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40054-69-1,MFCD00867532
Catalog No.:AA0039GG

40054-69-1 | 4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0039GG
Chemical Name:
4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
CAS Number:
40054-69-1
Molecular Formula:
C17H15ClN4S
Molecular Weight:
342.8458
MDL Number:
MFCD00867532
SMILES:
CCc1cc2c(s1)n1c(CN=C2c2ccccc2Cl)nnc1C
Properties
Computed Properties
 
Complexity:
474  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
2.6  

Literature

Title: Anxiolytics reduce residual dizziness after successful canalith repositioning maneuvers in benign paroxysmal positional vertigo.

Journal: Acta oto-laryngologica 20120301

Title: 2-Amino-N-[3-(2-chloro-benzo-yl)-5-ethyl-thio-phen-2-yl]acetamide.

Journal: Acta crystallographica. Section E, Structure reports online 20120201

Title: A double-suicide autopsy case of potassium poisoning by intravenous administration of potassium aspartate after intake of some psychopharmaceuticals.

Journal: Human & experimental toxicology 20110701

Title: An autopsy case of multiple psychotropic drug poisoning.

Journal: Soudni lekarstvi 20110701

Title: A case of thalamic pain successfully treated with Kampo medicine.

Journal: Journal of alternative and complementary medicine (New York, N.Y.) 20110601

Title: [Comparison of four immunoassay screening devices for detection of benzodiazepine and its metabolites in urine: mainly detection of etizolam, thienodiazepine and its metabolites].

Journal: Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology 20110301

Title: [Chronic subdural hematoma--recurrence and prevention].

Journal: Brain and nerve = Shinkei kenkyu no shinpo 20110101

Title: Twelve cases of drug-induced blepharospasm improved within 2 months of psychotropic cessation.

Journal: Drug, healthcare and patient safety 20110101

Title: Monolithic spin column: a new extraction device for analysis of drugs in urine and serum by GC/MS and HPLC/MS.

Journal: Journal of AOAC International 20110101

Title: Positive Correlation between Severity of Blepharospasm and Thalamic Glucose Metabolism.

Journal: Case reports in ophthalmology 20110101

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research 20101201

Title: Medication use as a risk factor for inpatient falls in an acute care hospital: a case-crossover study.

Journal: British journal of clinical pharmacology 20100501

Title: Fluvoxamine for blonanserin-associated akathisia in patients with schizophrenia: report of five cases.

Journal: Annals of general psychiatry 20100101

Title: Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects.

Journal: Annals of general psychiatry 20100101

Title: Effects of treatment with etizolam 0.5 mg BID on cognitive performance: a 3-week, multicenter, randomized, double-blind, placebo-controlled, two-treatment, three-period, noninferiority crossover study in patients with anxiety disorder.

Journal: Clinical therapeutics 20091201

Title: Inclusion of thienodiazepines in prescription rate of anxiolytics.

Journal: Psychiatry and clinical neurosciences 20090601

Title: Benzodiazepine prescription and length of hospital stay at a Japanese university hospital.

Journal: BioPsychoSocial medicine 20090101

Title: [A case of serotonin syndrome following minimum doses of sertraline].

Journal: Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 20090101

Title: Fluvoxamine monotherapy for psychotic depression: the potential role of sigma-1 receptors.

Journal: Annals of general psychiatry 20090101

Title: Case report: Etizolam and its major metabolites in two unnatural death cases.

Journal: Forensic science international 20081120

Title: Rebound insomnia induced by abrupt withdrawal of hypnotics in sleep-disturbed rats.

Journal: European journal of pharmacology 20081112

Title: Benzodiazepine metabolism: an analytical perspective.

Journal: Current drug metabolism 20081001

Title: Absence status associated with focal activity and polydipsia-induced hyponatremia.

Journal: Neuropsychiatric disease and treatment 20080401

Title: Effects of genetic polymorphism of cytochrome P450 enzymes on the pharmacokinetics of benzodiazepines.

Journal: Journal of clinical pharmacy and therapeutics 20070801

Title: Accidental etizolam ingestion in a child.

Journal: Pediatric emergency care 20070701

Title: Effects of different cyclodextrins on the morphology, loading and release properties of poly (DL-lactide-co-glycolide)-microparticles containing the hypnotic agent etizolam.

Journal: Journal of microencapsulation 20070501

Title: Serotonin syndrome in a case of depression with various somatic symptoms: the difficulty in differential diagnosis.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070130

Title: Multi-center randomized control trial of etizolam plus NSAID combination for tension-type headache.

Journal: Internal medicine (Tokyo, Japan) 20070101

Title: Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060401

Title: Pharmacokinetics and pharmacodynamics of etizolam are influenced by polymorphic CYP2C19 activity.

Journal: European journal of clinical pharmacology 20051201

Title: Effect of platelet-activating factor receptor antagonist, etizolam, on resolution of chronic subdural hematoma--a prospective study to investigate use as conservative therapy.

Journal: Neurologia medico-chirurgica 20051201

Title: Low tolerance and dependence liabilities of etizolam: molecular, functional, and pharmacological correlates.

Journal: European journal of pharmacology 20050905

Title: Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs.

Journal: Biological & pharmaceutical bulletin 20050901

Title: Inhibitory effects of psychotropic drugs on mexiletine metabolism in human liver microsomes: prediction of in vivo drug interactions.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050601

Title: Induction of the metabolism of etizolam by carbamazepine in humans.

Journal: European journal of clinical pharmacology 20050501

Title: Pharmacokinetic interactions between Japanese traditional Kampo medicine and modern medicine (IV). Effect of Kamisyoyosan and Tokisyakuyakusan on the pharmacokinetics of etizolam in rats.

Journal: Biological & pharmaceutical bulletin 20050201

Title: Effects of concomitant fluvoxamine on the plasma concentration of etizolam in Japanese psychiatric patients: wide interindividual variation in the drug interaction.

Journal: Therapeutic drug monitoring 20041201

Title: [Case report of pentazocine dependence from a standpoint of the cognitive therapy].

Journal: Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 20041001

Title: Inhibition of the metabolism of etizolam by itraconazole in humans: evidence for the involvement of CYP3A4 in etizolam metabolism.

Journal: European journal of clinical pharmacology 20040801

Title: [Practical analysis of toxic substances useful for clinical toxicology--10--benzodiazepine].

Journal: Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology 20040401

Title: Etizolam and benzodiazepine induced blepharospasm.

Journal: Journal of neurology, neurosurgery, and psychiatry 20040301

Title: Delirium induced by abrupt discontinuation of paroxetine.

Journal: The Journal of neuropsychiatry and clinical neurosciences 20040101

Title: [Case of prolonged recovery from serotonin syndrome caused by paroxetine].

Journal: Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 20030101

Title: Nightmares and panic disorder associated with carvedilol overdose.

Journal: The Annals of pharmacotherapy 20021101

Title: Etizolam, an anti-anxiety agent, attenuates recurrence of chronic subdural hematoma--evaluation by computed tomography.

Journal: Neurologia medico-chirurgica 20020201

Title: [A patient with Parkinson's disease complicated by hypothyroidism who developed malignant syndrome after discontinuation of etizolam].

Journal: Rinsho shinkeigaku = Clinical neurology 20020201

Title: Etizolam-induced superficial erythema annulare centrifugum.

Journal: Clinical and experimental dermatology 20020101

Title: Molecular and neurochemical evaluation of the effects of etizolam on GABAA receptors under normal and stress conditions.

Journal: Arzneimittel-Forschung 19990201

Title: Single and multiple dose pharmacokinetics of etizolam in healthy subjects.

Journal: European journal of clinical pharmacology 19910101

Title: Etizolam in the treatment of generalized anxiety disorder: a double-blind study versus placebo.

Journal: Current medical research and opinion 19900101

Title: Etizolam in the treatment of generalized anxiety disorder: a controlled clinical trial.

Journal: The Journal of international medical research 19890101

Title: Etizolam in the treatment of generalized anxiety disorder associated with depressive symptoms.

Journal: Current medical research and opinion 19890101

Title: An antagonistic activity of etizolam on platelet-activating factor (PAF). In vitro effects on platelet aggregation and PAF receptor binding.

Journal: Japanese journal of pharmacology 19870801

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Tags:40054-69-1 Molecular Formula|40054-69-1 MDL|40054-69-1 SMILES|40054-69-1 4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine