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39627-84-4,MFCD00016810
Catalog No.:AA003HOJ

39627-84-4 | 2-Naphthhydrazide

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Purity
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250mg
98%
in stock  
$22.00   $15.00
- +
1g
98%
in stock  
$34.00   $24.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003HOJ
Chemical Name:
2-Naphthhydrazide
CAS Number:
39627-84-4
Molecular Formula:
C11H10N2O
Molecular Weight:
186.2099
MDL Number:
MFCD00016810
SMILES:
NNC(=O)c1ccc2c(c1)cccc2
Properties
Properties
 
Form:
Solid  
MP:
146-148 °C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
217  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
2.3  

Downstream Synthesis Route
39627-84-4    555-16-8   
LASSBio-1524 

[1]Locationinpatent:experimentalpartAvila,CarolinaM.;Lopes,AlexandraB.;Gonalves,ArlanS.;DaSilva,LeandroL.;Romeiro,NelilmaC.;Miranda,AnaLuisaP.;Sant'Anna,CarlosM.R.;Barreiro,EliezerJ.;Fraga,CarlosA.M.[EuropeanJournalofMedicinalChemistry,2011,vol.46,#4,p.1245-1253]

[2]Goldstein;Studer[HelveticaChimicaActa,1934,vol.17,p.1485,1486]

[1]Avila,CarolinaM.;Lopes,AlexandraB.;Gonalves,ArlanS.;DaSilva,LeandroL.;Romeiro,NelilmaC.;Miranda,AnaLuisaP.;Sant'Anna,CarlosM.R.;Barreiro,EliezerJ.;Fraga,CarlosA.M.[EuropeanJournalofMedicinalChemistry,2011,vol.46,#4,p.1245-1253]

[2]CurrentPatentAssignee:SEMICONDUCTORENERGYLABORATORYCO.,LTD.-WO2011/52516,2011,A1Locationinpatent:Page/Pagecolumn114

[3]Cordeiro,NatáliaM.;Freitas,RosanaH.C.N.;Fraga,CarlosA.M.;Fernandes,PatriciaD.[PLoSONE,2016,vol.11,#5]

[4]Alves,MarinaA.;Chaves,LorraneS.;Fernandes,PatríciaD.;Fraga,CarlosA.M.;Guerra,FabianaS.;Rodrigues,DanielA.;Sagrillo,FernandaS.;Sant'Anna,CarlosM.R.;Thota,Sreekanth;deSenaM.Pinheiro,Pedro[ChemMedChem,2020]

[5]Caboni,Laura;Egan,Billy;Kelly,Brendan;Blanco,Fernando;Fayne,Darren;Meegan,MaryJ.;Lloyd,DavidG.[JournalofChemicalInformationandModeling,2013,vol.53,#8,p.2116-2130]

[6]Fu,Jian;Fu,Huixiao;Dieu,Marc;Halloum,Iman;Kremer,Laurent;Xia,Yufen;Pan,Weidong;Vincent,StéphaneP.[ChemicalCommunications,2017,vol.53,#77,p.10632-10635]

[7]Guedes,IsabellaA.;Freitas,RosanaH.C.N.;Cordeiro,NatliaM.;DoNascimento,ThasS.;Valerio,TaynaS.;Fernandes,PatrciaD.;Dardenne,LaurentE.;Fraga,CarlosA.M.[ChemMedChem,2016,vol.11,#2,p.234-244]

[8]Freitas,RosanaH.C.N.;Cordeiro,NatáliaM.;Carvalho,PatríciaR.;Alves,MarinaA.;Guedes,IsabellaA.;Valerio,TaynaS.;Dardenne,LaurentE.;Lima,LídiaM.;Barreiro,EliezerJ.;Fernandes,PatríciaD.;Fraga,CarlosA.M.[ChemicalBiologyandDrugDesign,2018,vol.91,#2,p.391-397]

[9]Giancotti,Gilda;Cancellieri,Michela;Balboni,Andrea;Giustiniano,Mariateresa;Novellino,Ettore;Delang,Leen;Neyts,Johan;Leyssen,Pieter;Brancale,Andrea;Bassetto,Marcella[EuropeanJournalofMedicinalChemistry,2018,vol.149,p.56-68]

[10]CurrentPatentAssignee:ZHEJIANGUNIVERSITY-CN108329232,2018,ALocationinpatent:Paragraph0111;0112

[11]Khan,KhalidMohammad;Rasheed,Maimona;Ullah,Zia;Hayat,Safdar;Kaukab,Farhana;Choudhary,M.Iqbal;Ur-Rahman,Atta;Perveen,Shahnaz[BioorganicandMedicinalChemistry,2003,vol.11,#7,p.1381-1387]

[12]Wu,Dehua;Song,Jintong;Qu,Lang;Zhou,Weilan;Wang,Lei;Zhou,Xiangge;Xiang,Haifeng[Chemistry-AnAsianJournal,2020,vol.15,#20,p.3370-3378]

[13]Ono,Katsuhiko;Wakida,Mayuko;Hosokawa,Ryohei;Saito,Katsuhiro;Nishida,Jun-ichi;Yamashita,Yoshiro[Heterocycles,2007,vol.72,p.85-90]

[14]Locationinpatent:schemeortableLee,Suho;Jung,Kwan-Young;Park,Joohyun;Cho,Joong-Heui;Kim,Yong-Chul;Chang,Sunghoe[BioorganicandMedicinalChemistryLetters,2010,vol.20,#16,p.4858-4864]

[15]Vechorkin,Oleg;Hirt,Nathalie;Hu,Xile[OrganicLetters,2010,vol.12,#15,p.3567-3569]

[16]Yu,Bole;Chen,Ying;Hong,Mei;Duan,Pingping;Gan,Shifeng;Chao,Hui;Zhao,Zujin;Zhao,Jing[ChemicalCommunications,2015,vol.51,#76,p.14365-14368]

[17]McClure,JesseJ.;Zhang,Cheng;Inks,ElizabethS.;Peterson,YuriK.;Li,Jiaying;JamesChou[JournalofMedicinalChemistry,2016,vol.59,#21,p.9942-9959]

39627-84-4    3697-66-3   
1-<i>N</i>'-(naphthalene-2-carbonyl)-hydrazinocarbonyl-cyclopropanecarboxylicacidethylester 

[1]BioorganicandMedicinalChemistryLetters,2006,vol.16,p.4233-4236

59043-41-3    39627-84-4   
3-(2-naphthyl)-5-3-oxospiroisobenzofuran-1(3H),4'-piperidin-1'-yl-1H-1,2,4-triazole 

[1]CurrentPatentAssignee:MERCK&amp;COINC-EP1566384,2005,A1Locationinpatent:Page/Pagecolumn47-48

39627-84-4    447-61-0   
N'-{(1E)-2-(trifluoromethyl)phenyl-methylene}-2-naphthohydrazide 

[1]CurrentPatentAssignee:MERCK&amp;COINC-WO2005/97759,2005,A1Locationinpatent:Page/Pagecolumn37-38

Literature

Title: New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.

Journal: Bioorganic & medicinal chemistry 20100601

Title: Aromatic hydroxamic acids and hydrazides as inhibitors of the peroxidase activity of prostaglandin H2 synthase-2.

Journal: Archives of biochemistry and biophysics 20041101

Title: Mechanism of horseradish peroxidase inactivation by benzhydrazide: a critical evaluation of arylhydrazides as peroxidase inhibitors.

Journal: The Biochemical journal 20031101

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