Home Amines 33818-15-4
33818-15-4,MFCD00150508
Catalog No.:AA003OXI

33818-15-4 | sodium 2-(trimethylazaniumyl)ethyl ({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphonate

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100mg
97%
in stock  
$6.00   $4.00
- +
1g
97%
in stock  
$11.00   $8.00
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5g
97%
in stock  
$34.00   $24.00
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25g
98%
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$94.00   $66.00
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100g
98%
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$211.00   $148.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003OXI
Chemical Name:
sodium 2-(trimethylazaniumyl)ethyl ({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphonate
CAS Number:
33818-15-4
Molecular Formula:
C14H25N4NaO11P2
Molecular Weight:
510.3058
MDL Number:
MFCD00150508
SMILES:
O[C@@H]1[C@@H](COP(=O)(OP(=O)([O-])[O-])OCC[N+](C)(C)C)O[C@H]([C@@H]1O)n1ccc(nc1=O)N.[Na+]
Properties
Properties
 
Form:
Solid  
MP:
259-268°C  
Solubility:
H2O: 100mg/mL  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
813  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
10  

Literature

Title: Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke.

Journal: Journal of neurochemistry 20130901

Title: A rapid LC-ESI-MS/MS method for the quantitation of choline, an active metabolite of citicoline: Application to in vivo pharmacokinetic and bioequivalence study in Indian healthy male volunteers.

Journal: Journal of pharmaceutical and biomedical analysis 20121201

Title: Citicoline in pre-clinical animal models of stroke: a meta-analysis shows the optimal neuroprotective profile and the missing steps for jumping into a stroke clinical trial.

Journal: Journal of neurochemistry 20121001

Title: CDP-choline at high doses is as effective as i.v. thrombolysis in experimental animal stroke.

Journal: Neurological research 20120901

Title: Stroke: Treatment for acute stroke--the end of the citicoline saga.

Journal: Nature reviews. Neurology 20120901

Title: Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial).

Journal: Lancet (London, England) 20120728

Title: How effective is citicoline for acute ischaemic stroke?

Journal: Lancet (London, England) 20120728

Title: Citicoline enhances neuroregenerative processes after experimental stroke in rats.

Journal: Stroke 20120701

Title: Improvements in quantitative EEG following consumption of a natural citicoline-enhanced beverage.

Journal: International journal of food sciences and nutrition 20120601

Title: Intraperitoneal administration of CDP-choline or a combination of cytidine plus choline improves nerve regeneration and functional recovery in a rat model of sciatic nerve injury.

Journal: Neurological research 20120401

Title: Efficacy of cytidine-5'-diphosp-bocholine combined with compound anisodine in the treatment of early optic nerve contusion.

Journal: Eye science 20120301

Title: Intravenous CDP-choline activates neurons in supraoptic and paraventricular nuclei and induces hormone secretion.

Journal: Brain research bulletin 20120210

Title: CDP-choline treatment induces brain plasticity markers expression in experimental animal stroke.

Journal: Neurochemistry international 20120201

Title: Probably role of citicoline in stroke rehabilitation: review of the literature.

Journal: Revista de neurologia 20120201

Title: Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome.

Journal: Clinical interventions in aging 20120101

Title: [Neuroprotective treatment with citicoline (ceraxon) in patients with ischemic stroke].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20120101

Title: [Influence of neuroprotectors with choline-positive action on the level of brain-injury markers during acute ischemic stroke].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20120101

Title: Prevention of epidural fibrosis in rats by local or systemic administration of citicoline.

Journal: Turkish neurosurgery 20120101

Title: Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis.

Journal: Biochimica et biophysica acta 20111201

Title: CDP-choline and its endogenous metabolites, cytidine and choline, promote the nerve regeneration and improve the functional recovery of injured rat sciatic nerves.

Journal: Neurological research 20110901

Title: The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models.

Journal: Behavioural pharmacology 20110901

Title: Investigational therapies for ischemic stroke: neuroprotection and neurorecovery.

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20110701

Title: CDP-choline treatment increases circulating endothelial progenitor cells in acute ischemic stroke.

Journal: Neurological research 20110701

Title: Eight weeks of citicoline treatment does not perturb sleep/wake cycles in cocaine-dependent adults.

Journal: Pharmacology, biochemistry, and behavior 20110601

Title: CDP-choline as a biological supplement during neurorecovery: a focused review.

