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34552-83-5,MFCD00058581
Catalog No.:AA003RAB

34552-83-5 | 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride

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250mg
98%
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1g
98%(HPLC)
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5g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003RAB
Chemical Name:
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride
CAS Number:
34552-83-5
Molecular Formula:
C29H34Cl2N2O2
Molecular Weight:
513.4985
MDL Number:
MFCD00058581
SMILES:
Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1.Cl
Properties
Properties
 
Form:
Solid  
MP:
223-225°C  
Refractive Index:
1.6100 (estimate)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
623  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  

Literature

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Title: Not your regular high: cardiac dysrhythmias caused by loperamide.

Journal: Clinical toxicology (Philadelphia, Pa.) 20160601

Title: Current and emerging drug options in the treatment of diarrhea predominant irritable bowel syndrome.

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Title: Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp.

Journal: PloS one 20130101

Title: Antinociceptive effect of intrathecal loperamide: role of mu-opioid receptor and calcium channels.

Journal: European journal of pharmacology 20121205

Title: P-glycoprotein, multidrug-resistance associated protein 2, Cyp3a, and carboxylesterase affect the oral availability and metabolism of vinorelbine.

Journal: Molecular pharmacology 20121001

Title: Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120901

Title: Loperamide effects on anxiety level and feeding behavior in rats. Role of vagal afferentation.

Journal: Bulletin of experimental biology and medicine 20120901

Title: Analgesic properties of loperamide differ following systemic and local administration to rats after spinal nerve injury.

Journal: European journal of pain (London, England) 20120801

Title: Garcinia buchananii bark extract is an effective anti-diarrheal remedy for lactose-induced diarrhea.

Journal: Journal of ethnopharmacology 20120713

Title: The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea.

Journal: Alimentary pharmacology & therapeutics 20120701

Title: Urinary bladder relaxation through activation of opioid μ-receptors induced by loperamide is increased in diabetic rats.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20120601

Title: Behavioral effects and central nervous system levels of the broadly available κ-agonist hallucinogen salvinorin A are affected by P-glycoprotein modulation in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20120601

Title: Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120501

Title: Dissecting the relative contribution of central versus peripheral opioid analgesia: are the analgesic and adverse effects of opioids inseparable?

Journal: European journal of pain (London, England) 20120501

Title: Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids.

Journal: European journal of pain (London, England) 20120501

Title: Assessment of the aversive effects of peripheral mu opioid receptor agonism in Fischer 344 and Lewis rats.

Journal: Pharmacology, biochemistry, and behavior 20120401

Title: Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening.

Journal: Bioorganic & medicinal chemistry letters 20120401

Title: [Evaluation of P-glycoprotein mediated in vitro loperamide biliary excretion with sandwich-cultured rat hepatocytes model].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120401

Title: Opiate-induced constipation related to activation of small intestine opioid μ2-receptors.

Journal: World journal of gastroenterology 20120328

Title: P-glycoprotein-based loperamide-cyclosporine drug interaction at the rat blood-brain barrier: prediction from in vitro studies and extrapolation to humans.

Journal: Molecular pharmaceutics 20120305

Title: Carboxylesterase expression in human dental pulp cells: role in regulation of BisGMA-induced prostanoid production and cytotoxicity.

Journal: Acta biomaterialia 20120301

Title: Loperamide, an antidiarrhea drug, has antitumor activity by inducing cell apoptosis.

Journal: Pharmacological research 20120301

Title: Effects of Ficus carica paste on loperamide-induced constipation in rats.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

Title: Antidiarrhetic loperamide hydrochloride.

Journal: Acta crystallographica. Section C, Crystal structure communications 20120301

Title: The influence of mass of [11C]-laniquidar and [11C]-N-desmethyl-loperamide on P-glycoprotein blockage at the blood-brain barrier.

Journal: Nuclear medicine and biology 20120101

Title: Effects of oral loperamide on efficacy of naltrexone, baclofen and AM-251 in blocking ethanol self-administration in rats.

Journal: Pharmacology, biochemistry, and behavior 20120101

Title: Irritable bowel syndrome.

Journal: BMJ clinical evidence 20120101

Title: Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats.

Journal: TheScientificWorldJournal 20120101

Title: Effect of colic vein ligature in rats with loperamide-induced constipation.

Journal: Journal of biomedicine & biotechnology 20120101

Title: Quantification of polyphenols and pharmacological analysis of water and ethanol-based extracts of cultivated agarwood leaves.

Journal: Journal of nutritional science and vitaminology 20120101

Title: Local loperamide injection reduces mechanosensitivity of rat cutaneous, nociceptive C-fibers.

Journal: PloS one 20120101

Title: Effect of acupuncture for gastrointestinal activity differs depending on the pathophysiological condition.

Journal: Acupuncture in medicine : journal of the British Medical Acupuncture Society 20111201

Title: Estimation of P-glycoprotein-mediated efflux in the oral absorption of P-gp substrate drugs from simultaneous analysis of drug dissolution and permeation.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20111120

Title: Pediatric lymphocytic colitis presenting with intractable diarrhea.

Journal: Journal of pediatric gastroenterology and nutrition 20111101

Title: Sterile hepatic abscess secondary to administration of parenteral fluids via an umbilical venous catheter in a premature baby.

Journal: Journal of pediatric gastroenterology and nutrition 20111101

Title: Determination of loperamide in mdr1a/1b knock-out mouse brain tissue using matrix-assisted laser desorption/ionization mass spectrometry and comparison with quantitative electrospray-triple quadrupole mass spectrometry analysis.

Journal: Archives of pharmacal research 20111101

Title: Loperamide.

Journal: Journal of pain and symptom management 20110801

Title: Can loperamide cause acute pancreatitis?

Journal: Pancreas 20110701

Title: Antidiarrheal effect of fractions from stem bark of Thespesia populnea in rodents: Possible antimotility and antisecretory mechanisms.

Journal: Asian Pacific journal of tropical medicine 20110601

Title: Toxicological evaluation of aqueous extract of Aloe ferox Mill. in loperamide-induced constipated rats.

Journal: Human & experimental toxicology 20110501

Title: Antimicrobial and antimotility agent use in persons with shiga toxin-producing Escherichia coli O157 infection in FoodNet Sites.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110501

Title: Investigation on mechanisms of glycopeptide nanoparticles for drug delivery across the blood-brain barrier.

Journal: Nanomedicine (London, England) 20110401

Title: Relapse of intestinal and hepatic amebiasis after treatment.

Journal: Digestive diseases and sciences 20110301

Title: Antiepileptic drugs modulate P-glycoproteins in the brain: a mice study with (11)C-desmethylloperamide.

Journal: Epilepsy research 20110301

Title: Loperamide-induced rat prostate relaxation through activation of peripheral µ-opioid receptors.

Journal: Neurourology and urodynamics 20110301

Title: Targeting the insulin receptor: nanoparticles for drug delivery across the blood-brain barrier (BBB).

Journal: Journal of drug targeting 20110201

Title: Loperamide, an FDA-approved antidiarrhea drug, effectively reverses the resistance of multidrug resistant MCF-7/MDR1 human breast cancer cells to doxorubicin-induced cytotoxicity.

Journal: Cancer investigation 20110201

Title: Changes in feeding behavior after peripheral loperamide administration in rats.

Journal: Bulletin of experimental biology and medicine 20110201

Title: An unusual treatment for protein losing enteropathy.

Journal: Congenital heart disease 20110101

Title: Activation of peripheral opioid µ-receptors in blood vessel may lower blood pressure in spontaneously hypertensive rats.

Journal: Pharmacology 20110101

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Title: Gastroenteritis in children.

Journal: BMJ clinical evidence 20110101

Title: Fitting the elementary rate constants of the P-gp transporter network in the hMDR1-MDCK confluent cell monolayer using a particle swarm algorithm.

Journal: PloS one 20110101

Title: Involvement of peripheral mu opioid receptors in scratching behavior in mice.

Journal: European journal of pharmacology 20101215

Title: Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20101208

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogs.

Journal: Journal of veterinary pharmacology and therapeutics 20101001

Title: Interference with P-glycoprotein improves ivermectin activity against adult resistant nematodes in sheep.

Journal: Veterinary parasitology 20100920

Title: Calcium channel blocking activity of Mentha longifolia L. explains its medicinal use in diarrhoea and gut spasm.

Journal: Phytotherapy research : PTR 20100901

Title: Peripheral administration of loperamide and methylnaloxone decreases the degree of anxiety in rats.

Journal: Bulletin of experimental biology and medicine 20100901

Title: Remarks and questions on the article 'Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes'.

Journal: European journal of clinical pharmacology 20100801

Title: Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats.

Journal: Journal of medicinal food 20100801

Title: Changes in β-endorphin level in the cingulate cortex in rats after peripheral loperamide and methylnaloxone administration at rest and during emotional stress.

Journal: Bulletin of experimental biology and medicine 20100801

Title: Traditional Chinese formula, lubricating gut pill, improves loperamide-induced rat constipation involved in enhance of Cl- secretion across distal colonic epithelium.

Journal: Journal of ethnopharmacology 20100720

Title: Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20100701

Title: Cattle nematodes resistant to macrocyclic lactones: comparative effects of P-glycoprotein modulation on the efficacy and disposition kinetics of ivermectin and moxidectin.

Journal: Experimental parasitology 20100601

Title: N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100601

Title: Review article: rifaximin, a minimally absorbed oral antibacterial, for the treatment of travellers' diarrhoea.

Journal: Alimentary pharmacology & therapeutics 20100601

Title: NPY Y2 receptor agonist PYY(3-36) inhibits diarrhea by reducing intestinal fluid secretion and slowing colonic transit in mice.

Journal: Peptides 20100401

Title: P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100401

Title: Effects of ketoconazole on the biodistribution and metabolism of [11C]loperamide and [11C]N-desmethyl-loperamide in wild-type and P-gp knockout mice.

Journal: Nuclear medicine and biology 20100401

Title: Loperamide and P-glycoprotein inhibition: assessment of the clinical relevance.

Journal: The Journal of pharmacy and pharmacology 20100401

Title: Administration of loperamide and addition of wheat bran to the diets of weaner pigs decrease the incidence of diarrhoea and enhance their gut maturation.

Journal: The British journal of nutrition 20100301

Title: Acceleration of the gastrointestinal transit by polyethylene glycol effectively treats unconjugated hyperbilirubinaemia in Gunn rats.

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Title: Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes.

Journal: European journal of clinical pharmacology 20100201

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Journal: Analytica chimica acta 20100125

Title: Antidiarrhoeal and spasmolytic activities of the methanolic crude extract of Alstonia scholaris L. are mediated through calcium channel blockade.

Journal: Phytotherapy research : PTR 20100101

Title: Improved measurement of drug exposure in the brain using drug-specific correction for residual blood.

