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Home Amines 391210-10-9
391210-10-9,MFCD08435926
Catalog No.:AA0037FN

391210-10-9 | N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$11.00   $8.00
- +
10mg
98%
in stock  
$33.00   $23.00
- +
100mg
98%
in stock  
$208.00   $146.00
- +
1g
98%
in stock  
$492.00   $344.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0037FN
Chemical Name:
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
CAS Number:
391210-10-9
Molecular Formula:
C16H14F3IN2O4
Molecular Weight:
482.1930
MDL Number:
MFCD08435926
SMILES:
OC[C@H](CONC(=O)c1ccc(c(c1Nc1ccc(cc1F)I)F)F)O
Properties
Properties
 
Form:
Solid  
MP:
112-114℃  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
465  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
7  
XLogP3:
3  

Downstream Synthesis Route

[1]Patent:US2005/85550,2005,A1.Locationinpatent:Page/Pagecolumn8

[2]Patent:WO2005/46665,2005,A1.Locationinpatent:Page/Pagecolumn10-11

[3]Patent:US2005/222163,2005,A1.Locationinpatent:Page/Pagecolumn28

[1]CurrentPatentAssignee:PFIZERINC-US2005/85550,2005,A1Locationinpatent:Page/Pagecolumn8

[2]CurrentPatentAssignee:PFIZERINC-WO2006/134469,2006,A1Locationinpatent:Page/Pagecolumn10;14-15

[3]CurrentPatentAssignee:PFIZERINC-WO2006/134469,2006,A1Locationinpatent:Page/Pagecolumn11;15

[4]CurrentPatentAssignee:PFIZERINC-US11066358,2021,B1Locationinpatent:Page/Pagecolumn21-22;24-25

[5]CurrentPatentAssignee:SPRINGWORKSTHERAPEUTICS,INC-US11084780,2021,B1Locationinpatent:Page/Pagecolumn96;99-100;102

Literature

Title: Barrett SD, et al. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6501-4.

Title: Judith S. Sebolt-Leopold, et al. The biological profile of PD 0325901: A second generation analog of CI-1040 with improved pharmaceutical potential

Title: Henderson YC, et al. MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivo. Mol Cancer Ther. 2010 Jul;9(7):1968-76.

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SDS
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Tags:391210-10-9 Molecular Formula|391210-10-9 MDL|391210-10-9 SMILES|391210-10-9 N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide