Title: Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.
Journal: Acta pharmacologica Sinica20170101
Title: Development and validation of HPLC method for simultaneous estimation of piperine and guggulsterones in compound Unani formulation (tablets) and a nanoreservoir system.
Journal: Biomedical chromatography : BMC20121001
Title: Enhanced antitumor effect of combination therapy with gemcitabine and guggulsterone in pancreatic cancer.
Journal: Pancreas20121001
Title: Guggulsterone enhances antitumor activity of gemcitabine in gallbladder cancer cells through suppression of NF-κB.
Journal: Journal of cancer research and clinical oncology20121001
Title: Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists.
Journal: Journal of medicinal chemistry20120823
Title: Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition.
Journal: Diabetes20120601
Title: [Progress in the ligands and their complex structures of farnesoid X receptor].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica20120601
Title: Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pump.
Journal: Journal of lipid research20120301
Title: Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target.
Journal: Carcinogenesis20120201
Title: Novel stereoselective synthesis and chromatographic evaluation of E-guggulsterone.
Journal: Steroids20120201
Title: Role of farnesoid X receptor (FXR) in the process of differentiation of bone marrow stromal cells into osteoblasts.
Journal: Bone20111201
Title: Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: involvement of ROS-dependent ER-stress.
Journal: Biochemical pharmacology20111201
Title: Effective separation and analysis of E- and Z-guggulsterones in Commiphora mukul resin, guggulipid and their pharmaceutical product by high performance thin-layer chromatography-densitometric method.
Journal: Journal of pharmaceutical and biomedical analysis20110910
Title: Simultaneous estimation of E- and Z-isomers of guggulsterone in rabbit plasma using liquid chromatography tandem mass spectrometry and its application to pharmacokinetic study.
Journal: Biomedical chromatography : BMC20110901
Title: Guggulsterone (GS) inhibits smokeless tobacco and nicotine-induced NF-κB and STAT3 pathways in head and neck cancer cells.
Journal: Carcinogenesis20110301
Title: Reversal of multidrug resistance by guggulsterone in drug-resistant MCF-7 cell lines.
Journal: Chemotherapy20110101
Title: Guggulsterone targets smokeless tobacco induced PI3K/Akt pathway in head and neck cancer cells.
Journal: PloS one20110101
Title: TO901317 regulating apolipoprotein M expression mediates via the farnesoid X receptor pathway in Caco-2 cells.
Journal: Lipids in health and disease20110101
Title: Guggulsterone suppresses LPS induced inflammation of human middle ear epithelial cells (HMEEC).
Journal: International journal of pediatric otorhinolaryngology20101201
Title: Prevention of endotoxin-induced uveitis in rats by plant sterol guggulsterone.
Journal: Investigative ophthalmology & visual science20101001
Title: Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.
Journal: Journal of lipid research20100801
Title: Novel guggulsterone derivative GG-52 inhibits NF-kappaB signaling in intestinal epithelial cells and attenuates acute murine colitis.
Journal: Laboratory investigation; a journal of technical methods and pathology20100701
Title: Guggulsterone suppresses bile acid-induced and constitutive caudal-related homeobox 2 expression in gut-derived adenocarcinoma cells.
Journal: Anticancer research20100601
Title: Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile.
Journal: Chemico-biological interactions20100330
Title: 14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in head and neck cancer cells.
Journal: BMC cancer20100101
Title: The plant sterol guggulsterone attenuates inflammation and immune dysfunction in murine models of inflammatory bowel disease.
Journal: Biochemical pharmacology20091101
Title: Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3.
Journal: Carcinogenesis20091101
Title: Effects of guggulsterone isolated from Commiphora mukul in high fat diet induced diabetic rats.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20091001
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Journal: Nature chemical biology20091001
Title: Reversal of P-glycoprotein-mediated multidrug resistance by guggulsterone in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.
Journal: Die Pharmazie20091001
Title: Anti-obesity effects of xanthohumol plus guggulsterone in 3T3-L1 adipocytes.
Journal: Journal of medicinal food20090801
Title: Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts.
Journal: Cancer letters20090628
Title: Guggulsterone, an anti-inflammatory phytosterol, inhibits tissue factor and arterial thrombosis.
Journal: Basic research in cardiology20090501
Title: Guggulsterone suppresses the activation of transcription factor IRF3 induced by TLR3 or TLR4 agonists.
Journal: International immunopharmacology20090101
Title: Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia.
Journal: Journal of natural products20090101
Title: Guggulsterone: a potent farnesoid X receptor antagonist and its rapidly evolving role as a systemic anticarcinogenic agent.
Journal: Hepatology (Baltimore, Md.)20081201
Title: Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells.
Journal: Oncology reports20081201
Title: Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by guggulsterone.
Journal: Yao xue xue bao = Acta pharmaceutica Sinica20081201
Title: Guggulsterone modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in SENCAR mice.
Journal: Carcinogenesis20081001
Title: Guggulsterone, a plant sterol, inhibits NF-kappaB activation and protects pancreatic beta cells from cytokine toxicity.
Journal: Molecular and cellular endocrinology20080716
Title: Guggulsterone blocks IL-1beta-mediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes.
Journal: Life sciences20080606
Title: Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1.
Journal: Cancer research20080601
Title: Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1.
Journal: Biochemical and biophysical research communications20080502
Title: Omega-(2-Naphthyloxy) amino alkanes as a novel class of anti-hyperglycemic and lipid lowering agents.
Journal: Bioorganic & medicinal chemistry20080301
Title: z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo.
Journal: Molecular cancer therapeutics20080101
Title: Guggulsterone inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 cells.
Journal: Obesity (Silver Spring, Md.)20080101
Title: Enhanced effects of guggulsterone plus 1,25(OH)2D3 on 3T3-L1 adipocytes.
Journal: Biochemical and biophysical research communications20071221
Title: Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase.
Journal: Cancer research20070801
Title: Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.
Journal: Biochemical pharmacology20070630
Title: Guggulsterone production in cell suspension cultures of the guggul tree, Commiphora wightii, grown in shake-flasks and bioreactors.
Journal: Biotechnology letters20070601
Title: Natural products as a gold mine for arthritis treatment.
Journal: Current opinion in pharmacology20070601
Title: Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist.
Journal: Bioorganic & medicinal chemistry20070401
Title: The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonism.
Journal: The Journal of pharmacology and experimental therapeutics20070301
Title: Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits.
Journal: Cardiovascular drug reviews20070101
Title: Enhanced pro-apoptotic and anti-adipogenic effects of genistein plus guggulsterone in 3T3-L1 adipocytes.
Journal: BioFactors (Oxford, England)20070101
Title: Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis.
Journal: Inflammatory bowel diseases20061201
Title: The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone.
Journal: Endocrinology20060901
Title: Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20060115
Title: Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro.
Journal: Molecular cancer20060101
Title: Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure.
Journal: Molecular cancer therapeutics20051201
Title: Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study.
Journal: Journal of medicinal chemistry20051103
Title: Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak.
Journal: Molecular cancer therapeutics20051101
Title: The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter.
Journal: The Journal of pharmacology and experimental therapeutics20050701
Title: Fungal metabolites of (E)-guggulsterone and their antibacterial and radical-scavenging activities.
Journal: Chemistry & biodiversity20050401
Title: Regulation of carbohydrate metabolism by the farnesoid X receptor.
Journal: Endocrinology20050301
Title: The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand.
Journal: Molecular pharmacology20050301
Title: Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis.
Journal: The Journal of biological chemistry20041105
Title: HPTLC method for guggulsterone. II. Stress degradation studies on guggulsterone.
Journal: Journal of pharmaceutical and biomedical analysis20040921
Title: HPTLC method for guggulsterone. I. Quantitative determination of E- and Z-guggulsterone in herbal extract and pharmaceutical dosage form.
Journal: Journal of pharmaceutical and biomedical analysis20040921
Title: Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor.
Journal: The Journal of pharmacology and experimental therapeutics20040801
Title: The hypolipidemic natural product Commiphora mukul and its component guggulsterone inhibit oxidative modification of LDL.
Journal: Atherosclerosis20040201
Title: Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial.
Journal: JAMA20030813
Title: Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.
Journal: Biochemical and biophysical research communications20030425
Title: Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump.
Journal: The Journal of biological chemistry20030321
Title: Guggulsterone: an old approach to a new problem.
Journal: Trends in endocrinology and metabolism: TEM20020901
Title: The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor.
Journal: Molecular endocrinology (Baltimore, Md.)20020701
Title: A natural product that lowers cholesterol as an antagonist ligand for FXR.
Journal: Science (New York, N.Y.)20020531
Title: Simultaneous determination of E- and Z-guggulsterones in dietary supplements containing Commiphora mukul extract (guggulipid) by liquid chromatography.
Journal: Journal of AOAC International20010101