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Title: Crohn's colitis with perianal disease complicated by collagenous colitis: discourse on management options.

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Title: Laxative activities of Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) leaf aqueous extract in rats.

Journal: BMC complementary and alternative medicine 20100101

Title: Antidiarrheal activity of aqueous extract of Hermannia incana Cav. leaves in Wistar rats.

Journal: Methods and findings in experimental and clinical pharmacology 20100101

Title: Anti-diarrhoeal activity of crude aqueous extract of Rubia tinctorum L. roots in rodents.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20100101

Title: Using PET studies of P-gp function to elucidate mechanisms underlying the disposition of drugs.

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Journal: BMC infectious diseases 20100101

Title: Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice.

Journal: Bioscience, biotechnology, and biochemistry 20100101

Title: The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in Wistar rats.

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Title: Irritable bowel syndrome.

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Title: P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090101

Title: Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats.

Journal: Anesthesia and analgesia 20090101

Title: Efficacy of methylcellulose and loperamide in managing fecal incontinence.

Journal: Acta obstetricia et gynecologica Scandinavica 20090101

Title: Expert review of the evidence base for self-therapy of travelers' diarrhea.

Journal: Journal of travel medicine 20090101

Title: Pathogenesis and management of irritable bowel syndrome.

Journal: Tropical gastroenterology : official journal of the Digestive Diseases Foundation 20090101

Title: Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models.

Journal: Pharmacology 20090101

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Journal: Neuroscience letters 20081231

Title: [Hazardous to give loperamide (Immodium etc) to children under three years of age].

Journal: Lakartidningen 20081217

Title: Comparison and validation of drug loading parameters of PEGylated nanoparticles purified by a diafiltration centrifugal device and tangential flow filtration.

Journal: Drug development and industrial pharmacy 20081201

Title: Potential utility of peripherally applied loperamide in oral chronic graft-versus-host disease related pain.

Journal: Japanese journal of clinical oncology 20081201

Title: Tariquidar, a selective P-glycoprotein inhibitor, does not potentiate loperamide's opioid brain effects in humans despite full inhibition of lymphocyte P-glycoprotein.

Journal: Anesthesiology 20081201

Title: Outcomes of combination treatment of fecal incontinence in women.

Journal: American journal of obstetrics and gynecology 20081201

Title: [A case of giant cell microscopic colitis?].

Journal: Annales de pathologie 20081201

Title: Antidiarrhoeal activity of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rodents.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20081201

Title: Hypothesis on reciprocal interactions between the central and peripheral components of the endogenous opioid system.

Journal: Bulletin of experimental biology and medicine 20081201

Title: Local loperamide inhibits thermal hyperalgesia but not mechanical allodynia induced by intratibial inoculation of melanoma cells in mice.

Journal: Cellular and molecular neurobiology 20081101

Title: Loperamide for the treatment of traveler's diarrhea: broad or narrow usefulness?

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20081015

Title: Effect of adjunctive loperamide in combination with antibiotics on treatment outcomes in traveler's diarrhea: a systematic review and meta-analysis.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20081015

Title: Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function.

Journal: Journal of medicinal chemistry 20081009

Title: The effects of herkinorin, the first mu-selective ligand from a salvinorin A-derived scaffold, in a neuroendocrine biomarker assay in nonhuman primates.

Journal: The Journal of pharmacology and experimental therapeutics 20081001

Title: Inappropriate use of loperamide worsens Clostridium difficile-associated diarrhoea.

Journal: The Journal of hospital infection 20081001

Title: Validation of 13C-acetic acid breath test by measuring effects of loperamide, morphine, mosapride, and itopride on gastric emptying in mice.

Journal: Biological & pharmaceutical bulletin 20081001

Title: Changes of intestinal mucosal and plasma PYY in a diarrhea model rat and influence of loperamide as the treatment agent for diarrhea.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080901

Title: Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury.

Journal: Pain 20080831

Title: Diarrhea in adults (acute).

Journal: American family physician 20080815

Title: In situ dissolution testing using potentiometric sensors.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20080807

Title: [Clinical efficacy of buzhong yiqi pill combined with imodium in treating post-operational diarrhea in patients of colonic cancer].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080801

Title: Drugs for traveler's diarrhea.

Journal: The Medical letter on drugs and therapeutics 20080728

Title: Fibre supplementation in addition to loperamide for faecal incontinence in adults: a randomized trial.

Journal: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20080701

Title: Cannabidiol, extracted from Cannabis sativa, selectively inhibits inflammatory hypermotility in mice.

Journal: British journal of pharmacology 20080701

Title: Effects of serotonin 5-HT(3) receptor antagonists on CRF-induced abnormal colonic water transport and defecation in rats.

Journal: European journal of pharmacology 20080610

Title: P-glycoprotein contributes to the blood-brain, but not blood-cerebrospinal fluid, barrier in a spontaneous canine p-glycoprotein knockout model.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080601

Title: [Topic: Treating travelers' diarrhea. When should medication be given?].

Journal: Der Urologe. Ausg. A 20080601

Title: Modest effect of impaired P-glycoprotein on the plasma concentrations of fexofenadine, quinidine, and loperamide following oral administration in collies.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080501

Title: Maternal use of loperamide in early pregnancy and delivery outcome.

Journal: Acta paediatrica (Oslo, Norway : 1992) 20080501

Title: Medical prevention and treatment of acute and chronic radiation induced enteritis--is there any proven therapy? a short review.

