Home Fluorides 421-85-2
421-85-2,MFCD00068714
Catalog No.:AA003UZO

421-85-2 | Trifluoromethanesulfonamide

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250mg
95%
in stock  
$6.00   $4.00
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1g
95%
in stock  
$11.00   $8.00
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2g
95%
in stock  
$13.00   $9.00
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5g
95%
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$23.00   $16.00
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10g
95%
in stock  
$27.00   $19.00
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25g
95%
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$66.00   $47.00
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100g
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$262.00   $184.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003UZO
Chemical Name:
Trifluoromethanesulfonamide
CAS Number:
421-85-2
Molecular Formula:
CH2F3NO2S
Molecular Weight:
149.0923
MDL Number:
MFCD00068714
SMILES:
FC(S(=O)(=O)N)(F)F
Properties
Properties
 
BP:
164.6°C at 760 mmHg  
Form:
Solid  
MP:
120-124 °C(lit.)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
161  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
8  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
XLogP3:
0.1  

Upstream Synthesis Route

[1]RussianJournalofOrganicChemistry,2011,vol.47,#12,p.1914-1916

[1]Patent:JP2018/39759,2018,A,.Locationinpatent:Paragraph0070-0074

Downstream Synthesis Route

[1]Patent:EP514133,1992,A1

[2]Patent:CN109232442,2019,A.Locationinpatent:Paragraph0092;0097;0098;0099

[3]Patent:US2732398,1954,

[1]Synlett,2017,vol.28,p.1478-1480

[2]AngewandteChemie-InternationalEdition,2016,vol.55,p.13200-13203    Angew.Chem.,2016,vol.128,p.13394-13397,4

[3]Patent:WO2017/37141,2017,A1.Locationinpatent:Page/Pagecolumn25

[4]ZeitschriftfurNaturforschung.TeilB.AnorganischeChemie,organischeChemie,Biochemie,Biophysik,Biologie,1970,vol.25b,p.252-254

112-70-9    421-85-2   
N,N-bis(tridecyl)trifluoromethanesulfonamide 

[1]JournalofFluorineChemistry,2005,vol.126,p.1524-1530

[1]AngewandteChemie-InternationalEdition,2019,vol.58,p.7485-7489    Angew.Chem.,2019,vol.131,p.7564-7568,5

[2]JournaloftheAmericanChemicalSociety,2007,vol.129,p.562-568

[1]Patent:US2008/58358,2008,A1.Locationinpatent:Page/Pagecolumn37

Literature

Title: Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.

Journal: Journal of medicinal chemistry 20120308

Title: Bis(tetra-phenyl-phospho-nium) bis-[N-(trifluoro-methyl-sulfon-yl)dithio-carbimato(2-)-κS,S']zincate(II).

Journal: Acta crystallographica. Section E, Structure reports online 20120101

Title: Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase.

Journal: Bioorganic & medicinal chemistry 20110601

Title: Synthesis of N-[2-(2,4-Difluorophenoxy)trifluoromethyl-3-pyridyl]sulfonamides and their inhibitory activities against secretory phospholipase A₂.

Journal: Chemical & pharmaceutical bulletin 20110101

Title: 4-[N-(substituted 4-pyrimidinyl)amino]benzenesulfonamides as inhibitors of carbonic anhydrase isozymes I, II, VII, and XIII.

Journal: Bioorganic & medicinal chemistry 20101101

Title: Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase.

Journal: European journal of medicinal chemistry 20100301

Title: Versatile Pd(OTf)2 x 2 H2O-catalyzed ortho-fluorination using NMP as a promoter.

Journal: Journal of the American Chemical Society 20090610

Title: Titration calorimetry standards and the precision of isothermal titration calorimetry data.

Journal: International journal of molecular sciences 20090601

Title: Automated potentiometric titrations in KCl/water-saturated octanol: method for quantifying factors influencing ion-pair partitioning.

Journal: Analytical chemistry 20090401

Title: Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists.

Journal: Bioorganic & medicinal chemistry letters 20080115

Title: Development of efficient Lewis acid catalysts for intramolecular cycloaddition reactions of ester-tethered substrates.

Journal: Chemical record (New York, N.Y.) 20070101

Title: LiTFSI structure and transport in ethylene carbonate from molecular dynamics simulations.

Journal: The journal of physical chemistry. B 20060316

Title: New metabolically stabilized analogues of lysophosphatidic acid: agonists, antagonists and enzyme inhibitors.

Journal: Biochemical Society transactions 20051201

Title: Direct, facile aldehyde and ketone alpha-selenenylation reactions promoted by L-prolinamide and pyrrolidine sulfonamide organocatalysts.

Journal: The Journal of organic chemistry 20050708

Title: Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors.

Journal: Journal of medicinal chemistry 20041230

Title: The synthesis and structure-activity relationships of 3-amino-4-benzylquinolin-2-ones; discovery of novel KCNQ2 channel openers.

Journal: Bioorganic & medicinal chemistry letters 20040405

Title: Variations of acidic functions at position 2 and substituents at positions 4, 5 and 6 of the indole moiety and their effect on NMDA-glycine site affinity.

Journal: European journal of medicinal chemistry 20031001

Title: Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases.

Journal: Bioorganic & medicinal chemistry 20030417

Title: Synthesis and structural comparison of triaryl(sulfonylimino)pnictoranes.

Journal: Inorganic chemistry 20020408

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