Home Other Building Blocks 39133-31-8
39133-31-8,MFCD00133873
Catalog No.:AA00I7NE

39133-31-8 | Trimebutine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5g
98%
in stock  
$24.00   $17.00
- +
25g
97%
in stock  
$70.00   $49.00
- +
100g
97%
in stock  
$187.00   $131.00
- +
500g
97%
in stock  
$635.00   $445.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I7NE
Chemical Name:
Trimebutine
CAS Number:
39133-31-8
Molecular Formula:
C22H29NO5
Molecular Weight:
387.4694
MDL Number:
MFCD00133873
SMILES:
CCC(c1ccccc1)(N(C)C)COC(=O)c1cc(OC)c(c(c1)OC)OC
Properties
Properties
 
BP:
513.42°C (rough estimate)  
Form:
Solid  
MP:
78-80°C  
Refractive Index:
1.5614 (estimate)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
466  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4  

Literature

Title: Targeting Ion Channels: An Important Therapeutic Implication in Gastrointestinal Dysmotility in Patients With Spinal Cord Injury.

Journal: Journal of neurogastroenterology and motility 20151001

Title: End point determination of blending process for trimebutine tablets using principle component analysis (PCA) and partial least squares (PLS) regression.

Journal: Archives of pharmacal research 20120901

Title: [Potential severity of self-poisoning with trimebutine].

Journal: Presse medicale (Paris, France : 1983) 20120601

Title: Acupuncture for treatment of irritable bowel syndrome.

Journal: The Cochrane database of systematic reviews 20120516

Title: Asian consensus report on functional dyspepsia.

Journal: Journal of neurogastroenterology and motility 20120401

Title: Effect of antispasmodic agents, alone or in combination, in the treatment of Irritable Bowel Syndrome: systematic review and meta-analysis.

Journal: Revista de gastroenterologia de Mexico 20120101

Title: A case of trimebutine-induced anaphylaxis.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20111201

Title: Pharmacologic and complementary and alternative medicine therapies for irritable bowel syndrome.

Journal: Gut and liver 20110901

Title: Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome.

Journal: The Cochrane database of systematic reviews 20110810

Title: [Comparative study on irritable bowel syndrome treated with acupuncture and western medicine].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20110701

Title: Stress-related alterations of visceral sensation: animal models for irritable bowel syndrome study.

Journal: Journal of neurogastroenterology and motility 20110701

Title: Trimebutine as a modulator of gastrointestinal motility.

Journal: Archives of pharmacal research 20110601

Title: Effects of trimebutine maleate on colonic motility through Ca²+-activated K+ channels and L-type Ca²+ channels.

Journal: Archives of pharmacal research 20110601

Title: Why pharmacokinetic differences among oral triptans have little clinical importance: a comment.

Journal: The journal of headache and pain 20110201

Title: [A medicine not so harmless as it appears: about an emergency case of acute voluntary poisoning with trimebutine (Debridat(®))].

Journal: Annales francaises d'anesthesie et de reanimation 20110101

Title: Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics?

Journal: BMC neurology 20110101

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research 20101201

Title: Development of a novel combination tablet containing trimebutine maleate and mosapride citrate for the treatment of functional dyspepsia.

Journal: International journal of pharmaceutics 20101115

Title: Effectiveness of trimebutine maleate on modulating intestinal hypercontractility in a mouse model of postinfectious irritable bowel syndrome.

Journal: European journal of pharmacology 20100625

Title: [Prokinetics in childhood].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20100601

Title: Risk factors of drug interaction between warfarin and nonsteroidal anti-inflammatory drugs in practical setting.

Journal: Journal of Korean medical science 20100301

Title: A nitro-arginine derivative of trimebutine (NO2-Arg-Trim) attenuates pain induced by colorectal distension in conscious rats.

Journal: Pharmacological research 20090501

Title: Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract.

Journal: Journal of gastroenterology and hepatology 20090401

Title: Effect of four medications associated with gastrointestinal motility on Oddi sphincter in the rabbit.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20090101

Title: Activation of peripheral opioid receptors has no effect on heart rate variability.

