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35691-65-7,MFCD00072483
Catalog No.:AA003P62

35691-65-7 | 1,2-Dibromo-2,4-dicyanobutane

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5g
>98.0%(GC)
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25g
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100g
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA003P62
Chemical Name:
1,2-Dibromo-2,4-dicyanobutane
CAS Number:
35691-65-7
Molecular Formula:
C6H6Br2N2
Molecular Weight:
265.9332
MDL Number:
MFCD00072483
SMILES:
N#CCCC(C#N)(CBr)Br
UN Number:
3261
Properties
Properties
 
BP:
212 °C  
Form:
Solid  
MP:
48-50°C  
Refractive Index:
1.6300 (estimate)  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
196  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1.4  

Literature

Title: An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20170401

Title: SENS-IS, a 3D reconstituted epidermis based model for quantifying chemical sensitization potency: Reproducibility and predictivity results from an inter-laboratory study.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160401

Title: Dual regulation of skin sensitizer-induced HMOX1 expression by Bach1 and Nrf2: Comparison to regulation of the AKR1C2-ARE element in the KeratinoSens cell line.

Journal: Toxicology and applied pharmacology 20151101

Title: Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20150601

Title: Development of a new in vitro skin sensitization assay (Epidermal Sensitization Assay; EpiSensA) using reconstructed human epidermis.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20131201

Title: NCTC 2544 and IL-18 production: a tool for the identification of contact allergens.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130401

Title: Development of an in vitro dendritic cell-based test for skin sensitizer identification.

Journal: Chemical research in toxicology 20130318

Title: Undisclosed methyldibromo glutaronitrile causing allergic contact dermatitis in a NSAID cream.

Journal: Contact dermatitis 20120901

Title: Simple and rapid analysis of methyldibromo glutaronitrile in cosmetic products by gas chromatography mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20111215

Title: An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20111201

Title: [Current contact allergens].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20111001

Title: Can exposure limitations for well-known contact allergens be simplified? An analysis of dose-response patch test data.

Journal: Contact dermatitis 20110601

Title: Contact hypersensitivity to epoxy resin, methyldibromoglutaronitrile, tixocortol pivalate and budesonide in Hungary: a study in 1448 patients.

Journal: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 20110201

Title: Patch testing in allergic contact dermatitis: is it useful to perform the cosmetic series in addition to the European standard series?

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20101001

Title: Ethosome formulation of contact allergens may enhance patch test reactions in patients.

Journal: Contact dermatitis 20101001

Title: Quantitative repeated open application testing with a rinse-off product in methyldibromo glutaronitrile-sensitive patients: results of the IVDK.

Journal: Contact dermatitis 20100601

Title: NTP technical report on the toxicology and carcinogenesis studies of 1,2-dibromo-2,4-dicyanobutane (CAS No. 35691-65-7) in F344/N rats and B6C3F1 mice (dermal studies).

Journal: National Toxicology Program technical report series 20100601

Title: Methyldibromoglutaronitrile: skin sensitization and quantitative risk assessment.

Journal: Cutaneous and ocular toxicology 20100301

Title: Temporal trends of preservative allergy in Denmark (1985-2008).

Journal: Contact dermatitis 20100201

Title: Patch testing with methyldibromoglutaronitrile in a localized population in the United States.

Journal: Dermatitis : contact, atopic, occupational, drug 20100101

Title: The dose-response relationship between the patch test and ROAT and the potential use for regulatory purposes.

Journal: Contact dermatitis 20091001

Title: Hand dermatitis: a focus on allergic contact dermatitis to biocides.

Journal: Dermatologic clinics 20090701

Title: [Contact sensitization to Euxyl K-400].

Journal: Actas dermo-sifiliograficas 20090401

Title: Patch test dose-response study: polysensitized individuals do not express lower elicitation thresholds than single/double-sensitized individuals.

Journal: The British journal of dermatology 20090101

Title: Methyldibromoglutaronitrile allergy: relationship between patch test and repeated open application test thresholds.

Journal: The British journal of dermatology 20081101

Title: New aspects in allergic contact dermatitis.

Journal: Current opinion in allergy and clinical immunology 20081001

Title: Proliferative responses in the local lymph node assay associated with concomitant exposure to 1,4-phenylenediamine and methyldibromo glutaronitrile: evidence for synergy?

Journal: Contact dermatitis 20080801

Title: Decreasing trends in methyldibromo glutaronitrile contact allergy--following regulatory intervention.

Journal: Contact dermatitis 20080701

Title: Repeated open application tests with methyldibromoglutaronitrile in dermatitis patients with and without hypersensitivity to methyldibromoglutaronitrile.

Journal: Dermatitis : contact, atopic, occupational, drug 20071201

Title: Occupational allergic contact dermatitis to methyldibromoglutaronitrile in hand degreasing toilet paper.

Journal: Contact dermatitis 20070801

Title: Consort allergic dermatitis to cosmetic agents in a 10-year-old young girl.

Journal: Contact dermatitis 20070701

Title: A further characteristic of susceptibility to contact allergy: sensitization to a weak contact allergen is associated with polysensitization. Results of the IVDK.

Journal: Contact dermatitis 20070601

Title: Contact allergy epidemics and their controls.

Journal: Contact dermatitis 20070401

Title: Allergic contact dermatitis from methyldibromo glutaronitrile in a sanitary pad and review of Australian clinic data.

Journal: Contact dermatitis 20070301

Title: Variation in the amount of petrolatum preparation applied at patch testing.

Journal: Contact dermatitis 20070101

Title: Identification and classification of skin sensitizers: identifying false positives and false negatives.

Journal: Contact dermatitis 20061101

Title: Preservatives sensitivity in Israel: a 10-year overview (1995-2004).

Journal: Contact dermatitis 20061001

Title: [The most frequent allergens in allergic contact dermatitis].

Journal: Deutsche medizinische Wochenschrift (1946) 20060714

Title: Methyldibromoglutaronitrile contact allergy--the beginning of the end?

Journal: Contact dermatitis 20060401

Title: Connubial allergic contact dermatitis to Euxyl K 400.

Journal: Contact dermatitis 20060201

Title: A clinically relevant contact allergy to methyldibromo glutaronitrile at 1% (0.32 mg/cm) detected by a patch test.

Journal: Contact dermatitis 20060101

Title: Increased retest reactivity by both patch and use test with methyldibromoglutaronitrile in sensitized individuals.

Journal: Acta dermato-venereologica 20060101

Title: Allergic contact dermatitis due to methyldibromo glutaronitrile in make-up removal wipes.

Journal: Contact dermatitis 20051201

Title: Patch testing with patients' own cosmetics and toiletries--results of the IVDK*, 1998-2002.

Journal: Contact dermatitis 20051001

Title: Contact sensitivity to preservatives in Turkey.

Journal: Contact dermatitis 20050601

Title: Allergic contact dermatitis from methyldibromoglutaronitrile.

Journal: Dermatitis : contact, atopic, occupational, drug 20050601

Title: [Allergy to methyldibromoglutaronitrile (dibromodicyanobutane)].

Journal: Annales de dermatologie et de venereologie 20050501

Title: Quantitative patch and repeated open application testing in methyldibromo glutaronitrile-sensitive patients.

Journal: Contact dermatitis 20050401

Title: Contact allergy to methyldibromo glutaronitrile--data from a 'front line' network.

Journal: Contact dermatitis 20050301

Title: Methyldibromo glutaronitrile contact allergy: effect of single versus repeated daily exposure.

Journal: Contact dermatitis 20050201

Title: Allergic contact dermatitis from methyldibromo glutaronitrile--clinical cases from 2003.

Journal: Contact dermatitis 20050101

Title: Patch testing with methyldibromo glutaronitrile, a multicentre study within the EECDRG.

Journal: Contact dermatitis 20050101

Title: Repeated open application test with methyldibromo glutaronitrile, a multicentre study within the EECDRG.

Journal: Contact dermatitis 20050101

Title: Recommendation to include methyldibromo glutaronitrile in the European standard patch test series.

Journal: Contact dermatitis 20050101

Title: [Will methyldibromo glutaronitrile (Euxyl K400) be the contact allergen of the year 2005 in Navarra?].

Journal: Anales del sistema sanitario de Navarra 20050101

Title: Methyldibromoglutaronitrile in leave-on products elicits contact allergy at low concentration.

Journal: The British journal of dermatology 20041001

Title: Determination of methyldibromoglutaronitrile in cosmetic products by high-performance liquid chromatography with electrochemical detection. Method validation.

Journal: Journal of chromatography. A 20040326

Title: Methyldibromoglutaronitrile in rinse-off products causes allergic contact dermatitis: an experimental study.

Journal: The British journal of dermatology 20040101

Title: Influence of a detergent on skin response to methyldibromo glutaronitrile in sensitized individuals.

Journal: Contact dermatitis 20040101

Title: Post-coital contact dermatitis from methyldibromo glutaronitrile.

Journal: Contact dermatitis 20040101

Title: Hypersensitivity to preservatives.

Journal: Dermatologic therapy 20040101

Title: Stability of patch test preparations of methyldibromo glutaronitrile in petrolatum.

Journal: Contact dermatitis 20040101

Title: Increased positive patch test reactivity to methyldibromo glutaronitrile.

Journal: Contact dermatitis 20030801

Title: Methyldibromo glutaronitrile: clinical experience and exposure-based risk assessment.

Journal: Contact dermatitis 20030301

Title: Monitoring levels of preservative sensitivity in Europe. A 10-year overview (1991-2000).

Journal: Contact dermatitis 20020401

Title: Contact allergy to methyldibromo glutaronitrile in Euxyl K 400 in a cosmetic cream for protection against a permanent wave solution.

Journal: Contact dermatitis 20020401

Title: Occupational contact allergy to methyldibromo glutaronitrile in abrasive cleansers and work creams.

Journal: Contact dermatitis 20010501

Title: Allergic contact dermatitis due to methyldibromo glutaronitrile in Euxyl K 400 in an ultrasonic gel.

Journal: Contact dermatitis 20010101

Title: Allergic contact dermatitis due to deer-fat cream (Hirschtalgcreme).

Journal: Contact dermatitis 20010101

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