Journal: Zeitschrift fur Gastroenterologie 20080501

Title: Limited effects of beta-endorphin compared to loperamide or fentanyl in a neuroendocrine biomarker assay in non-human primates.

Journal: Psychoneuroendocrinology 20080401

Title: Binding site of loperamide: automated docking of loperamide in human mu- and delta-opioid receptors.

Journal: Chemical biology & drug design 20080401

Title: 11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080401

Title: Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles.

Journal: Bioorganic & medicinal chemistry letters 20080315

Title: Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay.

Journal: European journal of pharmacology 20080226

Title: Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080201

Title: Enhanced peripheral analgesia using virally mediated gene transfer of the mu-opioid receptor in mice.

Journal: Anesthesiology 20080201

Title: Inhibitory effects of ramosetron, a potent and selective 5-HT3-receptor antagonist, on conditioned fear stress-induced abnormal defecation and normal defecation in rats: comparative studies with antidiarrheal and spasmolytic agents.

Journal: Journal of pharmacological sciences 20080201

Title: Inhibition of phosphodiesterase type 4 decreases stress-induced defecation in rats and mice.

Journal: Pharmacology 20080101

Title: The role of loperamide in gastrointestinal disorders.

Journal: Reviews in gastroenterological disorders 20080101

Title: [Antibiotic-associated diarrheas in phthisiatric care: standardization of their diagnosis, treatment, prevention, examination of health care quality].

Journal: Problemy tuberkuleza i boleznei legkikh 20080101

Title: [Treating travelers' diarrhea. When should medication be given?].

Journal: Der Internist 20071201

Title: Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats.

Journal: European journal of pharmacology 20071114

Title: Specificity of procaine and ester hydrolysis by human, minipig, and rat skin and liver.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20071101

Title: Targeting the central nervous system: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20070911

Title: Purification of PEGylated nanoparticles using tangential flow filtration (TFF).

Journal: Drug development and industrial pharmacy 20070901

Title: Death due to anaphylactic shock after ingestion of Imodium instants (Loperamide).

Journal: Allergy 20070801

Title: [Diagnostic and therapeutic guidelines for entero-cutaneous fistulas. Personal experience and literature review].

Journal: Minerva chirurgica 20070801

Title: Azithromycin and loperamide are comparable to levofloxacin and loperamide for the treatment of traveler's diarrhea in United States military personnel in Turkey.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070801

Title: Relative contribution of peripheral versus central opioid receptors to antinociception.

Journal: Brain research 20070730

Title: Involvement of nitric oxide in the inhibition of bone cancer-induced hyperalgesia through the activation of peripheral opioid receptors in mice.

Journal: Neuropharmacology 20070701

Title: Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice.

Journal: Journal of pharmacological sciences 20070701

Title: Evaluation of the pharmacological profile of ramosetron, a novel therapeutic agent for irritable bowel syndrome.

Journal: Journal of pharmacological sciences 20070701

Title: Collagenous colitis in a patient with systemic sclerosis: a rare entity.

Journal: Journal of the National Medical Association 20070601

Title: Chemotherapy-induced mucositis: focusing on diarrhea.

Journal: The journal of supportive oncology 20070601

Title: A case of toxic megacolon secondary to Clostridium difficile-associated diarrhea worsened after administration of an antimotility agent and molecular analysis of recovered isolates.

Journal: Journal of gastroenterology 20070601

Title: Direct inhibition of Ih by analgesic loperamide in rat DRG neurons.

Journal: Journal of neurophysiology 20070501

Title: Randomized, double-blind, placebo-controlled clinical trial of loperamide plus simethicone versus loperamide alone and simethicone alone in the treatment of acute diarrhea with gas-related abdominal discomfort.

Journal: Current medical research and opinion 20070501

Title: Treatment of travelers' diarrhea: randomized trial comparing rifaximin, rifaximin plus loperamide, and loperamide alone.

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070401

Title: 86-year-old woman with abdominal pain and diarrhea.

Journal: Mayo Clinic proceedings 20070401

Title: Activation of mu-opioid receptors improves insulin sensitivity in obese Zucker rats.

Journal: Life sciences 20070327

Title: Pharmacological modulation of gut mucosal and large vessel blood flow.

Journal: Alimentary pharmacology & therapeutics 20070315

Title: Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20070312

Title: Pharmacotherapy for microscopic colitis.

Journal: Pharmacotherapy 20070301

Title: [Drug treatment of irritable bowel syndrome: an unmet need].

Journal: Gastroenterologia y hepatologia 20070301

Title: Loperamide therapy for acute diarrhea in children: systematic review and meta-analysis.

Journal: PLoS medicine 20070301

Title: Use of probiotics for prevention of radiation-induced diarrhea.

Journal: World journal of gastroenterology 20070214

Title: Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors.

Journal: Neuroscience letters 20070110

Title: Fulminant amoebic colitis following loperamide use.

Journal: Journal of travel medicine 20070101

Title: Loperamide cause of prolonged urinary retention after acute gastroenteritis.

Journal: European review for medical and pharmacological sciences 20070101

Title: Loperamide plus azithromycin more effectively treats travelers' diarrhea in Mexico than azithromycin alone.

Journal: Journal of travel medicine 20070101

Title: The benefits of loperamide in the treatment of patients with IBS or IBD. Introduction.

Journal: Reviews in gastroenterological disorders 20070101

Title: Loperamide: a pharmacological review.

