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Home Deuterated Building Blocks 374750-30-8
374750-30-8,MFCD13194756
Catalog No.:AA00C9ZR

374750-30-8 | 2'-C-Methylguanosine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥95%
in stock  
$73.00   $51.00
- +
10mg
≥95%
in stock  
$118.00   $82.00
- +
25mg
≥95%
in stock  
$236.00   $165.00
- +
250mg
97%
in stock  
$311.00   $218.00
- +
1g
97%
in stock  
$809.00   $567.00
- +
5g
97%
in stock  
$2,804.00   $1,963.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C9ZR
Chemical Name:
2'-C-Methylguanosine
CAS Number:
374750-30-8
Molecular Formula:
C11H15N5O5
Molecular Weight:
297.2673
MDL Number:
MFCD13194756
SMILES:
OC[C@H]1O[C@H]([C@]([C@@H]1O)(C)O)n1cnc2c1nc(N)[nH]c2=O
Properties
Properties
 
BP:
733.1°C at 760 mmHg  
Form:
Solid  
Solubility:
H2O: soluble5mg/mL, clear (warmed)  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
488  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
2  
XLogP3:
-1.7  

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,2004,vol.47,p.2283-2295

[1]BioorganicandMedicinalChemistryLetters,2009,vol.19,p.4316-4320

[2]JournalofOrganicChemistry,2006,vol.71,p.4018-4020

[3]Patent:WO2008/62206,2008,A2.Locationinpatent:Page/Pagecolumn25-26

142629-80-9    374750-30-8   
2'-C-methylguanosine5'-phenylmethoxy-(S)-alaninylphosphate 
 
2'-C-methylguanosine5'-phenylmethoxy-(S)-alaninylphosphate 

[1]Patent:US2007/265222,2007,A1.Locationinpatent:Page/Pagecolumn10-11

[1]JournalofOrganicChemistry,2006,vol.71,p.4018-4020

[2]JournalofOrganicChemistry,2006,vol.71,p.4018-4020

(2S/R,3R,4R,5R)-5-((benzoyloxy)methyl)-3-methyltetrahydrofuran-2,3,4-triyltribenzoate 
  374750-30-8 

[1]JournalofOrganicChemistry,2006,vol.71,p.4018-4020

[2]JournalofOrganicChemistry,2006,vol.71,p.4018-4020

[3]JournalofMedicinalChemistry,2004,vol.47,p.2283-2295

Literature

Title: Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.

Journal: Bioorganic & medicinal chemistry letters 20111115

Title: Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.

Journal: Journal of medicinal chemistry 20100708

Title: Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.

Journal: European journal of medicinal chemistry 20091001

Title: Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives.

Journal: Bioorganic & medicinal chemistry 20090701

Title: Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.

Journal: Bioorganic & medicinal chemistry letters 20060315

Title: Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.

Journal: Journal of medicinal chemistry 20041007

Title: Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase.

Journal: Journal of medicinal chemistry 20040422

Title: Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro.

Journal: The Journal of biological chemistry 20031205

Title: Non-HIV antivirals - a review of the recent patent literature.

Journal: IDrugs : the investigational drugs journal 20020801

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SDS
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