101
Title: Low incidence and severity of oral mucositis in allogeneic stem cell transplantation after conditioning with treosulfan and fludarabine.
Journal: European journal of haematology 20120101
Title: Treosulfan-based preparative regimens for allo-HSCT in childhood hematological malignancies: a retrospective study on behalf of the EBMT pediatric diseases working party.
Journal: Bone marrow transplantation 20111201
Title: CD40 ligand deficiency with grade III liver fibrosis, transplanted by a treosulphan-based conditioning regimen.
Journal: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20111001
Title: Reduced-toxicity conditioning with treosulfan and fludarabine in allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes: final results of an international prospective phase II trial.
Journal: Haematologica 20110901
Title: Treosulfan-based conditioning regimens for hematopoietic stem cell transplantation in children with primary immunodeficiency: United Kingdom experience.
Journal: Blood 20110421
Title: Retrospective analysis of treosulfan-based conditioning in comparison with standard conditioning in patients with myelodysplastic syndrome.
Journal: Bone marrow transplantation 20110401
Title: Conditioning with treosulfan and fludarabine followed by allogeneic hematopoietic cell transplantation for high-risk hematologic malignancies.
Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20110301
Title: Age has no significant impact on overall survival and on treatment tolerability in relapsed stage IV cutaneous malignant melanoma patients receiving Cisplatin, Gemcitabine, and Treosulfan.
Journal: American journal of clinical oncology 20110201
Title: High-dose treosulfan in conditioning prior to hematopoietic stem cell transplantation.
Journal: Expert opinion on investigational drugs 20101001
Title: Molecular basis of chemosensitivity of platinum pre-treated ovarian cancer to chemotherapy.
Journal: British journal of cancer 20100824
Title: The role of reduced intensity preparative regimens in patients with thalassemia given hematopoietic transplantation.
Journal: Annals of the New York Academy of Sciences 20100801
Title: Allogeneic hematopoietic stem-cell transplantation in patients with hematologic malignancies after dose-escalated treosulfan/fludarabine conditioning.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100710
Title: Treosulfan-based conditioning regimen in a second matched unrelated peripheral blood stem cell transplantation for a pediatric patient with CGD and invasive aspergillosis, who experienced initial graft failure after RIC.
Journal: International journal of hematology 20091201
Title: Chemotherapy: Topotecan or treosulfan--that is the question.
Journal: Nature reviews. Clinical oncology 20091001
Title: Topotecan versus treosulfan, an alkylating agent, in patients with epithelial ovarian cancer and relapse within 12 months following 1st-line platinum/paclitaxel chemotherapy. A prospectively randomized phase III trial by the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group (AGO-OVAR).
Journal: Gynecologic oncology 20090801
Title: Diffusion-weighted imaging as predictor of therapy response in an animal model of Ewing sarcoma.
Journal: Investigative radiology 20090501
Title: Preclinical analysis of treosulfan in combination with total body irradiation as conditioning regimen prior to bone marrow transplantation in rats.
Journal: Immunopharmacology and immunotoxicology 20090101
Title: Treosulphan as an alternative to busulphan for myeloablative conditioning in paediatric allogeneic transplantation.
Journal: British journal of haematology 20081201
Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Journal: Journal of medicinal chemistry 20081113
Title: Treosulfan-based conditioning regimen for allogeneic haematopoietic stem cell transplantation in patients with thalassaemia major.
Journal: British journal of haematology 20081101
Title: Cytotoxic effects of treosulfan and busulfan against leukemic cells of pediatric patients.
Journal: Cancer chemotherapy and pharmacology 20081001
Title: Pharmacokinetics of high-dose i.v. treosulfan in children undergoing treosulfan-based preparative regimen for allogeneic haematopoietic SCT.
Journal: Bone marrow transplantation 20081001
Title: Cisplatin, gemcitabine and treosulfan is effective in chemotherapy-pretreated relapsed stage IV uveal melanoma patients.
Journal: Cancer chemotherapy and pharmacology 20080901
Title: Treosulfan/fludarabine as an allogeneic hematopoietic stem cell transplant conditioning regimen for high-risk patients.