Journal: Reviews in gastroenterological disorders 20070101

Title: Treatment of diarrhea in patients with inflammatory bowel disease: concepts and cautions.

Journal: Reviews in gastroenterological disorders 20070101

Title: P-Glycoprotein (P-gp) expressed in a confluent monolayer of hMDR1-MDCKII cells has more than one efflux pathway with cooperative binding sites.

Journal: Biochemistry 20061226

Title: Investigation on the relationship between cannabinoid CB1 and opioid receptors in gastrointestinal motility in mice.

Journal: British journal of pharmacology 20060801

Title: Intrasperm Ca2+ modulation and human ejaculated sperm viability: influence of miconazole, clotrimazole and loperamide.

Journal: The Journal of pharmacy and pharmacology 20060801

Title: Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier.

Journal: The Journal of pharmacology and experimental therapeutics 20060601

Title: Covalent linkage of apolipoprotein e to albumin nanoparticles strongly enhances drug transport into the brain.

Journal: The Journal of pharmacology and experimental therapeutics 20060601

Title: Itraconazole, gemfibrozil and their combination markedly raise the plasma concentrations of loperamide.

Journal: European journal of clinical pharmacology 20060601

Title: Synthesis and pharmacological activity of 2-(substituted)-3-{2-[(4-phenyl-4-cyano)piperidino]ethyl}-1,3-thiazolidin-4-ones.

Journal: Chemical biology & drug design 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Effect of opioid mu-receptors activation on insulin signals damaged by tumor necrosis factor alpha in myoblast C2C12 cells.

Journal: Neuroscience letters 20060424

Title: In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060401

Title: mu-Opiate receptor agonists -- a new pharmacological approach to prevent motion sickness?

Journal: British journal of clinical pharmacology 20060101

Title: Synthesis and smooth muscle-selective relaxant activity of a piperidine analogue: 1-(4'-fluorophenacyl)-4-hydroxy-4-phenyl-piperidinium chloride.

Journal: Archives of pharmacal research 20060101

Title: Loperamide: a potential topical analgesic for the treatment of burn pain.

Journal: Journal of burn care & research : official publication of the American Burn Association 20060101

Title: Octreotide long-acting formulation (LAR) in chronic loperamide-refractory diarrhea not related to cancer treatment.

Journal: Anticancer research 20060101

Title: Drug interactions and pharmacogenetic reactions are the basis for chloroquine and mefloquine-induced psychosis.

Journal: Medical hypotheses 20060101

Title: Desorption electrospray ionisation mass spectrometry and tandem mass spectrometry of low molecular weight synthetic polymers.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Octreotide in the management of chemoradiotherapy-induced diarrhea refractory to loperamide in patients with rectal carcinoma.

Journal: Oncology 20060101

Title: Treatment of irritable bowel syndrome.

Journal: American family physician 20051215

Title: [New views on antidiarrheal effect of wood creosote: is wood creosote really a gastrointestinal antiseptic?].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20051201

Title: Analgesic effects of morphine and loperamide in the rat formalin test: interactions with NMDA receptor antagonists.

Journal: European journal of pharmacology 20051121

Title: Saccharomyces boulardii inhibits water and electrolytes changes induced by castor oil in the rat colon.

Journal: Digestive diseases and sciences 20051101

Title: [Traveller's diarrhea].

Journal: Ugeskrift for laeger 20051024

Title: Block of delayed-rectifier potassium channels by reduced haloperidol and related compounds in mouse cortical neurons.

Journal: The Journal of pharmacology and experimental therapeutics 20051001

Title: The steady-state Michaelis-Menten analysis of P-glycoprotein mediated transport through a confluent cell monolayer cannot predict the correct Michaelis constant Km.

Journal: Pharmaceutical research 20051001

Title: mu-Opiate receptor agonist loperamide blocks bethanechol-induced gallbladder contraction, despite higher cholecystokinin plasma levels in man.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20051001

Title: Tissue distribution of loperamide and N-desmethylloperamide following a fatal overdose.

Journal: Journal of analytical toxicology 20051001

Title: The effects of loperamide on continence problems and anorectal function in obese subjects taking orlistat.

Journal: Digestive diseases and sciences 20050901

Title: Activation of opioid mu-receptors by loperamide to improve interleukin-6-induced inhibition of insulin signals in myoblast C2C12 cells.

Journal: Diabetologia 20050701

Title: Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide.

Journal: The Journal of pharmacology and experimental therapeutics 20050601

Title: Acute colitis induction by oil of mustard results in later development of an IBS-like accelerated upper GI transit in mice.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050601

Title: Physical stability of the amorphous state of loperamide and two fragment molecules in solid dispersions with the polymers PVP-K30 and PVP-VA64.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050601

Title: Loperamide inhibits tachykinin NK3-receptor-triggered serotonin release without affecting NK2-receptor-triggered serotonin release from guinea pig colonic mucosa.

Journal: Journal of pharmacological sciences 20050601

Title: Gastroenteritis in children.

Journal: Clinical evidence 20050601

Title: Comparison between prospective and retrospective evaluation of Crohn's disease activity index.

Journal: The American journal of gastroenterology 20050501

Title: Analgesic effects of loperamide in bone cancer pain in mice.

Journal: Pharmacology, biochemistry, and behavior 20050501

Title: Acute analgesic effect of loperamide as compared to morphine after intrathecal administration in rat.