Journal: PM & R : the journal of injury, function, and rehabilitation 20110601

Title: Effect of choline-containing phospholipids on brain cholinergic transporters in the rat.

Journal: Journal of the neurological sciences 20110315

Title: CDP-choline-induced contractions in the mouse gastric fundus through purinoceptors and Rho/Rho-kinase signalling.

Journal: Life sciences 20110314

Title: Citicoline: pharmacological and clinical review, 2010 update.

Journal: Revista de neurologia 20110314

Title: Simple diffusion delivery via brain interstitial route for the treatment of cerebral ischemia.

Journal: Science China. Life sciences 20110301

Title: Effects of daily treatment with citicoline: a double-blind, placebo-controlled study in cocaine-dependent volunteers.

Journal: Journal of addiction medicine 20110301

Title: Serial MRI study of the enhanced therapeutic effects of liposome-encapsulated citicoline in cerebral ischemia.

Journal: International journal of pharmaceutics 20110227

Title: Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo.

Journal: Journal of lipid research 20110201

Title: Citicoline preclinical and clinical update 2009-2010.

Journal: Stroke 20110101

Title: Citicoline in vascular cognitive impairment and vascular dementia after stroke.

Journal: Stroke 20110101

Title: Neuroprotection and recovery: recent data at the bench on citicoline.

Journal: Stroke 20110101

Title: A random effects variance shift model for detecting and accommodating outliers in meta-analysis.

Journal: BMC medical research methodology 20110101

Title: Human tissue kallikrein promoted activation of the ipsilesional sensorimotor cortex after acute cerebral infarction.

Journal: European neurology 20110101

Title: Neuroprotective effects of citidine-5-diphosphocholine on impaired spatial memory in a rat model of cerebrovascular dementia.

Journal: Journal of pharmacological sciences 20110101

Title: Greatly improved neuroprotective efficiency of citicoline by stereotactic delivery in treatment of ischemic injury.

Journal: Drug delivery 20110101

Title: [The effect of parenteral citicoline on visual functions and life quality of patients with primary open-angle glaucoma].

Journal: Vestnik oftalmologii 20110101

Title: [Comparative aspects of using neuroprotectors in the management of patients with ischemic stroke].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

Title: [Ceraxon (citicoline) in the treatment of the mild cognitive impairment syndrome].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

Title: [Comparison of efficacy of different neurometabolic and vasoactive medicines in ischemic stroke patients's rehabilitation].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

Title: Mannosylated liposomal cytidine 5' diphosphocholine prevent age related global moderate cerebral ischemia reperfusion induced mitochondrial cytochrome c release in aged rat brain.

Journal: Neuroscience 20101229

Title: Citicoline, use in cognitive decline: vascular and degenerative.

Journal: Journal of the neurological sciences 20101215

Title: Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T.

Journal: Bipolar disorders 20101201

Title: Production of cytidine 5'-diphosphorylcholine with high utilization of ATP by whole cells of Saccharomyces cerevisiae.

Journal: Bioresource technology 20101101

Title: Citicoline and postconditioning provides neuroprotection in a rat model of ischemic spinal cord injury.

Journal: Acta neurochirurgica 20100601

Title: Choline or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemia.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20100601

Title: Citicoline for acute ischemic stroke in Mexican hospitals: a retrospective postmarketing analysis.

Journal: Methods and findings in experimental and clinical pharmacology 20100601

Title: Differential expression of choline kinase isoforms in skeletal muscle explains the phenotypic variability in the rostrocaudal muscular dystrophy mouse.

Journal: Biochimica et biophysica acta 20100401

Title: Neurochemical alterations in methamphetamine-dependent patients treated with cytidine-5'-diphosphate choline: a longitudinal proton magnetic resonance spectroscopy study.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100401

Title: Effect of repeatedly given CDP-choline on cardiovascular and tissue injury in spinal shock conditions: investigation of the acute phase.

Journal: The Journal of pharmacy and pharmacology 20100401

Title: Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20100201

Title: Involvement of the histaminergic system in cytidine 5'-diphosphocholine-induced reversal of critical haemorrhagic hypotension in rats.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100201

Title: Molecular mechanisms involved in farnesol-induced apoptosis.

