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328-90-5,MFCD01529657
Catalog No.:AA007IIX

328-90-5 | 2-Hydroxy-4-(trifluoromethyl)benzoic acid

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5g
97%
in stock  
$6.00   $4.00
- +
10g
97%
in stock  
$8.00   $6.00
- +
25g
97%
in stock  
$12.00   $8.00
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100g
95%
in stock  
$34.00   $24.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007IIX
Chemical Name:
2-Hydroxy-4-(trifluoromethyl)benzoic acid
CAS Number:
328-90-5
Molecular Formula:
C8H5F3O3
Molecular Weight:
206.1187
MDL Number:
MFCD01529657
SMILES:
OC(=O)c1ccc(cc1O)C(F)(F)F
Properties
Computed Properties
 
Complexity:
226  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
3.5  

Literature

Title: A phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new enteric-coated triflusal formulations in healthy male volunteers.

Journal: Expert opinion on drug metabolism & toxicology 20111201

Title: Comparative effects of triflusal, S-adenosylmethionine, and dextromethorphan over intestinal ischemia/reperfusion injury.

Journal: TheScientificWorldJournal 20110101

Title: Electrochemical behavior of triflusal, aspirin and their metabolites at glassy carbon and boron doped diamond electrodes.

Journal: Combinatorial chemistry & high throughput screening 20100801

Title: Eicosanoids in the innate immune response: TLR and non-TLR routes.

Journal: Mediators of inflammation 20100101

Title: Photonucleophilic addition of the epsilon-amino group of lysine to a triflusal metabolite as a mechanistic key to photoallergy mediated by the parent drug.

Journal: ChemMedChem 20090701

Title: Protective effects of triflusal on secondary thrombus growth and vascular cyclooxygenase-2.

Journal: Journal of thrombosis and haemostasis : JTH 20080801

Title: Salicylates increase insulin secretion in healthy obese subjects.

Journal: The Journal of clinical endocrinology and metabolism 20080701

Title: Spectroscopic and chromatographic characterization of triflusal delivery systems prepared by using supercritical impregnation technologies.

Journal: Journal of pharmaceutical and biomedical analysis 20080213

Title: A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment: the TRIMCI study.

Journal: Alzheimer disease and associated disorders 20080101

Title: The study of the influence of surfactant charge on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) using spectrophotometric methods.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070701

Title: Inhibition of cardiac hypertrophy by triflusal (4-trifluoromethyl derivative of salicylate) and its active metabolite.

Journal: Molecular pharmacology 20060401

Title: Access of HTB, main metabolite of triflusal, to cerebrospinal fluid in healthy volunteers.

Journal: European journal of clinical pharmacology 20050401

Title: Protective effect of triflusal and its main metabolite HTB in an in vitro model of anoxia-reoxygenation in rat brain slices: comparison with acetylsalicylic and salicylic acids.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050101

Title: Simultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in rat and human plasma by high-performance liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031225

Title: Activation of monocytic cells through Fc gamma receptors induces the expression of macrophage-inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020915

Title: Effects of the nuclear factor-kappaB inhibitors 2-hydroxy-4-trifluoromethylbenzoic acid and aspirin on micturition in rats with normal and inflamed bladder.

Journal: The Journal of urology 20011101

Title: Photochemistry of 2-hydroxy-4-trifluoromethylbenzoic acid, major metabolite of the photosensitizing platelet antiaggregant drug triflusal.

Journal: Photochemistry and photobiology 20010501

Title: Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid.

Journal: Molecular pharmacology 19990401

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