Journal: Indian journal of experimental biology 20050501

Title: Nociceptive sensitivity and opioid antinociception and antihyperalgesia in Freund's adjuvant-induced arthritic male and female rats.

Journal: The Journal of pharmacology and experimental therapeutics 20050401

Title: Loperamide.

Journal: Nursing times 20050401

Title: A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults.

Journal: World journal of gastroenterology 20050314

Title: Relationship between loperamide-induced sedative effect and digoxin pharmacokinetics in healthy Japanese subjects.

Journal: Pharmaceutical research 20050301

Title: [Time and again digestion problems. What really helps in irritable bowel syndrome?].

Journal: MMW Fortschritte der Medizin 20050224

Title: [Fixed drug eruption associated to loperamide].

Journal: Medicina clinica 20050212

Title: Validation of a liquid chromatographic-tandem mass spectrometric method for the determination of loperamide in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050125

Title: The elementary mass action rate constants of P-gp transport for a confluent monolayer of MDCKII-hMDR1 cells.

Journal: Biophysical journal 20050101

Title: Study of the physicochemical properties and stability of solid dispersions of loperamide and PEG6000 prepared by spray drying.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050101

Title: Loperamide inhibits the biliary excretion of irinotecan (CPT-11) in the rat isolated perfused liver.

Journal: The Journal of pharmacy and pharmacology 20050101

Title: Salt formation in solid dispersions consisting of polyacrylic acid as a carrier and three basic model compounds resulting in very high glass transition temperatures and constant dissolution properties upon storage.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050101

Title: Effects of fasting on evaluation of gastrointestinal transit with charcoal meal.

Journal: Journal of pharmacological and toxicological methods 20050101

Title: Effectiveness of step-wise intervention plan for managing nelfinavir-associated diarrhea: a pilot study.

Journal: HIV clinical trials 20050101

Title: Gastroenteritis in children.

Journal: Clinical evidence 20041201

Title: A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041115

Title: Liquid chromatography-tandem mass spectrometry determination of loperamide and its main metabolite desmethylloperamide in biological specimens and application to forensic cases.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041105

Title: LC-MS determination and bioavailability study of loperamide hydrochloride after oral administration of loperamide capsule in human volunteers.

Journal: Journal of pharmaceutical and biomedical analysis 20041029

Title: Antiallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates.

Journal: The Journal of pharmacology and experimental therapeutics 20041001

Title: New approaches to prevent intestinal toxicity of irinotecan-based regimens.

Journal: Cancer treatment reviews 20041001

Title: Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes.

Journal: European journal of clinical pharmacology 20041001

Title: Use of loperamide as a phenotypic probe of mdr1a status in CF-1 mice.

Journal: Pharmaceutical research 20041001

Title: Multicenter, double-blind, randomized comparison of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, and loperamide in adults with acute nonspecific diarrhea.

Journal: Clinical therapeutics 20041001

Title: Identification of an N-methyl-4-phenylpyridinium-like metabolite of the antidiarrheal agent loperamide in human liver microsomes: underlying reason(s) for the lack of neurotoxicity despite the bioactivation event.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040901

Title: [Severe adverse effects of certain veterinary drugs in collies and collie-like dogs].

Journal: Tijdschrift voor diergeneeskunde 20040901

Title: Phase behaviour analysis of solid dispersions of loperamide and two structurally related compounds with the polymers PVP-K30 and PVP-VA64.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040801

Title: Neomycin as secondary prophylaxis for irinotecan-induced diarrhea.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20040801

Title: [Loss of consciousness in a child due to loperamide].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20040701

Title: [Management of chemotherapy induced diarrhea].

Journal: Zeitschrift fur Gastroenterologie 20040601

Title: pH dependent uptake of loperamide across the gastrointestinal tract: an in vitro study.

Journal: Drug development and industrial pharmacy 20040501

Title: Effect of finite doses of propylene glycol on enhancement of in vitro percutaneous permeation of loperamide hydrochloride.

Journal: International journal of pharmaceutics 20040415

Title: [Type 1 Gaucher's disease in the adult. Nutritional management during initiation of treatment with miglustat].

Journal: Presse medicale (Paris, France : 1983) 20040410

Title: Signals in the activation of opioid mu-receptors by loperamide to enhance glucose uptake into cultured C2C12 cells.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040401

Title: Anaphylaxis due to loperamide.

Journal: Allergy 20040301

Title: Yogic versus conventional treatment in diarrhea-predominant irritable bowel syndrome: a randomized control study.

Journal: Applied psychophysiology and biofeedback 20040301

Title: Variable modulation of opioid brain uptake by P-glycoprotein in mice.

Journal: Biochemical pharmacology 20040115

Title: Loperamide toxicity in a collie with the MDR1 mutation associated with ivermectin sensitivity.

Journal: Journal of veterinary internal medicine 20040101

Title: Treatment of travelers' diarrhea among Austrian tourists.

Journal: Journal of travel medicine 20040101

Title: Loperamide modifies the tissue disposition kinetics of ivermectin in rats.

Journal: The Journal of pharmacy and pharmacology 20040101

Title: The clinical and pathologic significance of microscopic colitis.

Journal: Journal of clinical gastroenterology 20040101

Title: The effect of two antidiarrhoeal drugs on the psychosocial adjustment to illness in chronic functional diarrhoea.

Journal: Romanian journal of internal medicine = Revue roumaine de medecine interne 20040101

Title: Reduction of saquinavir exposure by coadministration of loperamide: a two-way pharmacokinetic interaction.

Journal: Clinical pharmacokinetics 20040101

Title: Lethal gastroenteritis associated with clozapine and loperamide.

Journal: The American journal of psychiatry 20031201

Title: Gastroenteritis in children.

Journal: Clinical evidence 20031201

Title: Irritable bowel syndrome.

Journal: The New England journal of medicine 20031127

Title: Potential roles of P-gp and calcium channels in loperamide and diphenoxylate transport.

Journal: Toxicology and applied pharmacology 20031115

Title: Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers.

Journal: Pharmacogenetics 20031101

Title: No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects.

Journal: Clinical pharmacology and therapeutics 20031101

Title: Development of tolerance to the inhibitory effect of loperamide on gastrointestinal transit in mice.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20031101

Title: Management of acute cancer treatment-induced diarrhea.

Journal: Seminars in oncology nursing 20031101

Title: Loperamide increases glucose ultilization in streptozotocin-induced diabetic rats.

Journal: Clinical and experimental pharmacology & physiology 20031001

Title: Chronic diarrhoea in HIV-1-infected adults in Nairobi, Kenya: evaluation of risk factors and the WHO treatment algorithm.

Journal: AIDS (London, England) 20030926

Title: [Current and future prospects of the treatment of the irritable bowel syndrome].

Journal: Revista clinica espanola 20030901

Title: Analgesic action of loperamide, an opioid agonist, and its blocking action on voltage-dependent Ca2+ channels.

Journal: Neuroscience research 20030801

Title: Loperamide suppositories in an adolescent with childhood-onset functional non-retentive fecal soiling.

Journal: Journal of pediatric gastroenterology and nutrition 20030801

Title: Sodium pentobarbital anesthesia transiently enhances the severity of infection following intragastric, but not intravenous, inoculation of Listeria monocytogenes in mice.

Journal: Microbial pathogenesis 20030801

Title: Watermelon colon: case report and review.

Journal: Gastrointestinal endoscopy 20030701

Title: Evaluation of different calorimetric methods to determine the glass transition temperature and molecular mobility below T(g) for amorphous drugs.

Journal: International journal of pharmaceutics 20030618

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Journal: International journal of pharmaceutics 20030618

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Journal: Deutsche medizinische Wochenschrift (1946) 20030606

Title: Peripheral opioids act as analgesics in bone cancer pain in mice.

Journal: Neuroreport 20030506

Title: Suspicion of microscopic colitis raised by sonographic examination.

Journal: Journal of clinical ultrasound : JCU 20030501

Title: Loperamide mobilizes intracellular Ca2+ stores in insulin-secreting HIT-T15 cells.

Journal: British journal of pharmacology 20030501

Title: I get occasional diarrhea. Is there anything nonprescription that's particularly effective for that?

Journal: Mayo Clinic health letter (English ed.) 20030501

Title: [Ileus after the use of loperamide in a child with acute diarrhea].

Journal: Nederlands tijdschrift voor geneeskunde 20030405

Title: Antidiarrhoeal activity of hot water extract of black tea (Camellia sinensis).

Journal: Phytotherapy research : PTR 20030401

Title: Effect of loperamide on gastro-oesophageal reflux.

Journal: Scandinavian journal of gastroenterology 20030401

Title: Dose-response relationship and mechanism of action of Saccharomyces boulardii in castor oil-induced diarrhea in rats.

Journal: Digestive diseases and sciences 20030401

Title: Racecadotril versus loperamide: antidiarrheal research revisited.

Journal: Digestive diseases and sciences 20030201

Title: Morphine and d-amphetamine nullify each others' hypothermic effects in mice.

Journal: Pharmacology & toxicology 20030201

Title: Potentiation of the antiproliferative activity of MKT-077 by loperamide, diltiazem and tamoxifen.

Journal: Oncology reports 20030101

Title: Effects of full-thickness burns on nociceptor sensitization in anesthetized rats.

Journal: Burns : journal of the International Society for Burn Injuries 20021201

Title: Acute gastroenteritis in children.

Journal: Clinical evidence 20021201

Title: Spreading depression: imaging and blockade in the rat neocortical brain slice.

Journal: Journal of neurophysiology 20021101

Title: Evidence-based position statement on the management of irritable bowel syndrome in North America.

Journal: The American journal of gastroenterology 20021101

Title: Systematic review on the management of irritable bowel syndrome in North America.

Journal: The American journal of gastroenterology 20021101

Title: Antipruritic and antihyperalgesic actions of loperamide and analogs.

Journal: Life sciences 20021025

Title: Antidiarrhoeal activity of seed extract of Albizzia lebbeck Benth.

Journal: Phytotherapy research : PTR 20020901

Title: [Travellers' acute diarrhea].

Journal: Revue medicale de la Suisse romande 20020901

Title: [Taking charge of adult's anal incontinence].

Journal: Revue medicale de la Suisse romande 20020901

Title: A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults.

Journal: Scandinavian journal of gastroenterology 20020601

Title: Acute gastroenteritis in children.

Journal: Clinical evidence 20020601

Title: Short bowel syndrome: a nutritional and medical approach.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20020514

Title: Fecal incontinence in anorectal malformations, neuropathy, and miscellaneous conditions.

Journal: Seminars in pediatric surgery 20020501

Title: Advice for travelers.

Journal: The Medical letter on drugs and therapeutics 20020415

Title: Spinal and peripheral mu opioids and the development of secondary tactile allodynia after thermal injury.

