Home Aldehydes 338992-53-3
338992-53-3,MFCD26960944
Catalog No.:AA00C6FD

338992-53-3 | ZD 6474 trifluoroacetate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
>98.00%
3 weeks  
$427.00   $299.00
- +
100mg
>98.00%
3 weeks  
$683.00   $478.00
- +
200mg
>98.00%
3 weeks  
$933.00   $653.00
- +
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00C6FD
Chemical Name:
ZD 6474 trifluoroacetate
CAS Number:
338992-53-3
Molecular Formula:
C24H25BrF4N4O4
Molecular Weight:
589.3773
MDL Number:
MFCD26960944
SMILES:
OC(=O)C(F)(F)F.COc1cc2c(ncnc2cc1OCC1CCN(CC1)C)Nc1ccc(cc1F)Br
Properties

Literature

Title: Wedge SR, et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. 2002 Aug 15;62(16):4645-55.

Title: Hegedus C, et al. Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: implications for the emergence and reversal of cancer drug resistance. Biochem Pharmacol. 2012 Aug 1;84(3):260-7.

Title: Takeda H, et al. Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency. Exp Cell Res. 2013 Feb 15;319(4):417-23.

Title: Inoue K, et al. Vandetanib, an inhibitor of VEGF receptor-2 and EGF receptor, suppresses tumor development and improves prognosis of liver cancer in mice. Clin Cancer Res. 2012 Jul 15;18(14):3924-33.

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