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Home Amines 391209-55-5
391209-55-5,MFCD32204456
Catalog No.:AA01EMTY

391209-55-5 | 3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)benzamide

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Purity
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Price(USD)
Quantity
  
100mg
95%
1 week  
$193.00   $135.00
- +
250mg
95%
1 week  
$288.00   $202.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01EMTY
Chemical Name:
3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)benzamide
CAS Number:
391209-55-5
Molecular Formula:
C15H12F3IN2O3
Molecular Weight:
452.1671
MDL Number:
MFCD32204456
SMILES:
OCCONC(=O)c1ccc(c(c1Nc1ccc(cc1F)I)F)F
Properties
Computed Properties
 
Complexity:
421  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
3.6  

Downstream Synthesis Route
391209-55-5    1066-54-2   
2-(4-(2-trimethylsilyl)ethynyl-2-fluorophenyl)amino-3,4-difluoro-N-(2-hydroxyethoxy)benzamide 

[1]CurrentPatentAssignee:PFIZERINC-US2004/6245,2004,A1Locationinpatent:Page27

391209-55-5    95010-17-6   
3,4-difluoro-2-(2-fluoro-4-vinylphenyl)amino-N-(2-hydroxyethoxy)benzamide 

[1]CurrentPatentAssignee:PFIZERINC-US2004/6245,2004,A1Locationinpatent:Page25

391209-55-5   
3,4-Difluoro-2-(2-fluoro-phenylamino)-N-(2-hydroxy-ethoxy)-benzamide 

[1]CurrentPatentAssignee:PFIZERINC-US2004/54172,2004,A1

C18H16F3IN2O3 
  391209-55-5 

[1]Locationinpatent:schemeortableBarrett,StephenD.;Bridges,AlexanderJ.;Dudley,DavidT.;Saltiel,AlanR.;Fergus,JamesH.;Flamme,CathlinM.;Delaney,AmyM.;Kaufman,Michael;LePage,Sophie;Leopold,WilburR.;Przybranowski,SallyA.;Sebolt-Leopold,Judith;VanBecelaere,Keri;Doherty,AnnetteM.;Kennedy,RobertM.;Marston,Dan;HowardJr.,W.Allen;Smith,Yvonne;Warmus,JosephS.;Tecle,Haile[BioorganicandMedicinalChemistryLetters,2008,vol.18,#24,p.6501-6504]

Literature

Title: The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.

Journal: Bioorganic & medicinal chemistry letters 20081215

Title: 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.

Journal: Journal of medicinal chemistry 20071018

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SDS
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Tags:391209-55-5 Molecular Formula|391209-55-5 MDL|391209-55-5 SMILES|391209-55-5 3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)benzamide