Journal: Cancer letters 20100128

Title: Citicoline affects appetite and cortico-limbic responses to images of high-calorie foods.

Journal: The International journal of eating disorders 20100101

Title: The protective effects of propofol and citicoline combination in experimental head injury in rats.

Journal: Turkish neurosurgery 20100101

Title: Effect of recombinant human erythropoietin on serum S100B protein and interleukin-6 levels after traumatic brain injury in the rat.

Journal: Neurologia medico-chirurgica 20100101

Title: [Efficacy and safety of the combined therapy with citicholine and actovegin in the acute period of ischemic stroke].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

Title: The citicoline brain injury treatment (COBRIT) trial: design and methods.

Journal: Journal of neurotrauma 20091201

Title: Effect of NH4+ and glycerol on cytidine 5'-diphosphocholine synthesis in Saccharomyces cerevisiae.

Journal: Bioresource technology 20091001

Title: Choline or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: involvement of the peripheral nicotinic acetylcholine receptors.

Journal: Shock (Augusta, Ga.) 20090901

Title: Citicoline (CDP-choline): What role in the treatment of complications of infectious diseases.

Journal: The international journal of biochemistry & cell biology 20090701

Title: ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum.

Journal: Journal of cell science 20090515

Title: Understanding the muscular dystrophy caused by deletion of choline kinase beta in mice.

Journal: Biochimica et biophysica acta 20090501

Title: The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptor.

Journal: Anesthesia and analgesia 20090501

Title: A robust quantitative solid phase immunoassay for the acute phase protein C-reactive protein (CRP) based on cytidine 5'-diphosphocholine coupled dendrimers.

Journal: Journal of immunological methods 20090415

Title: Efficacy of citicoline as an acute stroke treatment.

Journal: Expert opinion on pharmacotherapy 20090401

Title: Efficacy and safety of oral citicoline in acute ischemic stroke: drug surveillance study in 4,191 cases.

Journal: Methods and findings in experimental and clinical pharmacology 20090401

Title: Evaluation of a sequential global test of improved recovery following stroke as applied to the ICTUS trial of citicoline.

Journal: Pharmaceutical statistics 20090101

Title: Multifunctional actions of approved and candidate stroke drugs.

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20090101

Title: Single- and repeated-dose oral toxicity studies of citicoline free-base (choline cytidine 5'-pyrophosphate) in Sprague-Dawley rats.

Journal: International journal of toxicology 20090101

Title: [The use of citicoline in the acute cerebral stroke].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

Title: Effects of cytidine 5'-diphosphocholine (CDP-choline) on the thermal nociceptive threshold in streptozotocin-induced diabetic mice.

Journal: European journal of pharmacology 20081119

Title: Breast cancer is associated with an increase in the activity and expression of cholinephosphotransferase in rats.

Journal: Life sciences 20081107

Title: Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy.

Journal: NMR in biomedicine 20081101

Title: Effect of choline-containing phospholipids on transglutaminase activity in primary astroglial cell cultures.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20081101

Title: CDP-choline prevents cardiac arrhythmias and lethality induced by short-term myocardial ischemia-reperfusion injury in the rat: involvement of central muscarinic cholinergic mechanisms.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080901

Title: Central choline suppresses plasma renin response to graded haemorrhage in rats.

Journal: Clinical and experimental pharmacology & physiology 20080901

Title: Cytidine-5-diphosphocholine supplement in early life induces stable increase in dendritic complexity of neurons in the somatosensory cortex of adult rats.

Journal: Neuroscience 20080813

Title: Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involvement of the peripheral autonomic nervous system.

Journal: European journal of pharmacology 20080728

Title: Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells.

Journal: The Biochemical journal 20080701

Title: Cholinomimetic agents and neurocognitive impairment following head injury: a systematic review.

Journal: Brain injury 20080701

Title: [Clinical effect of ligustrazine combined with citicoline for treatment of diabetic peripheral neuropathy].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080701

Title: Cytidine-5'-diphosphocholine (Citicoline): a pilot study in patients with non-arteritic ischaemic optic neuropathy.

Journal: European journal of neurology 20080501

Title: Citicoline. Monograph.

Journal: Alternative medicine review : a journal of clinical therapeutic 20080301

Title: Effects of CDP-choline and the combination of CDP-choline and galantamine differ in an animal model of schizophrenia: development of a selective alpha7 nicotinic acetylcholine receptor agonist strategy.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080201

Title: Peripheral administration of CDP-choline and its cholinergic metabolites increases serum insulin: muscarinic and nicotinic acetylcholine receptors are both involved in their actions.