Journal: Clinical autonomic research : official journal of the Clinical Autonomic Research Society 20080601

Title: Effects of serotonin 5-HT3 receptor antagonists on stress-induced colonic hyperalgesia and diarrhoea in rats: a comparative study with opioid receptor agonists, a muscarinic receptor antagonist and a synthetic polymer.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20080501

Title: Inhibitory effects of ramosetron, a potent and selective 5-HT3-receptor antagonist, on conditioned fear stress-induced abnormal defecation and normal defecation in rats: comparative studies with antidiarrheal and spasmolytic agents.

Journal: Journal of pharmacological sciences 20080201

Title: Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis.

Journal: BMJ (Clinical research ed.) 20080101

Title: [A randomized and case-control clinical study on trimebutine maleate in treating functional dyspepsia coexisting with diarrhea-dominant irritable bowel syndrome].

Journal: Zhonghua nei ke za zhi 20071101

Title: Treatment of functional dyspepsia with serotonin agonists: a meta-analysis of randomized controlled trials.

Journal: Journal of gastroenterology and hepatology 20071001

Title: Acute migraine: Current treatment and emerging therapies.

Journal: Therapeutics and clinical risk management 20070601

Title: Spectrophotometric determination of some anti-tussive and anti-spasmodic drugs through ion-pair complex formation with thiocyanate and cobalt(II) or molybdenum(V).

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070401

Title: Meta-analysis of the effects of prokinetic agents in patients with functional dyspepsia.

Journal: Journal of gastroenterology and hepatology 20070301

Title: [Drug treatment of irritable bowel syndrome: an unmet need].

Journal: Gastroenterologia y hepatologia 20070301

Title: Pharmacokinetic and bioequivalence evaluation of two formulations of 100 mg trimebutine maleate (Recutin and Polybutin) in healthy male volunteers using the LC-MS/MS method.

Journal: Clinica chimica acta; international journal of clinical chemistry 20070101

Title: Increasing the effect of triptans in migraine.

Journal: Lancet (London, England) 20061014

Title: The use of combination therapies in the acute management of migraine.

Journal: Neuropsychiatric disease and treatment 20060901

Title: Rizatriptan vs. rizatriptan plus trimebutine for the acute treatment of migraine: a double-blind, randomized, cross-over, placebo-controlled study.

Journal: Cephalalgia : an international journal of headache 20060701

Title: The effect of trimebutine on the psychosocial adjustment to illness in the irritable bowel syndrome.

Journal: Romanian journal of internal medicine = Revue roumaine de medecine interne 20060101

Title: Effect of nor-trimebutine on neuronal activation induced by a noxious stimulus or an acute colonic inflammation in the rat.

Journal: Life sciences 20051021

Title: Pharmacokinetic study of trimebutine maleate in rabbit blood using in vivo microdialysis coupled to capillary electrophoresis.

Journal: Journal of pharmaceutical and biomedical analysis 20050915

Title: Novelty stress increases fecal pellet output in mongolian gerbils: effects of several drugs.

Journal: Journal of pharmacological sciences 20050801

Title: [Abdominal migraine as a cause of chronic recurrent abdominal pain in a 9-years-old girl--case report].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20050801

Title: Determination of trimebutine in pharmaceuticals by differential pulse voltammetry at a glassy carbon electrode.

Journal: Journal of pharmaceutical and biomedical analysis 20050715

Title: Rectal instillation of butyrate provides a novel clinically relevant model of noninflammatory colonic hypersensitivity in rats.

Journal: Gastroenterology 20050601

Title: A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRIND-based 3D-QSAR.

Journal: Journal of medicinal chemistry 20050421

Title: Prokinetic agents in childen with poor appetite.

Journal: Acta gastro-enterologica Belgica 20050101

Title: Beneficial effect of trimebutine and N-monodesmethyl trimebutine on trinitrobenzene sulfonic acid-induced colitis in rats.

Journal: Life sciences 20041203

Title: Delayed reaction urticaria due to trimebutine.

Journal: Allergy 20040701

Title: H pylori infection and reflux oesophagitis.

Journal: Gut 20040601

Title: [Pharmacokinetics and bioequivalence of trimebutine dispersive tablet in healthy subjects].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040301

Title: Acute treatment of migraine. Breaking the paradigm of monotherapy.

Journal: BMC neurology 20040101

Title: Establishing a comprehensive questionnaire for detecting drug-induced extrapyramidal symptoms.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20031001

Title: Spectrophotometric and liquid chromatographic determination of trimebutine maleate in the presence of its degradation products.

Journal: Journal of pharmaceutical and biomedical analysis 20030919

Title: Factors affecting gallbladder motility: drugs.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20030701

Title: Quantitative determination of trimebutine maleate and its three metabolites in human plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021105

Title: Preparation, characterization and taste-masking properties of polyvinylacetal diethylaminoacetate microspheres containing trimebutine.

Journal: The Journal of pharmacy and pharmacology 20021001

Title: Centrally acting agents and visceral sensitivity.

Journal: Gut 20020701

Title: Laxative and anti-diarrheal activity of polycarbophil in mice and rats.

Journal: Japanese journal of pharmacology 20020601

Title: The role of remote gut inflammation in duodenojejunal dysmotility.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20020401

Title: Effects of tachykinin NK1 receptor antagonists on the viscerosensory response caused by colorectal distention in rabbits.

Journal: The Journal of pharmacology and experimental therapeutics 20020301

Title: [Physicochemical and pharmacological characteristic and clinical efficacy of an anti-irritable bowel syndrome agent, polycarbophil calcium (Polyful)].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20020301

Title: [Prokinetics of gastrointestinal system; its newer aspects with regard to motillity stimulants].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020201

Title: Oesophageal motility disorders.

Journal: Lancet (London, England) 20020112

Title: Efficacy of trimebutine therapy in patients with gastroesophageal reflux disease and irritable bowel syndrome.

Journal: Hepato-gastroenterology 20020101

Title: Allergic contact dermatitis due to trimebutine.

Journal: Contact dermatitis 20010901

Title: [Dysfunction of the Oddi's sphincter].

Journal: Gastroenterologie clinique et biologique 20010901

Title: Effects of TAK-637, a novel neurokinin-1 receptor antagonist, on colonic function in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20010801

Title: Duodenogastric reflux following cholecystectomy in the dog: role of antroduodenal motor function.

Journal: Alimentary pharmacology & therapeutics 20010801

Title: Determination of trimebutine maleate in rat plasma and tissues by using capillary zone electrophoresis.

Journal: Biomedical chromatography : BMC 20010601

Title: Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome.

Journal: Alimentary pharmacology & therapeutics 20010301

Title: [HPCE determination of trimebutine maleate in rat plasma and its pharmacokinetics].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20010201

Title: Effect of YNS-15P, a new alpha-2 adrenoceptor antagonist, on stress-stimulated colonic propulsion in rats.

Journal: The Journal of pharmacology and experimental therapeutics 19981101

Title: Trimebutine: mechanism of action, effects on gastrointestinal function and clinical results.

Journal: The Journal of international medical research 19970101

Title: Comparison of the effects of trimebutine and YM114 (KAE-393), a novel 5-HT3 receptor antagonist, on stress-induced defecation.

Journal: European journal of pharmacology 19931207

Title: Effect of trimebutine on voltage-activated calcium current in rabbit ileal smooth muscle cells.

Journal: British journal of pharmacology 19930901

Title: Effect of trimebutine on K+ current in rabbit ileal smooth muscle cells.

Journal: European journal of pharmacology 19930428

Title: General pharmacology of the four gastrointestinal motility stimulants bethanechol, metoclopramide, trimebutine, and cisapride.

Journal: Arzneimittel-Forschung 19910601

Title: Studies of metabolic pathways of trimebutine by simultaneous administration of trimebutine and its deuterium-labeled metabolite.

Journal: Drug metabolism and disposition: the biological fate of chemicals 19890101

Title: Kaneto, H., M. Takahashi, and J. Watanabe, The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies. J Pharmacobiodyn, 1990. 13(7): p. 448-53.

Title: Roman, F.J., et al., Pharmacological properties of trimebutine and N-monodesmethyltrimebutine. J Pharmacol Exp Ther, 1999. 289(3): p. 1391-7.

Title: Hiyama, T., et al., Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract. J Gastroenterol Hepatol, 2009. 24(4): p. 537-46.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:39133-31-8 Molecular Formula|39133-31-8 MDL|39133-31-8 SMILES|39133-31-8 Trimebutine