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3131-03-1,MFCD01940050
Catalog No.:AA00C6IT

3131-03-1 | mikamycin B

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1mg
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$105.00   $73.00
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5mg
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$362.00   $253.00
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10mg
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$669.00   $468.00
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25mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C6IT
Chemical Name:
mikamycin B
CAS Number:
3131-03-1
Molecular Formula:
C45H54N8O10
Molecular Weight:
866.9579
MDL Number:
MFCD01940050
SMILES:
CCC1NC(=O)C(NC(=O)c2ncccc2O)C(C)OC(=O)C(NC(=O)C2N(C(=O)C(N(C(=O)C3N(C1=O)CCC3)C)Cc1ccc(cc1)N(C)C)CCC(=O)C2)c1ccccc1
NSC Number:
92554
Properties
Computed Properties
 
Complexity:
1700  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
63  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
7  
XLogP3:
2.8  

Literature

Title: Characterization of MLS(b) resistance among Staphylococcus aureus and Staphylococcus epidermidis isolates carrying different SCCmec types.

Journal: Microbiology and immunology 20120901

Title: Distribution, characterization and genetic bases of erythromycin resistance in staphylococci and enterococci originating from livestock.

Journal: Zoonoses and public health 20120501

Title: Comparison of BD Phoenix and bioMérieux Vitek 2 automated systems for the detection of macrolide-lincosamide-streptogramin B resistance among clinical isolates of Staphylococcus.

Journal: Diagnostic microbiology and infectious disease 20120301

Title: In vitro pharmacokinetic/pharmacodynamic activity of NXL103 versus clindamycin and linezolid against clinical Staphylococcus aureus and Streptococcus pyogenes isolates.

Journal: International journal of antimicrobial agents 20111001

Title: PCR ribotype prevalence and molecular basis of macrolide-lincosamide-streptogramin B (MLSB) and fluoroquinolone resistance in Irish clinical Clostridium difficile isolates.

Journal: The Journal of antimicrobial chemotherapy 20110901

Title: A study on erm(B)-mediated MLS resistance in Streptococcus pyogenes clinical isolates.

Journal: Diagnostic microbiology and infectious disease 20110701

Title: Phenotypic and genotypic study of macrolide, lincosamide and streptogramin B (MLSB) resistance in clinical isolates of Staphylococcus aureus in Tehran, Iran.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20110101

Title: Assessment of linezolid resistance mechanisms among Staphylococcus epidermidis causing bacteraemia in Rome, Italy.

Journal: The Journal of antimicrobial chemotherapy 20101101

Title: Molecular characterization and antimicrobial susceptibility profiles in Streptococcus agalactiae colonizing strains: association of erythromycin resistance with subtype III-1 genetic clone family.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20100901

Title: Macrolide, lincosamide, and streptogramin B-constitutive-type resistance in Corynebacterium pseudodiphtheriticum isolated from upper respiratory tract specimens.

Journal: Microbial drug resistance (Larchmont, N.Y.) 20100601

Title: Molecular ecology of macrolide-lincosamide-streptogramin B methylases in waste lagoons and subsurface waters associated with swine production.

Journal: Microbial ecology 20100401

Title: [Investigation of macrolide-lincosamide-streptogramin B (MLS(B)) and telithromycin resistance in clinical strains of staphylococci].

Journal: Mikrobiyoloji bulteni 20100401

Title: NXL-103, a combination of flopristin and linopristin, for the potential treatment of bacterial infections including community-acquired pneumonia and MRSA.

Journal: Current opinion in investigational drugs (London, England : 2000) 20100201

Title: Prevalence of erythromycin and clindamycin resistance among clinical isolates of the Streptococcus anginosus group in Germany.

Journal: Journal of medical microbiology 20090201

Title: Unusual resistance patterns in macrolide-resistant Streptococcus pyogenes harbouring erm(A).

Journal: The Journal of antimicrobial chemotherapy 20090101

Title: Technical note: Occurrence in fecal microbiota of genes conferring resistance to both macrolide-lincosamide-streptogramin B and tetracyclines concomitant with feeding of beef cattle with tylosin.

Journal: Journal of animal science 20080901

Title: Macrolide-lincosamide-streptogramin B resistance phenotypes in clinical staphylococcal isolates.

Journal: International journal of antimicrobial agents 20080401

Title: Foggy D-shaped zone of inhibition in Staphylococcus aureus owing to a dual character of both inducible and constitutive resistance to macrolide-lincosamide-streptogramin B.

Journal: The Journal of antimicrobial chemotherapy 20080301

Title: Prevalence and mechanisms of erythromycin and clindamycin resistance in clinical isolates of beta-haemolytic streptococci of Lancefield groups A, B, C and G in Seville, Spain.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20080101

Title: Macrolide-lincosamide-streptogramin B resistant phenotypes and genotypes for methicillin-resistant Staphylococcus aureus in Turkey, from 2003 to 2006.

Journal: Polish journal of microbiology 20080101

Title: Transposon characterization of vancomycin-resistant Enterococcus faecium (VREF) and dissemination of resistance associated with transferable plasmids.

Journal: The Journal of antimicrobial chemotherapy 20070801

Title: Structural insights into the non-additivity effects in the sequence-to-reactivity algorithm for serine peptidases and their inhibitors.

Journal: Journal of molecular biology 20070323

Title: Detection and prevalence of inducible clindamycin resistance in staphylococci.

Journal: Journal of medical microbiology 20070301

Title: Macrolide-lincosamide-streptogramin B resistance phenotypes and genotypes among Staphylococcus aureus clinical isolates in Japan.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20070301

Title: [The correlation between phenotypes and genotypes of macrolides, lincosamides and streptogramins B resistance in Staphylococcus aureus].

Journal: Medycyna doswiadczalna i mikrobiologia 20070101

Title: In vitro activity of telithromycin and quinupristin/dalfopristin against methicillin-resistant coagulase-negative staphylococci with defined resistance genotypes.

Journal: Folia microbiologica 20070101

Title: Prevalence and association of PCR ribotypes of Clostridium difficile isolated from symptomatic patients from Warsaw with macrolide-lincosamide-streptogramin B (MLSB) type resistance.

Journal: Journal of medical microbiology 20060201

Title: Macrolide, lincosamide and streptogramin B resistance in a dominant clone of Australian community methicillin-resistant Staphylococcus aureus.

Journal: The Journal of antimicrobial chemotherapy 20051101

Title: Chemoenzymatic approach to enantiopure streptogramin B variants: characterization of stereoselective pristinamycin I cyclase from Streptomyces pristinaespiralis.

Journal: Journal of the American Chemical Society 20050706

Title: Presence of macrolide-lincosamide-streptogramin B and tetracycline antimicrobials in swine waste treatment processes and amended soil.

Journal: Water environment research : a research publication of the Water Environment Federation 20050101

Title: Macrolide resistance phenotypes of commensal viridans group streptococci and Gemella spp. and PCR detection of resistance genes.

Journal: International journal of antimicrobial agents 20040601

Title: Pneumococcal resistance to macrolides, lincosamides, ketolides, and streptogramin B agents: molecular mechanisms and resistance phenotypes.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040515

Title: The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome.

Journal: Journal of molecular biology 20030725

Title: Prevalence and association of macrolide-lincosamide-streptogramin B (MLS(B)) resistance with resistance to moxifloxacin in Clostridium difficile.

Journal: The Journal of antimicrobial chemotherapy 20030301

Title: [Macrolide resistance phenotypes and genotypes in group G streptococci].

Journal: Mikrobiyoloji bulteni 20030101

Title: Purification and biochemical characterization of the ErmSF macrolide-lincosamide-streptogramin B resistance factor protein expressed as a hexahistidine-tagged protein in Escherichia coli.

Journal: Protein expression and purification 20020601

Title: Detection of transposon Tn5432-mediated macrolide-lincosamide-streptogramin B (MLSB) resistance in cutaneous propionibacteria from six European cities.

Journal: The Journal of antimicrobial chemotherapy 20020101

Title: Analysis of macrolide-lincosamide-streptogramin B (MLS(B)) resistance determinant in strains of Clostridium difficile.

Journal: Microbial drug resistance (Larchmont, N.Y.) 20020101

Title: Streptogramin resistance among Enterococcus faecium isolated from production animals in Denmark in 1997.

Journal: Microbial drug resistance (Larchmont, N.Y.) 20020101

Title: Unusual inducible cross resistance to macrolides, lincosamides, and streptogramins B by methylase production in clinical isolates of Staphylococcus aureus.

Journal: Microbial drug resistance (Larchmont, N.Y.) 20010101

Title: Phung-Ba V et al. Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells. Eur J Pharmacol. 1995 Jan 16;288(2):187-92.

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