443797-96-4 | JNJ-7706621

[1]Patent:WO2005/77922,2005,A2,.Locationinpatent:Page/Pagecolumn46-47

[1]Patent:WO2005/77922,2005,A2,.Locationinpatent:Page/Pagecolumn46

[2]Patent:WO2005/77922,2005,A2,.Locationinpatent:Page/Pagecolumn48-49

[3]Patent:WO2005/77922,2005,A2,.Locationinpatent:Page/Pagecolumn54-55

[4]Patent:WO2005/77922,2005,A2,.Locationinpatent:Page/Pagecolumn50-51

[5]Patent:WO2005/77922,2005,A2,.Locationinpatent:Page/Pagecolumn50-51

[6]Patent:WO2005/77922,2005,A2,.Locationinpatent:Page/Pagecolumn50-51

[7]Patent:WO2005/77922,2005,A2,.Locationinpatent:Page/Pagecolumn50-51

[8]Patent:WO2005/77922,2005,A2,.Locationinpatent:Page/Pagecolumn50-51

[9]Patent:WO2005/77922,2005,A2,.Locationinpatent:Page/Pagecolumn50-51

[10]Patent:WO2005/77922,2005,A2,.Locationinpatent:Page/Pagecolumn50-51

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[1]JournalofMedicinalChemistry,2005,vol.48,#13,p.4208-4211

[2]BioorganicandMedicinalChemistryLetters,2010,vol.20,#24,p.7454-7457

[1]JournalofMedicinalChemistry,2005,vol.48,#13,p.4208-4211

[1]JournalofMedicinalChemistry,2005,vol.48,#13,p.4208-4211

Title: Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.

Journal: ACS medicinal chemistry letters 20170608

Title: ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20150414

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Growth suppression and mitotic defect induced by JNJ-7706621, an inhibitor of cyclin-dependent kinases and aurora kinases.

Journal: Current cancer drug targets 20120701

Title: Mutants of protein kinase A that mimic the ATP-binding site of Aurora kinase.

Journal: The Biochemical journal 20111115

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.

Journal: European journal of medicinal chemistry 20110601

Title: Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3.

Journal: Bioorganic & medicinal chemistry letters 20101215

Title: Active and passive tumor targeting of a novel poorly soluble cyclin dependent kinase inhibitor, JNJ-7706621.

Journal: International journal of pharmaceutics 20100615

Title: A quantitative analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20080101

Title: Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor.

Journal: Molecular cancer therapeutics 20061001

Title: 1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.

Journal: Journal of medicinal chemistry 20050630

Title: Huang S, et al. Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3639-41. Epub 2006 May 6.

Title: Matsuhashi A, et al. Growth suppression and mitotic defect induced by JNJ-7706621, an inhibitor of cyclin-dependent kinases and aurora kinases. Curr Cancer Drug Targets. 2012 Jul;12(6):625-39.

Title: Emanuel S, et al. The in vitro and in vivo effects of JNJ-7706621: a dual inhibitor of cyclin-dependent kinases and aurora kinases. Cancer Res. 2005 Oct 1;65(19):9038-46.

Title: Danhier F, et al. Active and passive tumor targeting of a novel poorly soluble cyclin dependent kinase inhibitor, JNJ-7706621. Int J Pharm. 2010 Jun 15;392(1-2):20-8.