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Home Amines 443913-73-3
443913-73-3,MFCD07772346
Catalog No.:AA00I8CC

443913-73-3 | N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$6.00   $4.00
- +
5mg
98%
in stock  
$8.00   $6.00
- +
250mg
98%
in stock  
$80.00   $56.00
- +
1g
98%
in stock  
$137.00   $96.00
- +
5g
98%
in stock  
$279.00   $195.00
- +
10g
98%
in stock  
$544.00   $381.00
- +
25g
98%
in stock  
$1,208.00   $846.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00I8CC
Chemical Name:
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
CAS Number:
443913-73-3
Molecular Formula:
C22H24BrFN4O2
Molecular Weight:
475.3540
MDL Number:
MFCD07772346
SMILES:
COc1cc2c(ncnc2cc1OCC1CCN(CC1)C)Nc1ccc(cc1F)Br
Properties
Properties
 
BP:
538°C at 760 mmHg  
Form:
Solid  
MP:
240-243 °C  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
539  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
4.9  

Downstream Synthesis Route

[1]BioorganicandMedicinalChemistryLetters,2011,vol.21,p.3222-3226

[2]Patent:US2010/75916,2010,A1.Locationinpatent:Page/Pagecolumn23

[3]Patent:EP1244647,2006,B1.Locationinpatent:Page/Pagecolumn19

[1]Patent:WO2007/36713,2007,A2.Locationinpatent:Page/Pagecolumn59;60

[2]Patent:WO2007/36713,2007,A2.Locationinpatent:Page/Pagecolumn58;59

[3]Patent:EP1244647,2006,B1.Locationinpatent:Page/Pagecolumn20

[4]Patent:WO2007/36713,2007,A2.Locationinpatent:Page/Pagecolumn61

4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazolinehydrochloride 
  443913-73-3 

[1]Patent:EP1244647,2006,B1.Locationinpatent:Page/Pagecolumn21

443913-73-3   
4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazolinemonohydrate 

[1]Patent:WO2007/36717,2007,A1.Locationinpatent:Page/Pagecolumn26;27;27-28

Literature

Title: Wedge SR, et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. 2002 Aug 15;62(16):4645-55.

Title: Hegedus C, et al. Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: implications for the emergence and reversal of cancer drug resistance. Biochem Pharmacol. 2012 Aug 1;84(3):260-7.

Title: Takeda H, et al. Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency. Exp Cell Res. 2013 Feb 15;319(4):417-23.

Title: Inoue K, et al. Vandetanib, an inhibitor of VEGF receptor-2 and EGF receptor, suppresses tumor development and improves prognosis of liver cancer in mice. Clin Cancer Res. 2012 Jul 15;18(14):3924-33.

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SDS
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Tags:443913-73-3 Molecular Formula|443913-73-3 MDL|443913-73-3 SMILES|443913-73-3 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine