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348086-71-5,MFCD18633192
Catalog No.:AA00C6BN

348086-71-5 | N-Methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide

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1mg
95%
in stock  
$15.00   $11.00
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5mg
95%
in stock  
$37.00   $26.00
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10mg
95%
in stock  
$52.00   $36.00
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25mg
95%
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$73.00   $51.00
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250mg
95%
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$427.00   $299.00
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1g
95%
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$1,081.00   $757.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C6BN
Chemical Name:
N-Methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide
CAS Number:
348086-71-5
Molecular Formula:
C18H18N4O3S2
Molecular Weight:
402.4905
MDL Number:
MFCD18633192
SMILES:
O=C(N(c1nc(c(s1)S(=O)(=O)N)C)C)Cc1ccc(cc1)c1ccccn1
Properties
Computed Properties
 
Complexity:
617  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
2.1  

Downstream Synthesis Route
348086-68-0    5728-52-9   
N-5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl-N-methyl-2-4-(2-pyridinyl)-phenylacetamide 

[1]CurrentPatentAssignee:AICURISGMBH&CO.KG-US2004/6076,2004,A1Locationinpatent:Page16

[1]CurrentPatentAssignee:AICURISGMBH&CO.KG-EP2573086,2013,A1Locationinpatent:Paragraph0071

[2]CurrentPatentAssignee:AICURISGMBH&CO.KG-WO2013/45479,2013,A1Locationinpatent:Page/Pagecolumn22

[3]CurrentPatentAssignee:AICURISGMBH&CO.KG-US2004/6076,2004,A1Locationinpatent:Page16-17

[4]Carta,Fabrizio;Birkmann,Alexander;Pfaff,Tamara;Buschmann,Helmut;Schwab,Wilfried;Zimmermann,Holger;Maresca,Alfonso;Supuran,ClaudiuT.[JournalofMedicinalChemistry,2017,vol.60,#7,p.3154-3164]

[5]CurrentPatentAssignee:AICURISGMBH&CO.KG-WO2018/96170,2018,A1Locationinpatent:Page/Pagecolumn41;42

CASUnavailable 
  348086-71-5 

[1]CurrentPatentAssignee:AICURISGMBH&CO.KG-EP2573086,2013,A1

[1]CurrentPatentAssignee:AICURISGMBH&CO.KG-EP2573086,2013,A1

[1]CurrentPatentAssignee:AICURISGMBH&CO.KG-EP2573086,2013,A1Locationinpatent:Paragraph0072

[2]CurrentPatentAssignee:AICURISGMBH&CO.KG-WO2013/45479,2013,A1Locationinpatent:Page/Pagecolumn22-23

Literature

Title: Baseline sensitivity of HSV-1 and HSV-2 clinical isolates and defined acyclovir-resistant strains to the helicase-primase inhibitor pritelivir.

Journal: Antiviral research 20131101

Title: ASP2151, a novel helicase-primase inhibitor, possesses antiviral activity against varicella-zoster virus and herpes simplex virus types 1 and 2.

Journal: The Journal of antimicrobial chemotherapy 20100801

Title: Efficacy of a helicase-primase inhibitor in animal models of ocular herpes simplex virus type 1 infection.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080201

Title: Herpes simplex virus helicase-primase inhibitors: recent findings from the study of drug resistance mutations.

Journal: Antiviral chemistry & chemotherapy 20080101

Title: The helicase primase inhibitor, BAY 57-1293 shows potent therapeutic antiviral activity superior to famciclovir in BALB/c mice infected with herpes simplex virus type 1.

Journal: Antiviral research 20070701

Title: Superior efficacy of helicase-primase inhibitor BAY 57-1293 for herpes infection and latency in the guinea pig model of human genital herpes disease.

Journal: Antiviral chemistry & chemotherapy 20070101

Title: Antiviral therapies.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20040401

Title: Potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor BAY 57-1293.

Journal: Antimicrobial agents and chemotherapy 20020601

Title: New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease.

Journal: Nature medicine 20020401

Title: Ligat G, et al. Identification of Amino Acids Essential for Viral Replication in the HCMV Helicase-PrimaseComplex. Front Microbiol. 2018 Oct 23;9:2483.

Title: Wald A, et al. Helicase-primase inhibitor Pritelivir for HSV-2 infection. N Engl J Med. 2014 Jan 16;370(3):201-10.

Title: Quenelle DC, et al. Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis. Antiviral Res. 2018 Jan;149:1-6.

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