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330784-47-9,MFCD11977961
Catalog No.:AA0034EI

330784-47-9 | Avanafil

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
98%
in stock  
$7.00   $5.00
- +
50mg
98%
in stock  
$13.00   $9.00
- +
100mg
95%
in stock  
$18.00   $12.00
- +
250mg
95%
in stock  
$25.00   $17.00
- +
1g
95%
in stock  
$46.00   $32.00
- +
5g
98%
in stock  
$173.00   $121.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0034EI
Chemical Name:
Avanafil
CAS Number:
330784-47-9
Molecular Formula:
C23H26ClN7O3
Molecular Weight:
483.9506
MDL Number:
MFCD11977961
SMILES:
OC[C@@H]1CCCN1c1ncc(c(n1)NCc1ccc(c(c1)Cl)OC)C(=O)NCc1ncccn1
Properties
Properties
 
Form:
Solid  
MP:
150-152°C  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
642  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
XLogP3:
2.6  

Literature

Title: An update on pharmacological treatment of erectile dysfunction with phosphodiesterase type 5 inhibitors.

Journal: Expert opinion on pharmacotherapy 20130701

Title: Avanafil for the treatment of erectile dysfunction: initial data and clinical key properties.

Journal: Therapeutic advances in urology 20130201

Title: Avanafil for the treatment of erectile dysfunction: a multicenter, randomized, double-blind study in men with diabetes mellitus.

Journal: Mayo Clinic proceedings 20120901

Title: Re: Efficacy and safety of avanafil for treating erectile dysfunction: results of a multicentre, randomized, double-blind, placebo-controlled trial.

Journal: The Journal of urology 20120901

Title: Avanafil, a potent and highly selective phosphodiesterase-5 inhibitor for erectile dysfunction.

Journal: The Journal of urology 20120801

Title: Efficacy and satisfaction rates of oral PDE5is in the treatment of erectile dysfunction secondary to spinal cord injury: a review of literature.

Journal: The journal of spinal cord medicine 20120701

Title: FDA approves new ED remedy.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120601

Title: A randomized, double-blind, placebo-controlled evaluation of the safety and efficacy of avanafil in subjects with erectile dysfunction.

Journal: The journal of sexual medicine 20120401

Title: Avanafil for the treatment of erectile dysfunction.

Journal: Drugs of today (Barcelona, Spain : 1998) 20120101

Title: Avanafil for treatment of erectile dysfunction: review of its potential.

Journal: Vascular health and risk management 20120101

Title: cGMP Signaling, Phosphodiesterases and Major Depressive Disorder.

Journal: Current neuropharmacology 20111201

Title: Novel phosphodiesterase type 5 modulators: a patent survey (2008 - 2010).

Journal: Expert opinion on therapeutic patents 20111001

Title: Phosphodiesterase (PDE) inhibitors in the treatment of lower urinary tract dysfunction.

Journal: British journal of clinical pharmacology 20110801

Title: Future prospects in the treatment of erectile dysfunction: focus on avanafil.

Journal: Drug design, development and therapy 20110101

Title: Avanafil, a new rapid-onset phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction.

Journal: Expert opinion on investigational drugs 20101101

Title: Tolerability and pharmacokinetics of avanafil, a phosphodiesterase type 5 inhibitor: a single- and multiple-dose, double-blind, randomized, placebo-controlled, dose-escalation study in healthy Korean male volunteers.

Journal: Clinical therapeutics 20100601

Title: Diagnosis and treatment of erectile dysfunction--a practical update.

Journal: Journal of medicine and life 20091115

Title: Selective phosphodiesterase inhibitors: a promising target for cognition enhancement.

Journal: Psychopharmacology 20090101

Title: Novel phosphodiesterase-5 (PDE5) inhibitors in the alleviation of erectile dysfunction due to diabetes and ageing-induced oxidative stress.

Journal: Expert opinion on investigational drugs 20080601

Title: Looking to the future for erectile dysfunction therapies.

Journal: Drugs 20080101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20061201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20061001

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060901

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20040101

Title: Huyut Z, et, al. Effects of the Phosphodiesterase-5 (PDE-5) Inhibitors, Avanafil and Zaprinast, on Bone Remodeling and Oxidative Damage in a Rat Model of Glucocorticoid-Induced Osteoporosis. Med Sci Monit Basic Res. 2018 Mar 13;24:47-58.

Title: Yilmaz D, et, al. The effect of intracavernosal avanafil, a newer phosphodiesterase-5 inhibitor, on neonatal type 2 diabetic rats with erectile dysfunction. Urology. 2014 Feb;83(2):508.e7-12.

Title: Kotera J, et, al. Avanafil, a potent and highly selective phosphodiesterase-5 inhibitor for erectile dysfunction. J Urol. 2012 Aug;188(2):668-74.

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