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3613-73-8,MFCD00387540
Catalog No.:AA00I72R

3613-73-8 | Dimebolin

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1mg
≥98%
in stock  
$30.00   $21.00
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5mg
≥98%
in stock  
$128.00   $89.00
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10mg
≥98%
in stock  
$225.00   $157.00
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25mg
≥98%
in stock  
$488.00   $341.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I72R
Chemical Name:
Dimebolin
CAS Number:
3613-73-8
Molecular Formula:
C21H25N3
Molecular Weight:
319.4433
MDL Number:
MFCD00387540
SMILES:
CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(nc1)C
Properties
Properties
 
BP:
505.7°C at 760 mmHg  
Form:
Solid  
MP:
115-116 °C  
Refractive Index:
1.6380 (estimate)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
425  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
3.5  

Literature

Title: Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.

Journal: Journal of medicinal chemistry 20140911

Title: Glutamate receptor modulator dimebon stimulates consolidation and reconsolidation of weak memory in chicks.

Journal: Bulletin of experimental biology and medicine 20120901

Title: Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression.

Journal: Experimental gerontology 20120801

Title: Dimebon slows progression of proteinopathy in γ-synuclein transgenic mice.

Journal: Neurotoxicity research 20120701

Title: Double-blind placebo-controlled randomized efficacy and safety trial of add-on treatment of dimebon plus risperidone in schizophrenic patients during transition from acute psychotic episode to remission.

Journal: Psychiatria Danubina 20120601

Title: Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion.

Journal: Neurochemistry international 20120601

Title: The acute effects of dimebolin, a potential Alzheimer's disease treatment, on working memory in rhesus monkeys.

Journal: British journal of pharmacology 20111001

Title: Latrepirdine increases cerebral glucose utilization in aged mice as measured by [18F]-fluorodeoxyglucose positron emission tomography.

Journal: Neuroscience 20110825

Title: Dimebon does not ameliorate pathological changes caused by expression of truncated (1-120) human alpha-synuclein in dopaminergic neurons of transgenic mice.

Journal: Neuro-degenerative diseases 20110801

Title: Drugs: a tangled web of targets.

Journal: Nature 20110713

Title: Dimebolin in dementia.

Journal: CNS neuroscience & therapeutics 20110601

Title: Ruthenium-catalyzed γ-carbolinium ion formation from aryl azides; synthesis of dimebolin.

Journal: Organic letters 20110520

Title: [Geroprotective properties of dimebon: morphological characterization of organs and tissues in mice after long-term treatment].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20110101

Title: The rise and fall of Dimebon.

Journal: Drug news & perspectives 20101001

Title: Investigational medications for treatment of patients with Alzheimer disease.

Journal: The Journal of the American Osteopathic Association 20100901

Title: [Drug therapy for Alzheimer's disease].

Journal: Brain and nerve = Shinkei kenkyu no shinpo 20100701

Title: Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism.

Journal: The Journal of pharmacology and experimental therapeutics 20100601

Title: From anti-allergic to anti-Alzheimer's: Molecular pharmacology of Dimebon.

Journal: Current Alzheimer research 20100301

Title: 8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.

Journal: European journal of medicinal chemistry 20100201

Title: Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles.

Journal: Bioorganic & medicinal chemistry letters 20100101

Title: Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death.

Journal: Journal of Alzheimer's disease : JAD 20100101

Title: Synthesis and biological evaluation of novel 5,8-disubstituted-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b] indoles as 5-HT(6) and H(1) receptors antagonists.

Journal: Archiv der Pharmazie 20091201

Title: Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities.

Journal: Biochemical pharmacology 20091015

Title: Dimebon as a potential therapy for Alzheimer's disease.

Journal: CNS spectrums 20090801

Title: Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20090615

Title: [Progress in the research on multi-target-directed drugs against Alzheimer's disease].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090301

Title: [Therapy of Alzheimer disease].

Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20090301

Title: Alzheimer's disease: on the verges of treatment and prevention.

Journal: The Lancet. Neurology 20090101

Title: Progress in Alzheimer's disease drug discovery: an update.

Journal: Current opinion in investigational drugs (London, England : 2000) 20090101

Title: A promising new treatment for Alzheimer's disease?

Journal: The Lancet. Neurology 20080901

Title: Current and future therapy in Alzheimer's disease.

Journal: Fundamental & clinical pharmacology 20080601

Title: Evaluation of Dimebon in cellular model of Huntington's disease.

Journal: Molecular neurodegeneration 20080101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: [Mitochondria as the target for neuroprotectors].

Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk 20050101

Title: Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons.

Journal: Bulletin of experimental biology and medicine 20031101

Title: Mitochondria as a target for neurotoxins and neuroprotective agents.

Journal: Annals of the New York Academy of Sciences 20030501

Title: Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer.

Journal: Annals of the New York Academy of Sciences 20010601

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