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357336-20-0,MFCD13152385
Catalog No.:AA00C92K

357336-20-0 | brivaracetam

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  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C92K
Chemical Name:
brivaracetam
CAS Number:
357336-20-0
Molecular Formula:
C11H20N2O2
Molecular Weight:
212.2887
MDL Number:
MFCD13152385
SMILES:
CCC[C@H]1CN(C(=O)C1)[C@H](C(=O)N)CC
Properties
Computed Properties
 
Complexity:
253  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
1  

Literature

Title: Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action.

Journal: Epilepsia 20160201

Title: Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission.

Journal: Scientific reports 20160101

Title: Effect of gemfibrozil on the metabolism of brivaracetam in vitro and in human subjects.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120801

Title: Recent and future antiepileptic drugs and their impact on cognition: what can we expect?

Journal: Expert review of neurotherapeutics 20120601

Title: Clavulanic acid does not affect convulsions in acute seizure tests in mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20120101

Title: Rational polytherapy in the treatment of acute seizures and status epilepticus.

Journal: Epilepsia 20111001

Title: Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties.

Journal: European journal of pharmacology 20110816

Title: Brivaracetam for the treatment of epilepsy.

Journal: Expert opinion on pharmacotherapy 20110801

Title: Neurocognitive effects of brivaracetam, levetiracetam, and lorazepam.

Journal: Epilepsia 20110201

Title: Pharmacotherapy of epilepsy: newly approved and developmental agents.

Journal: CNS drugs 20110201

Title: Increased compactibility of acetames after roll compaction.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110101

Title: Progress report on new antiepileptic drugs: a summary of the Tenth Eilat Conference (EILAT X).

Journal: Epilepsy research 20101201

Title: New drugs for pediatric epilepsy.

Journal: Seminars in pediatric neurology 20101201

Title: Emerging drugs for partial onset seizures.

Journal: Expert opinion on emerging drugs 20100901

Title: Brivaracetam does not alter spatial learning and memory in both normal and amygdala-kindled rats.

Journal: Epilepsy research 20100901

Title: Antiepileptic drug interactions - principles and clinical implications.

Journal: Current neuropharmacology 20100901

Title: Adjunctive brivaracetam for refractory partial-onset seizures: a randomized, controlled trial.

Journal: Neurology 20100810

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20100401

Title: Recent advances in adjunctive therapy for epilepsy: focus on sodium channel blockers as third-generation antiepileptic drugs.

Journal: Drugs of today (Barcelona, Spain : 1998) 20100401

Title: Physiologically based pharmacokinetic/pharmacodynamic animal-to-man prediction of therapeutic dose in a model of epilepsy.

Journal: Basic & clinical pharmacology & toxicology 20100301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20100301

Title: Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders.

Journal: Drugs 20100212

Title: Discovery of indolone acetamides as novel SV2A ligands with improved potency toward seizure suppression.

Journal: ChemMedChem 20100201

Title: Brivaracetam (ucb 34714) inhibits Na(+) current in rat cortical neurons in culture.

Journal: Epilepsy research 20100101

Title: What is the promise of new antiepileptic drugs in status epilepticus? Focus on brivaracetam, carisbamate, lacosamide, NS-1209, and topiramate.

Journal: Epilepsia 20091201

Title: Brivaracetam inhibits spreading depression in rat neocortical slices in vitro.

Journal: Seizure 20090701

Title: Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX).

Journal: Epilepsy research 20090101

Title: SVOP is a nucleotide binding protein.

Journal: PloS one 20090101

Title: Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions.

Journal: Pharmacological reports : PR 20090101

Title: Brivaracetam and seletracetam, two new SV2A ligands, improve paroxysmal dystonia in the dt sz mutant hamster.

Journal: European journal of pharmacology 20081228

Title: Debate: Does genetic information in humans help us treat patients? PRO--genetic information in humans helps us treat patients. CON--genetic information does not help at all.

Journal: Epilepsia 20081201

Title: Treatment of Lennox-Gastaut syndrome: overview and recent findings.

Journal: Neuropsychiatric disease and treatment 20081201

Title: Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A.

Journal: British journal of pharmacology 20080801

Title: Brivaracetam: a rational drug discovery success story.

Journal: British journal of pharmacology 20080801

Title: Effect of brivaracetam on cardiac repolarisation--a thorough QT study.

Journal: Current medical research and opinion 20080801

Title: The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after multiple increasing oral doses in healthy men.

Journal: British journal of clinical pharmacology 20080701

Title: New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels.

Journal: Current neurology and neuroscience reports 20080701

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20080401

Title: Brivaracetam: a new drug in development for epilepsy and neuropathic pain.

Journal: Expert opinion on investigational drugs 20080301

Title: The effectiveness of anticonvulsants in psychiatric disorders.

Journal: Dialogues in clinical neuroscience 20080301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20080301

Title: Pharmacokinetics and metabolism of 14C-brivaracetam, a novel SV2A ligand, in healthy subjects.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080101

Title: Pharmacological management of epilepsy: recent advances and future prospects.

Journal: Drugs 20080101

Title: Modifications of antiepileptic drugs for improved tolerability and efficacy.

Journal: Perspectives in medicinal chemistry 20080101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20071201

Title: Evaluation of brivaracetam, a novel SV2A ligand, in the photosensitivity model.

Journal: Neurology 20070904

Title: The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after single increasing oral doses in healthy males.

Journal: British journal of clinical pharmacology 20070601

Title: [A new aspect in the research on antiepileptic drugs].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20070201

Title: Progress report on new antiepileptic drugs: a summary of the Eigth Eilat Conference (EILAT VIII).

Journal: Epilepsy research 20070101

Title: Brivaracetam (UCB 34714).

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20070101

Title: Brivaracetam is superior to levetiracetam in a rat model of post-hypoxic myoclonus.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20070101

Title: Diverse mechanisms of antiepileptic drugs in the development pipeline.

Journal: Epilepsy research 20060601

Title: New antiepileptic drugs that are second generation to existing antiepileptic drugs.

Journal: Expert opinion on investigational drugs 20060601

Title: Brivaracetam UCB.

Journal: Current opinion in investigational drugs (London, England : 2000) 20050701

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20050101

Title: Antiepileptic drug discovery: lessons from the past and future challenges.

Journal: Acta neurologica Scandinavica. Supplementum 20050101

Title: Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity.

Journal: Journal of medicinal chemistry 20040129

Title: Symposium: the city: a viable environment for the elderly? Phase III: planning and delivery of health services. Background.

Journal: The Gerontologist 19760201

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