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38620-77-8
Catalog No.:AA00CLTN

38620-77-8 | Filipin II

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2.5mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00CLTN
Chemical Name:
Filipin II
CAS Number:
38620-77-8
Molecular Formula:
C35H58O10
Molecular Weight:
638.8290
SMILES:
CCCCCC[C@@H]1[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(=C/C=C/C=C/C=C/C=C/[C@@H]([C@H](OC1=O)C)O)/C
Properties
Computed Properties
 
Complexity:
958  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Defined Bond Stereocenter Count:
5  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
5  
XLogP3:
4  

Literature

Title: 27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells.

Journal: Neurotoxicology 20170301

Title: Brain region-specific immunolocalization of the lipolysis-stimulated lipoprotein receptor (LSR) and altered cholesterol distribution in aged LSR+/- mice.

Journal: Journal of neurochemistry 20121101

Title: Surface masking shapes the traffic of the neuropeptide Y Y2 receptor.

Journal: Peptides 20120901

Title: Effect of 6-O-α-maltosyl-β cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells.

Journal: Carbohydrate research 20120801

Title: Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice.

Journal: Atherosclerosis 20120801

Title: Caveolin-1 and dynamin-2 are essential for removal of the complement C5b-9 complex via endocytosis.

Journal: The Journal of biological chemistry 20120608

Title: Cholesterol and the biosynthesis of glycosphingolipids are required for sperm activation in Caenorhabditis elegans.

Journal: Biochimica et biophysica acta 20120601

Title: [Inhibitory effect of caveolin-1 on endoplasmic reticulum stress-induced apoptosis in macrophages via p38 MAPK pathway].

Journal: Sheng li xue bao : [Acta physiologica Sinica] 20120425

Title: HaCaT keratinocytes exhibit a cholesterol and plasma membrane viscosity gradient during directed migration.

Journal: Experimental cell research 20120415

Title: Identification and biocontrol efficacy of Streptomyces miharaensis producing filipin III against Fusarium wilt.

Journal: Journal of basic microbiology 20120401

Title: Enhanced phosphorylation of caveolar PKC-α limits peptide internalization in lung endothelial cells.

Journal: Molecular and cellular biochemistry 20120101

Title: High glucose-induced RhoA activation requires caveolae and PKCβ1-mediated ROS generation.

Journal: American journal of physiology. Renal physiology 20120101

Title: Lipid raft/caveolae signaling is required for Cryptococcus neoformans invasion into human brain microvascular endothelial cells.

Journal: Journal of biomedical science 20120101

Title: Analysis of cholesterol trafficking with fluorescent probes.

Journal: Methods in cell biology 20120101

Title: A Filipino woman with autoimmune polyglandular syndrome.

Journal: BMJ case reports 20120101

Title: [Assembly of actin filaments induced by sequestration of membrane cholesterol in transformed cells].

Journal: Tsitologiia 20120101

Title: The role of lipid raft aggregation in the infection of type II pneumocytes by Mycobacterium tuberculosis.

Journal: PloS one 20120101

Title: Fluorescence image screening for chemical compounds modifying cholesterol metabolism and distribution.

Journal: Journal of lipid research 20111101

Title: Membrane cholesterol modulates the fluid shear stress response of polymorphonuclear leukocytes via its effects on membrane fluidity.

Journal: American journal of physiology. Cell physiology 20110801

Title: The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis.

Journal: Microbiology (Reading, England) 20110801

Title: Endocytosis of resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells.

Journal: Cancer prevention research (Philadelphia, Pa.) 20110701

Title: Filipin recognizes both GM1 and cholesterol in GM1 gangliosidosis mouse brain.

Journal: Journal of lipid research 20110701

Title: Presynaptic impairment in Niemann-Pick C1-deficient neurons: not dependent on presence of glial cells.

Journal: Neuroscience letters 20110527

Title: Niemann-Pick Type C disease: characterizing lipid levels in patients with variant lysosomal cholesterol storage.

Journal: Journal of lipid research 20110401

Title: Internalization of Sambucus nigra agglutinins I and II in insect midgut CF-203 cells.

Journal: Archives of insect biochemistry and physiology 20110401

Title: Fluorescent in situ visualization of sterols in Arabidopsis roots.

Journal: Nature protocols 20110401

Title: Anatomically defined neuron-based rescue of neurodegenerative Niemann-Pick type C disorder.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110323

Title: Caveolin-1 negatively regulates a metalloprotease-dependent epidermal growth factor receptor transactivation by angiotensin II.

Journal: Journal of molecular and cellular cardiology 20110301

Title: Involvement of cholesterol-enriched microdomains in class A scavenger receptor-mediated responses in human macrophages.

Journal: Atherosclerosis 20110301

Title: [Extracellular Ca(2+)-sensing receptor-induced extracellular Ca2+ influx is down-regulated by caveolin-1 in human umbilical vein endothelial cells].

