376348-65-1,MFCD09953791
Catalog No.:AA00I7C1

376348-65-1 | Maraviroc

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$86.00   $60.00
- +
10mg
≥98%
in stock  
$160.00   $112.00
- +
25mg
≥98%
in stock  
$272.00   $190.00
- +
250mg
95%
in stock  
$500.00   $350.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00I7C1
Chemical Name:
Maraviroc
CAS Number:
376348-65-1
Molecular Formula:
C29H41F2N5O
Molecular Weight:
513.6655
MDL Number:
MFCD09953791
SMILES:
O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1C[C@H](C2)n1c(C)nnc1C(C)C
Properties
Computed Properties
 
Complexity:
751  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
5.1  

Downstream Synthesis Route

[1]EuropeanJournalofOrganicChemistry,2018,vol.2018,p.1821-1832

[2]TetrahedronLetters,2005,vol.46,p.5005-5007

[1]TetrahedronLetters,2005,vol.46,p.5005-5007

[2]OrganicLetters,2018,vol.20,p.4959-4963

[1]TetrahedronLetters,2005,vol.46,p.5005-5007

[2]OrganicLetters,2018,vol.20,p.4959-4963

[1]TetrahedronLetters,2005,vol.46,p.5005-5007

[2]TetrahedronLetters,2005,vol.46,p.5005-5007

[1]TetrahedronLetters,2005,vol.46,p.5005-5007

Literature

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Title: Synergistic activity profile of carbosilane dendrimer G2-STE16 in combination with other dendrimers and antiretrovirals as topical anti-HIV-1 microbicide.

Journal: Nanomedicine : nanotechnology, biology, and medicine 20140401

Title: Preparation and activities of macromolecule conjugates of the CCR5 antagonist Maraviroc.

Journal: ACS medicinal chemistry letters 20140213

Title: Design, synthesis and biological evaluation of novel piperazine derivatives as CCR5 antagonists.

Journal: PloS one 20130101

Title: Mutations in variable domains of the HIV-1 envelope gene can have a significant impact on maraviroc and vicriviroc resistance.

Journal: AIDS research and therapy 20130101

Title: Monitoring the emergence of resistance mutations in patients infected with HIV-1 under salvage therapy with raltegravir in Rio de Janeiro, Brazil: a follow-up study.

Journal: Journal of medical virology 20121201

Title: Chemokine receptor antagonists.

Journal: Journal of medicinal chemistry 20121126

Title: Pharmacokinetic interaction between maraviroc and etravirine in HIV-infected patients receiving regimens containing both drugs and no ritonavir-boosted protease inhibitor.

Journal: The Journal of antimicrobial chemotherapy 20121101

Title: Next-generation oral preexposure prophylaxis: beyond tenofovir.

Journal: Current opinion in HIV and AIDS 20121101

Title: Population-based sequencing of the V3-loop can predict the virological response to maraviroc in treatment-naive patients of the MERIT trial.

Journal: Journal of acquired immune deficiency syndromes (1999) 20121101

Title: Immune recovery and T cell subset analysis during effective treatment with maraviroc.

Journal: The Journal of antimicrobial chemotherapy 20121001

Title: Antiretroviral neurotoxicity.

Journal: Journal of neurovirology 20121001

Title: Anti-retroviral drugs do not facilitate hepatitis C virus (HCV) infection in vitro.

Journal: Antiviral research 20121001

Title: Long-term glucose tolerance in highly experienced HIV-infected patients receiving nucleoside analogue-sparing regimens.

Journal: AIDS (London, England) 20120910

Title: Allosteric modulators of rhodopsin-like G protein-coupled receptors: opportunities in drug development.

Journal: Pharmacology & therapeutics 20120901

Title: Patients on a combined antiretroviral therapy after maraviroc clinical test show no immunovirological impairment.

Journal: Antiviral research 20120901

Title: HIV-1 CRF01_AE coreceptor usage prediction using kernel methods based logistic model trees.

Journal: Computers in biology and medicine 20120901

Title: Clinical studies with chemokine receptor-5 (CCR5)-inhibitors.

Journal: Current opinion in HIV and AIDS 20120901

Title: HIV population genotypic tropism testing and its clinical significance.

Journal: Current opinion in HIV and AIDS 20120901

Title: Phenotyping methods for determining HIV tropism and applications in clinical settings.

Journal: Current opinion in HIV and AIDS 20120901

Title: A pilot trial of adding maraviroc to suppressive antiretroviral therapy for suboptimal CD4⁺ T-cell recovery despite sustained virologic suppression: ACTG A5256.

Journal: The Journal of infectious diseases 20120815

Title: CCR5 antagonist blocks metastasis of basal breast cancer cells.

Journal: Cancer research 20120801

Title: The lowest X4 Geno2Pheno false-positive rate is associated with greater CD4 depletion in HIV-1 infected patients.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20120801

Title: From in vitro EC₅₀ to in vivo dose-response for antiretrovirals using an HIV disease model. Part I: a framework.

Journal: Journal of pharmacokinetics and pharmacodynamics 20120801

Title: Chemokine receptor blockade in graft-versus-host disease.

Journal: The Lancet. Oncology 20120801

Title: New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors.

Journal: Journal of medicinal chemistry 20120726

Title: Blockade of lymphocyte chemotaxis in visceral graft-versus-host disease.

Journal: The New England journal of medicine 20120712

Title: Virological failure at one year in triple-class experienced patients switching to raltegravir-based regimens is not predicted by baseline factors.

Journal: International journal of STD & AIDS 20120701

Title: V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc.

Journal: Virology 20120605

Title: Impact of triplicate testing on HIV genotypic tropism prediction in routine clinical practice.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20120601

Title: Evolution of proviral DNA HIV-1 tropism under selective pressure of maraviroc-based therapy.

Journal: The Journal of antimicrobial chemotherapy 20120601

Title: Amino acid derivatives of the (-) enantiomer of gossypol are effective fusion inhibitors of human immunodeficiency virus type 1.

Journal: Antiviral research 20120601

Title: CCR5 inhibitors: emergence, success, and challenges.

Journal: Expert opinion on emerging drugs 20120601

Title: A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model.

Journal: PLoS pathogens 20120601

Title: CCR5 antagonist TD-0680 uses a novel mechanism for enhanced potency against HIV-1 entry, cell-mediated infection, and a resistant variant.

Journal: The Journal of biological chemistry 20120511

Title: Susceptibility of HIV type 2 primary isolates to CCR5 and CXCR4 monoclonal antibodies, ligands, and small molecule inhibitors.

Journal: AIDS research and human retroviruses 20120501

Title: Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival.

Journal: Drug discovery today 20120501

Title: Naturally occurring resistance mutations to HIV-1 entry inhibitors in subtypes B, C, and CRF31_BC.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20120501

Title: Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7.

Journal: PLoS pathogens 20120501

Title: Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration.

Journal: AIDS (London, England) 20120424

Title: Design and synthesis of a bivalent ligand to explore the putative heterodimerization of the mu opioid receptor and the chemokine receptor CCR5.

Journal: Organic & biomolecular chemistry 20120407

Title: Drug resistance and coreceptor usage in HIV type 1 subtype C-infected children initiating or failing highly active antiretroviral therapy in South Africa.

Journal: AIDS research and human retroviruses 20120401

Title: T-cell changes after a short-term exposure to maraviroc in HIV-infected patients are related to antiviral activity.

Journal: The Journal of infection 20120401

Title: Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies.

Journal: PLoS pathogens 20120401

Title: [Integrase inhibitors and CCR5 receptor antagonists].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20120401

Title: Pharmacological modulation of chemokine receptor function.

Journal: British journal of pharmacology 20120301

Title: Efficacy of new antiretroviral drugs in treatment-experienced HIV-infected patients: a systematic review and meta-analysis of recent randomized controlled trials.

Journal: HIV medicine 20120301

Title: Once daily maraviroc 300 mg or 150 mg in combination with ritonavir-boosted darunavir 800/100 mg.

Journal: The Journal of antimicrobial chemotherapy 20120301

Title: [Allogeneic stem cell transplantation for acute myeloid leukemia and HIV infection--case 3/2012].

Journal: Deutsche medizinische Wochenschrift (1946) 20120301

Title: Novel approaches to inhibit HIV entry.

Journal: Viruses 20120201

Title: CNS effects of a CCR5 inhibitor in HIV-infected subjects: a pharmacokinetic and cerebral metabolite study.

Journal: The Journal of antimicrobial chemotherapy 20120101

Title: Modulatory effects of the CCR5 antagonist maraviroc on microglial pro-inflammatory activation elicited by gp120.

Journal: Journal of neurochemistry 20120101

Title: CCR5 antagonism in HIV infection: current concepts and future opportunities.

Journal: Annual review of medicine 20120101

Title: In vitro phenotypic susceptibility of HIV-2 clinical isolates to CCR5 inhibitors.

Journal: Antimicrobial agents and chemotherapy 20120101

Title: Drug safety evaluation of maraviroc for the treatment of HIV infection.

Journal: Expert opinion on drug safety 20120101

Title: Recent progress in small molecule CCR5 antagonists as potential HIV-1 entry inhibitors.

Journal: Current pharmaceutical design 20120101

Title: Interactions between prostaglandins, leukotrienes and HIV-1: possible implications for the central nervous system.

Journal: Retrovirology 20120101

Title: Immunologic effectiveness of maraviroc- and raltegravir-containing regimens (R+M+) versus raltegravir-based regimens that do not include maraviroc (R+M-).

Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20120101

Title: Maraviroc, a chemokine receptor-5 antagonist, fails to demonstrate efficacy in the treatment of patients with rheumatoid arthritis in a randomized, double-blind placebo-controlled trial.

Journal: Arthritis research & therapy 20120101

Title: The epidemiology and clinical correlates of HIV-1 co-receptor tropism in non-subtype B infections from India, Uganda and South Africa.

Journal: Journal of the International AIDS Society 20120101

Title: Targets for inhibition of HIV replication: entry, enzyme action, release and maturation.

Journal: Intervirology 20120101

Title: Responses to switching to maraviroc-based antiretroviral therapy in treated patients with suppressed plasma HIV-1-RNA load.

Journal: Intervirology 20120101

Title: Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains.

Journal: PloS one 20120101

Title: Baseline susceptibility of primary HIV-2 to entry inhibitors.

Journal: Antiviral therapy 20120101

Title: Antiviral effect of maraviroc in semen: a case report.

Journal: Antiviral therapy 20120101

Title: Novel agents for the treatment of HIV-2 infection.

Journal: Antiviral therapy 20120101

Title: Review of the safety, efficacy, and pharmacokinetics of elvitegravir with an emphasis on resource-limited settings.

Journal: HIV/AIDS (Auckland, N.Z.) 20120101

Title: The use of preexposure treatments for HIV prophylaxis.

Journal: HIV/AIDS (Auckland, N.Z.) 20120101

Title: CCR5Δ32 genotype leads to a Th2 type directed immune response in ESRD patients.

Journal: PloS one 20120101

Title: A high performance liquid chromatographic assay of mefloquine in saliva after a single oral dose in healthy adult Africans.

Journal: Malaria journal 20120101

Title: The role of chemokines in mediating graft versus host disease: opportunities for novel therapeutics.

Journal: Frontiers in pharmacology 20120101

Title: Impaired maraviroc and raltegravir clearance in a human immunodeficiency virus-infected patient with end-stage liver disease and renal impairment: a management dilemma.

Journal: Pharmacotherapy 20120101

Title: In-depth characterization of viral isolates from plasma and cells compared with plasma circulating quasispecies in early HIV-1 infection.

Journal: PloS one 20120101

Title: Conference highlights of the 5th international workshop on HIV persistence during therapy, 6-9 December 2011, St. Maartin, West Indies.

Journal: AIDS research and therapy 20120101

Title: HIV-1 promotes intake of Leishmania parasites by enhancing phosphatidylserine-mediated, CD91/LRP-1-dependent phagocytosis in human macrophages.

Journal: PloS one 20120101

Title: Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue.

Journal: Retrovirology 20120101

Title: Controversies in HIV cure research.

Journal: Journal of the International AIDS Society 20120101

Title: Analysis of high-depth sequence data for studying viral diversity: a comparison of next generation sequencing platforms using Segminator II.

Journal: BMC bioinformatics 20120101

Title: Incomplete immune recovery in HIV infection: mechanisms, relevance for clinical care, and possible solutions.

Journal: Clinical & developmental immunology 20120101

Title: Structural insights from binding poses of CCR2 and CCR5 with clinically important antagonists: a combined in silico study.

Journal: PloS one 20120101

Title: Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection.

Journal: PloS one 20120101

Title: HIV RNA suppression and immune restoration: can we do better?

Journal: Clinical & developmental immunology 20120101

Title: Monocytes contribute to differential immune pressure on R5 versus X4 HIV through the adipocytokine visfatin/NAMPT.

Journal: PloS one 20120101

Title: What is the future of CCR5 antagonists in rheumatoid arthritis?

Journal: Arthritis research & therapy 20120101

Title: Novel therapeutic strategies targeting HIV integrase.

Journal: BMC medicine 20120101

Title: Safety profile of maraviroc in patients coinfected with HIV-1 and hepatitis B or C included in the maraviroc expanded access program.

Journal: HIV clinical trials 20120101

Title: Molecular Understanding of HIV-1 Latency.

Journal: Advances in virology 20120101

Title: New option for management of HIV-1 infection in treatment-naive patients: once-daily, fixed-dose combination of rilpivirine-emtricitabine-tenofovir.

Journal: HIV/AIDS (Auckland, N.Z.) 20120101

Title: Impact of short-term HAART initiated during the chronic stage or shortly post-exposure on SIV infection of male genital organs.

Journal: PloS one 20120101

Title: Efficacy, stability, and biosafety of sifuvirtide gel as a microbicide candidate against HIV-1.

Journal: PloS one 20120101

Title: Antiretroviral drugs: critical issues and recent advances.

Journal: Indian journal of pharmacology 20120101

Title: Levels of soluble endothelial protein C receptor are associated with CD4+ changes in Maraviroc-treated HIV-infected patients.

Journal: PloS one 20120101

Title: Self-reported adherence supports patient preference for the single tablet regimen (STR) in the current cART era.

Journal: Patient preference and adherence 20120101

Title: Update on clinical and methodological recommendations for genotypic determination of HIV tropism to guide the usage of CCR5 antagonists.

Journal: AIDS reviews 20120101

Title: Alterations in cerebrospinal fluid chemokines are associated with maraviroc exposure and in vivo metabolites measurable by magnetic resonance spectroscopy.

Journal: HIV clinical trials 20120101

Title: Stochastic model of in-vivo X4 emergence during HIV infection: implications for the CCR5 inhibitor maraviroc.

Journal: PloS one 20120101

Title: A genotypic test for HIV-1 tropism combining Sanger sequencing with ultradeep sequencing predicts virologic response in treatment-experienced patients.

Journal: PloS one 20120101

Title: Non-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20111210

Title: Boosted tipranavir versus darunavir in treatment-experienced patients: observational data from the randomized POTENT trial.

Journal: Drugs in R&D 20111201

Title: Rescue of HIV-1 long-time archived X4 strains to escape maraviroc.

Journal: Antiviral research 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Does GSS still maintain relevance on HAART outcome after the introduction of newest active antiretroviral drugs? 48 weeks results.

Journal: Current HIV research 20111201

Title: [Methods for determination of HIV tropism and their clinical use].

Journal: Enfermedades infecciosas y microbiologia clinica 20111201

Title: Microbicides: a new hope for HIV prevention.

Journal: The Indian journal of medical research 20111201

Title: How much do antiretroviral drugs penetrate into the central nervous system?

Journal: Journal of medicine and life 20111114

Title: Host factors mediating HIV-1 replication.

Journal: Virus research 20111101

Title: In vitro activity of antiretroviral drugs against Plasmodium falciparum.

Journal: Antimicrobial agents and chemotherapy 20111101

Title: In vitro effect of anti-human immunodeficiency virus CCR5 antagonist maraviroc on chemotactic activity of monocytes, macrophages and dendritic cells.

Journal: Clinical and experimental immunology 20111101

Title: Viral determinants of HIV-1 macrophage tropism.

Journal: Viruses 20111101

Title: Prospective CCR5 small molecule antagonist compound design using a combined mutagenesis/modeling approach.

Journal: Journal of the American Chemical Society 20111019

Title: Deep V3 sequencing for HIV type 1 tropism in treatment-naive patients: a reanalysis of the MERIT trial of maraviroc.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20111001

Title: Allosteric model of maraviroc binding to CC chemokine receptor 5 (CCR5).

Journal: The Journal of biological chemistry 20110923

Title: Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C.

Journal: Virology 20110901

Title: A computational study of CYP3A4 mediated drug interaction profiles for anti-HIV drugs.

Journal: Journal of molecular modeling 20110801

Title: Pharmacokinetics of the raltegravir/maraviroc/etravirine combination.

Journal: The Journal of antimicrobial chemotherapy 20110801

Title: Identification and characterization of INCB9471, an allosteric noncompetitive small-molecule antagonist of C-C chemokine receptor 5 with potent inhibitory activity against monocyte migration and HIV-1 infection.

Journal: The Journal of pharmacology and experimental therapeutics 20110701

Title: Cell disposition of raltegravir and newer antiretrovirals in HIV-infected patients: high inter-individual variability in raltegravir cellular penetration.

Journal: The Journal of antimicrobial chemotherapy 20110701

Title: A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection.

Journal: PLoS pathogens 20110701

Title: Common adverse effects of antiretroviral therapy for HIV disease.

Journal: American family physician 20110615

Title: Novel 4,4-disubstituted piperidine-based C-C chemokine receptor-5 inhibitors with high potency against human immunodeficiency virus-1 and an improved human ether-a-go-go related gene (hERG) profile.

Journal: Journal of medicinal chemistry 20110609

Title: Agonist-induced internalization of CC chemokine receptor 5 as a mechanism to inhibit HIV replication.

Journal: The Journal of pharmacology and experimental therapeutics 20110601

Title: Synergistic inhibition of R5 HIV-1 by maraviroc and CCR5 antibody HGS004 in primary cells: implications for treatment and prevention.

Journal: AIDS (London, England) 20110601

Title: Maraviroc intensification for suboptimal CD4⁺ T cell response in a perinatally HIV-infected adolescent.

Journal: AIDS (London, England) 20110601

Title: Lessons from maraviroc clinical trials.

Journal: Expert review of anti-infective therapy 20110601

Title: Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing.

Journal: PLoS pathogens 20110601

Title: HIV-1 efficient entry in inner foreskin is mediated by elevated CCL5/RANTES that recruits T cells and fuels conjugate formation with Langerhans cells.

Journal: PLoS pathogens 20110601

Title: Single and multiple dose pharmacokinetics of maraviroc in saliva, semen, and rectal tissue of healthy HIV-negative men.

Journal: The Journal of infectious diseases 20110515

Title: HIV-1 entry inhibition by small-molecule CCR5 antagonists: a combined molecular modeling and mutant study using a high-throughput assay.

Journal: Virology 20110510

Title: A combination of polymorphic mutations in V3 loop of HIV-1 gp120 can confer noncompetitive resistance to maraviroc.

Journal: Virology 20110510

Title: [CCR5 antagonist Maraviroc: effective and well tolerated. 'A very promising substance'].

Journal: MMW Fortschritte der Medizin 20110505

Title: [Utilizing the potential of maraviroc early. 'Clear in second line therapy' (interview by Dr. Felicitas Zorn)].

Journal: MMW Fortschritte der Medizin 20110505

Title: Analysis of co-receptor usage of circulating viral and proviral HIV genome quasispecies by ultra-deep pyrosequencing in patients who are candidates for CCR5 antagonist treatment.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20110501

Title: Rapid analysis of pharmacology for infectious diseases.

Journal: Current topics in medicinal chemistry 20110501

Title: HIV-1 integrase inhibitor resistance and its clinical implications.

Journal: The Journal of infectious diseases 20110501

Title: [Characteristics of antiretroviral drugs].

Journal: Enfermedades infecciosas y microbiologia clinica 20110501

Title: Combinations of 3-hydroxyphthalic anhydride-modified ovalbumin with antiretroviral drug-based microbicide candidates display synergistic and complementary effects against HIV-1 infection.

Journal: Journal of acquired immune deficiency syndromes (1999) 20110415

Title: Proper laboratory notebook practices: protecting your intellectual property.

Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20110401

Title: Chemokine receptor CCR5: from AIDS to atherosclerosis.

Journal: British journal of pharmacology 20110401

Title: Approaches for understanding and predicting drug interactions in human immunodeficiency virus-infected patients.

Journal: Expert opinion on drug metabolism & toxicology 20110401

Title: Clinical pharmacokinetic and pharmacodynamic profile of the HIV integrase inhibitor elvitegravir.

Journal: Clinical pharmacokinetics 20110401

Title: HIV-1 dual/mixed tropic isolates show different genetic and phenotypic characteristics and response to maraviroc in vitro.

Journal: Antiviral research 20110401

Title: Durability and safety of a novel salvage therapy in R5-tropic HIV-infected patients: maraviroc, raltegravir, etravirine.

Journal: Journal of acquired immune deficiency syndromes (1999) 20110401

Title: CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic (R5/X4) HIV-1 infection.

Journal: European journal of immunology 20110401

Title: Maraviroc is able to inhibit dual-R5 viruses in a dual/mixed HIV-1-infected patient.

Journal: The Journal of antimicrobial chemotherapy 20110401

Title: Potential of novel antiretrovirals to modulate expression and function of drug transporters in vitro.

Journal: The Journal of antimicrobial chemotherapy 20110401

Title: Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases.

Journal: PLoS pathogens 20110401

Title: Clinical management of HIV drug resistance.

Journal: Viruses 20110401

Title: CCR5 blockade in combination with cyclosporine increased cardiac graft survival and generated alternatively activated macrophages in primates.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20110315

Title: CCR5 antibodies HGS004 and HGS101 preferentially inhibit drug-bound CCR5 infection and restore drug sensitivity of Maraviroc-resistant HIV-1 in primary cells.

Journal: Virology 20110301

Title: Synthesis and evaluation of 2-phenyl-1,4-butanediamine-based CCR5 antagonists for the treatment of HIV-1.

Journal: Bioorganic & medicinal chemistry letters 20110301

Title: Theoretical studies on the interactions and interferences of HIV-1 glycoprotein gp120 and its coreceptor CCR5.

Journal: Journal of chemical information and modeling 20110227

Title: New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infection.

Journal: The Journal of biological chemistry 20110218

Title: The use of the SAEM algorithm in MONOLIX software for estimation of population pharmacokinetic-pharmacodynamic-viral dynamics parameters of maraviroc in asymptomatic HIV subjects.

Journal: Journal of pharmacokinetics and pharmacodynamics 20110201

Title: Emerging antiretroviral drug interactions.

Journal: The Journal of antimicrobial chemotherapy 20110201

Title: Discordance rates between Trofile test and short-term virological response to maraviroc.

Journal: Antiviral research 20110201

Title: Direct measurement of thermal stability of expressed CCR5 and stabilization by small molecule ligands.

Journal: Biochemistry 20110201

Title: Efficacy and safety of nucleoside reverse transcriptase inhibitor-sparing salvage therapy for multidrug-resistant HIV-1 infection based on new-class and new-generation antiretrovirals.

Journal: The Journal of antimicrobial chemotherapy 20110201

Title: Comparison of phenotypic and genotypic tropism determination in triple-class-experienced HIV patients eligible for maraviroc treatment.

Journal: The Journal of antimicrobial chemotherapy 20110201

Title: Small molecule HIV entry inhibitors: Part I. Chemokine receptor antagonists: 2004 - 2010.

Journal: Expert opinion on therapeutic patents 20110201

Title: Deep sequencing to infer HIV-1 co-receptor usage: application to three clinical trials of maraviroc in treatment-experienced patients.

Journal: The Journal of infectious diseases 20110115

Title: An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798).

Journal: Journal of medicinal chemistry 20110113

Title: Recent advances in antiretroviral drugs.

Journal: Expert opinion on pharmacotherapy 20110101

Title: Indications for the use of next-generation antiretroviral drugs in current clinical practice.

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20110101

Title: Long-term CD4+ T-cell count evolution after switching from regimens including HIV nucleoside reverse transcriptase inhibitors (NRTI) plus protease inhibitors to regimens containing NRTI plus non-NRTI or only NRTI.

Journal: BMC infectious diseases 20110101

Title: Introducing the issue on 'differential use of CCR5 versus CXCR4 by HIV-1. Pathogenic, translational and clinical open questions'.

Journal: Journal of translational medicine 20110101

Title: R5X4 HIV-1 coreceptor use in primary target cells: implications for coreceptor entry blocking strategies.

Journal: Journal of translational medicine 20110101

Title: Natural anti-CCR5 antibodies in HIV-infection and -exposure.

Journal: Journal of translational medicine 20110101

Title: Clinical significance of HIV-1 coreceptor usage.

Journal: Journal of translational medicine 20110101

Title: Clinical use of CCR5 inhibitors in HIV and beyond.

Journal: Journal of translational medicine 20110101

Title: [Variability in HIV viral tropism determination using different genotypic algorithms in patients infected with B versus non-B HIV-1 subtypes].

Journal: Enfermedades infecciosas y microbiologia clinica 20110101

Title: Penicillium marneffei Infection in AIDS.

Journal: Pathology research international 20110101

Title: Update on microbicide research and development - seeking new HIV prevention tools for women.

Journal: European journal of medical research 20110101

Title: Prevalence of potential drug-drug interactions involving antiretroviral drugs in a large Kenyan cohort.

Journal: PloS one 20110101

Title: Maraviroc can improve lipid profiles in dyslipidemic patients with HIV: results from the MERIT trial.

Journal: HIV clinical trials 20110101

Title: The costs of full suppression of plasma HIV RNA in highly antiretroviral-experienced patients.

Journal: AIDS reviews 20110101

Title: Susceptibility of HIV-1 subtypes B', CRF07_BC and CRF01_AE that are predominantly circulating in China to HIV-1 entry inhibitors.

Journal: PloS one 20110101

Title: Genetic characteristics, coreceptor usage potential and evolution of Nigerian HIV-1 subtype G and CRF02_AG isolates.

Journal: PloS one 20110101

Title: Use of maraviroc-, raltegravir-, and etravirine-containing regimens in treatment-experienced patients: a case-series study.

Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20110101

Title: HIV quasispecies dynamics during pro-active treatment switching: impact on multi-drug resistance and resistance archiving in latent reservoirs.

Journal: PloS one 20110101

Title: Comparison of intima-media thickness and ophthalmic artery resistance index for assessing subclinical atherosclerosis in HIV-1-infected patients.

Journal: Cardiovascular ultrasound 20110101

Title: Results of antiretroviral treatment interruption and intensification in advanced multi-drug resistant HIV infection from the OPTIMA trial.

Journal: PloS one 20110101

Title: Antiretroviral Therapy for HIV-2 Infection: Recommendations for Management in Low-Resource Settings.

Journal: AIDS research and treatment 20110101

Title: Outcomes of Universal Access to Antiretroviral Therapy (ART) in Georgia.

Journal: AIDS research and treatment 20110101

Title: Mutations in gp41 are correlated with coreceptor tropism but do not improve prediction methods substantially.

Journal: Antiviral therapy 20110101

Title: Baseline CD4(+) T-cell counts and weighted background susceptibility scores strongly predict response to maraviroc regimens in treatment-experienced patients.

Journal: Antiviral therapy 20110101

Title: Create a translational medicine knowledge repository--research downsizing, mergers and increased outsourcing have reduced the depth of in-house translational medicine expertise and institutional memory at many pharmaceutical and biotech companies: how will they avoid relearning old lessons?

Journal: Journal of translational medicine 20110101

Title: Selected amino acid mutations in HIV-1 B subtype gp41 are associated with specific gp120v₃ signatures in the regulation of co-receptor usage.

Journal: Retrovirology 20110101

Title: Genotypic tropism testing by massively parallel sequencing: qualitative and quantitative analysis.

Journal: BMC medical informatics and decision making 20110101

Title: Clinical utility of maraviroc.

Journal: Clinical drug investigation 20110101

Title: Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis.

Journal: Malaria journal 20110101

Title: Contraception in HIV-positive female adolescents.

Journal: AIDS research and therapy 20110101

Title: Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues.

Journal: Retrovirology 20110101

Title: HIV and HAART-Associated Dyslipidemia.

Journal: The open cardiovascular medicine journal 20110101

Title: Solution structure of LC4 transmembrane segment of CCR5.

Journal: PloS one 20110101

Title: Estimating the threshold surface density of Gp120-CCR5 complexes necessary for HIV-1 envelope-mediated cell-cell fusion.

Journal: PloS one 20110101

Title: Inhibition of HIV-1 Env-Mediated Cell-Cell Fusion by Lectins, Peptide T-20, and Neutralizing Antibodies.

Journal: The open virology journal 20110101

Title: A topical microbicide gel formulation of CCR5 antagonist maraviroc prevents HIV-1 vaginal transmission in humanized RAG-hu mice.

Journal: PloS one 20110101

Title: Humanized Rag1-/- γc-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes.

Journal: PloS one 20110101

Title: Validation of case-finding algorithms derived from administrative data for identifying adults living with human immunodeficiency virus infection.

Journal: PloS one 20110101

Title: Should patents for antiretrovirals be waived in the developing world? Annual Varsity Medical Debate--London, 21 January 2011.

Journal: Philosophy, ethics, and humanities in medicine : PEHM 20110101

Title: Genotypic prediction of HIV-1 subtype D tropism.

Journal: Retrovirology 20110101

Title: Resistance to the CCR5 inhibitor 5P12-RANTES requires a difficult evolution from CCR5 to CXCR4 coreceptor use.

Journal: PloS one 20110101

Title: [Analysis of the prevalence of CCR5 coreceptor antagonist resistance mutations among HIV-1 variants in Russia].

Journal: Voprosy virusologii 20110101

Title: Pre-exposure prophylaxis of HIV.

Journal: Indian journal of sexually transmitted diseases and AIDS 20110101

Title: Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate.

Journal: PloS one 20110101

Title: The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment.

Journal: Retrovirology 20110101

Title: Genotypic and functional properties of early infant HIV-1 envelopes.

Journal: Retrovirology 20110101

Title: Origin and epidemiological history of HIV-1 CRF14_BG.

Journal: PloS one 20110101

Title: Resource utilization and cost-effectiveness of counselor- vs. provider-based rapid point-of-care HIV screening in the emergency department.

Journal: PloS one 20110101

Title: [Our experience with maraviroc treatment in HIV positive patients].

Journal: Casopis lekaru ceskych 20110101

Title: A comparison of parallel pyrosequencing and sanger clone-based sequencing and its impact on the characterization of the genetic diversity of HIV-1.

Journal: PloS one 20110101

Title: HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry.

Journal: Retrovirology 20110101

Title: An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors.

Journal: PloS one 20110101

Title: It is time to consider third-line options in antiretroviral-experienced paediatric patients?

Journal: Journal of the International AIDS Society 20110101

Title: 8-Modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcription.

Journal: PloS one 20110101

Title: Combined phytochemistry and chemotaxis assays for identification and mechanistic analysis of anti-inflammatory phytochemicals in Fallopia japonica.

Journal: PloS one 20110101

Title: Safety, efficacy, and pharmacokinetics of rilpivirine: systematic review with an emphasis on resource-limited settings.

Journal: HIV/AIDS (Auckland, N.Z.) 20110101

Title: Role of raltegravir in the management of HIV-1 infection.

Journal: HIV/AIDS (Auckland, N.Z.) 20110101

Title: Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the fetal compartment (placenta and amniotic fluid).

Journal: Antiviral therapy 20110101

Title: Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the male and female genital tract.

Journal: Antiviral therapy 20110101

Title: SHIV-162P3 infection of rhesus macaques given maraviroc gel vaginally does not involve resistant viruses.

Journal: PloS one 20110101

Title: Applications of next-generation sequencing technologies to diagnostic virology.

Journal: International journal of molecular sciences 20110101

Title: Intensification of antiretroviral therapy with a CCR5 antagonist in patients with chronic HIV-1 infection: effect on T cells latently infected.

Journal: PloS one 20110101

Title: In vitro downregulation of matrix metalloproteinase-9 in rat glial cells by CCR5 antagonist maraviroc: therapeutic implication for HIV brain infection.

Journal: PloS one 20110101

Title: Modeling dynamic interactions between pre-exposure prophylaxis interventions & treatment programs: predicting HIV transmission & resistance.

Journal: Scientific reports 20110101

Title: Grand challenges.

Journal: Frontiers in immunology 20110101

Title: Clinical Use of Inhibitors of HIV-1 Integration: Problems and Prospects.

Journal: Acta naturae 20110101

Title: Two-year safety and virologic efficacy of maraviroc in treatment-experienced patients with CCR5-tropic HIV-1 infection: 96-week combined analysis of MOTIVATE 1 and 2.

Journal: Journal of acquired immune deficiency syndromes (1999) 20101215

Title: Maraviroc concentrations in cerebrospinal fluid in HIV-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999) 20101215

Title: Treatment intensification has no effect on the HIV-1 central nervous system infection in patients on suppressive antiretroviral therapy.

Journal: Journal of acquired immune deficiency syndromes (1999) 20101215

Title: Maraviroc concentrations in seminal plasma in HIV-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999) 20101215

Title: C-C chemokine receptor type 5 (CCR5) utilization of transmitted and early founder human immunodeficiency virus type 1 envelopes and sensitivity to small-molecule CCR5 inhibitors.

Journal: The Journal of general virology 20101201

Title: Evolution of CCR5 antagonist resistance in an HIV-1 subtype C clinical isolate.

Journal: Journal of acquired immune deficiency syndromes (1999) 20101201

Title: Primary resistance to maraviroc in a large set of R5-V3 viral sequences from HIV-1-infected patients.

Journal: The Journal of antimicrobial chemotherapy 20101201

Title: TROCAI (tropism coreceptor assay information): a new phenotypic tropism test and its correlation with Trofile enhanced sensitivity and genotypic approaches.

Journal: Journal of clinical microbiology 20101201

Title: Evaluation of primary resistance to HIV entry inhibitors among brazilian patients failing reverse transcriptase/protease inhibitors treatment reveal high prevalence of maraviroc resistance-related mutations.

Journal: AIDS research and human retroviruses 20101201

Title: Glioblastoma: synergy of growth promotion between CCL5 and NK-1R can be thwarted by blocking CCL5 with miraviroc, an FDA approved anti-HIV drug and blocking NK-1R with aprepitant, an FDA approved anti-nausea drug.

Journal: Journal of clinical pharmacy and therapeutics 20101201

Title: An LC-MS-MS method for quantitative determination of maraviroc (UK-427,857) in human plasma, urine and cerebrospinal fluid.

Journal: Biomedical chromatography : BMC 20101201

Title: Cost-effectiveness of maraviroc for antiretroviral treatment-experienced HIV-infected individuals in Mexico.

Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20101201

Title: [Pharmacological profile and clinical findings of Maraviroc (Celsentri® Tablets)].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20101201

Title: The evolutionary analysis of emerging low frequency HIV-1 CXCR4 using variants through time--an ultra-deep approach.

Journal: PLoS computational biology 20101201

Title: Maraviroc is a substrate for OATP1B1 in vitro and maraviroc plasma concentrations are influenced by SLCO1B1 521 T>C polymorphism.

Journal: Pharmacogenetics and genomics 20101201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20101201

Title: Comparison of the Mechanisms of Drug Resistance among HIV, Hepatitis B, and Hepatitis C.

Journal: Viruses 20101201

Title: Cost-effectiveness of optimized background therapy plus maraviroc for previously treated patients with R5 HIV-1 infection from the perspective of the Spanish health care system.

Journal: Clinical therapeutics 20101201

Title: A report from the XVIII International AIDS Conference. (July 18-23, 2010-Vienna, Austria).

Journal: Drugs of today (Barcelona, Spain : 1998) 20101201

Title: Maraviroc does not affect humoral response to the pandemic influenza A-H1N1v 2009 adjuvanted vaccine in HIV-1-infected patients.

Journal: AIDS (London, England) 20101127

Title: Hepatic safety and tolerability in the maraviroc clinical development program.

Journal: AIDS (London, England) 20101113

Title: Recognition and management of significant drug interactions in HIV patients: challenges in using available data to guide therapy.

Journal: Clinical pharmacology and therapeutics 20101101

Title: Emerging concepts and approaches for chemokine-receptor drug discovery.

Journal: Expert opinion on drug discovery 20101101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20101101

Title: It's official...but not infallible.

Journal: Prescrire international 20101101

Title: Maraviroc first-line therapy for HIV infection. Too risky.

Journal: Prescrire international 20101101

Title: Population-based V3 genotypic tropism assay: a retrospective analysis using screening samples from the A4001029 and MOTIVATE studies.

Journal: AIDS (London, England) 20101023

Title: Maternal-fetal pharmacokinetics and dynamics of a single intrapartum dose of maraviroc in rhesus macaques.

Journal: Antimicrobial agents and chemotherapy 20101001

Title: A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5.

Journal: Journal of virology 20101001

Title: Novel antiretroviral combinations in treatment-experienced patients with HIV infection: rationale and results.

Journal: Drugs 20100910

Title: An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes.

Journal: Virology 20100901

Title: Protection of rhesus macaques from vaginal infection by vaginally delivered maraviroc, an inhibitor of HIV-1 entry via the CCR5 co-receptor.

Journal: The Journal of infectious diseases 20100901

Title: Long-term immunovirogical effect and tolerability of a maraviroc-containing regimen in routine clinical practice.

Journal: Current HIV research 20100901

Title: Maraviroc-containing regimen suppresses HIV replication in the cerebrospinal fluid of patients with neurological symptoms.

Journal: AIDS (London, England) 20100824

Title: CD4+ T-cell restoration after 48 weeks in the maraviroc treatment-experienced trials MOTIVATE 1 and 2.

Journal: Journal of acquired immune deficiency syndromes (1999) 20100801

Title: Characterization of a SHIV162P3 variant evolved in an infected rhesus macaque with persistent plasma viremia.

Journal: Virus research 20100801

Title: Improved detection of CXCR4-using HIV by V3 genotyping: application of population-based and 'deep' sequencing to plasma RNA and proviral DNA.

Journal: Journal of acquired immune deficiency syndromes (1999) 20100801

Title: Evaluation of the genotypic prediction of HIV-1 coreceptor use versus a phenotypic assay and correlation with the virological response to maraviroc: the ANRS GenoTropism study.

Journal: Antimicrobial agents and chemotherapy 20100801

Title: Pharmacogenetic testing and therapeutic drug monitoring are complementary tools for optimal individualization of drug therapy.

Journal: European journal of clinical pharmacology 20100801

Title: Downregulation of leukocyte migration after treatment with CCR5 antagonist maraviroc.

Journal: Journal of acquired immune deficiency syndromes (1999) 20100801

Title: Development and application of a simple LC-MS method for the determination of plasma maraviroc concentrations.

Journal: The journal of medical investigation : JMI 20100801

Title: A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo.

Journal: PLoS pathogens 20100801

Title: Dynamics of HIV tropism under suppressive antiretroviral therapy: implications for tropism testing in subjects with undetectable viraemia.

Journal: The Journal of antimicrobial chemotherapy 20100701

Title: Hemodynamic effects of single-dose vardenafil in subjects receiving maraviroc.

Journal: Journal of acquired immune deficiency syndromes (1999) 20100701

Title: Short communication: antiretroviral therapy resistance mutations present in the HIV type 1 subtype C pol and env regions from therapy-naive patients in Zambia.

Journal: AIDS research and human retroviruses 20100701

Title: Role of CXCR4 in HIV infection and its potential as a therapeutic target.

Journal: Future microbiology 20100701

Title: Patterns of HIV-1 protein interaction identify perturbed host-cellular subsystems.

Journal: PLoS computational biology 20100701

Title: Maraviroc: a review of its use in the management of CCR5-tropic HIV-1 infection.

Journal: Drugs 20100618

Title: Validation of a rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assay for the simultaneous determination of existing and new antiretroviral compounds.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601

Title: Shift in phenotypic susceptibility suggests a competition mechanism in a case of acquired resistance to maraviroc.

Journal: AIDS (London, England) 20100601

Title: HIV-1 tropism.

Journal: Protein & cell 20100601

Title: Novel hexahydropyrrolo[3,4-c]pyrrole CCR5 antagonists.

Journal: Bioorganic & medicinal chemistry letters 20100515

Title: Clinical outcome in resistant HIV-2 infection treated with raltegravir and maraviroc.

Journal: Antiviral research 20100501

Title: Protection against HIV-envelope-induced neuronal cell destruction by HIV attachment inhibitors.

Journal: Archives of virology 20100501

Title: Raltegravir plasma concentrations in treatment-experienced patients receiving salvage regimens based on raltegravir with and without maraviroc coadministration.

Journal: The Annals of pharmacotherapy 20100501

Title: Treatment of HIV infection with the CCR5 antagonist maraviroc.

Journal: Expert opinion on pharmacotherapy 20100501

Title: [CCR5-antagonists: contribution of a new antiretroviral class to the management of HIV infection].

Journal: Medecine et maladies infectieuses 20100501

Title: Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides.

Journal: Chemical biology & drug design 20100501

Title: HIV-1 Entry, Inhibitors, and Resistance.

Journal: Viruses 20100501

Title: Using density functional theory to rationalise the mass spectral fragmentation of maraviroc and its metabolites.

Journal: Rapid communications in mass spectrometry : RCM 20100415

Title: CCR5 antagonists: host-targeted antiviral agents for the treatment of HIV infection, 4 years on.

Journal: Antiviral chemistry & chemotherapy 20100414

Title: Basic PK/PD principles of drug effects in circular/proliferative systems for disease modelling.

Journal: Journal of pharmacokinetics and pharmacodynamics 20100401

Title: Are the proposed env mutations actually associated with resistance to maraviroc?

Journal: Journal of acquired immune deficiency syndromes (1999) 20100401

Title: Prediction of co-receptor usage of HIV-1 from genotype.

Journal: PLoS computational biology 20100401

Title: HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate.

Journal: Viruses 20100401

Title: Raltegravir, maraviroc, etravirine: an effective protease inhibitor and nucleoside reverse transcriptase inhibitor-sparing regimen for salvage therapy in HIV-infected patients with triple-class experience.

Journal: AIDS (London, England) 20100327

Title: A lectin isolated from bananas is a potent inhibitor of HIV replication.

Journal: The Journal of biological chemistry 20100319

Title: Maraviroc versus efavirenz, both in combination with zidovudine-lamivudine, for the treatment of antiretroviral-naive subjects with CCR5-tropic HIV-1 infection.

Journal: The Journal of infectious diseases 20100315

Title: Maraviroc for treatment-naive patients with HIV-1 infection: is the glass half empty or half full?

Journal: The Journal of infectious diseases 20100315

Title: Clinical implications of genotypic resistance to the newer antiretroviral drugs in HIV-1-infected patients with virological failure.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100315

Title: Different selection patterns of resistance and cross-resistance to HIV-1 agents targeting CCR5.

Journal: The Journal of antimicrobial chemotherapy 20100301

Title: Anti-chemokine small molecule drugs: a promising future?

Journal: Expert opinion on investigational drugs 20100301

Title: Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc.

Journal: Bioorganic & medicinal chemistry letters 20100301

Title: Novel CCR5 antagonists for the treatment of HIV infection: a review of compounds patented in 2006 - 2008.

Journal: Expert opinion on therapeutic patents 20100301

Title: [Current topics on drug-resistant HIV in Japan].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20100301

Title: Drug-class specific impact of antivirals on the reproductive capacity of HIV.

Journal: PLoS computational biology 20100301

Title: Pharmacokinetic interaction of ritonavir-boosted elvitegravir and maraviroc.

Journal: Journal of acquired immune deficiency syndromes (1999) 20100201

Title: A validated high-performance liquid chromatography-ultraviolet method for quantification of the CCR5 inhibitor maraviroc in plasma of HIV-infected patients.

Journal: Therapeutic drug monitoring 20100201

Title: HIV entry inhibitors: progress in development and application.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100201

Title: [The newest developments in anti-HIV-1 drugs].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100201

Title: CCR5: From Natural Resistance to a New Anti-HIV Strategy.

Journal: Viruses 20100201

Title: Pharmacokinetics and drug-drug interactions of antiretrovirals: an update.

Journal: Antiviral research 20100101

Title: Entry inhibitors in the treatment of HIV-1 infection.

Journal: Antiviral research 20100101

Title: Long-lasting enfuvirtide carrier pentasaccharide conjugates with potent anti-human immunodeficiency virus type 1 activity.

Journal: Antimicrobial agents and chemotherapy 20100101

Title: Foscarnet as salvage therapy in HIV-2-infected patient with antiretroviral treatment failure.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20100101

Title: HIV type 1 from a patient with baseline resistance to CCR5 antagonists uses drug-bound receptor for entry.

Journal: AIDS research and human retroviruses 20100101

Title: Assessment of the pharmacokinetics of co-administered maraviroc and raltegravir.

Journal: British journal of clinical pharmacology 20100101

Title: Formal reasoning on qualitative models of coinfection of HIV and Tuberculosis and HAART therapy.

Journal: BMC bioinformatics 20100101

Title: Towards a Patent Pool for HIV Medicines: The Background.

Journal: The open AIDS journal 20100101

Title: Patent Pooling for Promoting Access to Antiretroviral Drugs (ARVs) - A Strategic Option for India.

Journal: The open AIDS journal 20100101

Title: Pooling ARV Drug Patents: A Pro-Access Fitting Strategy?

Journal: The open AIDS journal 20100101

Title: Profile of etravirine for the treatment of HIV infection.

Journal: Therapeutics and clinical risk management 20100101

Title: [Approach to establishing and evaluating clinical relevance of drug interactions in HIV patients: 2009 update].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20100101

Title: Frequent CXCR4 tropism of HIV-1 subtype A and CRF02_AG during late-stage disease--indication of an evolving epidemic in West Africa.

Journal: Retrovirology 20100101

Title: HIV-1 fusion inhibitor peptides enfuvirtide and T-1249 interact with erythrocyte and lymphocyte membranes.

Journal: PloS one 20100101

Title: Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage.

Journal: Retrovirology 20100101

Title: Maleic anhydride-modified chicken ovalbumin as an effective and inexpensive anti-HIV microbicide candidate for prevention of HIV sexual transmission.

Journal: Retrovirology 20100101

Title: Optimal management of cytomegalovirus retinitis in patients with AIDS.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20100101

Title: Forecasting drug utilization and expenditure in a metropolitan health region.

Journal: BMC health services research 20100101

Title: Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2.

Journal: Retrovirology 20100101

Title: Semen may harbor HIV despite effective HAART: another piece in the puzzle.

Journal: PloS one 20100101

Title: Recent key advances in human immunodeficiency virus medicine and implications for China.

Journal: AIDS research and therapy 20100101

Title: Effects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine-CCR5 interactions.

Journal: Antiviral therapy 20100101

Title: A microsimulation of the cost-effectiveness of maraviroc for antiretroviral treatment-experienced HIV-infected individuals.

Journal: HIV clinical trials 20100101

Title: Positive selection of HIV host factors and the evolution of lentivirus genes.

Journal: BMC evolutionary biology 20100101

Title: Comparative determination of HIV-1 co-receptor tropism by Enhanced Sensitivity Trofile, gp120 V3-loop RNA and DNA genotyping.

Journal: Retrovirology 20100101

Title: Comparison of HIV-1 genotypic resistance test interpretation systems in predicting virological outcomes over time.

Journal: PloS one 20100101

Title: Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India.

Journal: AIDS research and therapy 20100101

Title: Acyclovir inhibition of IDO to decrease Tregs as a glioblastoma treatment adjunct.

Journal: Journal of neuroinflammation 20100101

Title: Maraviroc in treatment-experienced patients with HIV-1 infection - experience from routine clinical practice.

Journal: European journal of medical research 20100101

Title: Efficacy and safety of maraviroc versus efavirenz, both with zidovudine/lamivudine: 96-week results from the MERIT study.

Journal: HIV clinical trials 20100101

Title: Impact of baseline antiretroviral resistance status on efficacy outcomes among patients receiving maraviroc plus optimized background therapy in the MOTIVATE 1 and 2 trials.

Journal: HIV clinical trials 20100101

Title: Anti-inflammatory effect of maraviroc in an HIV-infected patient with concomitant myositis: a case report.

Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20100101

Title: HIV-1 V3 envelope deep sequencing for clinical plasma specimens failing in phenotypic tropism assays.

Journal: AIDS research and therapy 20100101

Title: Structure activity relationship of dendrimer microbicides with dual action antiviral activity.

Journal: PloS one 20100101

Title: From bench to clinic: accessing promising investigational medications for patients with HIV infection in an urban family health center.

Journal: Journal of the American Board of Family Medicine : JABFM 20100101

Title: Clinical perspective on antiretroviral drug-drug interactions with the non-nucleoside reverse transcriptase inhibitor etravirine.

Journal: Antiviral therapy 20100101

Title: Genotypic determination of HIV tropism - clinical and methodological recommendations to guide the therapeutic use of CCR5 antagonists.

Journal: AIDS reviews 20100101

Title: Assessing the performance of a computer-based policy model of HIV and AIDS.

Journal: PloS one 20100101

Title: Clinical, virological and immunological responses in Danish HIV patients receiving raltegravir as part of a salvage regimen.

Journal: Clinical epidemiology 20100101

Title: Accurate and efficient gp120 V3 loop structure based models for the determination of HIV-1 co-receptor usage.

Journal: BMC bioinformatics 20100101

Title: Effects of maraviroc and efavirenz on markers of immune activation and inflammation and associations with CD4+ cell rises in HIV-infected patients.

Journal: PloS one 20100101

Title: Progress in antiretroviral drug delivery using nanotechnology.

Journal: International journal of nanomedicine 20100101

Title: Co-receptor usage and prediction of V3 genotyping algorithms in HIV-1 subtype B' from paid blood donors experienced anti-retroviral therapy in Chinese central province.

Journal: Virology journal 20100101

Title: Antiretroviral therapy optimisation without genotype resistance testing: a perspective on treatment history based models.

Journal: PloS one 20100101

Title: Structure of HIV-1 quasi-species as early indicator for switches of co-receptor tropism.

Journal: AIDS research and therapy 20100101

Title: Early development of non-hodgkin lymphoma following initiation of newer class antiretroviral therapy among HIV-infected patients - implications for immune reconstitution.

Journal: AIDS research and therapy 20100101

Title: Transmitted drug resistance in persons with acute/early HIV-1 in San Francisco, 2002-2009.

Journal: PloS one 20100101

Title: Grifonin-1: a small HIV-1 entry inhibitor derived from the algal lectin, Griffithsin.

Journal: PloS one 20100101

Title: Clinical management of treatment-experienced, HIV/AIDS patients in the combination antiretroviral therapy era.

Journal: PharmacoEconomics 20100101

Title: Oral pre-exposure prophylaxis by anti-retrovirals raltegravir and maraviroc protects against HIV-1 vaginal transmission in a humanized mouse model.

Journal: PloS one 20100101

Title: Incidence of Severe Hepatotoxicity Related to Antiretroviral Therapy in HIV/HCV Coinfected Patients.

Journal: AIDS research and treatment 20100101

Title: Lipid Metabolism and Cardiovascular Risk in HIV-1 Infection and HAART: Present and Future Problems.

Journal: Cholesterol 20100101

Title: Raltegravir in combination with other antiretroviral agents for the treatment of HIV infection.

Journal: Infection and drug resistance 20100101

Title: Optimizing management of treatment-naïve and treatment-experienced HIV+ patients: the role of maraviroc.

Journal: HIV/AIDS (Auckland, N.Z.) 20100101

Title: Role of etravirine in the management of treatment-experienced patients with human immunodeficiency virus type 1.

Journal: HIV/AIDS (Auckland, N.Z.) 20100101

Title: Profile of maraviroc: a CCR5 antagonist in the management of treatment-experienced HIV patients.

Journal: HIV/AIDS (Auckland, N.Z.) 20100101

Title: Canadian consensus guidelines for the optimal use of maraviroc in the treatment of HIV-infected adults.

Journal: The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale 20100101

Title: Towards Inhibition of Vif-APOBEC3G Interaction: Which Protein to Target?

Journal: Advances in virology 20100101

Title: HTS and hit finding in academia--from chemical genomics to drug discovery.

Journal: Drug discovery today 20091201

Title: Satisfactory cross-cultural validity of the ACTG symptom distress module in HIV-1-infected antiretroviral-naive patients.

Journal: Clinical trials (London, England) 20091201

Title: Antiretroviral therapy: new drugs, formulations, ideas, and strategies.

Journal: Topics in HIV medicine : a publication of the International AIDS Society, USA 20091201

Title: When and how to use maraviroc in HIV-infected patients.

Journal: AIDS (London, England) 20091127

Title: Cerebrospinal fluid maraviroc concentrations in HIV-1 infected patients.

Journal: AIDS (London, England) 20091127

Title: Is maraviroc beneficial in paradoxical progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome management?

Journal: AIDS (London, England) 20091127

Title: [Features and the method of application of a CCR5 antagonist, a new integrase inhibitor].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20091110

Title: Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4.

Journal: Journal of virology 20091101

Title: Efavirenz: a decade of clinical experience in the treatment of HIV.

Journal: The Journal of antimicrobial chemotherapy 20091101

Title: Maraviroc and raltegravir.

Journal: British journal of clinical pharmacology 20091101

Title: FDA advisory committee approves Selzentry.

Journal: AIDS patient care and STDs 20091101

Title: Novel drug classes: entry inhibitors [enfuvirtide, chemokine (C-C motif) receptor 5 antagonists].

Journal: Current opinion in HIV and AIDS 20091101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20091101

Title: Correlation between the Trofile test and virological response to a short-term maraviroc exposure in HIV-infected patients.

Journal: The Journal of antimicrobial chemotherapy 20091001

Title: New antiretroviral drugs: a review of the efficacy, safety, pharmacokinetics, and resistance profile of tipranavir, darunavir, etravirine, rilpivirine, maraviroc, and raltegravir.

Journal: Expert opinion on pharmacotherapy 20091001

Title: A liquid chromatography-tandem mass spectrometry assay for quantification of nevirapine, indinavir, atazanavir, amprenavir, saquinavir, ritonavir, lopinavir, efavirenz, tipranavir, darunavir and maraviroc in the plasma of patients infected with HIV.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091001

Title: Impact of adding maraviroc to antiretroviral regimens in patients with full viral suppression but impaired CD4 recovery.

Journal: AIDS (London, England) 20090910

Title: Planning Future Strategies for Domestic and International NeuroAIDS Research, July 24-25, 2008.

Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20090901

Title: CD4-BFFI: a novel, bifunctional HIV-1 entry inhibitor with high and broad antiviral potency.

Journal: Antiviral research 20090901

Title: New developments in HIV drug resistance.

Journal: The Journal of antimicrobial chemotherapy 20090901

Title: The history of antiretrovirals: key discoveries over the past 25 years.

Journal: Reviews in medical virology 20090901

Title: Maraviroc modelling strategy: use of early phase 1 data to support a semi-mechanistic population pharmacokinetic model.

Journal: British journal of clinical pharmacology 20090901

Title: [Immunorecovery after prolonged HIV-related immunosuppression: opportunities of the new antiretroviral classes].

Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20090901

Title: Maraviroc concentrates in the cervicovaginal fluid and vaginal tissue of HIV-negative women.

Journal: Journal of acquired immune deficiency syndromes (1999) 20090815

Title: Human immunodeficiency virus: 25 years of diagnostic and therapeutic strategies and their impact on hepatitis B and C virus.

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Title: Concurrent use of statins does not influence efficacy of maraviroc in Maraviroc versus Optimized Therapy in Viremic Antiretroviral Treatment-Experienced Patients 1 and 2 trials.

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Title: Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.

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Title: Maraviroc: perspectives for use in antiretroviral-naive HIV-1-infected patients.

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Journal: British journal of clinical pharmacology 20081001

Title: Discovery of a novel CCR5 antagonist lead compound through fragment assembly.

Journal: Molecules (Basel, Switzerland) 20081001

Title: Preclinical assessment of the distribution of maraviroc to potential human immunodeficiency virus (HIV) sanctuary sites in the central nervous system (CNS) and gut-associated lymphoid tissue (GALT).

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Title: Lopinavir/ritonavir in the treatment of HIV-1 infection: a review.

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Title: Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel.

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Title: The Relationship Between HIV Infection and Cardiovascular Disease.

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Title: Reviews of anti-infective agents: maraviroc: the first of a new class of antiretroviral agents.

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Title: Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes.

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Title: New treatment options for HIV salvage patients: an overview of second generation PIs, NNRTIs, integrase inhibitors and CCR5 antagonists.

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Title: New drugs08, part 2.

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Title: How developing world concerns need to be part of drug development plans: a case study of four emerging antiretrovirals.

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Title: Maraviroc: a CCR5-receptor antagonist for the treatment of HIV-1 infection.

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Title: CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer.

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Title: Maraviroc: integration of a new antiretroviral drug class into clinical practice.

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Title: Potential for new antiretrovirals to address unmet needs in the management of HIV-1 infection.

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Title: Maraviroc: new drug. Multiple antiretroviral treatment failure: too soon to reach conclusions.

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Title: Pharmacologic characteristics of investigational and recently approved agents for the treatment of HIV.

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Title: Assessment of the pharmacokinetics, safety and tolerability of maraviroc, a novel CCR5 antagonist, in healthy volunteers.

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Title: Effect of maraviroc on the pharmacokinetics of midazolam, lamivudine/zidovudine, and ethinyloestradiol/levonorgestrel in healthy volunteers.

Journal: British journal of clinical pharmacology 20080401

Title: Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers.

Journal: British journal of clinical pharmacology 20080401

Title: Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers.

Journal: British journal of clinical pharmacology 20080401

Title: The effects of cotrimoxazole or tenofovir co-administration on the pharmacokinetics of maraviroc in healthy volunteers.

Journal: British journal of clinical pharmacology 20080401

Title: A novel probe drug interaction study to investigate the effect of selected antiretroviral combinations on the pharmacokinetics of a single oral dose of maraviroc in HIV-positive subjects.

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Title: Assessment of the absorption, metabolism and absolute bioavailability of maraviroc in healthy male subjects.

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Title: Effect of single doses of maraviroc on the QT/QTc interval in healthy subjects.

Journal: British journal of clinical pharmacology 20080401

Title: A population pharmacokinetic meta-analysis of maraviroc in healthy volunteers and asymptomatic HIV-infected subjects.

Journal: British journal of clinical pharmacology 20080401

Title: Population pharmacokinetic/pharmacodynamic analysis of CCR5 receptor occupancy by maraviroc in healthy subjects and HIV-positive patients.

Journal: British journal of clinical pharmacology 20080401

Title: A receptor theory-based semimechanistic PD model for the CCR5 noncompetitive antagonist maraviroc.

Journal: British journal of clinical pharmacology 20080401

Title: New approaches in the treatment of HIV/AIDS - focus on maraviroc and other CCR5 antagonists.

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Title: 'One pill, once daily': what clinicians need to know about Atriplatrade mark.

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Title: Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists.

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Title: Two new drugs for HIV infection.

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Title: Post-exposure prophylaxis with a maraviroc-containing regimen after occupational exposure to a multi-resistant HIV-infected source person.

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Title: Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors.

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Title: The incidence of multidrug and full class resistance in HIV-1 infected patients is decreasing over time (2001-2006) in Portugal.

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Title: Distinct efficacy of HIV-1 entry inhibitors to prevent cell-to-cell transfer of R5 and X4 viruses across a human placental trophoblast barrier in a reconstitution model in vitro.

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Title: Highlights of the 15th Conference on Retroviruses and Opportunistic Infections. Advances in antiretroviral therapy.

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Title: Minor Variant Detection at Different Template Concentrations in HIV-1 Phenotypic and Genotypic Tropism Testing.

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Title: CCR5 antagonists: comparison of efficacy, side effects, pharmacokinetics and interactions--review of the literature.

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Title: CCR5 antagonists in the treatment of treatment-experienced patients infected with CCR5 tropic HIV-1.

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Title: CCR5 antagonists in the treatment of treatment-naive patients infected with CCR5 tropic HIV-1.

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Title: Treatment with CCR5 antagonists: which patient may have a benefit?

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Title: Maraviroc approved in the European Union.

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Title: Report from the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Maraviroc in treatment-experienced and treatment-naive patients.

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Title: Novel HIV treatment approved.

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Title: FDA approves maraviroc tablets.

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Title: Maraviroc reduces viral load in naive patients at 48 weeks.

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Title: FDA approval: maraviroc.

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Title: FDA notifications. Maraviroc approved as a CCR5 co-receptor antagonist.

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Title: Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands.

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Title: Maraviroc, a chemokine CCR5 receptor antagonist for the treatment of HIV infection and AIDS.

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Title: Report from the XVI International HIV Drug Resistance Workshop.

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Title: First medication in new class of ARTs poised to be available for salvage therapy. Tropism testing helps determine best patients for drug.

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Title: CCR5 small-molecule antagonists and monoclonal antibodies exert potent synergistic antiviral effects by cobinding to the receptor.

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Tags:376348-65-1 Molecular Formula|376348-65-1 MDL|376348-65-1 SMILES|376348-65-1 Maraviroc
Catalog No.: AA00I7C1
376348-65-1,MFCD09953791
376348-65-1 | Maraviroc
Pack Size: 5mg
Purity: ≥98%
in stock
$86.00 $60.00
Pack Size: 10mg
Purity: ≥98%
in stock
$160.00 $112.00
Pack Size: 25mg
Purity: ≥98%
in stock
$272.00 $190.00
Pack Size: 250mg
Purity: 95%
in stock
$500.00 $350.00
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Technical Information
Catalog Number: AA00I7C1
Chemical Name: Maraviroc
CAS Number: 376348-65-1
Molecular Formula: C29H41F2N5O
Molecular Weight: 513.6655
MDL Number: MFCD09953791
SMILES: O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1C[C@H](C2)n1c(C)nnc1C(C)C
Properties
Complexity: 751  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 3  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 37  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 8  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 5.1  
Downstream Synthesis Route
122665-97-8    376348-71-9    376348-65-1 

[1]EuropeanJournalofOrganicChemistry,2018,vol.2018,p.1821-1832

[2]TetrahedronLetters,2005,vol.46,p.5005-5007

178312-47-5    376348-65-1 

[1]TetrahedronLetters,2005,vol.46,p.5005-5007

[2]OrganicLetters,2018,vol.20,p.4959-4963

376348-70-8    376348-65-1 

[1]TetrahedronLetters,2005,vol.46,p.5005-5007

[2]OrganicLetters,2018,vol.20,p.4959-4963

17159-79-4    376348-65-1 

[1]TetrahedronLetters,2005,vol.46,p.5005-5007

[2]TetrahedronLetters,2005,vol.46,p.5005-5007

37088-66-7    376348-65-1 

[1]TetrahedronLetters,2005,vol.46,p.5005-5007

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Title: Clinical use of CCR5 inhibitors in HIV and beyond.

Journal: Journal of translational medicine20110101

Title: [Variability in HIV viral tropism determination using different genotypic algorithms in patients infected with B versus non-B HIV-1 subtypes].

Journal: Enfermedades infecciosas y microbiologia clinica20110101

Title: Penicillium marneffei Infection in AIDS.

Journal: Pathology research international20110101

Title: Update on microbicide research and development - seeking new HIV prevention tools for women.

Journal: European journal of medical research20110101

Title: Prevalence of potential drug-drug interactions involving antiretroviral drugs in a large Kenyan cohort.

Journal: PloS one20110101

Title: Maraviroc can improve lipid profiles in dyslipidemic patients with HIV: results from the MERIT trial.

Journal: HIV clinical trials20110101

Title: The costs of full suppression of plasma HIV RNA in highly antiretroviral-experienced patients.

Journal: AIDS reviews20110101

Title: Susceptibility of HIV-1 subtypes B', CRF07_BC and CRF01_AE that are predominantly circulating in China to HIV-1 entry inhibitors.

Journal: PloS one20110101

Title: Genetic characteristics, coreceptor usage potential and evolution of Nigerian HIV-1 subtype G and CRF02_AG isolates.

Journal: PloS one20110101

Title: Use of maraviroc-, raltegravir-, and etravirine-containing regimens in treatment-experienced patients: a case-series study.

Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)20110101

Title: HIV quasispecies dynamics during pro-active treatment switching: impact on multi-drug resistance and resistance archiving in latent reservoirs.

Journal: PloS one20110101

Title: Comparison of intima-media thickness and ophthalmic artery resistance index for assessing subclinical atherosclerosis in HIV-1-infected patients.

Journal: Cardiovascular ultrasound20110101

Title: Results of antiretroviral treatment interruption and intensification in advanced multi-drug resistant HIV infection from the OPTIMA trial.

Journal: PloS one20110101

Title: Antiretroviral Therapy for HIV-2 Infection: Recommendations for Management in Low-Resource Settings.

Journal: AIDS research and treatment20110101

Title: Outcomes of Universal Access to Antiretroviral Therapy (ART) in Georgia.

Journal: AIDS research and treatment20110101

Title: Mutations in gp41 are correlated with coreceptor tropism but do not improve prediction methods substantially.

Journal: Antiviral therapy20110101

Title: Baseline CD4(+) T-cell counts and weighted background susceptibility scores strongly predict response to maraviroc regimens in treatment-experienced patients.

Journal: Antiviral therapy20110101

Title: Create a translational medicine knowledge repository--research downsizing, mergers and increased outsourcing have reduced the depth of in-house translational medicine expertise and institutional memory at many pharmaceutical and biotech companies: how will they avoid relearning old lessons?

Journal: Journal of translational medicine20110101

Title: Selected amino acid mutations in HIV-1 B subtype gp41 are associated with specific gp120v₃ signatures in the regulation of co-receptor usage.

Journal: Retrovirology20110101

Title: Genotypic tropism testing by massively parallel sequencing: qualitative and quantitative analysis.

Journal: BMC medical informatics and decision making20110101

Title: Clinical utility of maraviroc.

Journal: Clinical drug investigation20110101

Title: Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis.

Journal: Malaria journal20110101

Title: Contraception in HIV-positive female adolescents.

Journal: AIDS research and therapy20110101

Title: Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues.

Journal: Retrovirology20110101

Title: HIV and HAART-Associated Dyslipidemia.

Journal: The open cardiovascular medicine journal20110101

Title: Solution structure of LC4 transmembrane segment of CCR5.

Journal: PloS one20110101

Title: Estimating the threshold surface density of Gp120-CCR5 complexes necessary for HIV-1 envelope-mediated cell-cell fusion.

Journal: PloS one20110101

Title: Inhibition of HIV-1 Env-Mediated Cell-Cell Fusion by Lectins, Peptide T-20, and Neutralizing Antibodies.

Journal: The open virology journal20110101

Title: A topical microbicide gel formulation of CCR5 antagonist maraviroc prevents HIV-1 vaginal transmission in humanized RAG-hu mice.

Journal: PloS one20110101

Title: Humanized Rag1-/- γc-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes.

Journal: PloS one20110101

Title: Validation of case-finding algorithms derived from administrative data for identifying adults living with human immunodeficiency virus infection.

Journal: PloS one20110101

Title: Should patents for antiretrovirals be waived in the developing world? Annual Varsity Medical Debate--London, 21 January 2011.

Journal: Philosophy, ethics, and humanities in medicine : PEHM20110101

Title: Genotypic prediction of HIV-1 subtype D tropism.

Journal: Retrovirology20110101

Title: Resistance to the CCR5 inhibitor 5P12-RANTES requires a difficult evolution from CCR5 to CXCR4 coreceptor use.

Journal: PloS one20110101

Title: [Analysis of the prevalence of CCR5 coreceptor antagonist resistance mutations among HIV-1 variants in Russia].

Journal: Voprosy virusologii20110101

Title: Pre-exposure prophylaxis of HIV.

Journal: Indian journal of sexually transmitted diseases and AIDS20110101

Title: Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate.

Journal: PloS one20110101

Title: The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment.

Journal: Retrovirology20110101

Title: Genotypic and functional properties of early infant HIV-1 envelopes.

Journal: Retrovirology20110101

Title: Origin and epidemiological history of HIV-1 CRF14_BG.

Journal: PloS one20110101

Title: Resource utilization and cost-effectiveness of counselor- vs. provider-based rapid point-of-care HIV screening in the emergency department.

Journal: PloS one20110101

Title: [Our experience with maraviroc treatment in HIV positive patients].

Journal: Casopis lekaru ceskych20110101

Title: A comparison of parallel pyrosequencing and sanger clone-based sequencing and its impact on the characterization of the genetic diversity of HIV-1.

Journal: PloS one20110101

Title: HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry.

Journal: Retrovirology20110101

Title: An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors.

Journal: PloS one20110101

Title: It is time to consider third-line options in antiretroviral-experienced paediatric patients?

Journal: Journal of the International AIDS Society20110101

Title: 8-Modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcription.

Journal: PloS one20110101

Title: Combined phytochemistry and chemotaxis assays for identification and mechanistic analysis of anti-inflammatory phytochemicals in Fallopia japonica.

Journal: PloS one20110101

Title: Safety, efficacy, and pharmacokinetics of rilpivirine: systematic review with an emphasis on resource-limited settings.

Journal: HIV/AIDS (Auckland, N.Z.)20110101

Title: Role of raltegravir in the management of HIV-1 infection.

Journal: HIV/AIDS (Auckland, N.Z.)20110101

Title: Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the fetal compartment (placenta and amniotic fluid).

Journal: Antiviral therapy20110101

Title: Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the male and female genital tract.

Journal: Antiviral therapy20110101

Title: SHIV-162P3 infection of rhesus macaques given maraviroc gel vaginally does not involve resistant viruses.

Journal: PloS one20110101

Title: Applications of next-generation sequencing technologies to diagnostic virology.

Journal: International journal of molecular sciences20110101

Title: Intensification of antiretroviral therapy with a CCR5 antagonist in patients with chronic HIV-1 infection: effect on T cells latently infected.

Journal: PloS one20110101

Title: In vitro downregulation of matrix metalloproteinase-9 in rat glial cells by CCR5 antagonist maraviroc: therapeutic implication for HIV brain infection.

Journal: PloS one20110101

Title: Modeling dynamic interactions between pre-exposure prophylaxis interventions & treatment programs: predicting HIV transmission & resistance.

Journal: Scientific reports20110101

Title: Grand challenges.

Journal: Frontiers in immunology20110101

Title: Clinical Use of Inhibitors of HIV-1 Integration: Problems and Prospects.

Journal: Acta naturae20110101

Title: Two-year safety and virologic efficacy of maraviroc in treatment-experienced patients with CCR5-tropic HIV-1 infection: 96-week combined analysis of MOTIVATE 1 and 2.

Journal: Journal of acquired immune deficiency syndromes (1999)20101215

Title: Maraviroc concentrations in cerebrospinal fluid in HIV-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999)20101215

Title: Treatment intensification has no effect on the HIV-1 central nervous system infection in patients on suppressive antiretroviral therapy.

Journal: Journal of acquired immune deficiency syndromes (1999)20101215

Title: Maraviroc concentrations in seminal plasma in HIV-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999)20101215

Title: C-C chemokine receptor type 5 (CCR5) utilization of transmitted and early founder human immunodeficiency virus type 1 envelopes and sensitivity to small-molecule CCR5 inhibitors.

Journal: The Journal of general virology20101201

Title: Evolution of CCR5 antagonist resistance in an HIV-1 subtype C clinical isolate.

Journal: Journal of acquired immune deficiency syndromes (1999)20101201

Title: Primary resistance to maraviroc in a large set of R5-V3 viral sequences from HIV-1-infected patients.

Journal: The Journal of antimicrobial chemotherapy20101201

Title: TROCAI (tropism coreceptor assay information): a new phenotypic tropism test and its correlation with Trofile enhanced sensitivity and genotypic approaches.

Journal: Journal of clinical microbiology20101201

Title: Evaluation of primary resistance to HIV entry inhibitors among brazilian patients failing reverse transcriptase/protease inhibitors treatment reveal high prevalence of maraviroc resistance-related mutations.

Journal: AIDS research and human retroviruses20101201

Title: Glioblastoma: synergy of growth promotion between CCL5 and NK-1R can be thwarted by blocking CCL5 with miraviroc, an FDA approved anti-HIV drug and blocking NK-1R with aprepitant, an FDA approved anti-nausea drug.

Journal: Journal of clinical pharmacy and therapeutics20101201

Title: An LC-MS-MS method for quantitative determination of maraviroc (UK-427,857) in human plasma, urine and cerebrospinal fluid.

Journal: Biomedical chromatography : BMC20101201

Title: Cost-effectiveness of maraviroc for antiretroviral treatment-experienced HIV-infected individuals in Mexico.

Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research20101201

Title: [Pharmacological profile and clinical findings of Maraviroc (Celsentri® Tablets)].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica20101201

Title: The evolutionary analysis of emerging low frequency HIV-1 CXCR4 using variants through time--an ultra-deep approach.

Journal: PLoS computational biology20101201

Title: Maraviroc is a substrate for OATP1B1 in vitro and maraviroc plasma concentrations are influenced by SLCO1B1 521 T>C polymorphism.

Journal: Pharmacogenetics and genomics20101201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20101201

Title: Comparison of the Mechanisms of Drug Resistance among HIV, Hepatitis B, and Hepatitis C.

Journal: Viruses20101201

Title: Cost-effectiveness of optimized background therapy plus maraviroc for previously treated patients with R5 HIV-1 infection from the perspective of the Spanish health care system.

Journal: Clinical therapeutics20101201

Title: A report from the XVIII International AIDS Conference. (July 18-23, 2010-Vienna, Austria).

Journal: Drugs of today (Barcelona, Spain : 1998)20101201

Title: Maraviroc does not affect humoral response to the pandemic influenza A-H1N1v 2009 adjuvanted vaccine in HIV-1-infected patients.

Journal: AIDS (London, England)20101127

Title: Hepatic safety and tolerability in the maraviroc clinical development program.

Journal: AIDS (London, England)20101113

Title: Recognition and management of significant drug interactions in HIV patients: challenges in using available data to guide therapy.

Journal: Clinical pharmacology and therapeutics20101101

Title: Emerging concepts and approaches for chemokine-receptor drug discovery.

Journal: Expert opinion on drug discovery20101101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20101101

Title: It's official...but not infallible.

Journal: Prescrire international20101101

Title: Maraviroc first-line therapy for HIV infection. Too risky.

Journal: Prescrire international20101101

Title: Population-based V3 genotypic tropism assay: a retrospective analysis using screening samples from the A4001029 and MOTIVATE studies.

Journal: AIDS (London, England)20101023

Title: Maternal-fetal pharmacokinetics and dynamics of a single intrapartum dose of maraviroc in rhesus macaques.

Journal: Antimicrobial agents and chemotherapy20101001

Title: A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5.

Journal: Journal of virology20101001

Title: Novel antiretroviral combinations in treatment-experienced patients with HIV infection: rationale and results.

Journal: Drugs20100910

Title: An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes.

Journal: Virology20100901

Title: Protection of rhesus macaques from vaginal infection by vaginally delivered maraviroc, an inhibitor of HIV-1 entry via the CCR5 co-receptor.

Journal: The Journal of infectious diseases20100901

Title: Long-term immunovirogical effect and tolerability of a maraviroc-containing regimen in routine clinical practice.

Journal: Current HIV research20100901

Title: Maraviroc-containing regimen suppresses HIV replication in the cerebrospinal fluid of patients with neurological symptoms.

Journal: AIDS (London, England)20100824

Title: CD4+ T-cell restoration after 48 weeks in the maraviroc treatment-experienced trials MOTIVATE 1 and 2.

Journal: Journal of acquired immune deficiency syndromes (1999)20100801

Title: Characterization of a SHIV162P3 variant evolved in an infected rhesus macaque with persistent plasma viremia.

Journal: Virus research20100801

Title: Improved detection of CXCR4-using HIV by V3 genotyping: application of population-based and 'deep' sequencing to plasma RNA and proviral DNA.

Journal: Journal of acquired immune deficiency syndromes (1999)20100801

Title: Evaluation of the genotypic prediction of HIV-1 coreceptor use versus a phenotypic assay and correlation with the virological response to maraviroc: the ANRS GenoTropism study.

Journal: Antimicrobial agents and chemotherapy20100801

Title: Pharmacogenetic testing and therapeutic drug monitoring are complementary tools for optimal individualization of drug therapy.

Journal: European journal of clinical pharmacology20100801

Title: Downregulation of leukocyte migration after treatment with CCR5 antagonist maraviroc.

Journal: Journal of acquired immune deficiency syndromes (1999)20100801

Title: Development and application of a simple LC-MS method for the determination of plasma maraviroc concentrations.

Journal: The journal of medical investigation : JMI20100801

Title: A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo.

Journal: PLoS pathogens20100801

Title: Dynamics of HIV tropism under suppressive antiretroviral therapy: implications for tropism testing in subjects with undetectable viraemia.

Journal: The Journal of antimicrobial chemotherapy20100701

Title: Hemodynamic effects of single-dose vardenafil in subjects receiving maraviroc.

Journal: Journal of acquired immune deficiency syndromes (1999)20100701

Title: Short communication: antiretroviral therapy resistance mutations present in the HIV type 1 subtype C pol and env regions from therapy-naive patients in Zambia.

Journal: AIDS research and human retroviruses20100701

Title: Role of CXCR4 in HIV infection and its potential as a therapeutic target.

Journal: Future microbiology20100701

Title: Patterns of HIV-1 protein interaction identify perturbed host-cellular subsystems.

Journal: PLoS computational biology20100701

Title: Maraviroc: a review of its use in the management of CCR5-tropic HIV-1 infection.

Journal: Drugs20100618

Title: Validation of a rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assay for the simultaneous determination of existing and new antiretroviral compounds.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20100601

Title: Shift in phenotypic susceptibility suggests a competition mechanism in a case of acquired resistance to maraviroc.

Journal: AIDS (London, England)20100601

Title: HIV-1 tropism.

Journal: Protein & cell20100601

Title: Novel hexahydropyrrolo[3,4-c]pyrrole CCR5 antagonists.

Journal: Bioorganic & medicinal chemistry letters20100515

Title: Clinical outcome in resistant HIV-2 infection treated with raltegravir and maraviroc.

Journal: Antiviral research20100501

Title: Protection against HIV-envelope-induced neuronal cell destruction by HIV attachment inhibitors.

Journal: Archives of virology20100501

Title: Raltegravir plasma concentrations in treatment-experienced patients receiving salvage regimens based on raltegravir with and without maraviroc coadministration.

Journal: The Annals of pharmacotherapy20100501

Title: Treatment of HIV infection with the CCR5 antagonist maraviroc.

Journal: Expert opinion on pharmacotherapy20100501

Title: [CCR5-antagonists: contribution of a new antiretroviral class to the management of HIV infection].

Journal: Medecine et maladies infectieuses20100501

Title: Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides.

Journal: Chemical biology & drug design20100501

Title: HIV-1 Entry, Inhibitors, and Resistance.

Journal: Viruses20100501

Title: Using density functional theory to rationalise the mass spectral fragmentation of maraviroc and its metabolites.

Journal: Rapid communications in mass spectrometry : RCM20100415

Title: CCR5 antagonists: host-targeted antiviral agents for the treatment of HIV infection, 4 years on.

Journal: Antiviral chemistry & chemotherapy20100414

Title: Basic PK/PD principles of drug effects in circular/proliferative systems for disease modelling.

Journal: Journal of pharmacokinetics and pharmacodynamics20100401

Title: Are the proposed env mutations actually associated with resistance to maraviroc?

Journal: Journal of acquired immune deficiency syndromes (1999)20100401

Title: Prediction of co-receptor usage of HIV-1 from genotype.

Journal: PLoS computational biology20100401

Title: HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate.

Journal: Viruses20100401

Title: Raltegravir, maraviroc, etravirine: an effective protease inhibitor and nucleoside reverse transcriptase inhibitor-sparing regimen for salvage therapy in HIV-infected patients with triple-class experience.

Journal: AIDS (London, England)20100327

Title: A lectin isolated from bananas is a potent inhibitor of HIV replication.

Journal: The Journal of biological chemistry20100319

Title: Maraviroc versus efavirenz, both in combination with zidovudine-lamivudine, for the treatment of antiretroviral-naive subjects with CCR5-tropic HIV-1 infection.

Journal: The Journal of infectious diseases20100315

Title: Maraviroc for treatment-naive patients with HIV-1 infection: is the glass half empty or half full?

Journal: The Journal of infectious diseases20100315

Title: Clinical implications of genotypic resistance to the newer antiretroviral drugs in HIV-1-infected patients with virological failure.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America20100315

Title: Different selection patterns of resistance and cross-resistance to HIV-1 agents targeting CCR5.

Journal: The Journal of antimicrobial chemotherapy20100301

Title: Anti-chemokine small molecule drugs: a promising future?

Journal: Expert opinion on investigational drugs20100301

Title: Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc.

Journal: Bioorganic & medicinal chemistry letters20100301

Title: Novel CCR5 antagonists for the treatment of HIV infection: a review of compounds patented in 2006 - 2008.

Journal: Expert opinion on therapeutic patents20100301

Title: [Current topics on drug-resistant HIV in Japan].

Journal: Nihon rinsho. Japanese journal of clinical medicine20100301

Title: Drug-class specific impact of antivirals on the reproductive capacity of HIV.

Journal: PLoS computational biology20100301

Title: Pharmacokinetic interaction of ritonavir-boosted elvitegravir and maraviroc.

Journal: Journal of acquired immune deficiency syndromes (1999)20100201

Title: A validated high-performance liquid chromatography-ultraviolet method for quantification of the CCR5 inhibitor maraviroc in plasma of HIV-infected patients.

Journal: Therapeutic drug monitoring20100201

Title: HIV entry inhibitors: progress in development and application.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20100201

Title: [The newest developments in anti-HIV-1 drugs].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20100201

Title: CCR5: From Natural Resistance to a New Anti-HIV Strategy.

Journal: Viruses20100201

Title: Pharmacokinetics and drug-drug interactions of antiretrovirals: an update.

Journal: Antiviral research20100101

Title: Entry inhibitors in the treatment of HIV-1 infection.

Journal: Antiviral research20100101

Title: Long-lasting enfuvirtide carrier pentasaccharide conjugates with potent anti-human immunodeficiency virus type 1 activity.

Journal: Antimicrobial agents and chemotherapy20100101

Title: Foscarnet as salvage therapy in HIV-2-infected patient with antiretroviral treatment failure.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology20100101

Title: HIV type 1 from a patient with baseline resistance to CCR5 antagonists uses drug-bound receptor for entry.

Journal: AIDS research and human retroviruses20100101

Title: Assessment of the pharmacokinetics of co-administered maraviroc and raltegravir.

Journal: British journal of clinical pharmacology20100101

Title: Formal reasoning on qualitative models of coinfection of HIV and Tuberculosis and HAART therapy.

Journal: BMC bioinformatics20100101

Title: Towards a Patent Pool for HIV Medicines: The Background.

Journal: The open AIDS journal20100101

Title: Patent Pooling for Promoting Access to Antiretroviral Drugs (ARVs) - A Strategic Option for India.

Journal: The open AIDS journal20100101

Title: Pooling ARV Drug Patents: A Pro-Access Fitting Strategy?

Journal: The open AIDS journal20100101

Title: Profile of etravirine for the treatment of HIV infection.

Journal: Therapeutics and clinical risk management20100101

Title: [Approach to establishing and evaluating clinical relevance of drug interactions in HIV patients: 2009 update].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria20100101

Title: Frequent CXCR4 tropism of HIV-1 subtype A and CRF02_AG during late-stage disease--indication of an evolving epidemic in West Africa.

Journal: Retrovirology20100101

Title: HIV-1 fusion inhibitor peptides enfuvirtide and T-1249 interact with erythrocyte and lymphocyte membranes.

Journal: PloS one20100101

Title: Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage.

Journal: Retrovirology20100101

Title: Maleic anhydride-modified chicken ovalbumin as an effective and inexpensive anti-HIV microbicide candidate for prevention of HIV sexual transmission.

Journal: Retrovirology20100101

Title: Optimal management of cytomegalovirus retinitis in patients with AIDS.

Journal: Clinical ophthalmology (Auckland, N.Z.)20100101

Title: Forecasting drug utilization and expenditure in a metropolitan health region.

Journal: BMC health services research20100101

Title: Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2.

Journal: Retrovirology20100101

Title: Semen may harbor HIV despite effective HAART: another piece in the puzzle.

Journal: PloS one20100101

Title: Recent key advances in human immunodeficiency virus medicine and implications for China.

Journal: AIDS research and therapy20100101

Title: Effects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine-CCR5 interactions.

Journal: Antiviral therapy20100101

Title: A microsimulation of the cost-effectiveness of maraviroc for antiretroviral treatment-experienced HIV-infected individuals.

Journal: HIV clinical trials20100101

Title: Positive selection of HIV host factors and the evolution of lentivirus genes.

Journal: BMC evolutionary biology20100101

Title: Comparative determination of HIV-1 co-receptor tropism by Enhanced Sensitivity Trofile, gp120 V3-loop RNA and DNA genotyping.

Journal: Retrovirology20100101

Title: Comparison of HIV-1 genotypic resistance test interpretation systems in predicting virological outcomes over time.

Journal: PloS one20100101

Title: Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India.

Journal: AIDS research and therapy20100101

Title: Acyclovir inhibition of IDO to decrease Tregs as a glioblastoma treatment adjunct.

Journal: Journal of neuroinflammation20100101

Title: Maraviroc in treatment-experienced patients with HIV-1 infection - experience from routine clinical practice.

Journal: European journal of medical research20100101

Title: Efficacy and safety of maraviroc versus efavirenz, both with zidovudine/lamivudine: 96-week results from the MERIT study.

Journal: HIV clinical trials20100101

Title: Impact of baseline antiretroviral resistance status on efficacy outcomes among patients receiving maraviroc plus optimized background therapy in the MOTIVATE 1 and 2 trials.

Journal: HIV clinical trials20100101

Title: Anti-inflammatory effect of maraviroc in an HIV-infected patient with concomitant myositis: a case report.

Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)20100101

Title: HIV-1 V3 envelope deep sequencing for clinical plasma specimens failing in phenotypic tropism assays.

Journal: AIDS research and therapy20100101

Title: Structure activity relationship of dendrimer microbicides with dual action antiviral activity.

Journal: PloS one20100101

Title: From bench to clinic: accessing promising investigational medications for patients with HIV infection in an urban family health center.

Journal: Journal of the American Board of Family Medicine : JABFM20100101

Title: Clinical perspective on antiretroviral drug-drug interactions with the non-nucleoside reverse transcriptase inhibitor etravirine.

Journal: Antiviral therapy20100101

Title: Genotypic determination of HIV tropism - clinical and methodological recommendations to guide the therapeutic use of CCR5 antagonists.

Journal: AIDS reviews20100101

Title: Assessing the performance of a computer-based policy model of HIV and AIDS.

Journal: PloS one20100101

Title: Clinical, virological and immunological responses in Danish HIV patients receiving raltegravir as part of a salvage regimen.

Journal: Clinical epidemiology20100101

Title: Accurate and efficient gp120 V3 loop structure based models for the determination of HIV-1 co-receptor usage.

Journal: BMC bioinformatics20100101

Title: Effects of maraviroc and efavirenz on markers of immune activation and inflammation and associations with CD4+ cell rises in HIV-infected patients.

Journal: PloS one20100101

Title: Progress in antiretroviral drug delivery using nanotechnology.

Journal: International journal of nanomedicine20100101

Title: Co-receptor usage and prediction of V3 genotyping algorithms in HIV-1 subtype B' from paid blood donors experienced anti-retroviral therapy in Chinese central province.

Journal: Virology journal20100101

Title: Antiretroviral therapy optimisation without genotype resistance testing: a perspective on treatment history based models.

Journal: PloS one20100101

Title: Structure of HIV-1 quasi-species as early indicator for switches of co-receptor tropism.

Journal: AIDS research and therapy20100101

Title: Early development of non-hodgkin lymphoma following initiation of newer class antiretroviral therapy among HIV-infected patients - implications for immune reconstitution.

Journal: AIDS research and therapy20100101

Title: Transmitted drug resistance in persons with acute/early HIV-1 in San Francisco, 2002-2009.

Journal: PloS one20100101

Title: Grifonin-1: a small HIV-1 entry inhibitor derived from the algal lectin, Griffithsin.

Journal: PloS one20100101

Title: Clinical management of treatment-experienced, HIV/AIDS patients in the combination antiretroviral therapy era.

Journal: PharmacoEconomics20100101

Title: Oral pre-exposure prophylaxis by anti-retrovirals raltegravir and maraviroc protects against HIV-1 vaginal transmission in a humanized mouse model.

Journal: PloS one20100101

Title: Incidence of Severe Hepatotoxicity Related to Antiretroviral Therapy in HIV/HCV Coinfected Patients.

Journal: AIDS research and treatment20100101

Title: Lipid Metabolism and Cardiovascular Risk in HIV-1 Infection and HAART: Present and Future Problems.

Journal: Cholesterol20100101

Title: Raltegravir in combination with other antiretroviral agents for the treatment of HIV infection.

Journal: Infection and drug resistance20100101

Title: Optimizing management of treatment-naïve and treatment-experienced HIV+ patients: the role of maraviroc.

Journal: HIV/AIDS (Auckland, N.Z.)20100101

Title: Role of etravirine in the management of treatment-experienced patients with human immunodeficiency virus type 1.

Journal: HIV/AIDS (Auckland, N.Z.)20100101

Title: Profile of maraviroc: a CCR5 antagonist in the management of treatment-experienced HIV patients.

Journal: HIV/AIDS (Auckland, N.Z.)20100101

Title: Canadian consensus guidelines for the optimal use of maraviroc in the treatment of HIV-infected adults.

Journal: The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale20100101

Title: Towards Inhibition of Vif-APOBEC3G Interaction: Which Protein to Target?

Journal: Advances in virology20100101

Title: HTS and hit finding in academia--from chemical genomics to drug discovery.

Journal: Drug discovery today20091201

Title: Satisfactory cross-cultural validity of the ACTG symptom distress module in HIV-1-infected antiretroviral-naive patients.

Journal: Clinical trials (London, England)20091201

Title: Antiretroviral therapy: new drugs, formulations, ideas, and strategies.

Journal: Topics in HIV medicine : a publication of the International AIDS Society, USA20091201

Title: When and how to use maraviroc in HIV-infected patients.

Journal: AIDS (London, England)20091127

Title: Cerebrospinal fluid maraviroc concentrations in HIV-1 infected patients.

Journal: AIDS (London, England)20091127

Title: Is maraviroc beneficial in paradoxical progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome management?

Journal: AIDS (London, England)20091127

Title: [Features and the method of application of a CCR5 antagonist, a new integrase inhibitor].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine20091110

Title: Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4.

Journal: Journal of virology20091101

Title: Efavirenz: a decade of clinical experience in the treatment of HIV.

Journal: The Journal of antimicrobial chemotherapy20091101

Title: Maraviroc and raltegravir.

Journal: British journal of clinical pharmacology20091101

Title: FDA advisory committee approves Selzentry.

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Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20091101

Title: Correlation between the Trofile test and virological response to a short-term maraviroc exposure in HIV-infected patients.

Journal: The Journal of antimicrobial chemotherapy20091001

Title: New antiretroviral drugs: a review of the efficacy, safety, pharmacokinetics, and resistance profile of tipranavir, darunavir, etravirine, rilpivirine, maraviroc, and raltegravir.

Journal: Expert opinion on pharmacotherapy20091001

Title: A liquid chromatography-tandem mass spectrometry assay for quantification of nevirapine, indinavir, atazanavir, amprenavir, saquinavir, ritonavir, lopinavir, efavirenz, tipranavir, darunavir and maraviroc in the plasma of patients infected with HIV.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20091001

Title: Impact of adding maraviroc to antiretroviral regimens in patients with full viral suppression but impaired CD4 recovery.

Journal: AIDS (London, England)20090910

Title: Planning Future Strategies for Domestic and International NeuroAIDS Research, July 24-25, 2008.

Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology20090901

Title: CD4-BFFI: a novel, bifunctional HIV-1 entry inhibitor with high and broad antiviral potency.

Journal: Antiviral research20090901

Title: New developments in HIV drug resistance.

Journal: The Journal of antimicrobial chemotherapy20090901

Title: The history of antiretrovirals: key discoveries over the past 25 years.

Journal: Reviews in medical virology20090901

Title: Maraviroc modelling strategy: use of early phase 1 data to support a semi-mechanistic population pharmacokinetic model.

Journal: British journal of clinical pharmacology20090901

Title: [Immunorecovery after prolonged HIV-related immunosuppression: opportunities of the new antiretroviral classes].

Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive20090901

Title: Maraviroc concentrates in the cervicovaginal fluid and vaginal tissue of HIV-negative women.

Journal: Journal of acquired immune deficiency syndromes (1999)20090815

Title: Human immunodeficiency virus: 25 years of diagnostic and therapeutic strategies and their impact on hepatitis B and C virus.

Journal: Medical microbiology and immunology20090801

Title: Accelerated immunodeficiency by anti-CCR5 treatment in HIV infection.

Journal: PLoS computational biology20090801

Title: Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry.

Journal: PLoS pathogens20090801

Title: 96-Week MERIT ES analysis shows efficacy of Celsentri=Selzentry.

Journal: AIDS patient care and STDs20090801

Title: Concurrent use of statins does not influence efficacy of maraviroc in Maraviroc versus Optimized Therapy in Viremic Antiretroviral Treatment-Experienced Patients 1 and 2 trials.

Journal: AIDS (London, England)20090731

Title: Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.

Journal: Journal of medicinal chemistry20090723

Title: Rapamycin enhances aplaviroc anti-HIV activity: implications for the clinical development of novel CCR5 antagonists.

Journal: Antiviral research20090701

Title: Detection of low-frequency pretherapy chemokine (CXC motif) receptor 4 (CXCR4)-using HIV-1 with ultra-deep pyrosequencing.

Journal: AIDS (London, England)20090619

Title: Maraviroc: perspectives for use in antiretroviral-naive HIV-1-infected patients.

Journal: The Journal of antimicrobial chemotherapy20090601

Title: A double-blind, placebo-controlled trial of maraviroc in treatment-experienced patients infected with non-R5 HIV-1.

Journal: The Journal of infectious diseases20090601

Title: Etravirine: new drug. Multidrug-resistant HIV: another option.

Journal: Prescrire international20090601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20090601

Title: The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research.

Journal: Antiviral research20090501

Title: Design and validation of new genotypic tools for easy and reliable estimation of HIV tropism before using CCR5 antagonists.

Journal: The Journal of antimicrobial chemotherapy20090501

Title: Immunotherapies in HIV-1 infection.

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Title: Gateways to clinical trials.

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Title: Maraviroc and CD4+ cell count recovery in patients with virologic suppression and blunted CD4+ cell response.

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Title: A LC-tandem MS assay for the simultaneous measurement of new antiretroviral agents: Raltegravir, maraviroc, darunavir, and etravirine.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20090415

Title: Maraviroc: a coreceptor CCR5 antagonist for management of HIV infection.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20090415

Title: Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV.

Journal: International journal of antimicrobial agents20090401

Title: The chemokine system and CCR5 antagonists: potential in HIV treatment and other novel therapies.

Journal: Journal of clinical pharmacy and therapeutics20090401

Title: Simultaneous determination of maraviroc and raltegravir in human plasma by HPLC-UV.

Journal: IUBMB life20090401

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20090401

Title: HIV entry inhibitors and their potential in HIV therapy.

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Title: The relative activity of 'function sparing' HIV-1 entry inhibitors on viral entry and CCR5 internalization: is allosteric functional selectivity a valuable therapeutic property?

Journal: Molecular pharmacology20090301

Title: 1-Amido-1-phenyl-3-piperidinylbutanes--CCR5 antagonists for the treatment of HIV: part 2.

Journal: Bioorganic & medicinal chemistry letters20090301

Title: Maraviroc, a CCR5 coreceptor antagonist that blocks entry of human immunodeficiency virus type 1.

Journal: Pharmacotherapy20090301

Title: HIV-1 entry inhibitors: an overview.

Journal: Current opinion in HIV and AIDS20090301

Title: A pièce de resistance: how HIV-1 escapes small molecule CCR5 inhibitors.

Journal: Current opinion in HIV and AIDS20090301

Title: The fusion inhibitor enfuvirtide in recent antiretroviral strategies.

Journal: Current opinion in HIV and AIDS20090301

Title: A note of caution on yellow fever vaccination during maraviroc treatment: a hypothesis on a potential dangerous interaction.

Journal: AIDS (London, England)20090220

Title: 1-Amido-1-phenyl-3-piperidinylbutanes - CCR5 antagonists for the treatment of HIV. Part 1.

Journal: Bioorganic & medicinal chemistry letters20090215

Title: Pharmacologic aspects of new antiretroviral drugs.

Journal: Current HIV/AIDS reports20090201

Title: HIV entry: new insights and implications for patient management.

Journal: Current opinion in infectious diseases20090201

Title: Maraviroc: a new CCR5 antagonist.

Journal: Expert review of anti-infective therapy20090201

Title: Inhibitors of viral entry.

Journal: Handbook of experimental pharmacology20090101

Title: Development of a panel of well-characterized human immunodeficiency virus type 1 isolates from newly diagnosed patients including acute and recent infections.

Journal: AIDS research and human retroviruses20090101

Title: Novel targets for antiretroviral therapy: clinical progress to date.

Journal: Drugs20090101

Title: Maraviroc approved for use in treatment-experienced CCR5-tropic HIV-1.

Journal: AIDS alert20090101

Title: Top stories of 2008. Newer drugs strikingly effective when given together.

Journal: AIDS clinical care20090101

Title: JNets: exploring networks by integrating annotation.

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Title: Role of atazanavir in the treatment of HIV infection.

Journal: Therapeutics and clinical risk management20090101

Title: CCR5 pharmacology methodologies and associated applications.

Journal: Methods in enzymology20090101

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Journal: Therapie20090101

Title: Drug interactions with new and investigational antiretrovirals.

Journal: Clinical pharmacokinetics20090101

Title: Differences in resistance mutations among HIV-1 non-subtype B infections: a systematic review of evidence (1996-2008).

Journal: Journal of the International AIDS Society20090101

Title: Complementation of diverse HIV-1 Env defects through cooperative subunit interactions: a general property of the functional trimer.

Journal: Retrovirology20090101

Title: Maraviroc: pharmacokinetics and drug interactions.

Journal: Antiviral therapy20090101

Title: Pharmacotherapy of pediatric and adolescent HIV infection.

Journal: Therapeutics and clinical risk management20090101

Title: Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir.

Journal: Therapeutics and clinical risk management20090101

Title: Discontinuation of enfuvirtide in heavily pretreated HIV-infected individuals.

Journal: HIV clinical trials20090101

Title: Optimizing care for patients on maraviroc salvage therapy.

Journal: HIV clinician20090101

Title: Pharmacokinetics, safety and tolerability of a single oral dose of maraviroc in HIV-negative subjects with mild and moderate hepatic impairment.

Journal: Antiviral therapy20090101

Title: Decoding the multifaceted HIV-1 virus-host interactome.

Journal: Journal of biology20090101

Title: Replication and drug resistant mutation of HIV-1 subtype B' (Thailand B) variants isolated from HAART treatment individuals in China.

Journal: Virology journal20090101

Title: Factors influencing global antiretroviral procurement prices.

Journal: BMC public health20090101

Title: Understanding the HIV coreceptor switch from a dynamical perspective.

Journal: BMC evolutionary biology20090101

Title: HIV-1 subtype and viral tropism determination for evaluating antiretroviral therapy options: an analysis of archived Kenyan blood samples.

Journal: BMC infectious diseases20090101

Title: Raltegravir: The evidence of its therapeutic value in HIV-1 infection.

Journal: Core evidence20090101

Title: Etravirine (TMC-125): The evidence for its place in the treatment of HIV-1 infection.

Journal: Core evidence20090101

Title: Cardiovascular, renal and liver events associated with human immunodeficiency virus type 1 infection and antiretroviral therapy.

Journal: F1000 medicine reports20090101

Title: CCR5 inhibitors: Emerging promising HIV therapeutic strategy.

Journal: Indian journal of sexually transmitted diseases and AIDS20090101

Title: Profile of darunavir in the management of treatment-experienced HIV patients.

Journal: HIV/AIDS (Auckland, N.Z.)20090101

Title: Pharmacologic and nonpharmacologic options for the management of HIV infection during pregnancy.

Journal: HIV/AIDS (Auckland, N.Z.)20090101

Title: Developing clinical role of a CCR5 co-receptor antagonist in HIV-1 infection.

Journal: Expert opinion on pharmacotherapy20081201

Title: More sensitive test leads to better results for Selzentry.

Journal: Project Inform perspective20081201

Title: Report from the 2008 joint ICAAC/IDSA meeting. Maraviroc vs. efavirenz: a reanalysis of MERIT.

Journal: AIDS clinical care20081201

Title: Optimal use of maraviroc in clinical practice.

Journal: AIDS (London, England)20081112

Title: Pharmacologic aspects of new antiretroviral drugs.

Journal: Current infectious disease reports20081101

Title: New insights into missed endpoint trial.

Journal: AIDS patient care and STDs20081101

Title: Antiretroviral treatment update from the 17th International AIDS Conference.

Journal: The AIDS reader20081101

Title: [Role of the new molecules in antiretroviral therapy. Position of raltegravir].

Journal: Enfermedades infecciosas y microbiologia clinica20081101

Title: Primary genotypic resistance of HIV-1 to CCR5 antagonists in CCR5 antagonist treatment-naive patients.

Journal: AIDS (London, England)20081018

Title: Maraviroc for previously treated patients with R5 HIV-1 infection.

Journal: The New England journal of medicine20081002

Title: Subgroup analyses of maraviroc in previously treated R5 HIV-1 infection.

Journal: The New England journal of medicine20081002

Title: A new class of anti-HIV therapy and new challenges.

Journal: The New England journal of medicine20081002

Title: Maraviroc: in vitro assessment of drug-drug interaction potential.

Journal: British journal of clinical pharmacology20081001

Title: Discovery of a novel CCR5 antagonist lead compound through fragment assembly.

Journal: Molecules (Basel, Switzerland)20081001

Title: Preclinical assessment of the distribution of maraviroc to potential human immunodeficiency virus (HIV) sanctuary sites in the central nervous system (CNS) and gut-associated lymphoid tissue (GALT).

Journal: Xenobiotica; the fate of foreign compounds in biological systems20081001

Title: [New CCR5 inhibitor antiretroviral drugs and integrase inhibitors].

Journal: Revista clinica espanola20081001

Title: [Introduction. A brief history of AIDS].

Journal: Enfermedades infecciosas y microbiologia clinica20081001

Title: [Viral entry as therapeutic target. Current situation of entry inhibitors].

Journal: Enfermedades infecciosas y microbiologia clinica20081001

Title: [Pharmacokinetics, interactions and mechanism of action of maraviroc].

Journal: Enfermedades infecciosas y microbiologia clinica20081001

Title: [Maraviroc efficacy in clinical studies on the development of the molecule].

Journal: Enfermedades infecciosas y microbiologia clinica20081001

Title: [Secondary effects of treatment with maraviroc and other CCR5 antagonists. Potential impact of the CCR5 blocker].

Journal: Enfermedades infecciosas y microbiologia clinica20081001

Title: [Mechanisms of resistance and failure of treatment with maraviroc].

Journal: Enfermedades infecciosas y microbiologia clinica20081001

Title: [At what time and with which combinations should maraviroc be indicated in the new antiretroviral treatment scenario?].

Journal: Enfermedades infecciosas y microbiologia clinica20081001

Title: [Methods for determining viral tropism: genotype and phenotype tests].

Journal: Enfermedades infecciosas y microbiologia clinica20081001

Title: [Conclusions and perspectives. Maraviroc].

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Title: [Chemical characteristics, mechanism of action and antiviral activity of darunavir].

Journal: Enfermedades infecciosas y microbiologia clinica20081001

Title: Lopinavir/ritonavir in the treatment of HIV-1 infection: a review.

Journal: Therapeutics and clinical risk management20081001

Title: A survey of the syntheses of active pharmaceutical ingredients for antiretroviral drug combinations critical to access in emerging nations.

Journal: Antiviral research20080901

Title: Maraviroc, risks and benefits: a review of the clinical literature.

Journal: Expert opinion on drug safety20080901

Title: HIV infection in the elderly.

Journal: Clinical interventions in aging20080901

Title: Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel.

Journal: JAMA20080806

Title: Neutralizing antibody and anti-retroviral drug sensitivities of HIV-1 isolates resistant to small molecule CCR5 inhibitors.

Journal: Virology20080801

Title: Combating HIV resistance - focus on darunavir.

Journal: Therapeutics and clinical risk management20080801

Title: The Relationship Between HIV Infection and Cardiovascular Disease.

Journal: Current cardiology reviews20080801

Title: Reviews of anti-infective agents: maraviroc: the first of a new class of antiretroviral agents.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America20080715

Title: Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes.

Journal: Clinical immunology (Orlando, Fla.)20080701

Title: New treatment options for HIV salvage patients: an overview of second generation PIs, NNRTIs, integrase inhibitors and CCR5 antagonists.

Journal: The Journal of infection20080701

Title: New drugs08, part 2.

Journal: Nursing20080701

Title: How developing world concerns need to be part of drug development plans: a case study of four emerging antiretrovirals.

Journal: Drug discovery today20080701

Title: Maraviroc: a CCR5-receptor antagonist for the treatment of HIV-1 infection.

Journal: Clinical therapeutics20080701

Title: CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer.

Journal: The Biochemical journal20080601

Title: Maraviroc: integration of a new antiretroviral drug class into clinical practice.

Journal: The Journal of antimicrobial chemotherapy20080601

Title: Potential for new antiretrovirals to address unmet needs in the management of HIV-1 infection.

Journal: AIDS patient care and STDs20080601

Title: Maraviroc: new drug. Multiple antiretroviral treatment failure: too soon to reach conclusions.

Journal: Prescrire international20080601

Title: Complexity of interactions between voriconazole and antiretroviral agents.

Journal: The Annals of pharmacotherapy20080501

Title: Pharmacologic characteristics of investigational and recently approved agents for the treatment of HIV.

Journal: Current opinion in HIV and AIDS20080501

Title: [Pretreated HIV patients profit from Maraviroc. Oral HIV fusion inhibitor opens new therapy chances].

Journal: MMW Fortschritte der Medizin20080428

Title: A review of the clinical pharmacology of maraviroc. Introduction.

Journal: British journal of clinical pharmacology20080401

Title: Assessment of the pharmacokinetics, safety and tolerability of maraviroc, a novel CCR5 antagonist, in healthy volunteers.

Journal: British journal of clinical pharmacology20080401

Title: Effect of maraviroc on the pharmacokinetics of midazolam, lamivudine/zidovudine, and ethinyloestradiol/levonorgestrel in healthy volunteers.

Journal: British journal of clinical pharmacology20080401

Title: Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers.

Journal: British journal of clinical pharmacology20080401

Title: Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers.

Journal: British journal of clinical pharmacology20080401

Title: The effects of cotrimoxazole or tenofovir co-administration on the pharmacokinetics of maraviroc in healthy volunteers.

Journal: British journal of clinical pharmacology20080401

Title: A novel probe drug interaction study to investigate the effect of selected antiretroviral combinations on the pharmacokinetics of a single oral dose of maraviroc in HIV-positive subjects.

Journal: British journal of clinical pharmacology20080401

Title: Assessment of the absorption, metabolism and absolute bioavailability of maraviroc in healthy male subjects.

Journal: British journal of clinical pharmacology20080401

Title: Effect of single doses of maraviroc on the QT/QTc interval in healthy subjects.

Journal: British journal of clinical pharmacology20080401

Title: A population pharmacokinetic meta-analysis of maraviroc in healthy volunteers and asymptomatic HIV-infected subjects.

Journal: British journal of clinical pharmacology20080401

Title: Population pharmacokinetic/pharmacodynamic analysis of CCR5 receptor occupancy by maraviroc in healthy subjects and HIV-positive patients.

Journal: British journal of clinical pharmacology20080401

Title: A receptor theory-based semimechanistic PD model for the CCR5 noncompetitive antagonist maraviroc.

Journal: British journal of clinical pharmacology20080401

Title: New approaches in the treatment of HIV/AIDS - focus on maraviroc and other CCR5 antagonists.

Journal: Therapeutics and clinical risk management20080401

Title: 'One pill, once daily': what clinicians need to know about Atriplatrade mark.

Journal: Therapeutics and clinical risk management20080401

Title: Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists.

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Title: [New drugs for HIV infection].

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Title: [CCR5 antagonists: a new class of antiretrovirals].

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Title: [Clinical pharmacokinetic of maraviroc].

Journal: Medecine et maladies infectieuses20080301

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Journal: Medecine et maladies infectieuses20080301

Title: Anti-HIV agents. Is PF-232798 a possible successor to maraviroc?

Journal: TreatmentUpdate20080301

Title: Anti-HIV-1 entry optimization of novel imidazopiperidine-tropane CCR5 antagonists.

Journal: Bioorganic & medicinal chemistry letters20080215

Title: Two new drugs for HIV infection.

Journal: The Medical letter on drugs and therapeutics20080114

Title: Post-exposure prophylaxis with a maraviroc-containing regimen after occupational exposure to a multi-resistant HIV-infected source person.

Journal: Journal of medical virology20080101

Title: Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors.

Journal: Retrovirology20080101

Title: The incidence of multidrug and full class resistance in HIV-1 infected patients is decreasing over time (2001-2006) in Portugal.

Journal: Retrovirology20080101

Title: Distinct efficacy of HIV-1 entry inhibitors to prevent cell-to-cell transfer of R5 and X4 viruses across a human placental trophoblast barrier in a reconstitution model in vitro.

Journal: Retrovirology20080101

Title: Highlights of the 15th Conference on Retroviruses and Opportunistic Infections. Advances in antiretroviral therapy.

Journal: Topics in HIV medicine : a publication of the International AIDS Society, USA20080101

Title: Closing two doors of viral entry: intramolecular combination of a coreceptor- and fusion inhibitor of HIV-1.

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Title: Microbicides 2008 conference: from discovery to advocacy.

Journal: AIDS research and therapy20080101

Title: Cyclin T1-dependent genes in activated CD4 T and macrophage cell lines appear enriched in HIV-1 co-factors.

Journal: PloS one20080101

Title: CCL3L1-CCR5 genotype improves the assessment of AIDS Risk in HIV-1-infected individuals.

Journal: PloS one20080101

Title: Overcoming hERG affinity in the discovery of maraviroc; a CCR5 antagonist for the treatment of HIV.

Journal: Current topics in medicinal chemistry20080101

Title: An in-depth look at the challenges of prescribing maraviroc.

Journal: HIV clinician20080101

Title: Emerging resistance profiles of newly approved antiretroviral drugs.

Journal: Topics in HIV medicine : a publication of the International AIDS Society, USA20080101

Title: Prevention of the sexual transmission of HIV-1: preparing for success.

Journal: Journal of the International AIDS Society20080101

Title: Topical application of entry inhibitors as 'virustats' to prevent sexual transmission of HIV infection.

Journal: Retrovirology20080101

Title: [Chemokine receptors and its importance in the replication cycle of human immunodeficiency virus: clinical and therapeutic implications].

Journal: Acta medica portuguesa20080101

Title: Minor Variant Detection at Different Template Concentrations in HIV-1 Phenotypic and Genotypic Tropism Testing.

Journal: The open virology journal20080101

Title: Maraviroc in the treatment of HIV infection.

Journal: Drug design, development and therapy20080101

Title: Raltegravir in the management of HIV-infected patients.

Journal: Drug design, development and therapy20080101

Title: Asymmetric allylboration of acyl imines catalyzed by chiral diols.

Journal: Journal of the American Chemical Society20071212

Title: Species selectivity of small-molecular antagonists for the CCR5 chemokine receptor.

Journal: International immunopharmacology20071205

Title: Allosteric modulation of heterodimeric G-protein-coupled receptors.

Journal: Trends in pharmacological sciences20071201

Title: Maraviroc (Celsentri) for multidrug-resistant human immunodeficiency virus (HIV)-1.

Journal: Issues in emerging health technologies20071201

Title: Randomized trials to optimize treatment of multidrug-resistant tuberculosis.

Journal: PLoS medicine20071101

Title: Maraviroc.

Journal: Drugs of today (Barcelona, Spain : 1998)20071101

Title: Changes in HIV-1 tropism: clinical and prognostic consequences.

Journal: European journal of medical research20071015

Title: CCR5 antagonists: comparison of efficacy, side effects, pharmacokinetics and interactions--review of the literature.

Journal: European journal of medical research20071015

Title: CCR5 antagonists in the treatment of treatment-experienced patients infected with CCR5 tropic HIV-1.

Journal: European journal of medical research20071015

Title: CCR5 antagonists in the treatment of treatment-naive patients infected with CCR5 tropic HIV-1.

Journal: European journal of medical research20071015

Title: How will CCR5 antagonists influence the recommendations for the antiretroviral treatment of HIV-1 infection.

Journal: European journal of medical research20071015

Title: Treatment with CCR5 antagonists: which patient may have a benefit?

Journal: European journal of medical research20071015

Title: Antiviral drugs in the treatment of AIDS: what is in the pipeline ?

Journal: European journal of medical research20071015

Title: Maraviroc approved in the European Union.

Journal: AIDS patient care and STDs20071001

Title: Report from the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Maraviroc in treatment-experienced and treatment-naive patients.

Journal: AIDS clinical care20071001

Title: Novel HIV treatment approved.

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Title: FDA approves drug for resistant HIV.

Journal: The AIDS reader20070901

Title: FDA approves maraviroc tablets.

Journal: AIDS patient care and STDs20070901

Title: Maraviroc reduces viral load in naive patients at 48 weeks.

Journal: AIDS patient care and STDs20070901

Title: FDA approval: maraviroc.

Journal: AIDS clinical care20070901

Title: FDA notifications. Maraviroc approved as a CCR5 co-receptor antagonist.

Journal: AIDS alert20070901

Title: Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands.

Journal: Virology20070801

Title: Maraviroc, a chemokine CCR5 receptor antagonist for the treatment of HIV infection and AIDS.

Journal: Current opinion in investigational drugs (London, England : 2000)20070801

Title: Report from the XVI International HIV Drug Resistance Workshop.

Journal: AIDS clinical care20070801

Title: V3 loop truncations in HIV-1 envelope impart resistance to coreceptor inhibitors and enhanced sensitivity to neutralizing antibodies.

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Title: First medication in new class of ARTs poised to be available for salvage therapy. Tropism testing helps determine best patients for drug.

Journal: AIDS alert20070801

Title: CCR5 small-molecule antagonists and monoclonal antibodies exert potent synergistic antiviral effects by cobinding to the receptor.

Journal: Molecular pharmacology20070701

Title: Escape of HIV-1 from a small molecule CCR5 inhibitor is not associated with a fitness loss.

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Title: Chemokines and their receptors in respiratory disease: a therapeutic target for respiratory syncytial virus infection.

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Title: FDA panel backs HIV drug.

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Title: Translational research: application to HIV/AIDS.

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Title: Novel CCR5 monoclonal antibodies with potent and broad-spectrum anti-HIV activities.

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Title: Access denied? The status of co-receptor inhibition to counter HIV entry.

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Title: Pivotal moments in HIV treatment: the 14th CROI.

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Title: Advances in HIV therapeutics: the 14th CROI.

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Title: More data on maraviroc in treatment-experienced patients.

Journal: AIDS patient care and STDs20070501

Title: Researchers buoyed by novel HIV drugs: will expand drug arsenal against resistant virus.

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Title: New HIV drug classes on the horizon.

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Title: New drugs offer options.

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Title: Retrovirus meeting. Hope on new AIDS drugs, but breast-feeding strategy backfires.

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Title: Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry.

Journal: Journal of virology20070301

Title: Structural descriptors of gp120 V3 loop for the prediction of HIV-1 coreceptor usage.

Journal: PLoS computational biology20070301

Title: Anti-HIV agents. New drugs, new hope, old lessons.

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Title: Carbohydrate-binding agents efficiently prevent dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-directed HIV-1 transmission to T lymphocytes.

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Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20070101

Title: Advances in antiretroviral therapy.

Journal: Topics in HIV medicine : a publication of the International AIDS Society, USA20070101

Title: Identifying safety concerns from genetic data: lessons from the development of CCR5 inhibitors.

Journal: Antiviral therapy20070101

Title: Assessing theoretical risk and benefit suggested by genetic association studies of CCR5: experience in a drug development programme for maraviroc.

Journal: Antiviral therapy20070101

Title: Anti-HIV agents. Getting to know your co-receptors.

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Title: Host factors influencing susceptibility to HIV infection and AIDS progression.

Journal: Retrovirology20070101

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Journal: Positively aware : the monthly journal of the Test Positive Aware Network20070101

Title: Phylodynamics of HIV-1 in lymphoid and non-lymphoid tissues reveals a central role for the thymus in emergence of CXCR4-using quasispecies.

Journal: PloS one20070101

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Title: New drugs: Maraviroc and Lanreotide.

Journal: Journal of the American Pharmacists Association : JAPhA20070101

Title: Anti-HIV agents. Maraviroc approved in Canada.

Journal: TreatmentUpdate20070101

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Journal: TreatmentUpdate20070101

Title: The 16th International Conference on AIDS: Will It Leave a Legacy?

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Title: Maraviroc: the evidence for its potential in the management of HIV.

Journal: Core evidence20070101

Title: Targeting human immunodeficiency virus type 1 assembly, maturation and budding.

Journal: Drug target insights20070101

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