Name: Name:N-Desmethyl Imatinib
Brand: AABLOCKS
SKU: AA0035AQ
Rating: 90 (10 reviews)

Catalog No.: AA0035AQ

404844-02-6 | N-Desmethyl Imatinib

Pack Size： 1mg

Purity： 98%(HPLC)

in stock

$91.00 $64.00

Pack Size： 25mg

Purity： 90%

in stock

$243.00 $170.00

Pack Size： 100mg

Purity： 90%

in stock

$677.00 $474.00

Pack Size： 500mg

Purity： 90%

in stock

$2,206.00 $1,544.00

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Technical Information

Catalog Number: AA0035AQ

Chemical Name: N-Desmethyl Imatinib

CAS Number: 404844-02-6

Molecular Formula: C28H29N7O

Molecular Weight: 479.5762

MDL Number: MFCD07369291

SMILES: O=C(c1ccc(cc1)CN1CCNCC1)Nc1ccc(c(c1)Nc1nccc(n1)c1cccnc1)C

Properties

Form: Solid

MP: 99-101°C

Storage: -20 ℃;

Complexity: 679

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 36

Hydrogen Bond Acceptor Count: 7

Hydrogen Bond Donor Count: 3

Isotope Atom Count: 0

Rotatable Bond Count: 7

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3

Downstream Synthesis Route

110-85-0

404844-11-7

N-DesmethylImatinib

[1]Patent:CN104844566,2018,B.Locationinpatent:Paragraph0132;0134

[2]AngewandteChemie-InternationalEdition,2015,vol.54,p.179-183 Angew.Chem.,2015,vol.127,p.181-185,5 AngewandteChemie,2015,vol.127,p.181-185,5

[3]Patent:US2004/102453,2004,A1

530-62-1

404844-02-6

1256080-10-0

[1]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-US2010/330130,2010,A1Locationinpatent:Page/Pagecolumn11

108-24-7

404844-02-6

1321600-77-4

[1]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2011/95835,2011,A1Locationinpatent:Page/Pagecolumn34

152460-10-1

404844-02-6

[1]Manley,PaulW.;Blasco,Francesca;Mestan,Jürgen;Aichholz,Reiner[BioorganicandMedicinalChemistry,2013,vol.21,#11,p.3231-3239]

[2]Korch,KaterinaM.;Eidamshaus,Christian;Behenna,DouglasC.;Stoltz,BrianM.;Nam,Sangkil;Horne,David[AngewandteChemie-InternationalEdition,2015,vol.54,#1,p.179-183][Angew.Chem.,2015,vol.127,#1,p.181-185,5][AngewandteChemie,2015,vol.127,#1,p.181-185,5]

[3]CurrentPatentAssignee:CHINESEACADEMYOFSCIENCES;HefeiInstitutesofPhysicalScience(in:CAS)-CN104844566,2018,B

[4]Yang,Yiqing;Gao,Hongying;Sun,Xiuyun;Sun,Yonghui;Qiu,Yueping;Weng,Qinjie;Rao,Yu[JournalofMedicinalChemistry,2020,vol.63,#15,p.8567-8583]

865-50-9

404844-02-6

1134803-18-1

[1]Manley,PaulW.;Blasco,Francesca;Mestan,Jürgen;Aichholz,Reiner[BioorganicandMedicinalChemistry,2013,vol.21,#11,p.3231-3239]

Literature fold

Title: Nonaqueous capillary electrophoresis of imatinib mesylate and related substances.

Journal: Journal of separation science20120801

Title: Robert A Parise, et al. Liquid chromatographic-mass spectrometric assay for quantitation of imatinib and its main metabolite (CGP 74588) in plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 5;791(1-2):39-44.