Home Other Building Blocks 41964-07-2
41964-07-2,MFCD00866900
Catalog No.:AA00C9N6

41964-07-2 | Mlr-1023

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥95%
in stock  
$72.00   $50.00
- +
10mg
≥95%
in stock  
$128.00   $89.00
- +
25mg
≥95%
in stock  
$299.00   $209.00
- +
50mg
in stock  
$483.00   $338.00
- +
100mg
in stock  
$788.00   $552.00
- +
250mg
≥98%(HPLC)
in stock  
$1,886.00   $1,320.00
- +
500mg
in stock  
$2,401.00   $1,681.00
- +
1000mg
in stock  
$3,803.00   $2,662.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C9N6
Chemical Name:
Mlr-1023
CAS Number:
41964-07-2
Molecular Formula:
C11H10N2O2
Molecular Weight:
202.2093
MDL Number:
MFCD00866900
SMILES:
Cc1cccc(c1)Oc1cnc(=O)[nH]c1
NSC Number:
314335
Properties
Computed Properties
 
Complexity:
310  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
1.4  

Downstream Synthesis Route
57-13-6   
(E)-3-(dimethylamino)-2-(meta-tolyloxy)acrylaldehyde 
  41964-07-2 

[1]CurrentPatentAssignee:BUKWANGPHARMACEUTICALCO.,LTD.-WO2019/139185,2019,A1Locationinpatent:Paragraph78-89

[2]Lipinski,C.A.;Stam,J.G.;Pereira,J.N.;Ackerman,N.R.;Hess,H.-J.[JournalofMedicinalChemistry,1980,vol.23,#9,p.1026-1031]

[1]Lipinski,C.A.;Stam,J.G.;Pereira,J.N.;Ackerman,N.R.;Hess,H.-J.[JournalofMedicinalChemistry,1980,vol.23,#9,p.1026-1031]

[1]Lipinski,C.A.;Stam,J.G.;Pereira,J.N.;Ackerman,N.R.;Hess,H.-J.[JournalofMedicinalChemistry,1980,vol.23,#9,p.1026-1031]

[1]CurrentPatentAssignee:BUKWANGPHARMACEUTICALCO.,LTD.-KR101827744,2018,B1

[2]CurrentPatentAssignee:BUKWANGPHARMACEUTICALCO.,LTD.-WO2019/139185,2019,A1

Literature

Title: The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes.

Journal: The Journal of pharmacology and experimental therapeutics 20120701

Title: MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20120701

Title: Saporito MS, et al. MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo. J Pharmacol Exp Ther. 2012 Jul;342(1):15-22.

Title: Ochman AR, et al. The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes. J Pharmacol Exp Ther. 2012 Jul;342(1):23-32.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 41964-07-2
Tags:41964-07-2 Molecular Formula|41964-07-2 MDL|41964-07-2 SMILES|41964-07-2 Mlr-1023