Home Other Building Blocks 97657-92-6
97657-92-6,MFCD17215933
Catalog No.:AA005YDG

97657-92-6 | Latrepirdine dihydrochloride

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1mg
≥98%
in stock  
$33.00   $23.00
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5mg
≥98%
in stock  
$143.00   $100.00
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10mg
in stock  
$209.00   $147.00
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25mg
99%
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$352.00   $247.00
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50mg
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$558.00   $390.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA005YDG
Chemical Name:
Latrepirdine dihydrochloride
CAS Number:
97657-92-6
Molecular Formula:
C21H27Cl2N3
Molecular Weight:
392.3652
MDL Number:
MFCD17215933
SMILES:
CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(nc1)C.Cl.Cl
Properties
Properties
 
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
425  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  

Downstream Synthesis Route

[1]CurrentPatentAssignee:BIGESPAS-WO2022/160066,2022,A1Locationinpatent:Paragraph0071-0072

[2]CurrentPatentAssignee:PFIZERINC-WO2009/111540,2009,A1Locationinpatent:Page/Pagecolumn27-28

[3]CurrentPatentAssignee:ACADEMYOFMILITARYMEDICALSCIENCES-EP2417973,2012,A1Locationinpatent:Page/Pagecolumn7;9;17

[4]CurrentPatentAssignee:ACADEMYOFMILITARYMEDICALSCIENCES-US2012/122914,2012,A1Locationinpatent:Page/Pagecolumn6

[5]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-US2010/125085,2010,A1Locationinpatent:Page/Pagecolumn18

[1]CurrentPatentAssignee:PFIZERINC-WO2011/39670,2011,A1Locationinpatent:Page/Pagecolumn56-57

97657-92-6   
CASUnavailable 

[1]Locationinpatent:experimentalpartAlekseyev;Ivanov;Kurkin;Yurovskaya[ChemistryofHeterocyclicCompounds,2011,vol.46,#10,p.1239-1249]

[1]Alekseyev;Ivanov;Kurkin;Yurovskaya[ChemistryofHeterocyclicCompounds,2011,vol.46,#10,p.1239-1249]

Literature

Title: Glutamate receptor modulator dimebon stimulates consolidation and reconsolidation of weak memory in chicks.

Journal: Bulletin of experimental biology and medicine 20120901

Title: Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression.

Journal: Experimental gerontology 20120801

Title: Dimebon slows progression of proteinopathy in γ-synuclein transgenic mice.

Journal: Neurotoxicity research 20120701

Title: Double-blind placebo-controlled randomized efficacy and safety trial of add-on treatment of dimebon plus risperidone in schizophrenic patients during transition from acute psychotic episode to remission.

Journal: Psychiatria Danubina 20120601

Title: Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion.

Journal: Neurochemistry international 20120601

Title: The acute effects of dimebolin, a potential Alzheimer's disease treatment, on working memory in rhesus monkeys.

Journal: British journal of pharmacology 20111001

Title: Latrepirdine increases cerebral glucose utilization in aged mice as measured by [18F]-fluorodeoxyglucose positron emission tomography.

Journal: Neuroscience 20110825

Title: Dimebon does not ameliorate pathological changes caused by expression of truncated (1-120) human alpha-synuclein in dopaminergic neurons of transgenic mice.

Journal: Neuro-degenerative diseases 20110801

Title: Drugs: a tangled web of targets.

Journal: Nature 20110713

Title: Dimebolin in dementia.

Journal: CNS neuroscience & therapeutics 20110601

Title: Ruthenium-catalyzed γ-carbolinium ion formation from aryl azides; synthesis of dimebolin.

Journal: Organic letters 20110520

Title: [Geroprotective properties of dimebon: morphological characterization of organs and tissues in mice after long-term treatment].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20110101

Title: The rise and fall of Dimebon.

Journal: Drug news & perspectives 20101001

Title: Investigational medications for treatment of patients with Alzheimer disease.

Journal: The Journal of the American Osteopathic Association 20100901

Title: [Drug therapy for Alzheimer's disease].

Journal: Brain and nerve = Shinkei kenkyu no shinpo 20100701

Title: Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism.

Journal: The Journal of pharmacology and experimental therapeutics 20100601

Title: From anti-allergic to anti-Alzheimer's: Molecular pharmacology of Dimebon.

Journal: Current Alzheimer research 20100301

Title: Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles.

Journal: Bioorganic & medicinal chemistry letters 20100101

Title: Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death.

Journal: Journal of Alzheimer's disease : JAD 20100101

Title: Synthesis and biological evaluation of novel 5,8-disubstituted-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b] indoles as 5-HT(6) and H(1) receptors antagonists.

Journal: Archiv der Pharmazie 20091201

Title: Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities.

Journal: Biochemical pharmacology 20091015

Title: Dimebon as a potential therapy for Alzheimer's disease.

Journal: CNS spectrums 20090801

Title: Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20090615

Title: [Progress in the research on multi-target-directed drugs against Alzheimer's disease].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090301

Title: [Therapy of Alzheimer disease].

Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20090301

Title: Alzheimer's disease: on the verges of treatment and prevention.

Journal: The Lancet. Neurology 20090101

Title: Progress in Alzheimer's disease drug discovery: an update.

Journal: Current opinion in investigational drugs (London, England : 2000) 20090101

Title: A promising new treatment for Alzheimer's disease?

Journal: The Lancet. Neurology 20080901

Title: Current and future therapy in Alzheimer's disease.

Journal: Fundamental & clinical pharmacology 20080601

Title: [Mitochondria as the target for neuroprotectors].

Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk 20050101

Title: Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons.

Journal: Bulletin of experimental biology and medicine 20031101

Title: Mitochondria as a target for neurotoxins and neuroprotective agents.

Journal: Annals of the New York Academy of Sciences 20030501

Title: Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer.

Journal: Annals of the New York Academy of Sciences 20010601

Title: Steele JW, et al. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Mol Psychiatry. 2013 Aug;18(8):889-97.

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Tags:97657-92-6 Molecular Formula|97657-92-6 MDL|97657-92-6 SMILES|97657-92-6 Latrepirdine dihydrochloride