Journal: Sheng li xue bao : [Acta physiologica Sinica] 20110225

Title: Intracellular fate of strains of Escherichia coli isolated from dairy cows with acute or chronic mastitis.

Journal: Veterinary research communications 20110201

Title: The extra-intestinal avian pathogenic Escherichia coli strain BEN2908 invades avian and human epithelial cells and survives intracellularly.

Journal: Veterinary microbiology 20110127

Title: Nonesterified cholesterol content of lysosomes modulates susceptibility to oxidant-induced permeabilization.

Journal: Free radical biology & medicine 20110115

Title: Characterization of 2-octenoyl-CoA carboxylase/reductase utilizing pteB from Streptomyce avermitilis.

Journal: Bioscience, biotechnology, and biochemistry 20110101

Title: [Effect of cholesterol on the functional activity of proteins responsible for the resistance of human lymphocytes to xenobiotics].

Journal: Biofizika 20110101

Title: Plasma membrane sterol complexation, generated by filipin, triggers signaling responses in tobacco cells.

Journal: Biochimica et biophysica acta 20101101

Title: Constitutive endocytosis and recycling of NKCC2 in rat thick ascending limbs.

Journal: American journal of physiology. Renal physiology 20101101

Title: Structural sterols are involved in both the initiation and tip growth of root hairs in Arabidopsis thaliana.

Journal: The Plant cell 20100901

Title: Lipid raft-dependent endocytosis: a new route for hepcidin-mediated regulation of ferroportin in macrophages.

Journal: Haematologica 20100801

Title: How adhesion/growth-regulatory galectins-1 and -3 attain cell specificity: case study defining their target on neuroblastoma cells (SK-N-MC) and marked affinity regulation by affecting microdomain organization of the membrane.

Journal: IUBMB life 20100801

Title: Regio- and stereospecificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis.

Journal: The Journal of biological chemistry 20100528

Title: T cell signal regulation by the actin cytoskeleton.

Journal: The Journal of biological chemistry 20100507

Title: Real-time monitoring of membrane cholesterol reveals new insights into epidermal differentiation.

Journal: The Journal of investigative dermatology 20100501

Title: Ubiquitin/proteasome-dependent down-regulation following clathrin-mediated internalization of histamine H1-receptors in Chinese hamster ovary cells.

Journal: Journal of neurochemistry 20100501

Title: Redox signaling via lipid raft clustering in homocysteine-induced injury of podocytes.

Journal: Biochimica et biophysica acta 20100401

Title: n-3 and n-6 Polyunsaturated fatty acids suppress sterol regulatory element binding protein activity and increase flow of non-esterified cholesterol in HepG2 cells.

Journal: The British journal of nutrition 20100101

Title: Targeted yeast vacuole disruption by polyene antibiotics with a macrocyclic lactone ring.

Journal: International journal of antimicrobial agents 20100101

Title: Cholesterol-protein interaction: methods and cholesterol reporter molecules.

Journal: Sub-cellular biochemistry 20100101

Title: Subtype-specific differences in corticotropin-releasing factor receptor complexes detected by fluorescence spectroscopy.

Journal: Molecular pharmacology 20091201

Title: Clathrin-independent internalization of normal cellular prion protein in neuroblastoma cells is associated with the Arf6 pathway.

Journal: Journal of cell science 20091115

Title: Membrane-dependent bystander effect contributes to amplification of the response to alpha-particle irradiation in targeted and nontargeted cells.

Journal: International journal of radiation oncology, biology, physics 20091115

Title: Dynamin- and lipid raft-dependent entry of decay-accelerating factor (DAF)-binding and non-DAF-binding coxsackieviruses into nonpolarized cells.

Journal: Journal of virology 20091101

Title: Caveolin-1 mediates endotoxin inhibition of endothelin-1-induced endothelial nitric oxide synthase activity in liver sinusoidal endothelial cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20091101

Title: Urokinase-receptor-mediated phenotypic changes in vascular smooth muscle cells require the involvement of membrane rafts.

Journal: The Biochemical journal 20091012

Title: Aggregated LDL in contact with macrophages induces local increases in free cholesterol levels that regulate local actin polymerization.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20091001

Title: Lipid microdomain polarization is required for NADPH oxidase-dependent ROS signaling in Picea meyeri pollen tube tip growth.

Journal: The Plant journal : for cell and molecular biology 20091001

Title: C-peptide is internalised in human endothelial and vascular smooth muscle cells via early endosomes.

Journal: Diabetologia 20091001

Title: PrPC-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site.

Journal: Cell research 20090901

Title: Association of autophagy with cholesterol-accumulated compartments in Niemann-Pick disease type C cells.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20090701

Title: Cholesterol-dependent attachment of human respiratory cells by Bordetella pertussis.

Journal: FEMS immunology and medical microbiology 20090701

Title: Oxidative stress induces lipid-raft-mediated activation of Src homology 2 domain-containing protein-tyrosine phosphatase 2 in astrocytes.

Journal: Free radical biology & medicine 20090615

Title: Isolation of a fission yeast mutant cell affected in MAP kinase signaling and sterol biosynthesis.

Journal: The Kobe journal of medical sciences 20090605

Title: The polyene antimycotics nystatin and filipin disrupt the plasma membrane, whereas natamycin inhibits endocytosis in germinating conidia of Penicillium discolor.

Journal: Journal of applied microbiology 20090601

Title: Endocytosis of MHC molecules by distinct membrane rafts.

Journal: Journal of cell science 20090515

Title: 900 MHz modulated electromagnetic fields accelerate the clathrin-mediated endocytosis pathway.

Journal: Bioelectromagnetics 20090401

Title: Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.

Journal: Journal of hepatology 20090401

Title: HIV entry in macrophages is dependent on intact lipid rafts.

Journal: Virology 20090330

Title: Saccades in adult Niemann-Pick disease type C reflect frontal, brainstem, and biochemical deficits.

Journal: Neurology 20090324

Title: Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formation.

Journal: Circulation research 20090313

Title: Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells.

Journal: Blood 20090219

Title: A proline-rich peptide improves cell transfection of solid lipid nanoparticle-based non-viral vectors.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20090105

Title: Membrane raft disruption promotes axonogenesis in n2a neuroblastoma cells.

Journal: Neurochemical research 20090101

Title: Cholesterol in the senile plaque: often mentioned, never seen.

Journal: Acta neuropathologica 20090101

Title: Lipid quantification and structure determination of nuclear envelope precursor membranes in the sea urchin.

Journal: Methods in molecular biology (Clifton, N.J.) 20090101

Title: Effects of sterols on the development and aging of Caenorhabditis elegans.

Journal: Methods in molecular biology (Clifton, N.J.) 20090101

Title: ARF6-mediated endosome recycling reverses lipid accumulation defects in Niemann-Pick Type C disease.

Journal: PloS one 20090101

Title: Gap junction remodeling associated with cholesterol redistribution during fiber cell maturation in the adult chicken lens.

Journal: Molecular vision 20090101

Title: Histochemistry and lipid profiling combine for insights into aging and age-related maculopathy.

Journal: Methods in molecular biology (Clifton, N.J.) 20090101

Title: [Mechanism of action of macrolide antibiotic filipin on cell and lipid membranes].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101

Title: S-nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding.

Journal: The Journal of biological chemistry 20081212

Title: Soapwort saponins trigger clathrin-mediated endocytosis of saporin, a type I ribosome-inactivating protein.

Journal: Chemico-biological interactions 20081125

Title: Differential signaling pathways in angiotensin II- and epidermal growth factor-stimulated hepatic C9 cells.

Journal: Molecular pharmacology 20081101

Title: Formation and function of ceramide-enriched membrane platforms with CD38 during M1-receptor stimulation in bovine coronary arterial myocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20081001

Title: FM dyes label sterol-rich plasma membrane domains and are internalized independently of the cytoskeleton in characean internodal cells.

Journal: Plant & cell physiology 20081001

Title: Cholesterol potentiates beta-amyloid-induced toxicity in human neuroblastoma cells: involvement of oxidative stress.

Journal: Neurochemical research 20080801

Title: Filipin is a reliable in situ marker of ergosterol in the plasma membrane of germinating conidia (spores) of Penicillium discolor and stains intensively at the site of germ tube formation.

Journal: Journal of microbiological methods 20080801

Title: Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation.

Journal: Developmental cell 20080801

Title: Neuronal loss of Drosophila NPC1a causes cholesterol aggregation and age-progressive neurodegeneration.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080625

Title: Transferrin uptake in Trypanosoma cruzi is impaired by interference on cytostome-associated cytoskeleton elements and stability of membrane cholesterol, but not by obstruction of clathrin-dependent endocytosis.

Journal: Experimental parasitology 20080501

Title: Lipid droplet changes in proliferating and quiescent 3T3 fibroblasts.

Journal: Histochemistry and cell biology 20080501

Title: ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina.

Journal: Investigative ophthalmology & visual science 20080401

Title: Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane.

Journal: The Journal of biological chemistry 20080307

Title: Images in neuroscience: psychosis and vertical supranuclear opthalmoplegia.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20080301

Title: Endocytosis inhibitors prevent poly(amidoamine) dendrimer internalization and permeability across Caco-2 cells.

Journal: Molecular pharmaceutics 20080101

Title: The absence of uPAR attenuates insulin-induced vascular smooth muscle cell migration and proliferation.

Journal: Thrombosis research 20080101

Title: Lipoprotein binding preference of CD36 is altered by filipin treatment.

Journal: Lipids in health and disease 20080101

Title: Cyclic-AMP initiates protein tyrosine phosphorylation independent of cholesterol efflux during ram sperm capacitation.

Journal: Reproduction, fertility, and development 20080101

Title: The Vpu-regulated endocytosis of HIV-1 Gag is clathrin-independent.

Journal: Virology 20071220

Title: Clustering of membrane raft proteins by the actin cytoskeleton.

Journal: The Journal of biological chemistry 20071214

Title: Cholesterol reporter molecules.

Journal: Bioscience reports 20071201

Title: Participation of macrophage membrane rafts in Trypanosoma cruzi invasion process.

Journal: Biochemical and biophysical research communications 20071123

Title: Intraparenchymal injections of acid sphingomyelinase results in regional correction of lysosomal storage pathology in the Niemann-Pick A mouse.

Journal: Experimental neurology 20071001

Title: Cholesterol accumulation is associated with lysosomal dysfunction and autophagic stress in Npc1 -/- mouse brain.

Journal: The American journal of pathology 20070901

Title: Glia-induced neuronal differentiation by transcriptional regulation.

Journal: Glia 20070815

Title: Distribution and composition of esterified and unesterified cholesterol in extra-macular drusen.

Journal: Experimental eye research 20070801

Title: Developmental analysis of CNS pathology in the lysosomal storage disease alpha-mannosidosis.

Journal: Journal of neuropathology and experimental neurology 20070801

Title: Brain-derived neurotrophic factor regulates cholesterol metabolism for synapse development.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070613

Title: Redistribution of P-selectin glycoprotein ligand-1 (PSGL-1) in chemokine-treated neutrophils: a role of lipid microdomains.

Journal: Journal of leukocyte biology 20070601

Title: Modulation of tissue factor-factor VIIa signaling by lipid rafts and caveolae.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20070601

Title: A clathrin, caveolae, and dynamin-independent endocytic pathway requiring free membrane cholesterol drives HIV-1 internalization and infection in polarized trophoblastic cells.

Journal: Journal of molecular biology 20070518

Title: Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI.

Journal: Journal of lipid research 20070501

Title: Endocytosis of the dermatan sulfate proteoglycan decorin utilizes multiple pathways and is modulated by epidermal growth factor receptor signaling.

Journal: Biochimie 20070501

Title: Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts.

Journal: The Journal of biological chemistry 20070427

Title: Disruption of endothelial caveolae is associated with impairment of both NO- as well as EDHF in acetylcholine-induced relaxation depending on their relative contribution in different vascular beds.

Journal: Life sciences 20070410

Title: Anti-bis(monoacylglycero)phosphate antibody accumulates acetylated LDL-derived cholesterol in cultured macrophages.

Journal: Journal of lipid research 20070301

Title: Cellular entry pathway and gene transfer capacity of TAT-modified lipoplexes.

Journal: Biochimica et biophysica acta 20070301

Title: Transcytotic passage of albumin through lens epithelial cells.

Journal: Investigative ophthalmology & visual science 20070301

Title: Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages.

Journal: The Journal of biological chemistry 20070223

Title: Constitutive internalization of murine MHC class I molecules.

Journal: Journal of cellular physiology 20070201

Title: Mechanical strain increases gene transfer to skeletal muscle cells.

Journal: Journal of biomechanics 20070101

Title: Gap junctions contain different amounts of cholesterol which undergo unique sequestering processes during fiber cell differentiation in the embryonic chicken lens.

Journal: Molecular vision 20070101

Title: Disruption of lipid rafts enhances activity of botulinum neurotoxin serotype A.

Journal: Toxicon : official journal of the International Society on Toxinology 20061215

Title: Lipid raft disruption prevents apoptosis induced by 2-chloro-2'-deoxyadenosine (Cladribine) in leukemia cell lines.

Journal: Leukemia research 20061201

Title: Syndecan-2 expression increases serum-withdrawal-induced apoptosis, mediated by re-distribution of Fas into lipid rafts, in stably transfected Swiss 3T3 cells.

Journal: Apoptosis : an international journal on programmed cell death 20061101

Title: Regulation of Pseudomonas aeruginosa internalization after contact lens wear in vivo and in serum-free culture by ocular surface cells.

Journal: Investigative ophthalmology & visual science 20060801

Title: Analysis of the endocytic pathway mediating the infectious entry of mosquito-borne flavivirus West Nile into Aedes albopictus mosquito (C6/36) cells.

Journal: Virology 20060605

Title: Raft-mediated Src homology 2 domain-containing proteintyrosine phosphatase 2 (SHP-2) regulation in microglia.

Journal: The Journal of biological chemistry 20060428

Title: Selective lysis of erythrocytes infected with the trophozoite stage of Plasmodium falciparum by polyene macrolide antibiotics.

Journal: Biochemical pharmacology 20060314

Title: Signal transduction events involved in human epithelial cell invasion by Campylobacter jejuni 81-176.

Journal: Microbial pathogenesis 20060301

Title: Niemann-Pick type C disease: novel NPC1 mutations and characterization of the concomitant acid sphingomyelinase deficiency.

Journal: Molecular genetics and metabolism 20060201

Title: Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.

Journal: Journal of lipid research 20060201

Title: Yeast lipid rafts?--an emerging view.

Journal: Trends in cell biology 20060101

Title: Trafficking of Streptococcus uberis in bovine mammary epithelial cells.

Journal: Microbial pathogenesis 20060101

Title: Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy.

Journal: Experimental eye research 20051201

Title: Angiotensin-converting enzyme as a GPIase: a critical reevaluation.

Journal: Nature medicine 20051101

Title: The complement inhibitor, CRIT, undergoes clathrin-dependent endocytosis.

Journal: Experimental cell research 20051015

Title: Cholesterol facilitates the native mechanism of Ca2+-triggered membrane fusion.

Journal: Journal of cell science 20051015

Title: Transcriptional signaling from membrane raft-associated glucocorticoid receptor.

Journal: Biochemical and biophysical research communications 20051014

Title: Clathrin-independent internalization of the human histamine H1-receptor in CHO-K1 cells.

Journal: British journal of pharmacology 20051001

Title: [The role of caveolae in shear stress-induced endothelial nitric-oxide synthase activation].

Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20051001

Title: In vitro and in vivo effects of unsaturated fatty acids on Schistosoma mansoni and S. haematobium lung-stage larvae.

Journal: The Journal of parasitology 20051001

Title: Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20050901

Title: Endocytosis of cholera toxin by human enterocytes is developmentally regulated.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050801

Title: Role of fission yeast myosin I in organization of sterol-rich membrane domains.

Journal: Current biology : CB 20050726

Title: Cholesterol-dependent lipid assemblies regulate the activity of the ecto-nucleotidase CD39.

Journal: The Journal of biological chemistry 20050715

Title: Evidence that membrane transduction of oligoarginine does not require vesicle formation.

Journal: Experimental cell research 20050701

Title: Methyl-beta-Cyclodextrin treatment and filipin staining reveal the role of cholesterol in surface membrane antigen sequestration of Schistosoma mansoni and S. haematobium lung-stage larvae.

Journal: The Journal of parasitology 20050601

Title: A central role for ceramide in the age-related acceleration of apoptosis in the female germline.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050501

Title: Extracellular matrix activity and caveolae events contribute to cell surface receptor activation that leads to MAP kinase activation in response to UV irradiation in cultured human keratinocytes.

Journal: International journal of molecular medicine 20050401

Title: Disruption of lipid rafts causes apoptotic cell death in HaCaT keratinocytes.

Journal: Experimental dermatology 20050401

Title: [Presentation of Niemann-Pick type C disease with psychiatric disturbance in an adult].

Journal: Revue neurologique 20050301

Title: Pathological cholesterol metabolism fails to modify electrophysiological properties of afflicted neurones in Niemann-Pick disease type C.

Journal: Neuroscience 20050101

Title: Molecular dissection of internalization of Porphyromonas gingivalis by cells using fluorescent beads coated with bacterial membrane vesicle.

Journal: Cell structure and function 20050101

Title: A comparative study of cytoplasmic granules imaged by the real-time microscope, Nile Red and Filipin in fibroblasts from patients with lipid storage diseases.

Journal: Journal of inherited metabolic disease 20050101

Title: Membrane cholesterol content modulates activation of BK channels in colonic epithelia.

Journal: Biochimica et biophysica acta 20041215

Title: Trafficking of exogenous peptides into proteasome-dependent major histocompatibility complex class I pathway following enterotoxin B subunit-mediated delivery.

Journal: The Journal of biological chemistry 20041203

Title: Decrease of P-glycoprotein activity in K562/ADR cells by MbetaCD and filipin and lack of effect induced by cholesterol oxidase indicate that this transporter is not located in rafts.

Journal: Journal of bioenergetics and biomembranes 20041201

Title: [Diagnosis of adult type of Niemann-Pick disease (type C) in two brothers by filipin staining of bone marrow smears].

Journal: No to shinkei = Brain and nerve 20041201

Title: Membrane-permeabilizing activities of amphidinol 3, polyene-polyhydroxy antifungal from a marine dinoflagellate.

Journal: Biochimica et biophysica acta 20041117

Title: Mechanistic similarities between cultured cell models of cystic fibrosis and niemann-pick type C.

Journal: American journal of respiratory cell and molecular biology 20041101

Title: Niemann-Pick type C disease: importance of N-glycosylation sites for function and cellular location of the NPC2 protein.

Journal: Molecular genetics and metabolism 20041101

Title: Local exposure of phosphatidylethanolamine on the yeast plasma membrane is implicated in cell polarity.

Journal: Genes to cells : devoted to molecular & cellular mechanisms 20041001

Title: Brefeldin A and filipin distinguish two globotriaosyl ceramide/verotoxin-1 intracellular trafficking pathways involved in Vero cell cytotoxicity.

Journal: Glycobiology 20040801

Title: The combinatorial extension method reveals a sphingolipid binding domain on pancreatic bile salt-dependent lipase: role in secretion.

Journal: Structure (London, England : 1993) 20040801

Title: [How to visualize cholesterol].

Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20040801

Title: Depletion of membrane cholesterol causes ligand-independent activation of Fas and apoptosis.

Journal: Biochemical and biophysical research communications 20040716

Title: Lipid raft polarization contributes to hyphal growth in Candida albicans.

Journal: Eukaryotic cell 20040601

Title: Cholesterol perturbing agents inhibit NMDA-dependent calcium influx in rat hippocampal primary culture.

Journal: FEBS letters 20040521

Title: Filipin orientation revealed by linear dichroism. Implication for a model of action.

Journal: Journal of the American Chemical Society 20040505

Title: Morphologic characteristics of lamellar channel deposits in the human eye: a case report.

Journal: Cornea 20040501

Title: Heparan sulphate proteoglycans modulate fibroblast growth factor-2 binding through a lipid raft-mediated mechanism.

Journal: The Biochemical journal 20040415

Title: Effect of saponin and filipin on antagonist binding to AT 1 receptors in intact cells.

Journal: Biochemical pharmacology 20040415

Title: Lipid rafts mediate chemotropic guidance of nerve growth cones.

Journal: Neuron 20040408

Title: Depletion of plasma membrane cholesterol dampens hydrostatic pressure and shear stress-induced mechanotransduction pathways in osteoblast cultures.

Journal: American journal of physiology. Cell physiology 20040401

Title: Depletion of cellular cholesterol and lipid rafts increases shedding of CD30.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20040401

Title: Increased iron staining in the cerebral cortex of cholesterol fed rabbits.

Journal: Mechanisms of ageing and development 20040401

Title: Dual mechanisms for shedding of the cellular prion protein.

Journal: The Journal of biological chemistry 20040319

Title: Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons.

Journal: Biochemical and biophysical research communications 20040305

Title: Lipid raft compartmentalization of urokinase receptor signaling in human neutrophils.

Journal: American journal of respiratory cell and molecular biology 20040201

Title: Involvement of cholesterol-rich lipid rafts in interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cells.

Journal: Endocrinology 20040201

Title: Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E.

Journal: Investigative ophthalmology & visual science 20040101

Title: Caveolae as an additional route for influenza virus endocytosis in MDCK cells.

Journal: Cellular & molecular biology letters 20040101

Title: Biglycan is internalized via a chlorpromazine-sensitive route.

Journal: Cellular & molecular biology letters 20040101

Title: Effects of endocytosis inhibitory drugs on rubella virus entry into VeroE6 cells.

Journal: Microbiology and immunology 20040101

Title: Depletion of cellular cholesterol interferes with intracellular trafficking of liposome-encapsulated ovalbumin.

Journal: Immunology and cell biology 20031201

Title: Membrane lipid microdomains differentially regulate intracellular signaling events in human neutrophils.

Journal: International immunopharmacology 20031201

Title: Degranulation and superoxide production depend on cholesterol in PLB-985 cells.

Journal: Biochemical and biophysical research communications 20031031

Title: Effect of a peroxysomal proliferator agent on intracellular cholesterol accumulation in cultured fibroblasts from Niemann-Pick type C disease patients.

Journal: Clinica chimica acta; international journal of clinical chemistry 20031001

Title: Fungal lectin, XCL, is internalized via clathrin-dependent endocytosis and facilitates uptake of other molecules.

Journal: European journal of cell biology 20031001

Title: Accumulation of cholesterol in the lesions of focal segmental glomerulosclerosis.

Journal: Nephrology (Carlton, Vic.) 20031001

Title: Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease.

Journal: Pharmacopsychiatry 20030901

Title: The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts.

Journal: Journal of cell science 20030801

Title: Ligand internalization by cloned neuropeptide Y Y5 receptors excludes Y2 and Y4 receptor-selective peptides.

Journal: European journal of pharmacology 20030801

Title: NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.

Journal: The Journal of biological chemistry 20030711

Title: Membrane cholesterol regulates LFA-1 function and lipid raft heterogeneity.

Journal: Blood 20030701

Title: Lipid rafts, caveolae, caveolin-1, and entry by Chlamydiae into host cells.

Journal: Experimental cell research 20030701

Title: Biotinylated theta-toxin derivative as a probe to examine intracellular cholesterol-rich domains in normal and Niemann-Pick type C1 cells.

Journal: Journal of lipid research 20030501

Title: Cholesterol storage and tau pathology in Niemann-Pick type C disease in the brain.

Journal: The Journal of pathology 20030501

Title: Host cell caveolae act as an entry-port for group A streptococci.

Journal: Cellular microbiology 20030501

Title: Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030415

Title: Accumulation of tyrosinase in the endolysosomal compartment is induced by U18666A.

Journal: Pigment cell research 20030401

Title: Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts.

Journal: Nature medicine 20030301

Title: Sterol-rich plasma membrane domains in the fission yeast Schizosaccharomyces pombe.

Journal: Journal of cell science 20030301

Title: Real-time analysis of the effects of cholesterol on lipid raft behavior using atomic force microscopy.

Journal: Biophysical journal 20030301

Title: Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes.

Journal: Journal of lipid research 20030201

Title: Pharmacological disintegration of lipid rafts decreases specific tetramer binding and disrupts the CD3 complex and CD8 heterodimer in human cytotoxic T lymphocytes.

Journal: Scandinavian journal of immunology 20030201

Title: The synaptophysin/synaptobrevin interaction critically depends on the cholesterol content.

Journal: Journal of neurochemistry 20030101

Title: Deficiency in ethanolamine plasmalogen leads to altered cholesterol transport.

Journal: Journal of lipid research 20030101

Title: A kinetics study of pig erythrocyte hemolysis induced by polyene antibiotics.

Journal: Cellular & molecular biology letters 20030101

Title: Changes of free cholesterol and neutral lipids after transient focal brain ischemia in rats.

Journal: Acta neurochirurgica. Supplement 20030101

Title: Cholesterol accumulates in cell bodies, but is decreased in distal axons, of Niemann-Pick C1-deficient neurons.

Journal: Journal of neurochemistry 20021201

Title: Mapping cholesteryl ester analogue uptake and intracellular flow in Paramecium by confocal fluorescence microscopy.

Journal: Journal of microscopy 20021201

Title: Interactions of STAT3 with caveolin-1 and heat shock protein 90 in plasma membrane raft and cytosolic complexes. Preservation of cytokine signaling during fever.

Journal: The Journal of biological chemistry 20021122

Title: Spatiotemporal changes of free cholesterol and neutral lipids after transient middle cerebral artery occlusion in rats.

Journal: Annals of the New York Academy of Sciences 20021101

Title: Alkyl-lysophospholipid accumulates in lipid rafts and induces apoptosis via raft-dependent endocytosis and inhibition of phosphatidylcholine synthesis.

Journal: The Journal of biological chemistry 20021018

Title: Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha.

Journal: The Journal of biological chemistry 20020927

Title: Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes.

Journal: The Journal of biological chemistry 20020913

Title: Uptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway.

Journal: Journal of lipid research 20020901

Title: Lipid microdomains are required sites for the selective endocytosis and nuclear translocation of IFN-gamma, its receptor chain IFN-gamma receptor-1, and the phosphorylation and nuclear translocation of STAT1alpha.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020815

Title: Agonist internalization by cloned Y1 neuropeptide Y (NPY) receptor in Chinese hamster ovary cells shows strong preference for NPY, endosome-linked entry and fast receptor recycling.

Journal: Regulatory peptides 20020715

Title: Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release.

Journal: The Journal of biological chemistry 20020712

Title: Capacitation induces cyclic adenosine 3',5'-monophosphate-dependent, but apoptosis-unrelated, exposure of aminophospholipids at the apical head plasma membrane of boar sperm cells.

Journal: Biology of reproduction 20020701

Title: The Salmonella-containing vacuole is a major site of intracellular cholesterol accumulation and recruits the GPI-anchored protein CD55.

Journal: Cellular microbiology 20020601

Title: Involvement of membrane signaling in the bystander effect in irradiated cells.

Journal: Cancer research 20020501

Title: A pool of Y2 neuropeptide Y receptors activated by modifiers of membrane sulfhydryl or cholesterol balance.

Journal: European journal of biochemistry 20020501

Title: Early events in the activation of Fc gamma RIIA in human neutrophils: stimulated insolubilization, translocation to detergent-resistant domains, and degradation of Fc gamma RIIA.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020415

Title: Virology. Rafting with Ebola.

Journal: Science (New York, N.Y.) 20020412

Title: Cholesterol-rich plasma membrane domains (lipid rafts) in keratinocytes: importance in the baseline and UVA-induced generation of reactive oxygen species.

Journal: The Journal of investigative dermatology 20020401

Title: Cholesterol storage defect in RSH/Smith-Lemli-Opitz syndrome fibroblasts.

Journal: Molecular genetics and metabolism 20020401

Title: Caveolae and cholesterol distribution in vascular smooth muscle cells of different phenotypes.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20020201

Title: Pathways for internalization and recycling of the chemokine receptor CCR5.

Journal: Blood 20020201

Title: The mechanism of the hemolytic activity of polyene antibiotics.

Journal: Cellular & molecular biology letters 20020101

Title: Alterations in membrane cholesterol that affect structure and function of caveolae.

Journal: Methods in enzymology 20020101

Title: Phospholipids in amelogenesis and dentinogenesis.

Journal: Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists 20020101

Title: Transendothelial transport of low-density lipoprotein and albumin across the rat peritoneum in vivo: effects of the transcytosis inhibitors NEM and filipin.

Journal: Journal of vascular research 20020101

Title: The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells.

Journal: Blood 20011215

Title: Albumin uptake and transcytosis in endothelial cells in vivo induced by albumin-binding protein.

Journal: American journal of physiology. Lung cellular and molecular physiology 20011201

Title: The chemokine receptor CCR2 mediates the binding and internalization of monocyte chemoattractant protein-1 along brain microvessels.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20011201

Title: High sensitivity of mouse neuronal cells to tetanus toxin requires a GPI-anchored protein.

Journal: Biochemical and biophysical research communications 20011130

Title: Murine high-fat diet and laser photochemical model of basal deposits in Bruch membrane.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20011101

Title: Foam cell formation containing lipid droplets enriched with free cholesterol by hyperlipidemic serum.

Journal: Journal of lipid research 20011101

Title: Bicarbonate stimulated phospholipid scrambling induces cholesterol redistribution and enables cholesterol depletion in the sperm plasma membrane.

Journal: Journal of cell science 20011001

Title: Internalization of cholera toxin by different endocytic mechanisms.

Journal: Journal of cell science 20011001

Title: Differential effects of filipin and methyl-beta-cyclodextrin on B cell receptor signaling.

Journal: Biochemical and biophysical research communications 20010914

Title: A verotoxin 1 B subunit-lambda CRO chimeric protein specifically binds both DNA and globotriaosylceramide (Gb(3)) to effect nuclear targeting of exogenous DNA in Gb(3) positive cells.

Journal: Experimental cell research 20010910

Title: Membrane cholesterol modulates serotonin transporter activity.

Journal: Biochemistry 20010904

Title: Fluid phase and receptor-mediated endocytosis in Paramecium primaurelia by fluorescence confocal laser scanning microscopy.

Journal: European biophysics journal : EBJ 20010901

Title: Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice.

Journal: Journal of neuropathology and experimental neurology 20010801

Title: Progressive neuronal loss in the ventral posterior lateral and medial nuclei of thalamus in Niemann-Pick disease type C mouse brain.

Journal: Brain & development 20010801

Title: Association of caveolin with Chlamydia trachomatis inclusions at early and late stages of infection.

Journal: Experimental cell research 20010610

Title: Alteration of plasmalemmal caveolae mimics endothelial dysfunction observed in atheromatous rabbit aorta.

Journal: Cardiovascular research 20010601

Title: Evidence for the role of alveolar epithelial gp60 in active transalveolar albumin transport in the rat lung.

Journal: The Journal of physiology 20010601

Title: Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons.

Journal: Acta neuropathologica 20010601

Title: Colocalization prostacyclin (PGI2) synthase--caveolin-1 in endothelial cells and new roles for PGI2 in angiogenesis.

Journal: Experimental cell research 20010515

Title: Oxidative stress impairs insulin internalization in endothelial cells in vitro.

Journal: Diabetologia 20010501

Title: Cholera toxin is found in detergent-insoluble rafts/domains at the cell surface of hippocampal neurons but is internalized via a raft-independent mechanism.

Journal: The Journal of biological chemistry 20010323

Title: Lysosomal cholesterol derived from mildly oxidized low density lipoprotein is resistant to efflux.

Journal: Journal of lipid research 20010301

Title: A photophysical study of the polyene antibiotic filipin. Self-aggregation and filipin--ergosterol interaction.

Journal: Biochimica et biophysica acta 20010209

Title: Membrane lipid domains distinct from cholesterol/sphingomyelin-rich rafts are involved in the ABCA1-mediated lipid secretory pathway.

Journal: The Journal of biological chemistry 20010202

Title: NEM and filipin increase albumin transport in lung microvessels.

Journal: American journal of physiology. Heart and circulatory physiology 20010101

Title: Accumulation of cholesterol with age in human Bruch's membrane.

Journal: Investigative ophthalmology & visual science 20010101

Title: Neurons in Niemann-Pick disease type C accumulate gangliosides as well as unesterified cholesterol and undergo dendritic and axonal alterations.

Journal: Journal of neuropathology and experimental neurology 20010101

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