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34104-67-1,MFCD00055102
Catalog No.:AA00C8XX

34104-67-1 | HALOPERIDOL METABOLITE II

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5mg
≥98%
in stock  
$89.00   $62.00
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10mg
≥98%
in stock  
$165.00   $115.00
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25mg
≥98%
in stock  
$363.00   $254.00
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50mg
≥98%
in stock  
$682.00   $477.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C8XX
Chemical Name:
HALOPERIDOL METABOLITE II
CAS Number:
34104-67-1
Molecular Formula:
C21H25ClFNO2
Molecular Weight:
377.8801
MDL Number:
MFCD00055102
SMILES:
Fc1ccc(cc1)C(CCCN1CCC(CC1)(O)c1ccc(cc1)Cl)O
Properties
Computed Properties
 
Complexity:
414  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.7  

Literature

Title: In vitro characterization of the oxidation of a pyridinium metabolite of haloperidol by human placenta: the effect of smoking.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20120101

Title: Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells.

Journal: European journal of medicinal chemistry 20110101

Title: Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.

Journal: Psychopharmacology 20090701

Title: Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.

Journal: Analytical chemistry 20061215

Title: Determination of haloperidol and reduced haloperidol in human serum by liquid chromatography after fluorescence labeling based on the Suzuki coupling reaction.

Journal: Analytical and bioanalytical chemistry 20061001

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol.

Journal: Therapeutic drug monitoring 20030401

Title: Comparison of SSI with APCI as an interface of HPLC-mass spectrometry for analysis of a drug and its metabolites.

Journal: Journal of the American Society for Mass Spectrometry 20020301

Title: Synthesis and structure-activity relationships of N-(1-benzylpiperidin-4-yl)arylacetamide analogues as potent sigma1 receptor ligands.

Journal: Journal of medicinal chemistry 20011206

Title: Potent inhibition of CYP2D6 by haloperidol metabolites: stereoselective inhibition by reduced haloperidol.

Journal: British journal of clinical pharmacology 20010101

Title: Reduced haloperidol does not interfere with the antipsychotic activity of haloperidol in the treatment of acute schizophrenia.

Journal: International clinical psychopharmacology 19990701

Title: Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19900901

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SDS
Tags:34104-67-1 Molecular Formula|34104-67-1 MDL|34104-67-1 SMILES|34104-67-1 HALOPERIDOL METABOLITE II