Home Other Building Blocks 3254-89-5
3254-89-5,MFCD00151479
Catalog No.:AA003D67

3254-89-5 | Difenidol, HCl

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25mg
98%
in stock  
$6.00   $4.00
- +
10g
≥98%
in stock  
$63.00   $44.00
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25g
≥98%
in stock  
$132.00   $92.00
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50g
≥98%
in stock  
$230.00   $161.00
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100g
≥98%
in stock  
$398.00   $278.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003D67
Chemical Name:
Difenidol, HCl
CAS Number:
3254-89-5
Molecular Formula:
C21H28ClNO
Molecular Weight:
345.9061
MDL Number:
MFCD00151479
SMILES:
OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1.Cl
NSC Number:
23012
Properties
Properties
 
BP:
473.3°C at 760 mmHg  
Form:
Solid  
MP:
218 - 220°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
307  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  

Literature

Title: Blockade of voltage-gated calcium channel Cav1.2 and α1-adrenoceptors increases vertebral artery blood flow induced by the antivertigo agent difenidol.

Journal: European journal of pharmacology 20120815

Title: Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol.

Journal: Pharmacological reports : PR 20120101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Diphenidol inhibited sodium currents and produced spinal anesthesia.

Journal: Neuropharmacology 20100601

Title: Generation of gold nanostructures at the surface of platinum electrode by electrodeposition for ECL detection for CE.

Journal: Electrophoresis 20100301

Title: Ultra-fast chromatographic micro-assay for quantification of diphenidol in plasma: application in an oral multi-dose switchability trial.

Journal: Biomedical chromatography : BMC 20081001

Title: Diphenidol-related diamines as novel muscarinic M4 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20080501

Title: Effects of endolymphatic sac drainage with steroids for intractable Meniere's disease: a long-term follow-up and randomized controlled study.

Journal: The Laryngoscope 20080501

Title: Synthesis and pharmacological profile of a series of 1-substituted-2-carbonyl derivatives of Diphenidol: novel M4 muscarinic receptor antagonists.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20080301

Title: Enzymatic preparation of cefaclor with immobilized penicillin acylase.

Journal: Preparative biochemistry & biotechnology 20080101

Title: Capillary electrophoresis with end-column electrochemiluminescence for the analysis of chloroquine phosphate and the study on its interaction with human serum albumin.

Journal: Journal of chromatography. A 20070622

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Determination of difenidol hydrochloride by capillary electrophoresis with electrochemiluminescence detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202

Title: Development of an HPLC method for determination of diphenidol in plasma and its application in an oral multi-dose bioequivalence study in a healthy female Mexican population.

Journal: Journal of pharmaceutical and biomedical analysis 20050715

Title: Diphenidol has no actual broad antiemetic activity in dogs and ferrets.

Journal: Journal of pharmacological sciences 20041101

Title: Synthesis and antagonistic activity at muscarinic receptor subtypes of some derivatives of diphenidol.

Journal: Farmaco (Societa chimica italiana : 1989) 20030901

Title: Leung YM, et al. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacol Rep. 2012;64(3):739-44.

Title: Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58(7):1147-52.

Title: Andersson M, et al. Muscarinic receptor subtypes involved in urothelium-derived relaxatory effects in the inflamed rat urinary bladder. Auton Neurosci. 2012 Sep 25;170(1-2):5-11.

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