Journal: Neuroscience letters 20080124

Title: Effect of oral CDP-choline on visual function in young amblyopic patients.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20080101

Title: Delayed post-ischemic administration of CDP-choline increases EAAT2 association to lipid rafts and affords neuroprotection in experimental stroke.

Journal: Neurobiology of disease 20080101

Title: Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations.

Journal: Autonomic & autacoid pharmacology 20080101

Title: First administration of cytidine diphosphocholine and galantamine in schizophrenia: a sustained alpha7 nicotinic agonist strategy.

Journal: Clinical neuropharmacology 20080101

Title: Efficiency of citicoline in increasing muscular strength of patients with nontraumatic cerebral hemorrhage: a double-blind randomized clinical trial.

Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20080101

Title: CDP-choline protects motor neurons against apoptotic changes in a model of chronic glutamate excitotoxicity in vitro.

Journal: Folia neuropathologica 20080101

Title: CDP-choline (citicoline) attenuates brain damage in a rat model of birth asphyxia.

Journal: Acta neurobiologiae experimentalis 20080101

Title: Evidence of the neuroprotective role of citicoline in glaucoma patients.

Journal: Progress in brain research 20080101

Title: Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair.

Journal: Reviews in neurological diseases 20080101

Title: Cardiovascular effects of CDP-choline and its metabolites: involvement of peripheral autonomic nervous system.

Journal: European journal of pharmacology 20071222

Title: Citicoline is not protective in experimental models of Huntington's disease.

Journal: Neurobiology of aging 20071201

Title: Citicoline improves functional recovery, promotes nerve regeneration, and reduces postoperative scarring after peripheral nerve surgery in rats.

Journal: Surgical neurology 20071201

Title: Citicoline reduces upregulated clusterin following kainic acid injection in the rat retina.

Journal: Current eye research 20071201

Title: A randomized, placebo-controlled trial of citicoline add-on therapy in outpatients with bipolar disorder and cocaine dependence.

Journal: Journal of clinical psychopharmacology 20071001

Title: Choline induces transcriptional repression and proteasomal degradation of the malarial phosphoethanolamine methyltransferase.

Journal: Eukaryotic cell 20070901

Title: CDP-choline reduces dopaminergic cell loss induced by MPP(+) and glutamate in primary mesencephalic cell culture.

Journal: The International journal of neuroscience 20070701

Title: Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation?

Journal: Journal of the neurological sciences 20070615

Title: Possible involvement of supraspinal opioid and GABA receptors in CDP-choline-induced antinociception in acute pain models in rats.

Journal: Neuroscience letters 20070613

Title: Interventions for preventing delirium in hospitalised patients.

Journal: The Cochrane database of systematic reviews 20070418

Title: A chronic treatment with CDP-choline improves functional recovery and increases neuronal plasticity after experimental stroke.

Journal: Neurobiology of disease 20070401

Title: Intraperitoneal administration of CDP-choline and its cholinergic and pyrimidinergic metabolites induce hyperglycemia in rats: involvement of the sympathoadrenal system.

Journal: Archives of physiology and biochemistry 20070101

Title: Citicoline and lithium rescue retinal ganglion cells following partial optic nerve crush in the rat.

Journal: Experimental eye research 20061101

Title: The antinociceptive effects of centrally administered CDP-choline on acute pain models in rats: the involvement of cholinergic system.

Journal: Brain research 20061030

Title: Citicoline--the first effective neuroprotectant to be combined with thrombolysis in acute ischemic stroke?

Journal: Journal of the neurological sciences 20060925

Title: Effect of combined therapy with thrombolysis and citicoline in a rat model of embolic stroke.

Journal: Journal of the neurological sciences 20060925

Title: Citicoline: pharmacological and clinical review, 2006 update.

Journal: Methods and findings in experimental and clinical pharmacology 20060901

Title: Citicoline (Cognizin) in the treatment of cognitive impairment.

Journal: Clinical interventions in aging 20060901

Title: Localization of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum to the Golgi apparatus.

Journal: The Journal of biological chemistry 20060728

Title: Medical treatment of amblyopia: present state and perspectives.

Journal: Strabismus 20060601

Title: Evaluation of the neuroprotective effects of citicoline after experimental spinal cord injury: improved behavioral and neuroanatomical recovery.

Journal: Neurochemical research 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Action of citicoline on rat retinal expression of extracellular-signal-regulated kinase (ERK1/2).

Journal: Brain research 20060407

Title: CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke.

Journal: The Journal of biological chemistry 20060310

Title: Vegetable lipid sources affect in vitro biosynthesis of triacylglycerols and phospholipids in the intestine of sea bream (Sparus aurata).

Journal: The British journal of nutrition 20060301

Title: [Effect of citicoline on spatial learning and memory of rats after focal cerebral ischemia].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060201

Title: Intravenous administration of choline or cdp-choline improves platelet count and platelet closure times in endotoxin-treated dogs.

Journal: Shock (Augusta, Ga.) 20060101

Title: Citicoline in intracerebral haemorrhage: a double-blind, randomized, placebo-controlled, multi-centre pilot study.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20060101

Title: Radioprotective effect of transferrin targeted citicoline liposomes.

Journal: Journal of drug targeting 20060101

Title: Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release.

Journal: Cellular and molecular neurobiology 20060101

Title: Targets of cytoprotection in acute ischemic stroke: present and future.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20060101

Title: Neurorepair versus neuroprotection in stroke.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20060101

Title: Thrombolysis and neuroprotection in cerebral ischemia.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20060101

Title: Cytidine 5'-diphosphocholine restores blood flow of superior mesenteric and renal arteries and prolongs survival time in haemorrhaged anaesthetized rats.

Journal: Clinical and experimental pharmacology & physiology 20060101

Title: Glycerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the Kennedy pathway.

Journal: The Journal of biological chemistry 20051118

Title: Effects of citicoline on experimental spinal cord injury.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20051101

Title: Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils.

Journal: Brain research 20051005

Title: CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke.

Journal: Brain research 20051005

Title: Neuroprotective effect of citicoline against KA-induced neurotoxicity in the rat retina.

Journal: Experimental eye research 20050901

Title: Neuroprotective effect of citicoline on retinal cell damage induced by kainic acid in rats.

Journal: Korean journal of ophthalmology : KJO 20050901

Title: Physiological regulation of phospholipid methylation alters plasma homocysteine in mice.

Journal: The Journal of biological chemistry 20050805

Title: Effects of simvastatin on the expression of intercellular adhesion molecule-1 mRNA in neonatal brain with hypoxic-ischemic damage.

Journal: Journal of nanoscience and nanotechnology 20050801

Title: Citicoline inhibits MAP kinase signalling pathways after focal cerebral ischaemia.

Journal: Neurochemical research 20050801

Title: Effect of Xuesaitong soft capsule on hemorrheology and in auxiliarily treating patients with acute cerebral infarction.

Journal: Chinese journal of integrative medicine 20050601

Title: [A case of interval form of carbon monoxide poisoning with a remarkable recovery].

Journal: Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20050501

Title: Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly.

Journal: The Cochrane database of systematic reviews 20050418

Title: Stachybotrys chartarum alters surfactant-related phospholipid synthesis and CTP:cholinephosphate cytidylyltransferase activity in isolated fetal rat type II cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050301

Title: Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport.

Journal: Neurobiology of disease 20050301

Title: Progressive morphometric and cognitive changes in vascular dementia.

Journal: Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists 20050301

Title: Effects of cataractogenesis on the CDP-choline pathway: increased phospholipid synthesis in lenses from galactosemic rats and 13/N guinea pigs.

Journal: Ophthalmic research 20050101

Title: Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20050101

Title: Cytidine 5'-diphosphocholine (CDP-choline) in stroke and other CNS disorders.

Journal: Neurochemical research 20050101

Title: Electrophysiological assessment of glaucomatous visual dysfunction during treatment with cytidine-5'-diphosphocholine (citicoline): a study of 8 years of follow-up.

Journal: Documenta ophthalmologica. Advances in ophthalmology 20050101

Title: The new approaches to preservation of graft cell integrity in preservation for transplantation.

Journal: Annals of transplantation 20050101

Title: CDP-choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement.

Journal: Fundamental & clinical pharmacology 20041001

Title: Elevated erythrocyte CDP-choline levels associated with beta-thalassaemia in patients with transfusion independent anaemia.

Journal: Nucleosides, nucleotides & nucleic acids 20041001

Title: Characterization of a lipid activated CTP:phosphocholine cytidylyltransferase from Drosophila melanogaster.

Journal: Biochimica et biophysica acta 20040705

Title: A choline-deficient diet in mice inhibits neither the CDP-choline pathway for phosphatidylcholine synthesis in hepatocytes nor apolipoprotein B secretion.

Journal: The Journal of biological chemistry 20040604

Title: Chronic treatment with a precursor of cellular phosphatidylcholine ameliorates morphological and behavioral effects of aging in the mouse [correction of rat] hippocampus.

Journal: Annals of the New York Academy of Sciences 20040601

Title: Regulation of phosphatidylcholine biosynthesis under salt stress involves choline kinases in Arabidopsis thaliana.

Journal: FEBS letters 20040521

Title: Cytidine-5'-diphosphocholine affects CTP-phosphocholine cytidylyltransferase and lyso-phosphatidylcholine after transient brain ischemia.

Journal: Journal of neuroscience research 20040501

Title: Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: a review of the literature.

Journal: Alternative medicine review : a journal of clinical therapeutic 20040301

Title: The effects of citicoline and lamotrigine alone and in combination following permanent middle cerebral artery occlusion in rats.

Journal: The International journal of neuroscience 20040201

Title: Centrally injected CDP-choline increases plasma vasopressin levels by central cholinergic activation.

Journal: Fundamental & clinical pharmacology 20040201

Title: Cell membranes and apoptosis: role of cardiolipin, phosphatidylcholine, and anticancer lipid analogues.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20040201

Title: Phospholipid biosynthesis in mammalian cells.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20040201

Title: A CDP-choline pathway for phosphatidylcholine biosynthesis in Treponema denticola.

Journal: Molecular microbiology 20040101

Title: Cytidinediphosphocholine (CDP choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly.

Journal: The Cochrane database of systematic reviews 20040101

Title: Brain cholinesterases: III. Future perspectives of AD research and clinical practice.

Journal: Medical hypotheses 20040101

Title: Neuroimaging correlates of dementia rating scale performance at baseline and 12-month follow-up among patients with vascular dementia.

Journal: Journal of geriatric psychiatry and neurology 20031201

Title: Neuroprotective effect of citicoline in 6-hydroxydopamine-lesioned rats and in 6-hydroxydopamine-treated SH-SY5Y human neuroblastoma cells.

Journal: Journal of the neurological sciences 20031115

Title: Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia.

Journal: Antioxidants & redox signaling 20031001

Title: Citicoline decreases phospholipase A2 stimulation and hydroxyl radical generation in transient cerebral ischemia.

Journal: Journal of neuroscience research 20030801

Title: Phosphorylation of Saccharomyces cerevisiae CTP synthetase at Ser424 by protein kinases A and C regulates phosphatidylcholine synthesis by the CDP-choline pathway.

Journal: The Journal of biological chemistry 20030627

Title: Regulation of the CDP-choline pathway by sterol regulatory element binding proteins involves transcriptional and post-transcriptional mechanisms.

Journal: The Biochemical journal 20030615

Title: Dietary cytidine (5')-diphosphocholine supplementation protects against development of memory deficits in aging rats.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20030601

Title: Stimulation of CDP-choline synthesis by uridine or cytidine in PC12 rat pheochromocytoma cells.

Journal: Brain research 20030509

Title: Intravenously injected CDP-choline increases blood pressure and reverses hypotension in haemorrhagic shock: effect is mediated by central cholinergic activation.

Journal: European journal of pharmacology 20030509

Title: Cytidinediphosphocholine treatment to decrease traumatic brain injury-induced hippocampal neuronal death, cortical contusion volume, and neurological dysfunction in rats.

Journal: Journal of neurosurgery 20030401

Title: The two biosynthetic routes leading to phosphatidylcholine in yeast produce different sets of molecular species. Evidence for lipid remodeling.

Journal: Biochemistry 20030318

Title: Oral citicoline treatment improves visual pathway function in glaucoma.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20030301

Title: Clinical correlates of cognitive decline in vascular dementia.

Journal: Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology 20030301

Title: Effects of cytidine 5'-diphosphocholine on plasma homocysteine levels in rat.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20030201

Title: CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons.

Journal: Journal of molecular neuroscience : MN 20030201

Title: Effects of citicholine and dimethylsulfoxide on transepithelial transport of passively diffused drugs in the Caco-2 cell culture model.

Journal: International journal of pharmaceutics 20030130

Title: Combined nimodipine and citicoline reduce infarct size, attenuate apoptosis and increase bcl-2 expression after focal cerebral ischemia.

Journal: Neuroscience 20030101

Title: Effect of CDP-choline on hippocampal acetylcholinesterase and Na+,K(+)-ATPase in adult and aged rats.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101

Title: Effects of cataractogenesis on the CDP-choline pathway: changes in ATP concentration and phosphocholine synthesis during and after exposure of rat lenses to sugars in vitro and in vivo.

Journal: Ophthalmic research 20030101

Title: Long-term citicoline (cytidine diphosphate choline) use in patients with vascular dementia: neuroimaging and neuropsychological outcomes.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20030101

Title: 'Brain-specific' nutrients: a memory cure?

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20030101

Title: Citicoline increases glutathione redox ratio and reduces caspase-3 activation and cell death in staurosporine-treated SH-SY5Y human neuroblastoma cells.

Journal: Brain research 20021206

Title: Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials.

Journal: Stroke 20021201

Title: Citicoline has a protective effect on damaged retinal ganglion cells in mouse culture retina.

Journal: Neuroreport 20021115

Title: Citicoline mechanisms and clinical efficacy in cerebral ischemia.

Journal: Journal of neuroscience research 20021015

Title: [Treatment of mild cognitive impairment: value of citicoline].

Journal: Revista de neurologia 20021001

Title: Phosphorylation of Saccharomyces cerevisiae choline kinase on Ser30 and Ser85 by protein kinase A regulates phosphatidylcholine synthesis by the CDP-choline pathway.

Journal: The Journal of biological chemistry 20020920

Title: Clinical use of cholinomimetic agents: a review.

Journal: The Journal of head trauma rehabilitation 20020801

Title: Effects of ganglioside GM3 on phospholipid turnover of human leukemic J6-2 cells.

Journal: Neurochemical research 20020801

Title: Argipressin(4-8) upregulate CTP: phosphocholine cytidylyltransferase in rat hippocampal neurons.

Journal: Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 20020701

Title: Quantifying heterogeneity in a meta-analysis.

Journal: Statistics in medicine 20020615

Title: Antidepressant-like effects of cytidine in the forced swim test in rats.

Journal: Biological psychiatry 20020601

Title: Cardiovascular effects of intracerebroventricularly injected CDP-choline in normotensive and hypotensive animals: the involvement of cholinergic system.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020501

Title: CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat.

Journal: Neuropharmacology 20020501

Title: Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study.

Journal: Psychopharmacology 20020501

Title: The serial position effect in mild and moderately severe vascular dementia.

Journal: Journal of the International Neuropsychological Society : JINS 20020501

Title: [Perspectives on the treatment of organic mental disorders by the use of nootropic agents].

Journal: Voenno-meditsinskii zhurnal 20020501

Title: News about neuroprotectants for the treatment of stroke.

Journal: JAMA 20020313

Title: Pharmacodynamics of citicoline relevant to the treatment of glaucoma.

Journal: Journal of neuroscience research 20020115

Title: Citicoline: neuroprotective mechanisms in cerebral ischemia.

Journal: Journal of neurochemistry 20020101

Title: Citicoline treatment increases retinal dopamine content in rabbits.

Journal: Ophthalmic research 20020101

Title: Membrane stabilizer: citicoline.

Journal: Current medical research and opinion 20020101

Title: [Reaction times during citicoline treatment].

Journal: La Clinica terapeutica 20020101

Title: Choline transport in Leishmania major promastigotes and its inhibition by choline and phosphocholine analogs.

Journal: Molecular and biochemical parasitology 20020101

Title: Application of 4-hydroxyantipyrine and acetaminophen O-sulfate as biodistribution promoter.

Journal: Biological & pharmaceutical bulletin 20011201

Title: Citicoline. Ferrer Internacional.

Journal: Current opinion in investigational drugs (London, England : 2000) 20011201

Title: A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients.

Journal: Neurology 20011113

Title: [Curative effect of soybean lecithin on cerebral infarction].

Journal: Zhonghua yi xue za zhi 20011110

Title: Effects of citicoline on phospholipid and glutathione levels in transient cerebral ischemia.

Journal: Stroke 20011001

Title: The effects of citicoline and/or MK-801 on survival, neurological and behavioral outcome of mice exposed to transient hyperglycemia and oligemic hypoxia.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20011001

Title: [Use of procholinergics in the prevention of postoperative delirium in hip fracture surgery in the elderly. A randomized controlled trial].

Journal: Revista de neurologia 20011001

Title: Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects.

Journal: Psychopharmacology 20010901

Title: Choline deficiency induced by Mycoplasma fermentans enhances apoptosis of rat astrocytes.

Journal: FEMS microbiology letters 20010724

Title: [Neuroprotection in acute ischemic stroke. Practicability of guidelines for treatment].

Journal: Revista de neurologia 20010501

Title: Ischemic brain injury caused by interrupted versus uninterrupted occlusion in hypotensive rats with subarachnoid hemorrhage: neuroprotective effects of citicoline.

Journal: Archives of physiology and biochemistry 20010401

Title: Highly saturated endonuclear phosphatidylcholine is synthesized in situ and colocated with CDP-choline pathway enzymes.

Journal: The Journal of biological chemistry 20010316

Title: Does CDP-choline modulate phospholipase activities after transient forebrain ischemia?

Journal: Brain research 20010302

Title: Cytidine (5') diphosphocholine-induced decrease in cerebral platelet activating factor is due to inactivation of its synthesizing enzyme cholinephosphotransferase in aged rats.

Journal: Neuroscience letters 20010223

Title: Turnover of phosphatidylcholine in Saccharomyces cerevisiae. The role of the CDP-choline pathway.

Journal: The Journal of biological chemistry 20010209

Title: Delayed administration of JTP-2942, a novel thyrotropin-releasing hormone analogue, improves cerebral blood flow and metabolism in rat postischaemic brain.

Journal: Clinical and experimental pharmacology & physiology 20010101

Title: Elevated activity of phospholipid biosynthetic enzymes in substantia nigra of patients with Parkinson's disease.

Journal: Neuroscience 20010101

Title: Modulation of biosynthesis of phosphatidylcholine via CDP-choline in rat liver: influence of ethanol on the microsomal cholinephosphotransferase activity.

Journal: Molecular and cellular biochemistry 20010101

Title: Performance on the Hooper Visual Organizational Test in patients diagnosed with subcortical vascular dementia: relation to naming performance.

Journal: Neuropsychiatry, neuropsychology, and behavioral neurology 20010101

Title: CDP-choline, but not cytidine, protects hippocampal CA1 neurones in the gerbil following transient forebrain ischaemia.

Journal: Folia neuropathologica 20010101

Title: Short-term treatment with citicoline (CDP-choline) attenuates some measures of craving in cocaine-dependent subjects: a preliminary report.

Journal: Psychopharmacology 19990201

Title: A randomized dose-response trial of citicoline in acute ischemic stroke patients. Citicoline Stroke Study Group.

Journal: Neurology 19970901

Title: Characterization of 2',3'-dideoxycytidine diphosphocholine and 2',3'-dideoxycytidine diphosphoethanolamine. Prominent phosphodiester metabolites of the anti-HIV nucleoside 2',3'-dideoxycytidine.

Journal: Drug metabolism and disposition: the biological fate of chemicals 19930101

Title: Effects of citicholine and of the combination citicholine + piracetam on the memory (experiments on mice).

Journal: Acta physiologica et pharmacologica Bulgarica 19900101

Title: Memory effects of the new derivative of the p-chlorophenoxyacetic acid adafenoxate compared to the effects of some cognition-enhancing drugs in rats.

Journal: Arzneimittel-Forschung 19890901

Title: Davinelli S, et al. Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells. Oxid Med Cell Longev. 2017;2017:2825703.

Title: Karpova MN, et al. Increase of the seizure threshold in C57BL/6 mice after citicoline administration. Bull Exp Biol Med. 2015 Jan;158(3):315-7.

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Tags:33818-15-4 Molecular Formula|33818-15-4 MDL|33818-15-4 SMILES|33818-15-4 sodium 2-(trimethylazaniumyl)ethyl ({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphonate