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145-14-2,MFCD00009823
Catalog No.:AA001KCZ

145-14-2 | Pregn-4-en-3-one, 20-hydroxy-, (20S)-

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5mg
95%
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$568.00   $398.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001KCZ
Chemical Name:
Pregn-4-en-3-one, 20-hydroxy-, (20S)-
CAS Number:
145-14-2
Molecular Formula:
C21H32O2
Molecular Weight:
316.4776
MDL Number:
MFCD00009823
SMILES:
O=C1CC[C@]2(C(=C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](O)C)C)C
Properties
Computed Properties
 
Complexity:
550  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
4.2  

Literature

Title: Important roles of the AKR1C2 and SRD5A1 enzymes in progesterone metabolism in endometrial cancer model cell lines.

Journal: Chemico-biological interactions 20150605

Title: Neuroprotective effects of progesterone in chronic experimental autoimmune encephalomyelitis.

Journal: Journal of neuroendocrinology 20120601

Title: LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals.

Journal: Neurochemistry international 20120501

Title: Modifications of neuroactive steroid levels in an experimental model of nigrostriatal degeneration: potential relevance to the pathophysiology of Parkinson's disease.

Journal: Journal of molecular neuroscience : MN 20120101

Title: Immune aspects and myometrial actions of progesterone and CRH in labor.

Journal: Clinical & developmental immunology 20120101

Title: Progesterone produces antinociceptive and neuroprotective effects in rats with microinjected lysophosphatidic acid in the trigeminal nerve root.

Journal: Molecular pain 20120101

Title: Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival.

Journal: Age (Dordrecht, Netherlands) 20111201

Title: Is progesterone a worthy candidate as a novel therapy for traumatic brain injury?

Journal: Dialogues in clinical neuroscience 20110901

Title: Mechanisms responsible for progesterone's protection against lordosis-inhibiting effects of restraint II. Role of progesterone metabolites.

Journal: Hormones and behavior 20110701

Title: Neurosteroid modulation of arterial baroreflex function in the rostral ventrolateral medulla.

Journal: Autonomic neuroscience : basic & clinical 20110426

Title: II. Cognitive performance of middle-aged female rats is influenced by capacity to metabolize progesterone in the prefrontal cortex and hippocampus.

Journal: Brain research 20110316

Title: I. Levels of 5α-reduced progesterone metabolite in the midbrain account for variability in reproductive behavior of middle-aged female rats.

Journal: Brain research 20110316

Title: Progesterone, administered before kainic acid, prevents decrements in cognitive performance in the Morris Water Maze.

Journal: Developmental neurobiology 20110201

Title: Juvenile offspring of rats exposed to restraint stress in late gestation have impaired cognitive performance and dysregulated progestogen formation.

Journal: Stress (Amsterdam, Netherlands) 20110101

Title: Gestational exposure to variable stressors produces decrements in cognitive and neural development of juvenile male and female rats.

Journal: Current topics in medicinal chemistry 20110101

Title: Progesterone prevents development of neuropathic pain in a rat model: Timing and duration of treatment are critical.

Journal: Journal of pain research 20110101

Title: Sex differences in the inflammatory response of primary astrocytes to lipopolysaccharide.

Journal: Biology of sex differences 20110101

Title: Endogenous synthesis of corticosteroids in the hippocampus.

Journal: PloS one 20110101

Title: Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review.

Journal: Frontiers in psychiatry 20110101

Title: Date fruit extract is a neuroprotective agent in diabetic peripheral neuropathy in streptozotocin-induced diabetic rats: a multimodal analysis.

Journal: Oxidative medicine and cellular longevity 20110101

Title: Neuroprotective actions of neurosteroids.

Journal: Frontiers in endocrinology 20110101

Title: Neurosteroid biosynthesis in the brain of amphibians.

Journal: Frontiers in endocrinology 20110101

Title: Neurosteroids as neuromodulators in the treatment of anxiety disorders.

Journal: Frontiers in endocrinology 20110101

Title: The Neurosteroid Progesterone Underlies Estrogen Positive Feedback of the LH Surge.

Journal: Frontiers in endocrinology 20110101

Title: The neurosteroid allopregnanolone modulates specific functions in central and peripheral glial cells.

Journal: Frontiers in endocrinology 20110101

Title: Role of neuroactive steroids in the peripheral nervous system.

Journal: Frontiers in endocrinology 20110101

Title: Dihydroprogesterone increases the gene expression of myelin basic protein in spinal cord of diabetic rats.

Journal: Journal of molecular neuroscience : MN 20101001

Title: Human 20α-hydroxysteroid dehydrogenase (AKR1C1)-dependent biotransformation with recombinant fission yeast Schizosaccharomyces pombe.

Journal: Journal of biotechnology 20101001

Title: Activation of the liver X receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100908

Title: Progress in dorsal root ganglion neurosteroidogenic activity: basic evidence and pathophysiological correlation.

Journal: Progress in neurobiology 20100901

Title: Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme.

Journal: Bioorganic & medicinal chemistry letters 20100901

Title: Conjugated equine estrogen, with medroxyprogesterone acetate, enhances formation of 5alpha-reduced progestogens and reduces anxiety-like behavior of middle-aged rats.

Journal: Behavioural pharmacology 20100901

Title: Sex-dimorphic changes in neuroactive steroid levels after chronic experimental autoimmune encephalomyelitis.

Journal: Journal of neurochemistry 20100801

Title: Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer.

Journal: The Journal of steroid biochemistry and molecular biology 20100215

Title: Is maternal progesterone actually independent of the fetal steroids?

Journal: Physiological research 20100101

Title: Acute experimental autoimmune encephalomyelitis induces sex dimorphic changes in neuroactive steroid levels.

Journal: Neurochemistry international 20100101

Title: Opposing actions of the progesterone metabolites, 5alpha-dihydroprogesterone (5alphaP) and 3alpha-dihydroprogesterone (3alphaHP) on mitosis, apoptosis, and expression of Bcl-2, Bax and p21 in human breast cell lines.

Journal: The Journal of steroid biochemistry and molecular biology 20100101

Title: Progesterone - new therapy in mild carpal tunnel syndrome? Study design of a randomized clinical trial for local therapy.

Journal: Journal of brachial plexus and peripheral nerve injury 20100101

Title: Determination of endocrine disrupting compounds using temperature-dependent inclusion chromatography: I. Optimization of separation protocol.

Journal: Journal of chromatography. A 20091030

Title: Detection and identification of plasma progesterone metabolites in the female Florida manatee (Trichechus manatus latirostris) using GC/MS/MS.

Journal: Theriogenology 20090801

Title: Progesterone reduces depression-like behavior in a murine model of Alzheimer's Disease.

Journal: Age (Dordrecht, Netherlands) 20090601

Title: Central opioid inhibition of neuroendocrine stress responses in pregnancy in the rat is induced by the neurosteroid allopregnanolone.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090520

Title: Progestins in the menopause in healthy women and breast cancer patients.

Journal: Maturitas 20090420

Title: Discovery of new inhibitors of aldo-keto reductase 1C1 by structure-based virtual screening.

Journal: Molecular and cellular endocrinology 20090325

Title: Derivatives of pyrimidine, phthalimide and anthranilic acid as inhibitors of human hydroxysteroid dehydrogenase AKR1C1.

Journal: Chemico-biological interactions 20090316

Title: Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs.

Journal: Chemico-biological interactions 20090316

Title: Docetaxel-induced peripheral neuropathy: protective effects of dihydroprogesterone and progesterone in an experimental model.

Journal: Journal of the peripheral nervous system : JPNS 20090301

Title: Regulation of the phosphoinositide-3 kinase and mitogen-activated protein kinase signaling pathways by progesterone and its reduced metabolites in the rat brain.

Journal: Journal of neuroscience research 20090201

Title: Measurement of ring A-reduced progesterone metabolites by enzyme-linked immunoassay with colorimetric detection: baseline levels of six metabolites, including pregnanolone, in male rat plasma.

Journal: Analytical chemistry 20090201

Title: Progesterone metabolism in adipose cells.

Journal: Molecular and cellular endocrinology 20090127

Title: Binding characteristics of the ovine membrane progesterone receptor alpha and expression of the receptor during the estrous cycle.

Journal: Reproductive biology and endocrinology : RB&E 20090101

Title: Finasteride treatment and neuroactive steroid formation.

Journal: Prague medical report 20090101

Title: Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.

Journal: The Journal of reproduction and development 20081201

Title: Studies on neurosteroids XXV. Influence of a 5alpha-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism.

Journal: Biological & pharmaceutical bulletin 20080901

Title: Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury.

Journal: Neuroscience 20080826

Title: Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway.

Journal: The Journal of endocrinology 20080701

Title: Estrogen and progesterone metabolism in the cervix during pregnancy and parturition.

Journal: The Journal of clinical endocrinology and metabolism 20080601

Title: Infusions of 3alpha,5alpha-THP to the VTA enhance exploratory, anti-anxiety, social, and sexual behavior and increase levels of 3alpha,5alpha-THP in midbrain, hippocampus, diencephalon, and cortex of female rats.

Journal: Behavioural brain research 20080211

Title: Studies on neurosteroids XXII. Liquid chromatography-tandem mass spectrometric method for profiling rat brain 3-oxo-4-ene-neuroactive steroids.

Journal: Biomedical chromatography : BMC 20080101

Title: Evaluation of neuroactive steroid levels by liquid chromatography-tandem mass spectrometry in central and peripheral nervous system: effect of diabetes.

Journal: Neurochemistry international 20080101

Title: The anti-aromatase effect of progesterone and of its natural metabolites 20alpha- and 5alpha-dihydroprogesterone in the MCF-7aro breast cancer cell line.

Journal: Anticancer research 20080101

Title: GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices.

Journal: The European journal of neuroscience 20071001

Title: Transgenic male mice expressing human hydroxysteroid dehydrogenase 2 indicate a role for the enzyme independent of its action on sex steroids.

Journal: Endocrinology 20070801

Title: Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.

Journal: The Journal of reproduction and development 20070601

Title: The non-genomic effects on Na+/H+-exchange 1 by progesterone and 20alpha-hydroxyprogesterone in human T cells.

Journal: Journal of cellular physiology 20070501

Title: Engaging in paced mating, but neither exploratory, anti-anxiety, nor social behavior, increases 5alpha-reduced progestin concentrations in midbrain, hippocampus, striatum, and cortex.

Journal: Reproduction (Cambridge, England) 20070301

Title: Effects of progesterone and its reduced metabolites, dihydroprogesterone and tetrahydroprogesterone, on the expression and phosphorylation of glycogen synthase kinase-3 and the microtubule-associated protein tau in the rat cerebellum.

Journal: Developmental neurobiology 20070301

Title: Progesterone and its derivatives are neuroprotective agents in experimental diabetic neuropathy: a multimodal analysis.

Journal: Neuroscience 20070223

Title: Progesterone derivatives increase expression of Krox-20 and Sox-10 in rat Schwann cells.

Journal: Journal of molecular neuroscience : MN 20070101

Title: Role of inhibin and activin in the modulation of gonadotropin- and steroid-induced oocyte maturation in the teleost Fundulus heteroclitus.

Journal: Reproductive biology and endocrinology : RB&E 20070101

Title: Infusions of 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) to the ventral tegmental area, but not the substantia nigra, enhance exploratory, anti-anxiety, social and sexual behaviours and concomitantly increase 3alpha,5alpha-THP concentrations in the hippocampus, diencephalon and cortex of ovariectomised oestrogen-primed rats.

Journal: Journal of neuroendocrinology 20061201

Title: Phytoestrogens as inhibitors of the human progesterone metabolizing enzyme AKR1C1.

Journal: Molecular and cellular endocrinology 20061019

Title: Progesterone metabolites in breast cancer.

Journal: Endocrine-related cancer 20060901

Title: Neuroactive steroids prevent peripheral myelin alterations induced by diabetes.

Journal: Neuroscience letters 20060710

Title: Human chorionic gonadotropin-dependent induction of an equine aldo-keto reductase (AKR1C23) with 20alpha-hydroxysteroid dehydrogenase activity during follicular luteinization in vivo.

Journal: Journal of molecular endocrinology 20060601

Title: Sex-dimorphic effects of progesterone and its reduced metabolites on gene expression of myelin proteins by rat Schwann cells.

Journal: Journal of the peripheral nervous system : JPNS 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Possible involvement of 5alpha-reduced neurosteroids in adrenergic and serotonergic stimulation of GFAP gene expression in rat C6 glioma cells.

Journal: Brain research 20060426

Title: AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer.

Journal: Molecular and cellular endocrinology 20060327

Title: Region-, age-, and sex-specific effects of fetal diazepam exposure on the postnatal development of neurosteroids.

Journal: Brain research 20060105

Title: Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.

Journal: The Journal of steroid biochemistry and molecular biology 20060101

Title: GABA receptor-mediated effects in the peripheral nervous system: A cross-interaction with neuroactive steroids.

Journal: Journal of molecular neuroscience : MN 20060101

Title: A new look at the 5alpha-reductase inhibitor finasteride.

Journal: CNS drug reviews 20060101

Title: [Effect of steroid biosynthesis modificators on the progesterone biotransformation by a recombinant yeasts expressing cytochrome P450c17].

Journal: Biomeditsinskaia khimiia 20060101

Title: Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20060101

Title: Progestin concentrations are increased following paced mating in midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous rats.

Journal: Neuroendocrinology 20060101

Title: Localization of 5alpha-reductase in the rat main olfactory bulb.

Journal: The Journal of comparative neurology 20051219

Title: Expression and regulation of progestin membrane receptors in the rat corpus luteum.

Journal: Endocrinology 20051201

Title: Transgene insertion on mouse chromosome 6 impairs function of the uterine cervix and causes failure of parturition.

Journal: Biology of reproduction 20051101

Title: Membrane 5alpha-pregnane-3,20-dione (5alphaP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5alphaP and down-regulated by the progesterone metabolites, 3alpha-dihydroprogesterone and 20alpha-dihydroprogesterone, with associated changes in cell proliferation and detachment.

Journal: The Journal of steroid biochemistry and molecular biology 20051101

Title: Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats.

Journal: Epilepsy & behavior : E&B 20050901

Title: Progesterone inhibits gallbladder motility through multiple signaling pathways.

Journal: Steroids 20050801

Title: Immunosteroid as a regulator for Th1/Th2 balance: its possible role in autoimmune diseases.

Journal: Autoimmunity 20050801

Title: Expression of 3beta-hydroxysteroid dehydrogenase type 1, P450 aromatase, and 17beta-hydroxysteroid dehydrogenase types 1, 2, 5 and 7 mRNAs in human early and mid-gestation placentas.

Journal: Placenta 20050501

Title: Expression and possible role of 20alpha-hydroxysteroid dehydrogenase in the placenta of the goat.

Journal: The Journal of reproduction and development 20050401

Title: Peripheral nerves: a target for the action of neuroactive steroids.

Journal: Brain research. Brain research reviews 20050401

Title: Expression and activity of steroid aldoketoreductases 1C in omental adipose tissue are positive correlates of adiposity in women.

Journal: American journal of physiology. Endocrinology and metabolism 20050201

Title: Expression and activity of 20alpha-hydroxysteroid dehydrogenase (AKR1C1) in abdominal subcutaneous and omental adipose tissue in women.

Journal: The Journal of clinical endocrinology and metabolism 20050101

Title: Inhibitory effects of flavonoids on the reduction of progesterone to 20alpha-hydroxyprogesterone in rat liver.

Journal: The Journal of steroid biochemistry and molecular biology 20050101

Title: [Pregna-D'-pentaranes, progestins, and antiprogestins: II. Pathways and realization mechanisms of separate biological functions of steroid hormones].

Journal: Bioorganicheskaia khimiia 20050101

Title: Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.

Journal: BMC biochemistry 20050101

Title: Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.

Journal: Cancer research 20041015

Title: Mammary steroid metabolizing enzymes in relation to hyperplasia and tumorigenesis in the dog.

Journal: The Journal of steroid biochemistry and molecular biology 20041001

Title: Influence of 17beta-estradiol on the synthesis of reduced neurosteroids in the brain (in vivo) and in glioma cells (in vitro): possible relevance to mental disorders in women.

Journal: Brain research 20040910

Title: [Determination of progesterone and its main metabolite in rat plasma and uterus using HPLC].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040801

Title: Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.

Journal: Brain research. Molecular brain research 20040618

Title: Molecular cloning of goat 20alpha-hydroxysteroid dehydrogenase cDNA.

Journal: The Journal of reproduction and development 20040601

Title: Expression of cytochrome P450c17 and other steroid-converting enzymes in the rat kidney throughout the life-span.

Journal: The Journal of steroid biochemistry and molecular biology 20040601

Title: Effects of progesterone derivatives, dihydroprogesterone and tetrahydroprogesterone, on the subependymal layer of the adult rat.

Journal: Journal of neurobiology 20040301

Title: Fundulus heteroclitus gonadotropins.5: Small scale chromatographic fractionation of pituitary extracts into components with different steroidogenic activities using homologous bioassays.

Journal: Reproductive biology and endocrinology : RB&E 20040101

Title: SRC-1 is involved in the control of the gene expression of myelin protein Po.

Journal: Journal of molecular neuroscience : MN 20040101

Title: Sex hormones and brain aging.

Journal: Experimental gerontology 20040101

Title: Changes in the activities of hydroxysteroid dehydrogenases in mouse oocytes during meiotic maturation.

Journal: The Journal of reproduction and development 20031201

Title: Steroid hormones and growth factors act in an integrated manner at the levels of hypothalamic astrocytes: a role in the neuroendocrine control of reproduction.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Neurogenesis in the subependymal layer of the adult rat: a role for neuroactive derivatives of progesterone.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Sex-related expression of 20alpha-hydroxysteroid dehydrogenase mRNA in the adult mouse.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20031101

Title: Actions of progesterone and its 5alpha-reduced metabolites on the major proteins of the myelin of the peripheral nervous system.

Journal: Steroids 20031101

Title: Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats.

Journal: Neurobiology of aging 20031001

Title: Neuroactive steroids influence peripheral myelination: a promising opportunity for preventing or treating age-dependent dysfunctions of peripheral nerves.

Journal: Progress in neurobiology 20030901

Title: The effects of a progesterone metabolite, 5 beta-dihydroprogesterone, on oxytocin receptor binding in human myometrial membranes.

Journal: BJOG : an international journal of obstetrics and gynaecology 20030601

Title: Effect of finasteride on the ovulatory function of normal women.

Journal: Fertility and sterility 20030601

Title: Effects of neuroactive steroids on myelin of peripheral nervous system.

Journal: The Journal of steroid biochemistry and molecular biology 20030601

Title: Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.

Journal: The Journal of reproduction and development 20030201

Title: The effect of continuous combined 17beta-oestradiol and dihydrodydrogesterone on apoptotic cell death and proliferation of human breast cancer cells in vitro.

Journal: European journal of cancer (Oxford, England : 1990) 20021101

Title: Progesterone metabolism in human leukemic monoblast U937 cells.

Journal: Endocrine journal 20021001

Title: Purification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2.

Journal: The Journal of biological chemistry 20020621

Title: Distribution and metabolism of 20 alpha-hydroxylated progestins in the female rat.

Journal: The Journal of steroid biochemistry and molecular biology 20020401

Title: Myometrial expression of 11 beta-hydroxysteroid dehydrogenase type 2 in rat pregnancy.

Journal: The Journal of endocrinology 20020301

Title: Expression, crystallization and preliminary X-ray analysis of human and rabbit 20alpha-hydroxysteroid dehydrogenases in complex with NADP(H) and various steroid substrates.

Journal: Acta crystallographica. Section D, Biological crystallography 20020101

Title: Pathogenesis of diabetic neuropathy--do hyperglycemia and aldose reductase inhibitors affect neuroactive steroid formation in the rat sciatic nerves?

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20020101

Title: Placentation in the African elephant, Loxodonta africana. I. Endocrinological aspects.

Journal: Reproduction (Cambridge, England) Supplement 20020101

Title: Afferent baroreceptor discharge in pregnant rats.

Journal: American journal of physiology. Heart and circulatory physiology 20011201

Title: Ventral tegmental area infusions of inhibitors of the biosynthesis and metabolism of 3alpha,5alpha-THP attenuate lordosis of hormone-primed and behavioural oestrous rats and hamsters.

Journal: Journal of neuroendocrinology 20011201

Title: Hormonal steroidogenesis in liver and small intestine of the green frog, Rana esculenta L.

Journal: Life sciences 20011102

Title: Biosynthesis of the neurosteroid 3 alpha-hydroxy-4-pregnen-20-one (3 alpha hp), a specific inhibitor of FSH release.

Journal: Endocrinology 20011101

Title: Increase in circulating levels of cardiac natriuretic peptides after hormone replacement therapy in postmenopausal women.

Journal: Clinical science (London, England : 1979) 20011101

Title: Studies on Bacillus stearothermophilus. Part 1. Transformation of progesterone to a new metabolite 9,10-seco-4-pregnene-3,9,20-trione.

Journal: The Journal of steroid biochemistry and molecular biology 20011101

Title: The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders.

Journal: Brain research. Brain research reviews 20011101

Title: Neuroactive steroids and peripheral myelin proteins.

Journal: Brain research. Brain research reviews 20011101

Title: Dependence on prolactin of the luteolytic effect of prostaglandin F2alpha in rat luteal cell cultures.

Journal: Biology of reproduction 20011001

Title: Steroid effects on the gene expression of peripheral myelin proteins.

Journal: Hormones and behavior 20010901

Title: Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties.

Journal: The Journal of biological chemistry 20010622

Title: Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on progestin biosynthesis in cultured luteal cells from rat ovary.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20010601

Title: Effects of CRH and ACTH administration on plasma and brain neurosteroid levels.

Journal: Neurochemical research 20010501

Title: Separation of steroids using temperature-dependent inclusion chromatography.

Journal: Journal of chromatography. A 20010330

Title: Actions of prostaglandin F2alpha and prolactin on intercellular adhesion molecule-1 expression and monocyte/macrophage accumulation in the rat corpus luteum.

Journal: Biology of reproduction 20010301

Title: Neurosteroid withdrawal model of perimenstrual catamenial epilepsy.

Journal: Epilepsia 20010301

Title: Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution.

Journal: The Journal of clinical endocrinology and metabolism 20010201

Title: The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene.

Journal: The Journal of biological chemistry 20010126

Title: Enzyme-mediated protection of the mineralocorticoid receptor against progesterone in the human kidney.

Journal: Molecular and cellular endocrinology 20010122

Title: Inhibitors of type II 17beta-hydroxysteroid dehydrogenase.

Journal: Molecular and cellular endocrinology 20010122

Title: Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).

Journal: Molecular and cellular endocrinology 20010122

Title: [Effect of the treatment with femoston on the cardiovascular system in postmenopausal women].

Journal: Terapevticheskii arkhiv 20010101

Title: Molecular cloning of cDNA for rat ovarian 20 alpha-hydroxysteroid dehydrogenase (HSD1).

Journal: The Biochemical journal 19940415

Title: Modulation of adrenal cell functions by cadmium salts. 1. Cadmium chloride effects on basal and ACTH-stimulated steroidogenesis.

Journal: Cell biology and toxicology 19930101

Title: Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity.

Journal: Molecular endocrinology (Baltimore, Md.) 19930101

Title: Effect of the progesterone antagonist mifepristone on the hypothalamo-hypophysial-ovarian axis in rats.

Journal: The Journal of endocrinology 19900301

Title: Placenta defects and embryonic lethality resulting from disruption of mouse hydroxysteroid (17-beta) dehydrogenase 2 gene.

Journal: Molecular endocrinology (Baltimore, Md.)

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Tags:145-14-2 Molecular Formula|145-14-2 MDL|145-14-2 SMILES|145-14-2 Pregn-4-en-3-one, 20-hydroxy-, (20S)-