Journal: American journal of hematology 20080901
Title: Preclinical studies of treosulfan demonstrate potent activity in Ewing's sarcoma.
Journal: Cancer chemotherapy and pharmacology 20080601
Title: Treosulfan and fludarabine low-toxicity conditioning for allogeneic haematopoietic stem cell transplantation in chronic myeloid leukaemia.
Journal: British journal of haematology 20080601
Title: Treosulfan-containing regimens achieve high rates of engraftment associated with low transplant morbidity and mortality in children with non-malignant disease and significant co-morbidities.
Journal: British journal of haematology 20080601
Title: Prognostic impact of combined fludarabine, treosulfan and mitoxantrone resistance profile in childhood acute myeloid leukemia.
Journal: Anticancer research 20080101
Title: Lessons of war: progress in transplant conditioning regimens.
Journal: Leukemia & lymphoma 20071201
Title: Fludarabine and treosulfan: a novel modified myeloablative regimen for allogeneic hematopoietic stem-cell transplantation with effective antileukemia activity in patients with acute myeloid leukemia and myelodysplastic syndromes.
Journal: Leukemia & lymphoma 20071201
Title: Cisplatin, gemcitabine, and treosulfan in relapsed stage IV cutaneous malignant melanoma patients.
Journal: British journal of cancer 20071119
Title: Treosulfan impedes the migration of immunocompetent cells.
Journal: Journal of neurology 20071001
Title: Engraftment kinetics and hematopoietic chimerism after reduced-intensity conditioning with fludarabine and treosulfan before allogeneic stem cell transplantation.
Journal: Annals of hematology 20070801
Title: Treatment of active secondary progressive multiple sclerosis with treosulfan.
Journal: Journal of neurology 20070701
Title: Comment on 'determination of treosulfan in plasma and urine by HPLC with refractometric detection; pharmacokinetic studies in children undergoing myeloablative treatment prior to haematopoietic stem cell transplantation' by F.K. Glowka et al. [J. Chromatogr. B 850 (2007) 569-574].
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615
Title: Determination of treosulfan in plasma and urine by HPLC with refractometric detection; pharmacokinetic studies in children undergoing myeloablative treatment prior to haematopoietic stem cell transplantation.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501
Title: Reduced-toxicity conditioning with fludarabine and treosulfan prior to allogeneic stem cell transplantation in multiple myeloma.
Journal: Bone marrow transplantation 20070401
Title: Substitution of cyclophosphamide and busulfan by fludarabine, treosulfan and melphalan in a preparative regimen for children and adolescents with Shwachman-Diamond syndrome.
Journal: Bone marrow transplantation 20070201
Title: Fludarabine, treosulfan and etoposide sensitivity and the outcome of hematopoietic stem cell transplantation in childhood acute myeloid leukemia.
Journal: Anticancer research 20070101
Title: Medical treatment of uveal melanoma.
Journal: Tumori 20070101
Title: Cytotoxic effects of treosulfan on prostate cancer cell lines.
Journal: Anticancer research 20070101
Title: A randomized phase II trial of gemcitabine plus treosulfan versus treosulfan alone in patients with metastatic uveal melanoma.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20061201
Title: In vitro drug sensitivity predicts response and survival after individualized sensitivity-directed chemotherapy in metastatic melanoma: a multicenter phase II trial of the Dermatologic Cooperative Oncology Group.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060915
Title: Cytotoxicity of treosulfan and busulfan on pediatric tumor cell lines.
Journal: Anti-cancer drugs 20060701
Title: A prospective single arm phase II study of dacarbazine and treosulfan as first-line therapy in metastatic uveal melanoma.
Journal: Melanoma research 20060601
Title: Reduced-toxicity conditioning with treosulfan, fludarabine and ATG as preparative regimen for allogeneic stem cell transplantation (alloSCT) in elderly patients with secondary acute myeloid leukemia (sAML) or myelodysplastic syndrome (MDS).
Journal: Bone marrow transplantation 20060201
Title: Unrelated donor bone marrow transplantation with treosulfan-based myeloablative conditioning for paroxysmal nocturnal hemoglobinuria--successful treatment despite multiple transplant-related risk factors for hemolysis including major Kidd group incompatibility.
Journal: Bone marrow transplantation 20060101
Title: A randomised comparison of treosulfan and carboplatin in patients with ovarian cancer: a study by the Scottish Gynaecological Cancer Trials Group (SGCTG).
Journal: European journal of cancer (Oxford, England : 1990) 20060101
Title: Myeloablative and immunosuppressive properties of treosulfan in mice.
Journal: Experimental hematology 20060101
Title: Evaluation of chemosensitivity of human bone marrow stromal cells--differences between common chemotherapeutic drugs.
Journal: Anticancer research 20060101
Title: Induction of tolerance across fully mismatched barriers by a nonmyeloablative treatment excluding antibodies or irradiation use.
Journal: Cell transplantation 20060101
Title: Treosulfan, cyclophosphamide and antithymocyte globulin for allogeneic hematopoietic cell transplantation in acquired severe aplastic anemia.
Journal: Annals of transplantation 20060101
Title: The results of treatment of epithelial ovarian cancer after centralisation of primary surgery. Results from North Jutland, Denmark.
Journal: Gynecologic oncology 20051201
Title: A two-cohort phase II clinical trial of gemcitabine plus treosulfan in patients with metastatic uveal melanoma.
Journal: Melanoma research 20051001
Title: [Allogeneic blood stem cell transplantation in high-risk patients after conditioning with treosulfan and fludarabine].
Journal: Deutsche medizinische Wochenschrift (1946) 20050923
Title: Two allogeneic hematopoietic stem cell transplantations without the use of blood-product support.
Journal: Haematologica 20050901
Title: Phase I trial combining gemcitabine and treosulfan in advanced cutaneous and uveal melanoma patients.
Journal: British journal of cancer 20050606
Title: Phase II trial of cisplatin, gemcitabine and treosulfan in patients with metastatic uveal melanoma.
Journal: Melanoma research 20050601
Title: Treosulfan and gemcitabine.
Journal: Journal of cancer research and clinical oncology 20050501
Title: Dose-escalated treosulphan in combination with cyclophosphamide as a new preparative regimen for allogeneic haematopoietic stem cell transplantation in patients with an increased risk for regimen-related complications.
Journal: Bone marrow transplantation 20050201
Title: Myeloablative conditioning in myelofibrosis using i.v. treosulfan and autologous peripheral blood progenitor cell transplantation with high doses of CD34+ cells results in hematologic responses - follow-up of three patients.
Journal: Haematologica 20050201
Title: [Metronomic chemotherapy. Should we change our thinking in the treatment of advanced tumors?].
Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20050101
Title: Myeloablative conditioning in myelofibrosis using i.v. treosulfan and autologous peripheral blood progenitor cell transplantation with high doses of CD34+ cells results in hematologic responses. A follow-up of three patients.
Journal: Haematologica 20050101
Title: Pharmacokinetics of treosulfan in a myeloablative combination with cyclophosphamide prior to allogeneic hematopoietic stem cell transplantation.
Journal: International journal of clinical pharmacology and therapeutics 20041101
Title: Treosulfan based conditioning for autologous and allogeneic hematopoietic stem cell transplantation.
Journal: International journal of clinical pharmacology and therapeutics 20041101
Title: High-dose treosulfan in patients with relapsed or refractory high-grade lymphoma receiving tandem autologous blood stem cell transplantation.
Journal: Bone marrow transplantation 20040901
Title: A clinical phase I trial of gemcitabine and treosulfan in uveal melanoma and other solid tumours.
Journal: European journal of cancer (Oxford, England : 1990) 20040901
Title: Clinical evaluation of in vitro chemosensitivity testing: the example of uveal melanoma.
Journal: Journal of cancer research and clinical oncology 20040701
Title: Addition of treosulfan to a nonmyeloablative conditioning regimen results in enhanced chimerism and immunologic tolerance in an experimental allogeneic bone marrow transplant model.
Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20040401
Title: Treosulfan and fludarabine: a new toxicity-reduced conditioning regimen for allogeneic hematopoietic stem cell transplantation.
Journal: Blood 20040115
Title: Toward a myeloablative regimen with clinical potential: II. Treosulfan induces specific skin graft tolerance across haploidentical MHC barriers.
Journal: Bone marrow transplantation 20040101
Title: Treosulfan-induced apoptosis in acute myeloid leukemia cells is accompanied by translocation of protein kinase C delta and enhanced by bryostatin-1.
Journal: Experimental hematology 20040101
Title: Treosulfan/fludarabine: a new conditioning regimen in allogeneic transplantation.
Journal: Annals of hematology 20040101
Title: The in vitro effect of gefitinib ('Iressa') alone and in combination with cytotoxic chemotherapy on human solid tumours.
Journal: BMC cancer 20040101
Title: Metronomic oral low-dose treosulfan chemotherapy combined with cyclooxygenase-2 inhibitor in pretreated advanced melanoma: a pilot study.
Journal: Cancer chemotherapy and pharmacology 20031101
Title: Action of treosulfan in myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis and human lymphocytes.
Journal: Journal of neuroimmunology 20031101
Title: Treosulfan is an effective inducer of cell death in myeloma cell lines and primary myeloma cells from patients.
Journal: British journal of haematology 20030901
Title: Towards a myeloablative regimen with clinical potential: I. Treosulfan conditioning and bone marrow transplantation allow induction of donor-specific tolerance for skin grafts across full MHC barriers.
Journal: Bone marrow transplantation 20030701
Title: Treosulfan and gemcitabine in metastatic uveal melanoma patients: results of a multicenter feasibility study.
Journal: Anti-cancer drugs 20030601
Title: Antileukaemic activity of treosulfan in xenografted human acute lymphoblastic leukaemias (ALL).
Journal: European journal of cancer (Oxford, England : 1990) 20030401
Title: Femoral head necrosis in three patients with relapsed ovarian cancer receiving high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation.
Journal: Bone marrow transplantation 20030301
Title: Second-line chemotherapy of metastatic malignant melanoma with intravenous treosulfan: a phase II multicentre trial.
Journal: Melanoma research 20030201
Title: Treosulfan in the treatment of metastatic melanoma: from chemosensitivity testing to clinical trials.
Journal: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20030101
Title: Neoadjuvant gemcitabine/treosulfan chemotherapy for newly diagnosed glioblastoma: a phase II study.
Journal: Journal of neuro-oncology 20020901
Title: CD95/CD95 ligand-independent potentiation of treosulfan cytotoxicity by BSO in malignant glioma cells in vitro and in vivo.
Journal: International journal of oncology 20020701
Title: Use of an ATP-based chemosensitivity assay to design new combinations of high-concentration doxorubicin with other drugs for recurrent ovarian cancer.
Journal: Anti-cancer drugs 20020701
Title: Rationale for combination therapy of chronic myelogenous leukaemia with imatinib and irradiation or alkylating agents: implications for pretransplant conditioning.
Journal: British journal of cancer 20020506
Title: The role of gemcitabine-based doublets in the management of ovarian carcinoma.
Journal: Seminars in oncology 20020201
Title: Chemotherapy versus hormonal treatment in platinum- and paclitaxel-refractory ovarian cancer: a randomised trial of the German Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) Study Group Ovarian Cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20020201
Title: Individualized long-term chemotherapy for recurrent ovarian cancer after failing high-dose treatment.
Journal: Anti-cancer drugs 20020201
Title: Treosulfan in the treatment of advanced ovarian cancer: a randomised co-operative multicentre phase III-study.
Journal: Anticancer research 20020101
Title: Progression of Parkinson's disease with impairment of vision under carboplatin/cyclophosphamide therapy for ovarian cancer.
Journal: Cancer chemotherapy and pharmacology 19980101
Title: Nitsch E, et al. Synergistic cytotoxic activity of treosulfan and LY 188011 in pancreatic cancer cell lines. Anticancer Res. 2014 Apr;34(4):1779-84.
Title: Peter T, et al. Programmed erythrocyte death following in vitro Treosulfan treatment. Cell Physiol Biochem. 2015;35(4):1372-80.
Title: Sjöö F, et al. Myeloablative and immunosuppressive properties of treosulfan in mice. Exp Hematol. 2006 Jan;34(1):115-21.
