Home Amines 30377-37-8
30377-37-8,MFCD22207595
Catalog No.:AA002ZUN

30377-37-8 | 2H-Purine-2,8(3H)-dione, 6-amino-7,9-dihydro-

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2.5mg
95%
2 weeks  
$1,008.00   $705.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA002ZUN
Chemical Name:
2H-Purine-2,8(3H)-dione, 6-amino-7,9-dihydro-
CAS Number:
30377-37-8
Molecular Formula:
C5H5N5O2
Molecular Weight:
167.1255
MDL Number:
MFCD22207595
SMILES:
O=c1nc(N)c2c([nH]1)[nH]c(=O)[nH]2
Properties
Properties
 
BP:
852.7°C at 760 mmHg  
Form:
Solid  
MP:
>300°C (dec.)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
342  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
4  
XLogP3:
-1.9  

Literature

Title: 2,8-Dihydroxyadenine uroliths in a dog.

Journal: Journal of the American Veterinary Medical Association 20121115

Title: Adenine phosphoribosyltransferase deficiency.

Journal: Clinical journal of the American Society of Nephrology : CJASN 20120901

Title: Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS.

Journal: Clinica chimica acta; international journal of clinical chemistry 20120322

Title: Computer-assisted imaging algorithms facilitate histomorphometric quantification of kidney damage in rodent renal failure models.

Journal: Journal of pathology informatics 20120101

Title: A Japanese boy with adenine phosphoribosyltransferase (APRT) deficiency caused by compound heterozygosity including a novel missense mutation in APRT gene.

Journal: Acta paediatrica (Oslo, Norway : 1992) 20111201

Title: [A case of bilateral renal calculi in a 1-year-old female with adenine phosphoribosyl transferase partial deficiency].

Journal: Hinyokika kiyo. Acta urologica Japonica 20111001

Title: Matrix Gla protein metabolism in vascular smooth muscle and role in uremic vascular calcification.

Journal: The Journal of biological chemistry 20110819

Title: Chronic kidney disease in kidney stone formers.

Journal: Clinical journal of the American Society of Nephrology : CJASN 20110801

Title: Long-term treatment with lanthanum carbonate reduces mineral and bone abnormalities in rats with chronic renal failure.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110601

Title: [2,8-dihydroxyadenine urolithiasis: case report and literature review].

Journal: Urologia 20110101

Title: Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis.

Journal: PloS one 20110101

Title: Acquired DHA nephropathy in rats.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101001

Title: Decreased kidney function and crystal deposition in the tubules after kidney transplant.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20100901

Title: Novel N-methylated 8-oxoisoguanines from Pacific sponges with diverse neuroactivities.

Journal: Journal of medicinal chemistry 20100826

Title: Crystalline nephropathy due to 2,8-dihydroxyadeninuria: an under-recognized cause of irreversible renal failure.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100601

Title: 2,8-dihydroxyadenine nephrolithiasis induces developmental stage-specific alterations in gene expression in mouse kidney.

Journal: Urology 20100401

Title: Phenotype and genotype characterization of adenine phosphoribosyltransferase deficiency.

Journal: Journal of the American Society of Nephrology : JASN 20100401

Title: Diagnostic examination of the child with urolithiasis or nephrocalcinosis.

Journal: Pediatric nephrology (Berlin, Germany) 20100301

Title: Nephrolithiasis related to inborn metabolic diseases.

Journal: Pediatric nephrology (Berlin, Germany) 20100301

Title: HPLC-UV measurements of metabolites in the supernatant of endothelial cells exposed to oxidative stress.

Journal: Analytical and bioanalytical chemistry 20100301

Title: Rapid measurements of 2,8-dihydroxyadenine (2,8-DHA) with a nanostructured electrochemical sensor in 5-fold diluted supernatants of endothelial cells exposed to oxidative stress.

Journal: The Analyst 20100201

Title: Medical treatment of pediatric urolithiasis.

Journal: Pediatric nephrology (Berlin, Germany) 20091101

Title: Progressive renal dysfunction and macrophage infiltration in interstitial fibrosis in an adenine-induced tubulointerstitial nephritis mouse model.

Journal: Histochemistry and cell biology 20090401

Title: 2, 8 Dihydroxyadenine urolithiasis: A case report and review of literature.

Journal: Indian journal of nephrology 20090101

Title: Uraemic hyperparathyroidism causes a reversible inflammatory process of aortic valve calcification in rats.

Journal: Cardiovascular research 20080801

Title: [Adenine phosphoribosyltransferase deficiency and its purine metabolism].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20080401

Title: In situ evaluation of heavy metal-DNA interactions using an electrochemical DNA biosensor.

Journal: Bioelectrochemistry (Amsterdam, Netherlands) 20080201

Title: Electrochemical behaviour of 2,8-dihydroxyadenine at a glassy carbon electrode.

Journal: Bioelectrochemistry (Amsterdam, Netherlands) 20070101

Title: [2,8-dihydroxyadenine nephrolithiasis: from diagnosis to therapy].

Journal: Annales de biologie clinique 20070101

Title: Evaluation of children with urolithiasis.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20070101

Title: Voltammetric determination of gamma radiation-induced DNA damage.

Journal: Analytical biochemistry 20060801

Title: Expression profiling of crystal-induced injury in human kidney epithelial cells.

Journal: Nephron. Physiology 20060101

Title: Aprt/Opn double knockout mice: osteopontin is a modifier of kidney stone disease severity.

Journal: Kidney international 20050901

Title: Methylated purines in urinary stones.

Journal: Clinical chemistry 20050801

Title: Simultaneous determination of 16 purine derivatives in urinary calculi by gradient reversed-phase high-performance liquid chromatography with UV detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050525

Title: 2,8-dihydroxyadeninuria: are there no cases in Scandinavia?

Journal: Scandinavian journal of urology and nephrology 20050101

Title: Identification of two novel mutations in adenine phosphoribosyltransferase gene in patients with 2,8-dihydroxyadenine urolithiasis.

Journal: Nucleosides, nucleotides & nucleic acids 20041001

Title: Dietary fiber suppresses elevation of uric acid and urea nitrogen concentrations in serum of rats with renal dysfunction induced by dietary adenine.

Journal: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20040701

Title: Three-dimensional structure of human adenine phosphoribosyltransferase and its relation to DHA-urolithiasis.

Journal: Biochemistry 20040622

Title: 2,8-Dihydroxyadenine renal stones in a 41-year-old man.

Journal: Annals of clinical biochemistry 20040301

Title: Four consecutive renal transplantations in a patient with adenine phosphoribosyltransferase deficiency.

Journal: Clinical nephrology 20040301

Title: Clinical value of crystalluria and quantitative morphoconstitutional analysis of urinary calculi.

Journal: Nephron. Physiology 20040101

Title: [Acute renal failure and 2,8-dihydroxyadeninuria].

Journal: Nephrologie 20040101

Title: Evaluation of urinary calculi by infrared spectroscopy.

Journal: Urology journal 20040101

Title: Impaired expression of an organic cation transporter, IMPT1, in a knockout mouse model for kidney stone disease.

Journal: Urological research 20030801

Title: [2,8-dihydoroxyadenine (DHA) urolithiasis: a case report].

Journal: Hinyokika kiyo. Acta urologica Japonica 20030801

Title: [Pathophysiology, diagnosis and conservative therapy of non-calcium kidney calculi].

Journal: Therapeutische Umschau. Revue therapeutique 20030201

Title: Gender- and age-dependent changes in kidney androgen protein mRNA expression in a knockout mouse model for nephrolithiasis.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20021201

Title: [Hyperuricemia and gout--diagnosis].

Journal: Deutsche medizinische Wochenschrift (1946) 20020201

Title: Capillary electrophoresis for detection of inherited disorders of purine and pyrimidine metabolism: a selective approach.

Journal: Electrophoresis 20020201

Title: Induction of alpha-catenin, integrin alpha3, integrin beta6, and PDGF-B by 2,8-dihydroxyadenine crystals in cultured kidney epithelial cells.

Journal: Experimental nephrology 20020101

Title: Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae.

Journal: Biochemistry 20010911

Title: Sequential analysis of kidney stone formation in the Aprt knockout mouse.

Journal: Kidney international 20010901

Title: Clinical features and genotype of adenine phosphoribosyltransferase deficiency in iceland.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20010901

Title: 2,8-Dihydroxyadenine urolithiasis in a patient with considerable residual adenine phosphoribosyltransferase activity in cell extracts but with mutations in both copies of APRT.

Journal: Molecular genetics and metabolism 20010301

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Tags:30377-37-8 Molecular Formula|30377-37-8 MDL|30377-37-8 SMILES|30377-37-8 2H-Purine-2,8(3H)-dione, 6-amino-7,9-dihydro-