Journal: Anesthesia and analgesia 20020401

Title: Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein.

Journal: Anesthesiology 20020401

Title: Urinary retention with loperamide.

Journal: Prescrire international 20020401

Title: Loperamide-induced enhancement of moxidectin availability in cattle.

Journal: Journal of veterinary pharmacology and therapeutics 20020401

Title: Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats.

Journal: Neuropharmacology 20020201

Title: Determination of the active ingredient loperamide hydrochloride in pharmaceutical caplets by high performance thin layer chromatography with ultraviolet absorption densitometry of fluorescence quenched zones.

Journal: Acta poloniae pharmaceutica 20020101

Title: Efficacy of prophylactic anti-diarrhoeal treatment in patients receiving Campto for advanced colorectal cancer.

Journal: Anticancer research 20020101

Title: Effects of yogurt supplemented with brewer's yeast cell wall on constipation and intestinal microflora in rats.

Journal: Journal of nutritional science and vitaminology 20011201

Title: Ritonavir increases loperamide plasma concentrations without evidence for P-glycoprotein involvement.

Journal: Clinical pharmacology and therapeutics 20011101

Title: From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands.

Journal: Journal of medicinal chemistry 20011011

Title: Clinical evaluation and management of acute infectious diarrhea in adults.

Journal: Gastroenterology clinics of North America 20010901

Title: Traveler's diarrhea.

Journal: Gastroenterology clinics of North America 20010901

Title: [Colonic microflora and motility. Physiological data and during irritable bowel syndrome].

Journal: Gastroenterologie clinique et biologique 20010901

Title: Effects of loperamide and other opioid-related substances on the transcriptional regulation of the rat pro-opiomelanocortin gene in AtT20 cells.

Journal: Neuroendocrinology 20010801

Title: Increase of opioid mu-receptor gene expression in streptozotocin-induced diabetic rats.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20010801

Title: Recent concepts in fecal incontinence.

Journal: Current women's health reports 20010801

Title: [What is effective in traveler's diarrhea? Current recommendations on prevention, therapy and after care].

Journal: MMW Fortschritte der Medizin 20010719

Title: A scintigraphic study to investigate the potential for altered gut distribution of loperamide from a loperamide-simethicone formulation in man.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010701

Title: Antisecretory effect of loperamide in colon epithelial cells by inhibition of basolateral K+ conductance.

Journal: Scandinavian journal of gastroenterology 20010701

Title: [Loperamide abuse in anxiety disorder].

Journal: Der Nervenarzt 20010701

Title: Sulfated polysaccharides, but not cellulose, increase colonic mucus in rats with loperamide-induced constipation.

Journal: Digestive diseases and sciences 20010701

Title: Guidelines for adults on self-medication for the treatment of acute diarrhoea.

Journal: Alimentary pharmacology & therapeutics 20010601

Title: Control of irinotecan-induced diarrhea by octreotide after loperamide failure.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20010601

Title: [Travelers' diarrhea].

Journal: Therapeutische Umschau. Revue therapeutique 20010601

Title: Does loperamide affect motor activity after proctocolectomy and ileal pouch-anal anastomosis? An experimental study in dogs.

Journal: International journal of colorectal disease 20010601

Title: Early pregnancy termination with vaginal misoprostol combined with loperamide and acetaminophen prophylaxis.

Journal: Contraception 20010401

Title: Effects of brewer's yeast cell wall on constipation and defecation in experimentally constipated rats.

Journal: Bioscience, biotechnology, and biochemistry 20010401

Title: Management of the irritable bowel syndrome.

Journal: Gastroenterology 20010201

Title: Drug transporters revisited.

Journal: Journal of clinical psychopharmacology 20010201

Title: Optimal dosing of ofloxacin with loperamide in the treatment of non-dysenteric travelers' diarrhea.

Journal: Journal of travel medicine 20010101

Title: The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats.

Journal: European journal of pharmacology 19991112

Title: Herbal medicines as a factor in delirium.

Journal: Psychiatric services (Washington, D.C.) 19990701

Title: Effect of the 5-hydroxytryptamine3 (5-HT3)-receptor antagonist KB-R6933 on experimental diarrhea models.

Journal: Japanese journal of pharmacology 19990501

Title: Role of tachykinins in castor oil diarrhoea in rats.

Journal: British journal of pharmacology 19970501

Title: Antidiarrhoeal activity of new thiazolidinones related to loperamide.

Journal: The Journal of pharmacy and pharmacology 19960701

Title: Difenoxin and loperamide: studies on possible mechanisms of intestinal antisecretory action.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19930201

Title: Toxic delirium possibly caused by loperamide.

Journal: The Journal of pediatrics 19910401

Title: Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors.

Journal: European journal of pharmacology 19871201

Title: Loperamide toxicity in severe protracted diarrhoea.

Journal: Archives of disease in childhood 19830701

Title: [Neurological symptoms precipitated by loperamide (author's transl)].

Journal: Anales espanoles de pediatria 19801201

Title: In vivo antimotility and antidiarrheal activity of lidamidine hydrochloride (WHR-1142A), a novel antidiarrheal agent. Comparison with diphenoxylate and loperamide.

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Title: Hatfield MJ, et al. Carboxylesterase inhibitors. Expert Opin Ther Pat. 2011 Aug;21(8):1159-71.

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Tags:34552-83-5 Molecular Formula|34552-83-5 MDL|34552-83-5 SMILES|34552-83-5 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride