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328087-38-3,MFCD06407804
Catalog No.:AA00CN7Y

328087-38-3 | Phortress

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$132.00   $93.00
- +
5mg
≥98%
in stock  
$139.00   $97.00
- +
10mg
≥98%
in stock  
$263.00   $184.00
- +
50mg
≥98%
in stock  
$820.00   $574.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00CN7Y
Chemical Name:
Phortress
CAS Number:
328087-38-3
Molecular Formula:
C20H25Cl2FN4OS
Molecular Weight:
459.4081
MDL Number:
MFCD06407804
SMILES:
NCCCC[C@@H](C(=O)Nc1ccc(cc1C)c1nc2c(s1)ccc(c2)F)N.Cl.Cl
Properties
Computed Properties
 
Complexity:
497  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
7  

Literature

Title: Preclinical toxicokinetic evaluation of phortress [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride] in two rodent species.

Journal: Pharmacology 20090101

Title: In vitro cytotoxicity of Phortress against colorectal cancer.

Journal: International journal of oncology 20061101

Title: Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20041201

Title: The experimental antitumor agents Phortress and doxorubicin are equiactive against human-derived breast carcinoma xenograft models.

Journal: Breast cancer research and treatment 20040901

Title: The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate.

Journal: Current medicinal chemistry 20040401

Title: Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2-(4-aminophenyl)benzothiazole amino acid prodrugs.

Journal: Journal of medicinal chemistry 20020131

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