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Title: Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20181001
Title: TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells.
Journal: Toxicology and applied pharmacology 20180801
Title: Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.
Journal: Archives of toxicology 20180401
Title: 4-Methylthio-3-butenyl isothiocyanate mediates nuclear factor (erythroid-derived 2)-like 2 activation by regulating reactive oxygen species production in human esophageal epithelial cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180101
Title: Tussilagonone-induced Nrf2 pathway activation protects HepG2 cells from oxidative injury.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171001
Title: Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2H-Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stress.
Journal: The Journal of pharmacology and experimental therapeutics 20171001
Title: Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo.
Journal: Toxicology 20170815
Title: Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway.
Journal: Environmental toxicology 20170801
Title: Sulforaphene enhances radiosensitivity of hepatocellular carcinoma through suppression of the NF-κB pathway.
Journal: Journal of biochemical and molecular toxicology 20170801
Title: Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease.
Journal: Environmental health perspectives 20170801
Title: Sulforaphane attenuates di-N-butylphthalate-induced reproductive damage in pubertal mice: Involvement of the Nrf2-antioxidant system.
Journal: Environmental toxicology 20170701
Title: In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children.
Journal: Environmental health perspectives 20170401
Title: Ablation of Akt2 prevents paraquat-induced myocardial mitochondrial injury and contractile dysfunction: Role of Nrf2.
Journal: Toxicology letters 20170305
Title: Sulforaphane induces differential modulation of mitochondrial biogenesis and dynamics in normal cells and tumor cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170201
Title: Sulforaphane-induced apoptosis in human leukemia HL-60 cells through extrinsic and intrinsic signal pathways and altering associated genes expression assayed by cDNA microarray.
Journal: Environmental toxicology 20170101
Title: Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells.
Journal: Chemico-biological interactions 20161225
Title: Nrf2-dependent protection against acute sodium arsenite toxicity in zebrafish.
Journal: Toxicology and applied pharmacology 20160815
Title: Benzoquinone toxicity is not prevented by sulforaphane in CD-1 mouse fetal liver cells.
Journal: Journal of applied toxicology : JAT 20160801
Title: Iron depletion in HCT116 cells diminishes the upregulatory effect of phenethyl isothiocyanate on heme oxygenase-1.
Journal: Toxicology and applied pharmacology 20160415
Title: Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation.
Journal: Acta pharmacologica Sinica 20160201
Title: Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1).
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20160101
Title: Phytonutrients Differentially Stimulate NAD(P)H:Quinone Oxidoreductase, Inhibit Proliferation, and Trigger Mitotic Catastrophe in Hepa1c1c7 Cells.
Journal: Journal of medicinal food 20160101
Title: Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration.
Journal: Nature communications 20160101
Title: Nrf2 activators as potential modulators of injury in human kidney cells.
Journal: Toxicology reports 20160101
Title: Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.
Journal: Chemical research in toxicology 20151116
Title: Regulation of the expression of renal drug transporters in KEAP1-knockdown human tubular cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20150801
Title: Neuroprotective effect of sulforaphane against methylglyoxal cytotoxicity.
Journal: Chemical research in toxicology 20150615
Title: Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor.
Journal: Journal of biochemical and molecular toxicology 20150601
Title: Sulforaphane protects against acetaminophen-induced hepatotoxicity.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20150601
Title: Resveratrol dimers, nutritional components in grape wine, are selective ROS scavengers and weak Nrf2 activators.
Journal: Food chemistry 20150415
Title: Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1.
Journal: Toxicology and applied pharmacology 20150101
Title: Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon.
Journal: Clinical epigenetics 20150101
Title: Aldosterone activates transcription factor Nrf2 in kidney cells both in vitro and in vivo.
Journal: Antioxidants & redox signaling 20141120
Title: Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line.
Journal: Toxicology and applied pharmacology 20141115
Title: Modulation of cisplatin sensitivity in human ovarian carcinoma A2780 and SKOV3 cell lines by sulforaphane.
Journal: Toxicology letters 20141104
Title: The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20141001
Title: Hepatic sulfotransferase as a nephropreventing target by suppression of the uremic toxin indoxyl sulfate accumulation in ischemic acute kidney injury.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140901
Title: Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function.
Journal: Toxicology and applied pharmacology 20140901
Title: Phytochemical modulators of mitochondria: the search for chemopreventive agents and supportive therapeutics.
Journal: Pharmaceuticals (Basel, Switzerland) 20140901
Title: Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis.
Journal: Cell cycle (Georgetown, Tex.) 20140701
Title: The antioxidant effects of isorhamnetin contribute to inhibit COX-2 expression in response to inflammation: a potential role of HO-1.
Journal: Inflammation 20140601
Title: Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoter.
Journal: Biochimica et biophysica acta 20140601
Title: Repeated Nrf2 stimulation using sulforaphane protects fibroblasts from ionizing radiation.
Journal: Toxicology and applied pharmacology 20140501
Title: Pau d'arco activates Nrf2-dependent gene expression via the MEK/ERK-pathway.
Journal: The Journal of toxicological sciences 20140401
Title: Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.
Journal: Journal of medicinal chemistry 20140327
Title: Transcriptomic responses of cancerous and noncancerous human colon cells to sulforaphane and selenium.
Journal: Chemical research in toxicology 20140317
Title: Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms.
Journal: Free radical biology & medicine 20140201
Title: Sub-chronic sulforaphane exposure in CD-1 pregnant mice enhances maternal NADPH quinone oxidoreductase 1 (NQO1) activity and mRNA expression of NQO1, glutathione S-transferase, and glutamate-cysteine ligase: potential implications for fetal protection against toxicant exposure.
Journal: Reproductive toxicology (Elmsford, N.Y.) 20140101
Title: Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells.
Journal: PloS one 20140101
Title: Sulforaphane attenuation of type 2 diabetes-induced aortic damage was associated with the upregulation of Nrf2 expression and function.
Journal: Oxidative medicine and cellular longevity 20140101
Title: Inhibition of Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells by dietary sulforaphane.
Journal: Molecular carcinogenesis 20131201
Title: A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways.
Journal: Toxicology and applied pharmacology 20131101
Title: Calcineurin inhibitors recruit protein kinases JAK2 and JNK, TLR signaling and the UPR to activate NF-κB-mediated inflammatory responses in kidney tubular cells.
Journal: Toxicology and applied pharmacology 20131101
Title: Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells.
Journal: Pharmacological research 20131001
Title: The aryl hydrocarbon receptor and estrogen receptor alpha differentially modulate nuclear factor erythroid-2-related factor 2 transactivation in MCF-7 breast cancer cells.
Journal: Toxicology and applied pharmacology 20130715
Title: Sulforaphane inhibits CYP1A1 activity and promotes genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro.
Journal: Toxicology and applied pharmacology 20130615
Title: Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner.
Journal: Molecular and cellular biology 20130601
Title: Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease.
Journal: Neurotoxicology 20130501
Title: Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2.
Journal: Chemico-biological interactions 20130225
Title: Role of Nrf2 antioxidant defense in mitigating cadmium-induced oxidative stress in the olfactory system of zebrafish.
Journal: Toxicology and applied pharmacology 20130115
Title: Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease.
Journal: Antioxidants & redox signaling 20130110
Title: Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo.
Journal: Toxicology and applied pharmacology 20130101
Title: Sulforaphane as a potential protective phytochemical against neurodegenerative diseases.
Journal: Oxidative medicine and cellular longevity 20130101
Title: Chemoprevention of pancreatic cancer using solid-lipid nanoparticulate delivery of a novel aspirin, curcumin and sulforaphane drug combination regimen.
Journal: International journal of oncology 20121201
Title: Interactions of sulforaphane and dimethyl sulfoxide with methyl methanesulfonate, urethane, 4-nitroquinoline-1-oxide and hydrogen peroxide in the Drosophila melanogaster wing spot test.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121201
Title: Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial.
Journal: International journal of food sciences and nutrition 20121101
Title: Sulforaphane inhibits restenosis by suppressing inflammation and the proliferation of vascular smooth muscle cells.
Journal: Atherosclerosis 20121101
Title: Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways.
Journal: Oncology reports 20121101
Title: Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion.
Journal: Molecular nutrition & food research 20121101
Title: Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli.
Journal: Nutrition reviews 20121101
Title: A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level.
Journal: The Journal of biological chemistry 20121019
Title: Sulphoraphane, a naturally occurring isothiocyanate induces apoptosis in breast cancer cells by targeting heat shock proteins.
Journal: Biochemical and biophysical research communications 20121012
Title: Sulforaphane induced adipolysis via hormone sensitive lipase activation, regulated by AMPK signaling pathway.
Journal: Biochemical and biophysical research communications 20121005
Title: The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor.
Journal: Archives of toxicology 20121001
Title: Activation of the stress proteome as a mechanism for small molecule therapeutics.
Journal: Human molecular genetics 20121001
Title: The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism.
Journal: The Journal of nutritional biochemistry 20121001
Title: TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death.
Journal: Biochimica et biophysica acta 20121001
Title: Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes.
Journal: Molecular pharmaceutics 20121001
Title: Sulforaphane protects primary cultures of cortical neurons against injury induced by oxygen-glucose deprivation/reoxygenation via antiapoptosis.
Journal: Neuroscience bulletin 20121001
Title: Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2.
Journal: Biochemical pharmacology 20120915
Title: Natural sulforaphane as a functional chemopreventive agent: including a review of isolation, purification and analysis methods.
Journal: Critical reviews in biotechnology 20120901
Title: Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model.
Journal: Journal of neuroscience research 20120901
Title: Major differences among chemopreventive organoselenocompounds in the sustained elevation of cytoprotective genes.
Journal: Journal of biochemical and molecular toxicology 20120901
Title: Isothiocyanates ameliorate the symptom of heart dysfunction and mortality in a murine AIDS model by inhibiting apoptosis in the left ventricle.
Journal: Journal of medicinal food 20120901
Title: Metabolic effects of sulforaphane oral treatment in streptozotocin-diabetic rats.
Journal: Journal of medicinal food 20120901
Title: NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes.
Journal: Free radical biology & medicine 20120815
Title: Validation of the multiple sensor mechanism of the Keap1-Nrf2 system.
Journal: Free radical biology & medicine 20120815
Title: Nrf2-ARE pathway regulates induction of Sestrin-2 expression.
Journal: Free radical biology & medicine 20120815
Title: Quantitative profiling of glucosinolates by LC-MS analysis reveals several cultivars of cabbage and kale as promising sources of sulforaphane.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120815
Title: Characterization of products from the reaction of glucosinolate-derived isothiocyanates with cysteine and lysine derivatives formed in either model systems or broccoli sprouts.
Journal: Journal of agricultural and food chemistry 20120808
Title: Influence of broccoli extract and various essential oils on performance and expression of xenobiotic- and antioxidant enzymes in broiler chickens.
Journal: The British journal of nutrition 20120801
Title: Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis.
Journal: Journal of gastroenterology 20120801
Title: Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging.
Journal: The international journal of biochemistry & cell biology 20120801
Title: Sulforaphane, a cruciferous vegetable-derived isothiocyanate, inhibits protein synthesis in human prostate cancer cells.
Journal: Biochimica et biophysica acta 20120801
Title: Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120801
Title: Improvement in determination of isothiocyanates using high-temperature reversed-phase HPLC.
Journal: Journal of separation science 20120801
Title: Sulforaphane potentiates the efficacy of imatinib against chronic leukemia cancer stem cells through enhanced abrogation of Wnt/β-catenin function.
Journal: Journal of agricultural and food chemistry 20120718
Title: Protective effect of sulforaphane against oxidative stress: recent advances.
Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120701
Title: Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine.
Journal: Psychopharmacology 20120701
Title: Sulforaphane inhibits mitotic clonal expansion during adipogenesis through cell cycle arrest.
Journal: Obesity (Silver Spring, Md.) 20120701
Title: Isothiocyanates inhibit psoriasis-related proinflammatory factors in human skin.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120701
Title: Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by sulforaphane through the activation of Nrf2 nuclear translocation.
Journal: Molecular medicine reports 20120701
Title: Effect of sulforaphane on growth inhibition in human brain malignant glioma GBM 8401 cells by means of mitochondrial- and MEK/ERK-mediated apoptosis pathway.
Journal: Cell biochemistry and biophysics 20120701
Title: Protective effects of isothiocyanates on blood-CSF barrier disruption induced by oxidative stress.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20120701
Title: Cancer stem cells: potential target for bioactive food components.
Journal: The Journal of nutritional biochemistry 20120701
Title: Effects of sulforophane and curcumin on oxidative stress created by acute malathion toxicity in rats.
Journal: European review for medical and pharmacological sciences 20120701
Title: Characterization of the temporal induction of hepatic xenobiotic-metabolizing enzymes by glucosinolates and isothiocyanates: requirement for at least a 6 h exposure to elicit complete induction profile.
Journal: Journal of agricultural and food chemistry 20120606
Title: Concurrent sulforaphane and eugenol induces differential effects on human cervical cancer cells.
Journal: Integrative cancer therapies 20120601
Title: Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures.
Journal: Neurochemistry international 20120601
Title: Toward an understanding of bisretinoid autofluorescence bleaching and recovery.
Journal: Investigative ophthalmology & visual science 20120601
Title: Glucosinolates and isothiocyanates in health and disease.
Journal: Trends in molecular medicine 20120601
Title: Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane.
Journal: Free radical biology & medicine 20120601
Title: Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent.
Journal: The Journal of biological chemistry 20120511
Title: Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy.
Journal: The Journal of nutritional biochemistry 20120501
Title: Myrosinase hydrolysates of Brassica oleraceae L. var. italica reduce the risk of colon cancer.
Journal: Phytotherapy research : PTR 20120501
Title: Molecular and life-history effects of a natural toxin on herbivorous and non-target soil arthropods.
Journal: Ecotoxicology (London, England) 20120501
Title: In vivo biological activity of rocket extracts (Eruca vesicaria subsp. sativa (Miller) Thell) and sulforaphane.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501
Title: Reducing progoitrin and enriching glucoraphanin in Brassica napus seeds through silencing of the GSL-ALK gene family.
Journal: Plant molecular biology 20120501
Title: Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma.
Journal: BMB reports 20120501
Title: Sulforaphane retards the growth of UM-UC-3 xenographs, induces apoptosis, and reduces survivin in athymic mice.
Journal: Nutrition research (New York, N.Y.) 20120501
Title: [Antibacterial mechanism of sulforaphane on Escherichia coli].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20120501
Title: Effects of phytochemicals sulforaphane on uridine diphosphate-glucuronosyltransferase expression as well as cell-cycle arrest and apoptosis in human colon cancer Caco-2 cells.
Journal: The Chinese journal of physiology 20120430
Title: Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect.
Journal: Age (Dordrecht, Netherlands) 20120401
Title: Anti-inflammatory potential of allyl-isothiocyanate--role of Nrf2, NF-(κ) B and microRNA-155.
Journal: Journal of cellular and molecular medicine 20120401
Title: Metabolism of [6]-shogaol in mice and in cancer cells.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120401
Title: Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120401
Title: Antibacterial effects of glucosinolate-derived hydrolysis products against enterobacteriaceae and enterococci isolated from pig ileum segments.
Journal: Foodborne pathogens and disease 20120401
Title: Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress.
Journal: The Journal of biological chemistry 20120323
Title: Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells.
Journal: The Journal of biological chemistry 20120323
Title: Activation of the nuclear factor E2-related factor 2/antioxidant response element pathway is neuroprotective after spinal cord injury.
Journal: Journal of neurotrauma 20120320
Title: PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress.
Journal: Biochemical and biophysical research communications 20120316
Title: Cell signalling by reactive lipid species: new concepts and molecular mechanisms.
Journal: The Biochemical journal 20120315
Title: Bioactive food components prevent carcinogenic stress via Nrf2 activation in BRCA1 deficient breast epithelial cells.
Journal: Toxicology letters 20120307
Title: Synergistic anti-inflammatory effects of nobiletin and sulforaphane in lipopolysaccharide-stimulated RAW 264.7 cells.
Journal: Journal of agricultural and food chemistry 20120307
Title: Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.
Journal: Cell metabolism 20120307
Title: Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply.
Journal: Carcinogenesis 20120301
Title: Metabolism of glucosinolate-derived isothiocyanates to glutathione conjugates in generalist lepidopteran herbivores.
Journal: Insect biochemistry and molecular biology 20120301
Title: Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity by increasing expression of heme oxygenase-1 in a PI3K/Akt-dependent manner.
Journal: Molecular medicine reports 20120301
Title: Autophagy and cancer.
Journal: Experimental & molecular medicine 20120227
Title: A synthetic chalcone as a potent inducer of glutathione biosynthesis.
Journal: Journal of medicinal chemistry 20120209
Title: Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles.
Journal: Breast cancer research and treatment 20120201
Title: Cyanidin does not affect sulforaphane-mediated Nrf2 induction in cultured human keratinocytes.
Journal: The British journal of nutrition 20120201
Title: D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc.
Journal: Journal of cellular biochemistry 20120201
Title: Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120201
Title: Nutritional influences on epigenetics and age-related disease.
Journal: The Proceedings of the Nutrition Society 20120201
Title: The dietary phase 2 protein inducer sulforaphane can normalize the kidney epigenome and improve blood pressure in hypertensive rats.
Journal: American journal of hypertension 20120201
Title: Screening for natural chemoprevention agents that modify human Keap1.
Journal: Analytical biochemistry 20120201
Title: Allyl isothiocyanate as a potential inducer of paraoxonase-1--studies in cultured hepatocytes and in mice.
Journal: IUBMB life 20120201
Title: Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling.
Journal: Free radical biology & medicine 20120201
Title: Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality.
Journal: European journal of medicinal chemistry 20120201
Title: Protective effect of sulphoraphane against oxidative stress mediated toxicity induced by CuO nanoparticles in mouse embryonic fibroblasts BALB 3T3.
Journal: The Journal of toxicological sciences 20120201
Title: Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome.
Journal: Chemical research in toxicology 20120113
Title: Physiological and biochemical metabolism of germinating broccoli seeds and sprouts.
Journal: Journal of agricultural and food chemistry 20120111
Title: 6-Benzylaminopurine delays senescence and enhances health-promoting compounds of harvested broccoli.
Journal: Journal of agricultural and food chemistry 20120111
Title: Phytochemicals resveratrol and sulforaphane as potential agents for enhancing the anti-tumor activities of conventional cancer therapies.
Journal: Current pharmaceutical biotechnology 20120101
Title: Apoptosis Induction in Primary Human Colorectal Cancer Cell Lines and Retarded Tumor Growth in SCID Mice by Sulforaphane.
Journal: Evidence-based complementary and alternative medicine : eCAM 20120101
Title: Tumor angiogenesis as a target for dietary cancer prevention.
Journal: Journal of oncology 20120101
Title: Ethnobiology and Ethnopharmacology of Lepidium meyenii (Maca), a Plant from the Peruvian Highlands.
Journal: Evidence-based complementary and alternative medicine : eCAM 20120101
Title: Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China.
Journal: Carcinogenesis 20120101
Title: Sulforaphane suppresses vascular adhesion molecule-1 expression in TNF-α-stimulated mouse vascular smooth muscle cells: involvement of the MAPK, NF-κB and AP-1 signaling pathways.
Journal: Vascular pharmacology 20120101
Title: The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes.
Journal: Journal of oncology 20120101
Title: Analysis of tanshinone IIA induced cellular apoptosis in leukemia cells by genome-wide expression profiling.
Journal: BMC complementary and alternative medicine 20120101
Title: A new model for raf kinase inhibitory protein induced chemotherapeutic resistance.
Journal: PloS one 20120101
Title: Autophagy in pancreatic cancer.
Journal: International journal of cell biology 20120101
Title: Astroglial pentose phosphate pathway rates in response to high-glucose environments.
Journal: ASN neuro 20120101
Title: Comparison of three tocopherol analogs as an inhibitor of production of proinflammatory mediators in macrophages.
Journal: Journal of pharmacological sciences 20120101
Title: Induction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins a, C, and e.
Journal: Frontiers in genetics 20120101
Title: Protein kinases and transcription factors activation in response to UV-radiation of skin: implications for carcinogenesis.
Journal: International journal of molecular sciences 20120101
Title: Procyanidins from wild grape (Vitis amurensis) seeds regulate ARE-mediated enzyme expression via Nrf2 coupled with p38 and PI3K/Akt pathway in HepG2 cells.
Journal: International journal of molecular sciences 20120101
Title: Impact of heat treatment on size, structure, and bioactivity of elemental selenium nanoparticles.
Journal: International journal of nanomedicine 20120101
Title: L-cysteine administration attenuates pancreatic fibrosis induced by TNBS in rats by inhibiting the activation of pancreatic stellate cell.
Journal: PloS one 20120101
Title: Thioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicum.
Journal: PloS one 20120101
Title: Cancer stem cells and novel targets for antitumor strategies.
Journal: Current pharmaceutical design 20120101
Title: Swainsonine activates mitochondria-mediated apoptotic pathway in human lung cancer A549 cells and retards the growth of lung cancer xenografts.
Journal: International journal of biological sciences 20120101
Title: Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts.
Journal: Cell communication and signaling : CCS 20120101
Title: Phytochemicals from plants to combat cardiovascular disease.
Journal: Current medicinal chemistry 20120101
Title: Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors.
Journal: Clinical epigenetics 20120101
Title: Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways.
Journal: PloS one 20120101
Title: Inhibition of intestinal adenoma formation in APC(Min/+) mice by Riccardin D, a natural product derived from liverwort plant Dumortiera hirsuta.
Journal: PloS one 20120101
Title: Protective Effect of the Fruit Hull of Gleditsia sinensis on LPS-Induced Acute Lung Injury Is Associated with Nrf2 Activation.
Journal: Evidence-based complementary and alternative medicine : eCAM 20120101
Title: Chromium stress mitigation by polyamine-brassinosteroid application involves phytohormonal and physiological strategies in Raphanus sativus L.
Journal: PloS one 20120101
Title: Exposure to ozone modulates human airway protease/antiprotease balance contributing to increased influenza A infection.
Journal: PloS one 20120101
Title: The safety of cruciferous plants in humans: a systematic review.
Journal: Journal of biomedicine & biotechnology 20120101
Title: Glutathione homeostasis and functions: potential targets for medical interventions.
Journal: Journal of amino acids 20120101
Title: A versatile ΦC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture.
Journal: PloS one 20120101
Title: Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells.
Journal: PloS one 20120101
Title: Platelet-rich plasma peptides: key for regeneration.
Journal: International journal of peptides 20120101
Title: The absence of Nrf2 enhances NF-κB-dependent inflammation following scratch injury in mouse primary cultured astrocytes.
Journal: Mediators of inflammation 20120101
Title: Role of serine racemase in behavioral sensitization in mice after repeated administration of methamphetamine.
Journal: PloS one 20120101
Title: Sulforaphane potentiates RNA damage induced by different xenobiotics.
Journal: PloS one 20120101
Title: Mechanism of chemical activation of Nrf2.
Journal: PloS one 20120101
Title: Modulation of experimental herpes encephalitis-associated neurotoxicity through sulforaphane treatment.
Journal: PloS one 20120101
Title: Epigenetics and breast cancers.
Journal: Obstetrics and gynecology international 20120101
Title: Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat.
Journal: PloS one 20120101
Title: Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus.
Journal: PloS one 20120101
Title: Camel milk modulates the expression of aryl hydrocarbon receptor-regulated genes, Cyp1a1, Nqo1, and Gsta1, in murine hepatoma Hepa 1c1c7 cells.
Journal: Journal of biomedicine & biotechnology 20120101
Title: Malabaricone-A induces a redox imbalance that mediates apoptosis in U937 cell line.
Journal: PloS one 20120101
Title: Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells.
Journal: PloS one 20120101
Title: Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention.
Journal: International journal of nanomedicine 20120101
Title: Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy.
Journal: Experimental diabetes research 20120101
Title: The yin and yang of nrf2-regulated selenoproteins in carcinogenesis.
Journal: International journal of cell biology 20120101
Title: Alternative strategy for Alzheimer's disease: stress response triggers.
Journal: International journal of Alzheimer's disease 20120101
Title: Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modifications.
Journal: PloS one 20120101
Title: Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5.
Journal: PloS one 20120101
Title: Anticancer activity of green tea polyphenols in prostate gland.
Journal: Oxidative medicine and cellular longevity 20120101
Title: Glycerol supplementation enhances L. reuteri's protective effect against S. Typhimurium colonization in a 3-D model of colonic epithelium.
Journal: PloS one 20120101
Title: Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects.
Journal: Oxidative medicine and cellular longevity 20120101
Title: Mechanisms of anticancer activity of sulforaphane from Brassica oleracea in HEp-2 human epithelial carcinoma cell line.
Journal: Asian Pacific journal of cancer prevention : APJCP 20120101
Title: Photothrombosis-induced infarction of the mouse cerebral cortex is not affected by the Nrf2-activator sulforaphane.
Journal: PloS one 20120101
Title: Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer.
Journal: Journal of carcinogenesis 20120101
Title: Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal.
Journal: PloS one 20120101
Title: Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation.
Journal: Oxidative medicine and cellular longevity 20120101
Title: Activating Nrf-2 signaling depresses unilateral ureteral obstruction-evoked mitochondrial stress-related autophagy, apoptosis and pyroptosis in kidney.
Journal: PloS one 20120101
Title: Lipids, blood pressure, kidney - what was new in 2011?
Journal: Archives of medical science : AMS 20111231
Title: Sulforaphane inhibits mitochondrial permeability transition and oxidative stress.
Journal: Free radical biology & medicine 20111215
Title: Hydrogen sulfide mediates the anti-survival effect of sulforaphane on human prostate cancer cells.
Journal: Toxicology and applied pharmacology 20111215
Title: Transthiocarbamoylation of proteins by thiolated isothiocyanates.
Journal: The Journal of biological chemistry 20111209
Title: Cancer chemoprevention by targeting the epigenome.
Journal: Current drug targets 20111201
Title: Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice.
Journal: Pharmaceutical research 20111201
Title: Novel insights into the regulation of antioxidant-response-element-mediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2.
Journal: The Biochemical journal 20111201
Title: Health benefits and possible risks of broccoli - an overview.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111201
Title: Nutritional antioxidants and adaptive cell responses: an update.
Journal: Current molecular medicine 20111201
Title: GSTT1 is upregulated by oxidative stress through p38-MK2 signaling pathway in human granulosa cells: possible association with mitochondrial activity.
Journal: Aging 20111201
Title: Toxicological aspects of the use of phenolic compounds in disease prevention.
Journal: Interdisciplinary toxicology 20111201
Title: An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells.
Journal: Marine drugs 20111201
Title: Induction of glutathione synthesis and conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants.
Journal: Toxicology 20111118
Title: Sulforaphane inhibits oral carcinoma cell migration and invasion in vitro.
Journal: Phytotherapy research : PTR 20111101
Title: Quinoprotein adducts accumulate in the substantia nigra of aged rats and correlate with dopamine-induced toxicity in SH-SY5Y cells.
Journal: Neurochemical research 20111101
Title: Sulforaphane suppresses polycomb group protein level via a proteasome-dependent mechanism in skin cancer cells.
Journal: Molecular pharmacology 20111101
Title: Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design.
Journal: Pharmacological research 20111101
Title: Transcriptional modulation of the NAD(P)H:quinone oxidoreductase 1 by mercury in human hepatoma HepG2 cells.
Journal: Free radical biology & medicine 20111101
Title: Glucoraphanin does not reduce plasma homocysteine in rats with sufficient Se supply via the induction of liver ARE-regulated glutathione biosynthesis enzymes.
Journal: Food & function 20111101
Title: Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients.
Journal: The Journal of clinical investigation 20111101
Title: Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes.
Journal: Current neurovascular research 20111101
Title: Nrf2 activators as attractive therapeutics for diabetic nephropathy.
Journal: Diabetes 20111101
Title: Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy.
Journal: Diabetes 20111101
Title: Sulforaphane induces antioxidative and antiproliferative responses by generating reactive oxygen species in human bronchial epithelial BEAS-2B cells.
Journal: Journal of Korean medical science 20111101
Title: Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement.
Journal: Journal of agricultural and food chemistry 20111026
Title: Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells.
Journal: Clinical epigenetics 20111026
Title: Identification of potential protein targets of isothiocyanates by proteomics.
Journal: Chemical research in toxicology 20111017
Title: Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding.
Journal: Antioxidants & redox signaling 20111015
Title: Transforming growth factor-β and nuclear factor E2–related factor 2 regulate antioxidant responses in airway smooth muscle cells: role in asthma.
Journal: American journal of respiratory and critical care medicine 20111015
Title: Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20111001
Title: Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin.
Journal: Molecular nutrition & food research 20111001
Title: Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway.
Journal: Biochimica et biophysica acta 20111001
Title: Impaired integrity of DNA after recovery from inflammation causes persistent dysfunction of colonic smooth muscle.
Journal: Gastroenterology 20111001
Title: Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathway.
Journal: Cancer prevention research (Philadelphia, Pa.) 20111001
Title: Novel function of transcription factor Nrf2 as an inhibitor of RON tyrosine kinase receptor-mediated cancer cell invasion.
Journal: The Journal of biological chemistry 20110916
Title: Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds.
Journal: The Journal of nutritional biochemistry 20110901
Title: Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice.
Journal: Oncology reports 20110901
Title: Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.
Journal: Disease models & mechanisms 20110901
Title: Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway.
Journal: Toxicology and applied pharmacology 20110901
Title: Transcription factor Nrf2 protects the spinal cord from inflammation produced by spinal cord injury.
Journal: The Journal of surgical research 20110901
Title: Radiosensitization of head and neck cancer cells by the phytochemical agent sulforaphane.
Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20110901
Title: Pharmaconutrition for the obese, critically ill patient.
Journal: JPEN. Journal of parenteral and enteral nutrition 20110901
Title: Nrf2, a PPARγ alternative pathway to promote CD36 expression on inflammatory macrophages: implication for malaria.
Journal: PLoS pathogens 20110901
Title: Cruciferous vegetable phytochemical sulforaphane affects phase II enzyme expression and activity in rat cardiomyocytes through modulation of Akt signaling pathway.
Journal: Journal of food science 20110901
Title: Protective effect of sulforaphane pretreatment against cisplatin-induced liver and mitochondrial oxidant damage in rats.
Journal: Toxicology 20110815
Title: Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice.
Journal: Toxicology and applied pharmacology 20110815
Title: LC-MS/MS quantification of sulforaphane and indole-3-carbinol metabolites in human plasma and urine after dietary intake of selenium-fortified broccoli.
Journal: Journal of agricultural and food chemistry 20110810
Title: Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality.
Journal: Archives of toxicology 20110801
Title: Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury.
Journal: Environmental health perspectives 20110801
Title: The role of constitutive androstane receptor in oxazaphosphorine-mediated induction of drug-metabolizing enzymes in human hepatocytes.
Journal: Pharmaceutical research 20110801
Title: 3,3'-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts.
Journal: Free radical research 20110801
Title: Nrf-2 regulates cyclosporine-stimulated HO-1 expression in gingiva.
Journal: Journal of dental research 20110801
Title: Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma.
Journal: Haematologica 20110801
Title: Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells.
Journal: Free radical biology & medicine 20110715
Title: Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells.
Journal: Molecular nutrition & food research 20110701
Title: Sulforaphane protects human chondrocytes against cell death induced by various stimuli.
Journal: Journal of cellular physiology 20110701
Title: Autophagy and cell death signaling following dietary sulforaphane act independently of each other and require oxidative stress in pancreatic cancer.
Journal: International journal of oncology 20110701
Title: Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110701
Title: Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells.
Journal: Drug and chemical toxicology 20110701
Title: Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.
Journal: Biopharmaceutics & drug disposition 20110701
Title: Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications.
Journal: Annals of the New York Academy of Sciences 20110701
Title: The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics.
Journal: Chemico-biological interactions 20110630
Title: Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.
Journal: Journal of medicinal chemistry 20110623
Title: The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer.
Journal: International journal of cancer 20110615
Title: Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism.
Journal: Antioxidants & redox signaling 20110615
Title: Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells.
Journal: Cancer epidemiology 20110601
Title: Sulforaphane inhibits de novo synthesis of IL-8 and MCP-1 in human epithelial cells generated by cigarette smoke extract.
Journal: Journal of immunotoxicology 20110601
Title: Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane.
Journal: Molecular carcinogenesis 20110601
Title: Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals.
Journal: Nutrition reviews 20110601
Title: Phytochemical analysis and antimicrobial activity of Cardaria draba (L.) Desv. volatiles.
Journal: Chemistry & biodiversity 20110601
Title: Epigallocatechin-3-gallate Regulates Inducible Nitric Oxide Synthase Expression in Human Umbilical Vein Endothelial Cells.
Journal: Laboratory animal research 20110601
Title: Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29.
Journal: Chemico-biological interactions 20110530
Title: 3,4-methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition.
Journal: Toxicology letters 20110530
Title: Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties.
Journal: British journal of cancer 20110510
Title: Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death.
Journal: Cancer chemotherapy and pharmacology 20110501
Title: Sulforaphane-mediated reduction of aflatoxin B₁-N⁷-guanine in rat liver DNA: impacts of strain and sex.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110501
Title: Intrinsic and extrinsic regulation of innate immune receptors.
Journal: Yonsei medical journal 20110501
Title: Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents.
Journal: Drug metabolism reviews 20110501
Title: Modification of keap1 cysteine residues by sulforaphane.
Journal: Chemical research in toxicology 20110418
Title: Characterization of the threshold for NAD(P)H:quinone oxidoreductase activity in intact sulforaphane-treated pulmonary arterial endothelial cells.
Journal: Free radical biology & medicine 20110415
Title: Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model.
Journal: Science translational medicine 20110413
Title: Role of alpha class glutathione transferases (GSTs) in chemoprevention: GSTA1 and A4 overexpressing human leukemia (HL60) cells resist sulforaphane and curcumin induced toxicity.
Journal: Phytotherapy research : PTR 20110401
Title: Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage.
Journal: Journal of neuroscience research 20110401
Title: Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages.
Journal: Archives of biochemistry and biophysics 20110401
Title: Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways.
Journal: Cell death & disease 20110401
Title: [Inhibition of glucoraphenin enzymolysis in Raphani Semen by processing].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110401
Title: Food: The omnivore's labyrinth.
Journal: Nature 20110324
Title: Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress.
Journal: Biochemical and biophysical research communications 20110311
Title: Pseudomonas sax genes overcome aliphatic isothiocyanate-mediated non-host resistance in Arabidopsis.
Journal: Science (New York, N.Y.) 20110304
Title: Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin.
Journal: Lung cancer (Amsterdam, Netherlands) 20110301
Title: Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China.
Journal: Cancer prevention research (Philadelphia, Pa.) 20110301
Title: Heme oxygenase-1: a novel therapeutic target for gastrointestinal diseases.
Journal: Journal of clinical biochemistry and nutrition 20110301
Title: Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls.
Journal: Toxicology and applied pharmacology 20110215
Title: Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.
Journal: Journal of medicinal chemistry 20110210
Title: Stimulation of phagocytosis by sulforaphane.
Journal: Biochemical and biophysical research communications 20110204
Title: Protective role of sulforaphane against oxidative stress mediated mitochondrial dysfunction induced by benzo(a)pyrene in female Swiss albino mice.
Journal: Pulmonary pharmacology & therapeutics 20110201
Title: Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells.
Journal: Carcinogenesis 20110201
Title: Role of sulforaphane in the anti-initiating mechanism of lung carcinogenesis in vivo by modulating the metabolic activation and detoxification of benzo(a)pyrene.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110201
Title: Human CYP2A6 is regulated by nuclear factor-erythroid 2 related factor 2.
Journal: Biochemical pharmacology 20110115
Title: Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20110104
Title: Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes.
Journal: Environmental health perspectives 20110101
Title: Involvement of caspase-9 in autophagy-mediated cell survival pathway.
Journal: Biochimica et biophysica acta 20110101
Title: Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage.
Journal: Neuropharmacology 20110101
Title: Dietary phenethyl isothiocyanate alters gene expression in human breast cancer cells.
Journal: Evidence-based complementary and alternative medicine : eCAM 20110101
Title: Bioactive food components and cancer-specific metabonomic profiles.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells.
Journal: Frontiers in bioscience (Elite edition) 20110101
Title: Selenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents.
Journal: BMC genomics 20110101
Title: Sulforaphane absorption and excretion following ingestion of a semi-purified broccoli powder rich in glucoraphanin and broccoli sprouts in healthy men.
Journal: Nutrition and cancer 20110101
Title: Molecular basis for vulnerability to mitochondrial and oxidative stress in a neuroendocrine CRI-G1 cell line.
Journal: PloS one 20110101
Title: Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes - Incorporation of cellular antioxidant response and threshold-dependent behavior.
Journal: BMC systems biology 20110101
Title: Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells.
Journal: Nutrition and cancer 20110101
Title: Cruciferous vegetable supplementation in a controlled diet study alters the serum peptidome in a GSTM1-genotype dependent manner.
Journal: Nutrition journal 20110101
Title: Exposure to isothiocyanates suppresses urinary mutagenicity in rats treated with heterocyclic amine IQ: lack of association with CYP1 activity.
Journal: Nutrition and cancer 20110101
Title: Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition.
Journal: PloS one 20110101
Title: The endotoxin-induced neuroinflammation model of Parkinson's disease.
Journal: Parkinson's disease 20110101
Title: Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)--antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate.
Journal: Journal of pharmacological sciences 20110101
Title: The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease.
Journal: Parkinson's disease 20110101
Title: Discovery of molecular mechanisms of traditional Chinese medicinal formula Si-Wu-Tang using gene expression microarray and connectivity map.
Journal: PloS one 20110101
Title: Sulforaphane blocks hypoxia-mediated resistance to TRAIL-induced tumor cell death.
Journal: Molecular medicine reports 20110101
Title: Drosophila models of Parkinson's disease: discovering relevant pathways and novel therapeutic strategies.
Journal: Parkinson's disease 20110101
Title: Chemopreventive role of sulforaphane by upholding the GSH redox cycle in pre- and post-initiation phases of experimental lung carcinogenesis.
Journal: Asian Pacific journal of cancer prevention : APJCP 20110101
Title: Stroma regulates increased epithelial lateral cell adhesion in 3D culture: a role for actin/cadherin dynamics.
Journal: PloS one 20110101
Title: Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells.
Journal: PloS one 20110101
Title: Sulforaphane enhances protection and repair of gastric mucosa against oxidative stress in vitro, and demonstrates anti-inflammatory effects on Helicobacter pylori-infected gastric mucosae in mice and human subjects.
Journal: Current pharmaceutical design 20110101
Title: NNK-Induced Lung Tumors: A Review of Animal Model.
Journal: Journal of oncology 20110101
Title: Age-related retinopathy in NRF2-deficient mice.
Journal: PloS one 20110101
Title: Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.
Journal: Molecular cancer 20110101
Title: Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway.
Journal: International journal of Alzheimer's disease 20110101
Title: Of cabbages and kings.
Journal: Gut microbes 20110101
Title: Combination treatment with 5-fluorouracil and isothiocyanates shows an antagonistic effect in Chinese hamster fibroblast cells line-V79.
Journal: Acta poloniae pharmaceutica 20110101
Title: The role of blood flow in determining the sites of atherosclerotic plaques.
Journal: F1000 medicine reports 20110101
Title: Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay.
Journal: PloS one 20110101
Title: Separation and purification of sulforaphane from broccoli by solid phase extraction.
Journal: International journal of molecular sciences 20110101
Title: Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium.
Journal: Journal of biomedical science 20110101
Title: Induction of G₂/M arrest and apoptosis by sulforaphane in human osteosarcoma U2-OS cells.
Journal: Molecular medicine reports 20110101
Title: Inhibition of premature death by isothiocyanates through immune restoration in LP-BM5 leukemia retrovirus-infected C57BL/6 mice.
Journal: Bioscience, biotechnology, and biochemistry 20110101
Title: NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease.
Journal: PloS one 20110101
Title: Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system.
Journal: Respiratory research 20110101
Title: Identification of NF-κB modulation capabilities within human intestinal commensal bacteria.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms.
Journal: PloS one 20110101
Title: Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2'-O-acetyl-α-L-rhamnosyloxy)benzyl]isothiocyanate from Moringa oleifera.
Journal: Nutrition and cancer 20110101
Title: Benzyl isothiocyanate, a major component from the roots of Salvadora persica is highly active against Gram-negative bacteria.
Journal: PloS one 20110101
Title: Photo-products of retinal pigment epithelial bisretinoids react with cellular thiols.
Journal: Molecular vision 20110101
Title: Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species.
Journal: PloS one 20110101
Title: Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function.
Journal: Nutrition and cancer 20110101
Title: Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study.
Journal: Journal of clinical bioinformatics 20110101
Title: Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning.
Journal: Oxidative medicine and cellular longevity 20110101
Title: Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors.
Journal: PloS one 20110101
Title: Antimelanogenic effect of c-phycocyanin through modulation of tyrosinase expression by upregulation of ERK and downregulation of p38 MAPK signaling pathways.
Journal: Journal of biomedical science 20110101
Title: Evidence for oxidative stress and defective antioxidant response in guinea pigs with tuberculosis.
Journal: PloS one 20110101
Title: Galectin-3 and Beclin1/Atg6 genes in human cancers: using cDNA tissue panel, qRT-PCR, and logistic regression model to identify cancer cell biomarkers.
Journal: PloS one 20110101
Title: Targeted deletion of Nrf2 reduces urethane-induced lung tumor development in mice.
Journal: PloS one 20110101
Title: Notch activation by phenethyl isothiocyanate attenuates its inhibitory effect on prostate cancer cell migration.
Journal: PloS one 20110101
Title: Tissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles.
Journal: PloS one 20110101
Title: Shattering the underpinnings of neoplastic architecture in LNCap: synergistic potential of nutraceuticals in dampening PDGFR/EGFR signaling and cellular proliferation.
Journal: Journal of experimental therapeutics & oncology 20110101
Title: Butyrate enhances disease resistance of chickens by inducing antimicrobial host defense peptide gene expression.
Journal: PloS one 20110101
Title: A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells.
Journal: PloS one 20110101
Title: Development and validation of an LC-MS-MS method for the simultaneous determination of sulforaphane and its metabolites in rat plasma and its application in pharmacokinetic studies.
Journal: Journal of chromatographic science 20110101
Title: Low intracellular ATP levels exacerbate carcinogen-induced inflammatory stress response and inhibit in vitro tubulogenesis in human brain endothelial cells.
Journal: Journal of inflammation research 20110101
Title: New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer.
Journal: Prostate cancer 20110101
Title: Adolescent idiopathic scoliosis (AIS), environment, exposome and epigenetics: a molecular perspective of postnatal normal spinal growth and the etiopathogenesis of AIS with consideration of a network approach and possible implications for medical therapy.
Journal: Scoliosis 20110101
Title: Effect of Turkish propolis extracts on proteome of prostate cancer cell line.
Journal: Proteome science 20110101
Title: MRI to assess chemoprevention in transgenic adenocarcinoma of mouse prostate (TRAMP).
Journal: BMC medical imaging 20110101
Title: Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?
Journal: Medical gas research 20110101
Title: Strategies for reducing or preventing the generation of oxidative stress.
Journal: Oxidative medicine and cellular longevity 20110101
Title: Chinese herb mix Tiáo-Gēng-Tāng possesses antiaging and antioxidative effects and upregulates expression of estrogen receptors alpha and beta in ovariectomized rats.
Journal: BMC complementary and alternative medicine 20110101
Title: The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia.
Journal: PloS one 20110101
Title: Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells.
Journal: Clinical epigenetics 20110101
Title: Compositional studies: antioxidant and antidiabetic activities of Capparis decidua (Forsk.) Edgew.
Journal: International journal of molecular sciences 20110101
Title: Epigenomics of ovarian cancer and its chemoprevention.
Journal: Frontiers in genetics 20110101
Title: Epigenetic Contributions to the Relationship between Cancer and Dietary Intake of Nutrients, Bioactive Food Components, and Environmental Toxicants.
Journal: Frontiers in genetics 20110101
Title: Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284.
Journal: Journal of medicinal chemistry 20101223
Title: Anti-oxidant and Anti-hypercholesterolemic Activities of Wasabia japonica.
Journal: Evidence-based complementary and alternative medicine : eCAM 20101201
Title: The Chinese herbal medicine Sophora flavescens activates pregnane X receptor.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201
Title: Sulforaphane modulates the expression of Cyp6a2 and Cyp6g1 in larvae of the ST and HB crosses of the Drosophila wing spot test and is genotoxic in the ST cross.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20101201
Title: Organosulfur compounds and cardiovascular disease.
Journal: Molecular aspects of medicine 20101201
Title: Determination of new biomarkers to monitor the dietary consumption of isothiocyanates.
Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20101201
Title: Brain mitochondria from rats treated with sulforaphane are resistant to redox-regulated permeability transition.
Journal: Journal of bioenergetics and biomembranes 20101201
Title: Anticancer activity of a broccoli derivative, sulforaphane, in barrett adenocarcinoma: potential use in chemoprevention and as adjuvant in chemotherapy.
Journal: Translational oncology 20101201
Title: [Sulforaphane--a possible agent in prevention and therapy of cancer].
Journal: Postepy higieny i medycyny doswiadczalnej (Online) 20101129
Title: Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27.
Journal: The Journal of biological chemistry 20101112
Title: Protective effect of sulforaphane against cisplatin-induced mitochondrial alterations and impairment in the activity of NAD(P)H: quinone oxidoreductase 1 and γ glutamyl cysteine ligase: studies in mitochondria isolated from rat kidney and in LLC-PK1 cells.
Journal: Toxicology letters 20101110
Title: Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables.
Journal: Toxicology 20101109
Title: Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain.
Journal: Environmental health perspectives 20101101
Title: Sulforaphane inhibits endothelial lipase expression through NF-κB in endothelial cells.
Journal: Atherosclerosis 20101101
Title: Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissues.
Journal: Carcinogenesis 20101101
Title: Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products.
Journal: Biological chemistry 20101101
Title: The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice.
Journal: Acta pharmacologica Sinica 20101101
Title: Sulforaphane suppresses TARC/CCL17 and MDC/CCL22 expression through heme oxygenase-1 and NF-κB in human keratinocytes.
Journal: Archives of pharmacal research 20101101
Title: Glucoraphanin hydrolysis by microbiota in the rat cecum results in sulforaphane absorption.
Journal: Food & function 20101101
Title: A cautionary note on using N-acetylcysteine as an antagonist to assess isothiocyanate-induced reactive oxygen species-mediated apoptosis.
Journal: Analytical biochemistry 20101015
Title: Regulation of human carbonyl reductase 3 (CBR3; SDR21C2) expression by Nrf2 in cultured cancer cells.
Journal: Biochemistry 20101005
Title: Isothiocyanate sulforaphane inhibits protooncogenic ornithine decarboxylase activity in colorectal cancer cells via induction of the TGF-β/Smad signaling pathway.
Journal: Molecular nutrition & food research 20101001
Title: Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway.
Journal: Cancer letters 20100928
Title: Heteroaromatic 4-arylquinols are novel inducers of nuclear factor-erythroid 2-related factor 2 (Nrf2).
Journal: European journal of pharmacology 20100925
Title: Mutant TAR DNA-binding protein-43 induces oxidative injury in motor neuron-like cell.
Journal: Neuroscience 20100915
Title: Modular, homochiral, porous coordination polymers: rational design, enantioselective guest exchange sorption and ab initio calculations of host-guest interactions.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20100910
Title: Modulation of NAD(P)H:quinone oxidoreductase by vanadium in human hepatoma HepG2 cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100901
Title: Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response.
Journal: Toxicology and applied pharmacology 20100901
Title: Hexane extract of Raphanus sativus L. roots inhibits cell proliferation and induces apoptosis in human cancer cells by modulating genes related to apoptotic pathway.
Journal: Plant foods for human nutrition (Dordrecht, Netherlands) 20100901
Title: Dietary polyphenol quercetin targets pancreatic cancer stem cells.
Journal: International journal of oncology 20100901
Title: The inhibition of autophagy potentiates anti-angiogenic effects of sulforaphane by inducing apoptosis.
Journal: Angiogenesis 20100901
Title: Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells.
Journal: Acta pharmacologica Sinica 20100901
Title: Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.
Journal: Cancer metastasis reviews 20100901
Title: Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells.
Journal: Anticancer research 20100901
Title: Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells.
Journal: Anticancer research 20100901
Title: Independent effects of the broccoli-derived compound sulforaphane on Ca²⁺ influx and apoptosis in Madin-Darby canine renal tubular cells.
Journal: The Chinese journal of physiology 20100831
Title: Sensitization of non-small cell lung cancer cells to cisplatin by naturally occurring isothiocyanates.
Journal: Chemical research in toxicology 20100816
Title: Sulforaphane suppresses ultraviolet B-induced inflammation in HaCaT keratinocytes and HR-1 hairless mice.
Journal: The Journal of nutritional biochemistry 20100801
Title: Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100801
Title: Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells.
Journal: The Journal of nutrition 20100801
Title: Induction of detoxification enzymes by feeding unblanched Brussels sprouts containing active myrosinase to mice for 2 wk.
Journal: Journal of food science 20100801
Title: Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme.
Journal: Brain research 20100709
Title: Sulforaphane induces DNA single strand breaks in cultured human cells.
Journal: Mutation research 20100707
Title: Does molecular docking reveal alternative chemopreventive mechanism of activation of oxidoreductase by sulforaphane isothiocyanates?
Journal: Journal of molecular modeling 20100701
Title: Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR.
Journal: European journal of medicinal chemistry 20100701
Title: Sulforaphane protects liver injury induced by intestinal ischemia reperfusion through Nrf2-ARE pathway.
Journal: World journal of gastroenterology 20100628
Title: Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.
Journal: Journal of proteomics 20100616
Title: Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics.
Journal: Cancer research 20100615
Title: Analysis and anti-Helicobacter activity of sulforaphane and related compounds present in broccoli ( Brassica oleracea L.) sprouts.
Journal: Journal of agricultural and food chemistry 20100609
Title: Sulforaphane suppresses LPS-induced inflammation in primary rat microglia.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20100601
Title: Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress.
Journal: Environmental health perspectives 20100601
Title: The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100601
Title: Regulation of neutrophil elastase-induced MUC5AC expression by nuclear factor erythroid-2 related factor 2 in human airway epithelial cells.
Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20100601
Title: Protective effect of sulforaphane on human vascular endothelial cells against lipopolysaccharide-induced inflammatory damage.
Journal: Cardiovascular toxicology 20100601
Title: Cancer prevention with natural compounds.
Journal: Seminars in oncology 20100601
Title: Inactivation of Aconitase by Tetrahydrobiopterin in DArgic Cells: Relevance to PD.
Journal: Experimental neurobiology 20100601
Title: Electrophilic tuning of the chemoprotective natural product sulforaphane.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20100525
Title: Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis.
Journal: Free radical biology & medicine 20100515
Title: Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation.
Journal: Journal of neuroscience research 20100501
Title: Sulforaphane and alpha-lipoic acid upregulate the expression of the pi class of glutathione S-transferase through c-jun and Nrf2 activation.
Journal: The Journal of nutrition 20100501
Title: A complex interplay of three R2R3 MYB transcription factors determines the profile of aliphatic glucosinolates in Arabidopsis.
Journal: Plant physiology 20100501
Title: Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100501
Title: Antitumor activity and COMPARE analysis of bis-indole derivatives.
Journal: Bioorganic & medicinal chemistry 20100501
Title: Identification and characterization of novel Nrf2 inducers designed to target the intervening region of Keap1.
Journal: Chemical biology & drug design 20100501
Title: When food meets man: the contribution of epigenetics to health.
Journal: Nutrients 20100501
Title: New biomarkers for monitoring the levels of isothiocyanates in humans.
Journal: Chemical research in toxicology 20100419
Title: The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis.
Journal: Free radical biology & medicine 20100415
Title: Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.
Journal: Bioorganic & medicinal chemistry letters 20100415
Title: Role of lipid peroxidation in cellular responses to D,L-sulforaphane, a promising cancer chemopreventive agent.
Journal: Biochemistry 20100413
Title: HPLC method validation for measurement of sulforaphane level in broccoli by-products.
Journal: Biomedical chromatography : BMC 20100401
Title: Targeting NRF2 signaling for cancer chemoprevention.
Journal: Toxicology and applied pharmacology 20100401
Title: Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels.
Journal: Pharmacological research 20100401
Title: The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy.
Journal: Diabetes 20100401
Title: Deletion of the Chd6 exon 12 affects motor coordination.
Journal: Mammalian genome : official journal of the International Mammalian Genome Society 20100401
Title: Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes.
Journal: Molecular nutrition & food research 20100401
Title: p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells.
Journal: Oncology reports 20100401
Title: Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells.
Journal: Cancer prevention research (Philadelphia, Pa.) 20100401
Title: Phytochemicals in cancer prevention and therapy: truth or dare?
Journal: Toxins 20100401
Title: Biological profile of erucin: a new promising anticancer agent from cruciferous vegetables.
Journal: Toxins 20100401
Title: Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury.
Journal: The British journal of nutrition 20100301
Title: Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention.
Journal: The AAPS journal 20100301
Title: Sulforaphane protects against cisplatin-induced nephrotoxicity.
Journal: Toxicology letters 20100215
Title: Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy.
Journal: International journal of pharmaceutics 20100215
Title: The impact of loss of myrosinase on the bioactivity of broccoli products in F344 rats.
Journal: Journal of agricultural and food chemistry 20100210
Title: Enhancement of arsenic trioxide cytotoxicity by dietary isothiocyanates in human leukemic cells via a reactive oxygen species-dependent mechanism.
Journal: Leukemia research 20100201
Title: Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture.
Journal: Experimental dermatology 20100201
Title: Inhibition of autophagy potentiates sulforaphane-induced apoptosis in human colon cancer cells.
Journal: Annals of surgical oncology 20100201
Title: Mouse models for unraveling the importance of diet in colon cancer prevention.
Journal: The Journal of nutritional biochemistry 20100201
Title: Transcriptional regulation of human carboxylesterase 1A1 by nuclear factor-erythroid 2 related factor 2 (Nrf2).
Journal: Biochemical pharmacology 20100115
Title: Combination treatment with resveratrol and sulforaphane induces apoptosis in human U251 glioma cells.
Journal: Neurochemical research 20100101
Title: Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20100101
Title: Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate.
Journal: Arthritis and rheumatism 20100101
Title: Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice.
Journal: PloS one 20100101
Title: Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1.
Journal: PloS one 20100101
Title: Sulforaphane Increases Cyclin-Dependent Kinase Inhibitor, p21 Protein in Human Oral Carcinoma Cells and Nude Mouse Animal Model to Induce G(2)/M Cell Cycle Arrest.
Journal: Journal of clinical biochemistry and nutrition 20100101
Title: Allyl isothiocyanate that induces GST and UGT expression confers oxidative stress resistance on C. elegans, as demonstrated by nematode biosensor.
Journal: PloS one 20100101
Title: [Effect of tBHQ and sulforaphane on Nrf2-ARE signaling pathway of Caco2 cells].
Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20100101
Title: Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease.
Journal: BMC medical genetics 20100101
Title: Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.
Journal: Molecular cancer 20100101
Title: Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells.
Journal: Molecular cancer 20100101
Title: Sulforaphane inhibited melanin synthesis by regulating tyrosinase gene expression in B16 mouse melanoma cells.
Journal: Bioscience, biotechnology, and biochemistry 20100101
Title: Downregulation of Epidermal Growth Factor Receptor Expression Contributes to alpha-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines.
Journal: Journal of oncology 20100101
Title: NADPH oxidase limits innate immune responses in the lungs in mice.
Journal: PloS one 20100101
Title: Individual variation and intraclass correlation in arachidonic acid and eicosapentaenoic acid in chicken muscle.
Journal: Lipids in health and disease 20100101
Title: Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophages.
Journal: Mediators of inflammation 20100101
Title: Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study.
Journal: BMC cancer 20100101
Title: Transcript and protein profiling identify candidate gene sets of potential adaptive significance in New Zealand Pachycladon.
Journal: BMC evolutionary biology 20100101
Title: Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study.
Journal: Therapeutics and clinical risk management 20100101
Title: Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells.
Journal: BMC cancer 20100101
Title: Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines.
Journal: PloS one 20100101
Title: The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer.
Journal: Molecular cancer 20100101
Title: Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells.
Journal: BMC cancer 20100101
Title: Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer.
Journal: Journal of molecular signaling 20100101
Title: The characterisation of AOP2: a gene associated with the biosynthesis of aliphatic alkenyl glucosinolates in Arabidopsis thaliana.
Journal: BMC plant biology 20100101
Title: The role of tumor initiating cells in drug resistance of breast cancer: Implications for future therapeutic approaches.
Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20100101
Title: Sulforaphane induces glutathione S-transferase isozymes which detoxify aflatoxin B(1)-8,9-epoxide in AML 12 cells.
Journal: BioFactors (Oxford, England) 20100101
Title: Protective effect of combination of sulforaphane and riluzole on glutamate-mediated excitotoxicity.
Journal: Biological & pharmaceutical bulletin 20100101
Title: Activation of CD147 with cyclophilin a induces the expression of IFITM1 through ERK and PI3K in THP-1 cells.
Journal: Mediators of inflammation 20100101
Title: Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells.
Journal: Molecular cancer 20100101
Title: Sulforaphane attenuates matrix metalloproteinase-9 expression following spinal cord injury in mice.
Journal: Annals of clinical and laboratory science 20100101
Title: Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machinery.
Journal: International journal of cell biology 20100101
Title: Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways.
Journal: Chinese medicine 20100101
Title: Novel screening method for potential skin-whitening compounds by a luciferase reporter assay.
Journal: Bioscience, biotechnology, and biochemistry 20100101
Title: Purification of reversibly oxidized proteins (PROP) reveals a redox switch controlling p38 MAP kinase activity.
Journal: PloS one 20100101
Title: Cytokines in the Progression of Pancreatic β-Cell Dysfunction.
Journal: International journal of endocrinology 20100101
Title: Reactivating aberrantly hypermethylated p15 gene in leukemic T cells by a phenylhexyl isothiocyanate mediated inter-active mechanism on DNA and chromatin.
Journal: Journal of hematology & oncology 20100101
Title: Broccoli, PTEN deletion and prostate cancer: where is the link?
Journal: Molecular cancer 20100101
Title: Pharmacological targeting of β-adrenergic receptor functions abrogates NF-κB signaling and MMP-9 secretion in medulloblastoma cells.
Journal: OncoTargets and therapy 20100101
Title: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.
Journal: BMC cancer 20100101
Title: Expression and distribution of the class III ubiquitin-conjugating enzymes in the retina.
Journal: Molecular vision 20100101
Title: Down-regulation of phosphoglucomutase 3 mediates sulforaphane-induced cell death in LNCaP prostate cancer cells.
Journal: Proteome science 20100101
Title: Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells.
Journal: PloS one 20100101
Title: Effects of tert-butylhydroquinone on intestinal inflammatory response and apoptosis following traumatic brain injury in mice.
Journal: Mediators of inflammation 20100101
Title: Neuroprotective role of haptoglobin after intracerebral hemorrhage.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20091216
Title: Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity.
Journal: American journal of respiratory and critical care medicine 20091215
Title: Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species.
Journal: The Biochemical journal 20091210
Title: Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.
Journal: Journal of medicinal chemistry 20091210
Title: Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line.
Journal: Journal of neurochemistry 20091201
Title: Sulforaphane inhibits angiogenesis through activation of FOXO transcription factors.
Journal: Oncology reports 20091201
Title: Effect of sulforaphane on glutathione-adduct formation and on glutathione_S_transferase-dependent detoxification of acrylamide in Caco-2 cells.
Journal: Molecular nutrition & food research 20091201
Title: Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease.
Journal: Parkinsonism & related disorders 20091201
Title: Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma.
Journal: Oral oncology 20091101
Title: Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20091101
Title: Antioxidant anti-inflammatory treatment in type 2 diabetes.
Journal: Diabetes care 20091101
Title: Repeated intake of broccoli does not lead to higher plasma levels of sulforaphane in human volunteers.
Journal: Cancer letters 20091018
Title: Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery.
Journal: Biochemical and biophysical research communications 20091016
Title: Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells.
Journal: Journal of animal physiology and animal nutrition 20091001
Title: Modulation of thioredoxin reductase-2 expression in EAhy926 cells: implications for endothelial selenoprotein hierarchy.
Journal: Biochimica et biophysica acta 20091001
Title: Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway.
Journal: Pharmaceutical research 20091001
Title: Sulforaphane treatment protects skeletal muscle against damage induced by exhaustive exercise in rats.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20091001
Title: Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20090929
Title: Gene expression profile of primary prostate epithelial and stromal cells in response to sulforaphane or iberin exposure.
Journal: The Prostate 20090915
Title: Chemopreventive agent sulforaphane enhances radiosensitivity in human tumor cells.
Journal: International journal of cancer 20090901
Title: Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090901
Title: Protective effect of sulforaphane on indomethacin-induced cytotoxicity via heme oxygenase-1 expression in human intestinal Int 407 cells.
Journal: Molecular nutrition & food research 20090901
Title: Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer.
Journal: Cancer research 20090901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090901
Title: Evaluation of protective effects of sulforaphane on DNA damage caused by exposure to low levels of pesticide mixture using comet assay.
Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20090901
Title: Sulforaphane improves cognitive function administered following traumatic brain injury.
Journal: Neuroscience letters 20090828
Title: Enantiopure sulforaphane analogues with various substituents at the sulfinyl sulfur: asymmetric synthesis and biological activities.
Journal: The Journal of organic chemistry 20090821
Title: Sulforaphane enhances caspase-dependent apoptosis through inhibition of cyclooxygenase-2 expression in human oral squamous carcinoma cells and nude mouse xenograft model.
Journal: Oral oncology 20090801
Title: Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20090801
Title: The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090801
Title: Relevance of the aryl hydrocarbon receptor (AhR) for clinical toxicology.
Journal: Clinical toxicology (Philadelphia, Pa.) 20090801
Title: Modifying the alkylglucosinolate profile in Arabidopsis thaliana alters the tritrophic interaction with the herbivore Brevicoryne brassicae and parasitoid Diaeretiella rapae.
Journal: Journal of chemical ecology 20090801
Title: Select phytochemicals suppress human T-lymphocytes and mouse splenocytes suggesting their use in autoimmunity and transplantation.
Journal: Nutrition research (New York, N.Y.) 20090801
Title: Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling.
Journal: Gut 20090701
Title: Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species.
Journal: Pharmaceutical research 20090701
Title: Sulforaphane: from chemoprevention to pancreatic cancer treatment?
Journal: Gut 20090701
Title: The aliphatic isothiocyanates erucin and sulforaphane do not effectively up-regulate NAD(P)H:quinone oxidoreductase (NQO1) in human liver compared with rat.
Journal: Molecular nutrition & food research 20090701
Title: D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells.
Journal: Molecular cancer therapeutics 20090701
Title: Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential.
Journal: Journal of agricultural and food chemistry 20090624
Title: Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes.
Journal: The Journal of biological chemistry 20090619
Title: Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents.
Journal: Toxicology and applied pharmacology 20090615
Title: Potency of isothiocyanates to induce luciferase reporter gene expression via the electrophile-responsive element from murine glutathione S-transferase Ya.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090601
Title: Initial in vitro evaluations of the antibacterial activities of glucosinolate enzymatic hydrolysis products against plant pathogenic bacteria.
Journal: Journal of applied microbiology 20090601
Title: The antimicrobial effects of glucosinolates and their respective enzymatic hydrolysis products on bacteria isolated from the human intestinal tract.
Journal: Journal of applied microbiology 20090601
Title: Potential health benefits of broccoli- a chemico-biological overview.
Journal: Mini reviews in medicinal chemistry 20090601
Title: E. Solowiej, J. Solowiej, M. Godlewski, et al. Regarding the article 'Application of Sulforaphane: histopathological study of intraportal transplanted pancreatic islets into livers of diabetic rats,' Transplant Proc (2006 Jan/Feb) 38(1): pages 282-283.
Journal: Transplantation proceedings 20090601
Title: Nrf2 activators provide neuroprotection against 6-hydroxydopamine toxicity in rat organotypic nigrostriatal cocultures.
Journal: Journal of neuroscience research 20090515
Title: Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090512
Title: Fragrant unsaturated aldehydes elicit activation of the Keap1/Nrf2 system leading to the upregulation of thioredoxin expression and protection against oxidative stress.
Journal: Antioxidants & redox signaling 20090501
Title: Down-regulation of the detoxifying enzyme NAD(P)H:quinone oxidoreductase 1 by vanadium in Hepa 1c1c7 cells.
Journal: Toxicology and applied pharmacology 20090501
Title: Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation.
Journal: Glia 20090415
Title: An in vitro screening cascade to identify neuroprotective antioxidants in ALS.
Journal: Free radical biology & medicine 20090415
Title: Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds.
Journal: Environmental and molecular mutagenesis 20090401
Title: Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA-binding activity in human bladder T24 cells.
Journal: International journal of oncology 20090401
Title: Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.
Journal: Cancer prevention research (Philadelphia, Pa.) 20090401
Title: Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells.
Journal: Cancer letters 20090308
Title: Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane.
Journal: The Journal of nutritional biochemistry 20090301
Title: Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma.
Journal: Phytotherapy research : PTR 20090301
Title: Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway.
Journal: Clinical immunology (Orlando, Fla.) 20090301
Title: Sensory neurons and schwann cells respond to oxidative stress by increasing antioxidant defense mechanisms.
Journal: Antioxidants & redox signaling 20090301
Title: Chemical genomics of cancer chemopreventive dithiolethiones.
Journal: Carcinogenesis 20090301
Title: Effect of broccoli (Brassica oleracea) and its phytochemical sulforaphane in balanced diets on the detoxification enzymes levels of tilapia (Oreochromis niloticus) exposed to a carcinogenic and mutagenic pollutant.
Journal: Chemosphere 20090301
Title: Comparison of the effects of phenethyl isothiocyanate and sulforaphane on gene expression in breast cancer and normal mammary epithelial cells.
Journal: Experimental biology and medicine (Maywood, N.J.) 20090301
Title: Functionalized 3-benzylidene-indolin-2-ones: inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity.
Journal: Bioorganic & medicinal chemistry 20090301
Title: Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells.
Journal: Cancer research 20090301
Title: [Sulforaphane (1-isothiocyanato-4-(methylsulfinyl)-butane) content in cruciferous vegetables].
Journal: Archivos latinoamericanos de nutricion 20090301
Title: Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway.
Journal: Toxicology and applied pharmacology 20090215
Title: Sulforaphane suppresses TNF-alpha-mediated activation of NF-kappaB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3.
Journal: Cancer letters 20090208
Title: Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation.
Journal: Biochemical and biophysical research communications 20090206
Title: Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells.
Journal: The Prostate 20090201
Title: HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090201
Title: Sulforaphane stimulates activation of proapoptotic protein bax leading to apoptosis of endothelial progenitor cells.
Journal: Annals of surgical oncology 20090201
Title: Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors.
Journal: Photodermatology, photoimmunology & photomedicine 20090201
Title: Fenugreek: a naturally occurring edible spice as an anticancer agent.
Journal: Cancer biology & therapy 20090201
Title: Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane.
Journal: Chemico-biological interactions 20090127
Title: Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease.
Journal: American journal of respiratory and critical care medicine 20090115
Title: Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation.
Journal: Pharmaceutical research 20090101
Title: Receptor independent and receptor dependent CoMSA modeling with IVE-PLS: application to CBG benchmark steroids and reductase activators.
Journal: Journal of molecular modeling 20090101
Title: Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane.
Journal: Neurochemistry international 20090101
Title: Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1).
Journal: Nutrition and cancer 20090101
Title: Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.
Journal: BMC medical genomics 20090101
Title: Protection against amyloid beta cytotoxicity by sulforaphane: role of the proteasome.
Journal: Archives of pharmacal research 20090101
Title: Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene.
Journal: Journal of biochemical and molecular toxicology 20090101
Title: The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.
Journal: Nuclear receptor signaling 20090101
Title: Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level.
Journal: PloS one 20090101
Title: Potential skin antiinflammatory effects of 4-methylthiobutylisothiocyanate (MTBI) isolated from rocket (Eruca sativa) seeds.
Journal: BioFactors (Oxford, England) 20090101
Title: Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.
Journal: PloS one 20090101
Title: New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer.
Journal: Journal of hematology & oncology 20090101
Title: Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response.
Journal: PloS one 20090101
Title: Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells.
Journal: Cancer cell international 20090101
Title: Modulation of markers associated with aggressive phenotype in MDA-MB-231 breast carcinoma cells by sulforaphane.
Journal: Neoplasma 20090101
Title: LAS0811: from combinatorial chemistry to activation of antioxidant response element.
Journal: Journal of biomedicine & biotechnology 20090101
Title: DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.
Journal: PloS one 20090101
Title: Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells.
Journal: BMC cancer 20090101
Title: Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes.
Journal: PloS one 20090101
Title: Sulforaphane induces DNA double strand breaks predominantly repaired by homologous recombination pathway in human cancer cells.
Journal: Biochemical and biophysical research communications 20081212
Title: Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis.
Journal: British journal of cancer 20081209
Title: Isothiocyanate NB7M causes selective cytotoxicity, pro-apoptotic signalling and cell-cycle regression in ovarian cancer cells.
Journal: British journal of cancer 20081202
Title: A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction.
Journal: Journal of neurochemistry 20081201
Title: Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane.
Journal: Carcinogenesis 20081201
Title: Bioavailability and kinetics of sulforaphane in humans after consumption of cooked versus raw broccoli.
Journal: Journal of agricultural and food chemistry 20081126
Title: Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20081101
Title: Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
Journal: Journal of natural products 20081101
Title: Monodictyochromes A and B, dimeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis.
Journal: Journal of natural products 20081101
Title: Epithiospecifier protein activity in broccoli: the link between terminal alkenyl glucosinolates and sulphoraphane nitrile.
Journal: Phytochemistry 20081101
Title: Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081101
Title: Up-regulation of the CYP1 family in rat and human liver by the aliphatic isothiocyanates erucin and sulforaphane.
Journal: Toxicology 20081030
Title: Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway.
Journal: Biochemical pharmacology 20081015
Title: Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20081014
Title: Multi-targeted prevention of cancer by sulforaphane.
Journal: Cancer letters 20081008
Title: The dietary histone deacetylase inhibitor sulforaphane induces human beta-defensin-2 in intestinal epithelial cells.
Journal: Immunology 20081001
Title: Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease.
Journal: Diabetes 20081001
Title: Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents.
Journal: Planta medica 20081001
Title: Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry.
Journal: Chemical research in toxicology 20081001
Title: Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.
Journal: Journal of neurochemistry 20081001
Title: Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1.
Journal: American journal of respiratory and critical care medicine 20080915
Title: Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells.
Journal: International journal of cancer 20080915
Title: Modulation of rat hepatic and pulmonary cytochromes P450 and phase II enzyme systems by erucin, an isothiocyanate structurally related to sulforaphane.
Journal: Journal of agricultural and food chemistry 20080910
Title: Application of high-speed countercurrent chromatography for the isolation of sulforaphane from broccoli seed meal.
Journal: Journal of agricultural and food chemistry 20080910
Title: Computational discovery of novel low micromolar human pregnane X receptor antagonists.
Journal: Molecular pharmacology 20080901
Title: Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death.
Journal: Molecular and cellular neurosciences 20080901
Title: Cancer is a preventable disease that requires major lifestyle changes.
Journal: Pharmaceutical research 20080901
Title: Effect of (R)L-sulforaphane on 5-aminolevulinic acid-mediated photodynamic therapy.
Journal: Translational research : the journal of laboratory and clinical medicine 20080901
Title: Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications.
Journal: Current drug metabolism 20080901
Title: Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response.
Journal: Environmental health perspectives 20080901
Title: Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats.
Journal: Evidence-based complementary and alternative medicine : eCAM 20080901
Title: Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis.
Journal: The Journal of biological chemistry 20080808
Title: Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction.
Journal: Toxicology and applied pharmacology 20080801
Title: Genetic polymorphisms in the 5'-flanking region of human UDP-glucuronosyltransferase 2B7 affect the Nrf2-dependent transcriptional regulation.
Journal: Pharmacogenetics and genomics 20080801
Title: Stress-associated hormone, norepinephrine, increases proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary agent, sulforaphane.
Journal: International journal of oncology 20080801
Title: Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates.
Journal: Nutrition reviews 20080801
Title: Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo(a)pyrene and their mode of action.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701
Title: The transcription factor Nrf2 is a therapeutic target against brain inflammation.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080701
Title: Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells.
Journal: Cancer research 20080701
Title: Direct and indirect antioxidant properties of inducers of cytoprotective proteins.
Journal: Molecular nutrition & food research 20080601
Title: Translating knowledge generated by epidemiological and in vitro studies into dietary cancer prevention.
Journal: Molecular nutrition & food research 20080601
Title: Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme.
Journal: Biochemical pharmacology 20080601
Title: The diet-derived sulforaphane inhibits matrix metalloproteinase-9-activated human brain microvascular endothelial cell migration and tubulogenesis.
Journal: Molecular nutrition & food research 20080601
Title: Putative mechanisms of action for indole-3-carbinol in the prevention of colorectal cancer.
Journal: Expert opinion on therapeutic targets 20080601
Title: Growth inhibition of a spectrum of bacterial and fungal pathogens by sulforaphane, an isothiocyanate product found in broccoli and other cruciferous vegetables.
Journal: Planta medica 20080601
Title: Demonstration by redox fluorometry that sulforaphane protects retinal pigment epithelial cells against oxidative stress.
Journal: Investigative ophthalmology & visual science 20080601
Title: Resveratrol in prevention and treatment of common clinical conditions of aging.
Journal: Clinical interventions in aging 20080601
Title: Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells.
Journal: The Journal of allergy and clinical immunology 20080501
Title: Protective effects of an extract of young radish (Raphanus sativus L) cultivated with sulfur (sulfur-radish extract) and of sulforaphane on carbon tetrachloride-induced hepatotoxicity.
Journal: Bioscience, biotechnology, and biochemistry 20080501
Title: Sulforaphane and erucin increase MRP1 and MRP2 in human carcinoma cell lines.
Journal: The Journal of nutritional biochemistry 20080401
Title: Liquid microjunction surface sampling probe electrospray mass spectrometry for detection of drugs and metabolites in thin tissue sections.
Journal: Journal of mass spectrometry : JMS 20080401
Title: Synergistic neurotoxic effects of arsenic and dopamine in human dopaminergic neuroblastoma SH-SY5Y cells.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080401
Title: Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane.
Journal: Carcinogenesis 20080401
Title: Modulation of Nrf2-dependent antioxidant functions in the RPE by Zip2, a zinc transporter protein.
Journal: Investigative ophthalmology & visual science 20080401
Title: Essential roles of the PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE.
Journal: Investigative ophthalmology & visual science 20080401
Title: Identification, synthesis, and enzymology of non-natural glucosinolate chemopreventive candidates.
Journal: Chembiochem : a European journal of chemical biology 20080325
Title: Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat.
Journal: The British journal of nutrition 20080301
Title: Cytotoxic and antioxidant activity of 4-methylthio-3-butenyl isothiocyanate from Raphanus sativus L. (Kaiware Daikon) sprouts.
Journal: Journal of agricultural and food chemistry 20080213
Title: Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells.
Journal: Pharmaceutical research 20080201
Title: The significance of Nrf2 pathway in (photo)-oxidative stress response in melanocytes and keratinocytes of the human epidermis.
Journal: Pigment cell & melanoma research 20080201
Title: Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080109
Title: Evaluation of the safety and bioactivity of purified and semi-purified glucoraphanin.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080101
Title: Dietary factors, hormesis and health.
Journal: Ageing research reviews 20080101
Title: Sulforaphane inhibition of monocyte adhesion via the suppression of ICAM-1 and NF-kappaB is dependent upon glutathione depletion in endothelial cells.
Journal: Vascular pharmacology 20080101
Title: Prevention of Oxidative Stress-Induced Retinal Pigment Epithelial Cell Death by the PPARgamma Agonists, 15-Deoxy-Delta 12, 14-Prostaglandin J(2).
Journal: PPAR research 20080101
Title: The first generation of a BAC-based physical map of Brassica rapa.
Journal: BMC genomics 20080101
Title: Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate.
Journal: PloS one 20080101
Title: Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress.
Journal: Cardiovascular toxicology 20080101
Title: Induction of differentiation in human promyelocytic cells by the isothiocyanate sulforaphane.
Journal: In vivo (Athens, Greece) 20080101
Title: Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells.
Journal: Nutrition and cancer 20080101
Title: Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia.
Journal: Chinese medicine 20080101
Title: Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway.
Journal: Mediators of inflammation 20080101
Title: Strategies for prostate cancer prevention: Review of the literature.
Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20080101
Title: Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells.
Journal: Drug design, development and therapy 20080101
Title: Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration.
Journal: Journal of inflammation research 20080101
Title: Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes.
Journal: European journal of pharmacology 20071222
Title: Broccoli extract may help reduce UV skin damage.
Journal: JAMA 20071219
Title: Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 (COX-2) expression through the modulation of multiple targets in COX-2 gene promoter.
Journal: International immunopharmacology 20071215
Title: Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: a mechanism of cancer chemoprotection.
Journal: Cancer letters 20071208
Title: Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity.
Journal: Toxicology and applied pharmacology 20071201
Title: Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage.
Journal: Stroke 20071201
Title: Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells.
Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20071201
Title: Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo.
Journal: Oncology reports 20071101
Title: Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse.
Journal: Cancer research 20071015
Title: Separation and purification of sulforaphane from broccoli seeds by solid phase extraction and preparative high-performance liquid chromatography.
Journal: Journal of agricultural and food chemistry 20071003
Title: Dietary histone deacetylase inhibitors: from cells to mice to man.
Journal: Seminars in cancer biology 20071001
Title: Sulforaphane induces growth arrest and apoptosis in human ovarian cancer cells.
Journal: Acta obstetricia et gynecologica Scandinavica 20071001
Title: Role of NF-kappaB and MAPKs in light-induced photoreceptor apoptosis.
Journal: Investigative ophthalmology & visual science 20071001
Title: Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents.
Journal: Biological chemistry 20071001
Title: Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070919
Title: Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells.
Journal: Free radical biology & medicine 20070901
Title: Keap1 eye on the target: chemoprevention of liver cancer.
Journal: Acta pharmacologica Sinica 20070901
Title: Discovery and development of sulforaphane as a cancer chemopreventive phytochemical.
Journal: Acta pharmacologica Sinica 20070901
Title: Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea).
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20070801
Title: Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line.
Journal: Molecular nutrition & food research 20070801
Title: Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro.
Journal: Carcinogenesis 20070701
Title: Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast.
Journal: Carcinogenesis 20070701
Title: Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3.
Journal: Oncology reports 20070701
Title: The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells.
Journal: Cancer research 20070701
Title: Quinone reductase induction activity of methoxylated analogues of resveratrol.
Journal: European journal of medicinal chemistry 20070601
Title: Identification of a flavin-monooxygenase as the S-oxygenating enzyme in aliphatic glucosinolate biosynthesis in Arabidopsis.
Journal: The Plant journal : for cell and molecular biology 20070601
Title: Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells.
Journal: Carcinogenesis 20070501
Title: Delay of photoreceptor degeneration in tubby mouse by sulforaphane.
Journal: Journal of neurochemistry 20070501
Title: Molecular basis for chemoprevention by sulforaphane: a comprehensive review.
Journal: Cellular and molecular life sciences : CMLS 20070501
Title: Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line.
Journal: Molecular cancer therapeutics 20070501
Title: The metabolic fate of purified glucoraphanin in F344 rats.
Journal: Journal of agricultural and food chemistry 20070418
Title: Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070401
Title: Protective effect of sulforaphane against dopaminergic cell death.
Journal: The Journal of pharmacology and experimental therapeutics 20070401
Title: Effect of meal composition and cooking duration on the fate of sulforaphane following consumption of broccoli by healthy human subjects.
Journal: The British journal of nutrition 20070401
Title: Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070401
Title: Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.
Journal: Pharmacological research 20070301
Title: Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines.
Journal: Molecular cancer therapeutics 20070301
Title: The influence of processing and preservation on the retention of health-promoting compounds in broccoli.
Journal: Journal of food science 20070301
Title: Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells.
Journal: Journal of agricultural and food chemistry 20070221
Title: Sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization.
Journal: Vascular pharmacology 20070201
Title: Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.
Journal: Carcinogenesis 20070201
Title: Selenium and sulforaphane modify the expression of selenoenzymes in the human endothelial cell line EAhy926 and protect cells from oxidative damage.
Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20070201
Title: Variation of glucosinolates in vegetable crops of Brassica rapa.
Journal: Phytochemistry 20070201
Title: Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects.
Journal: Experimental biology and medicine (Maywood, N.J.) 20070201
Title: Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract.
Journal: American journal of physiology. Lung cellular and molecular physiology 20070101
Title: D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1.
Journal: Carcinogenesis 20070101
Title: The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor.
Journal: Molecular pharmacology 20070101
Title: Sulforaphane as a promising molecule for fighting cancer.
Journal: Mutation research 20070101
Title: Antiproliferative activity of sulforaphane in Akt-overexpressing ovarian cancer cells.
Journal: Molecular cancer therapeutics 20070101
Title: Differential response of human healthy lymphoblastoid and CCRF-SB leukemia cells to sulforaphane and its two analogues: 2-oxohexyl isothiocyanate and alyssin.
Journal: Pharmacological reports : PR 20070101
Title: Combination of doxorubicin and sulforaphane for reversing doxorubicin-resistant phenotype in mouse fibroblasts with p53Ser220 mutation.
Journal: Annals of the New York Academy of Sciences 20070101
Title: Diet, genetic polymorphisms, detoxification, and health risks.
Journal: Alternative therapies in health and medicine 20070101
Title: Chemoprotection against cancer: an idea whose time has come.
Journal: Alternative therapies in health and medicine 20070101
Title: Cell-cycle specificity of sulforaphane-mediated apoptosis in Jurkat T-leukemia cells.
Journal: In vivo (Athens, Greece) 20070101
Title: MAK-4 and -5 supplemented diet inhibits liver carcinogenesis in mice.
Journal: BMC complementary and alternative medicine 20070101
Title: Minocycline and sulforaphane inhibited lipopolysaccharide-mediated retinal microglial activation.
Journal: Molecular vision 20070101
Title: Modulation of cell-mediated immune response in B16F-10 melanoma-induced metastatic tumor-bearing C57BL/6 mice by sulforaphane.
Journal: Immunopharmacology and immunotoxicology 20070101
Title: Antioxidant enzyme induction: a new protective approach against the adverse effects of diesel exhaust particles.
Journal: Inhalation toxicology 20070101
Title: The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase.
Journal: BMC cancer 20070101
Title: Human agonistic TRAIL receptor antibodies Mapatumumab and Lexatumumab induce apoptosis in malignant mesothelioma and act synergistically with cisplatin.
Journal: Molecular cancer 20070101
Title: In vitro antiproliferative effects of sulforaphane on human colon cancer cell line SW620.
Journal: Acta medica (Hradec Kralove) 20070101
Title: Genomic loci modulating the retinal transcriptome in wound healing.
Journal: Gene regulation and systems biology 20070101
Title: Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts.
Journal: Journal of agricultural and food chemistry 20061213
Title: PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex.
Journal: The Journal of biological chemistry 20061208
Title: Quantitative measurement of sulforaphane, iberin and their mercapturic acid pathway metabolites in human plasma and urine using liquid chromatography-tandem electrospray ionisation mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061205
Title: Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice.
Journal: Biopharmaceutics & drug disposition 20061201
Title: Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.
Journal: Cancer letters 20061118
Title: Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutations.
Journal: Mutation research 20061010
Title: Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable.
Journal: Carcinogenesis 20061001
Title: Effect of sulforaphane on cell growth, G(0)/G(1) phase cell progression and apoptosis in human bladder cancer T24 cells.
Journal: International journal of oncology 20061001
Title: Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters.
Journal: Cancer letters 20060928
Title: Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain.
Journal: The Journal of biological chemistry 20060915
Title: Fatal enterocolitis in Asian elephants (Elephas maximus) caused by Clostridium difficile.
Journal: Veterinary microbiology 20060910
Title: Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells.
Journal: Carcinogenesis 20060901
Title: Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane.
Journal: Neuroscience 20060901
Title: Phase II enzymes induction blocks the enhanced IgE production in B cells by diesel exhaust particles.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20060901
Title: Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells.
Journal: Cancer research 20060901
Title: Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts.
Journal: Cancer letters 20060828
Title: Simultaneous determination of sulforaphane and its major metabolites from biological matrices with liquid chromatography-tandem mass spectroscopy.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060818
Title: Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.
Journal: Cancer research 20060815
Title: Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation.
Journal: The Journal of allergy and clinical immunology 20060801
Title: Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer.
Journal: Free radical research 20060801
Title: Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae.
Journal: Mutation research 20060725
Title: Haplotype-environment interactions that regulate the human glutathione S-transferase P1 promoter.
Journal: Cancer research 20060615
Title: Dietary agents as histone deacetylase inhibitors.
Journal: Molecular carcinogenesis 20060601
Title: Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells.
Journal: Cancer research 20060601
Title: Antimetastatic activity of Sulforaphane.
Journal: Life sciences 20060522
Title: Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion.
Journal: Cancer letters 20060508
Title: Aqueous extracts of selenium-fertilized broccoli increase selenoprotein activity and inhibit DNA single-strand breaks, but decrease the activity of quinone reductase in Hepa 1c1c7 cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060501
Title: Evaporative light-scattering analysis of sulforaphane in broccoli samples: Quality of broccoli products regarding sulforaphane contents.
Journal: Journal of agricultural and food chemistry 20060405
Title: Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells.
Journal: Carcinogenesis 20060401
Title: Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane.
Journal: Current drug targets 20060401
Title: Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract.
Journal: Molecular cancer therapeutics 20060401
Title: Isothiocyanates stimulating oviposition by the diamondback moth, Plutella xylostella.
Journal: Journal of chemical ecology 20060401
Title: Epithiospecifier protein from broccoli (Brassica oleracea L. ssp. italica) inhibits formation of the anticancer agent sulforaphane.
Journal: Journal of agricultural and food chemistry 20060322
Title: Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, induces phase-I xenobiotic metabolizing enzymes and increases free radical generation in rat liver.
Journal: Mutation research 20060320
Title: Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.
Journal: FEBS letters 20060320
Title: Effect of isothiocyanates on nuclear accumulation of NF-kappaB, Nrf2, and thioredoxin in caco-2 cells.
Journal: Journal of agricultural and food chemistry 20060308
Title: ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.
Journal: Carcinogenesis 20060301
Title: The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells.
Journal: The Journal of pharmacology and experimental therapeutics 20060301
Title: Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301
Title: The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells.
Journal: Anti-cancer drugs 20060301
Title: Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis.
Journal: Current cancer drug targets 20060301
Title: Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention.
Journal: Molecular cancer therapeutics 20060301
Title: Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza.
Journal: Journal of natural products 20060301
Title: Quinone reductase induction as a biomarker for cancer chemoprevention.
Journal: Journal of natural products 20060301
Title: Suppressive effects of young radish cultivated with sulfur on growth and metastasis of B16-F10 melanoma cells.
Journal: Archives of pharmacal research 20060301
Title: Chemoprotection by sulforaphane: keep one eye beyond Keap1.
Journal: Cancer letters 20060227
Title: p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.
Journal: Cancer chemotherapy and pharmacology 20060201
Title: Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?
Journal: Carcinogenesis 20060201
Title: Dietary approaches to positively influence fetal determinants of adult health.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060201
Title: Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.
Journal: Cancer research 20060201
Title: Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents.
Journal: Neuroscience letters 20060130
Title: Cancer chemopreventive activity of sulforamate derivatives.
Journal: European journal of medicinal chemistry 20060101
Title: Application of sulforaphane: histopathological study of intraportal transplanted pancreatic islets into livers of diabetic rats.
Journal: Transplantation proceedings 20060101
Title: Modest induction of phase 2 enzyme activity in the F-344 rat prostate.
Journal: BMC cancer 20060101
Title: Indirect antioxidant protection against photooxidative processes initiated in retinal pigment epithelial cells by a lipofuscin pigment.
Journal: Rejuvenation research 20060101
Title: Sulforaphane induces inhibition of human umbilical vein endothelial cells proliferation by apoptosis.
Journal: Angiogenesis 20060101
Title: Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.
Journal: Nutrition and cancer 20060101
Title: Pretreatment of human epidermal keratinocytes with D,L-sulforaphane protects against sulfur mustard cytotoxicity.
Journal: Cutaneous and ocular toxicology 20060101
Title: Augmentation of natural killer cell and antibody-dependent cellular cytotoxicity in BALB/c mice by sulforaphane, a naturally occurring isothiocyanate from broccoli through enhanced production of cytokines IL-2 and IFN-gamma.
Journal: Immunopharmacology and immunotoxicology 20060101
Title: Ethanol sensitivity: a central role for CREB transcription regulation in the cerebellum.
Journal: BMC genomics 20060101
Title: Sulforaphane inhibits osteoclastogenesis by inhibiting nuclear factor-kappaB.
Journal: Molecules and cells 20051231
Title: Purification of sulforaphane from Brassica oleracea seed meal using low-pressure column chromatography.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051215
Title: Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells.
Journal: Toxicology and applied pharmacology 20051201
Title: Effect of sulforaphane on micronucleus induction in cultured human lymphocytes by four different mutagens.
Journal: Environmental and molecular mutagenesis 20051201
Title: Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells.
Journal: Carcinogenesis 20051201
Title: Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane.
Journal: Chemical research in toxicology 20051201
Title: An anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of Morinda citrifolia (noni).
Journal: Journal of natural products 20051201
Title: Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury.
Journal: Journal of neuroscience research 20051115
Title: Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity.
Journal: International journal of cancer 20051110
Title: Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20051101
Title: [Effects of sulforaphane-rich broccoli sprouts on H. pylori-infected gastric mucosa].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20051101
Title: Chinese cabbage extracts and sulforaphane can protect H2O2-induced inhibition of gap junctional intercellular communication through the inactivation of ERK1/2 and p38 MAP kinases.
Journal: Journal of agricultural and food chemistry 20051019
Title: Overexpression of regucalcin suppresses cell proliferation of cloned normal rat kidney proximal tubular epithelial NRK52E cells.
Journal: International journal of molecular medicine 20051001
Title: Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051001
Title: Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
Journal: Cancer research 20050915
Title: Effect of NQO1 induction on the antitumor activity of RH1 in human tumors in vitro and in vivo.
Journal: Cancer chemotherapy and pharmacology 20050901
Title: Detoxication enzyme inducers modify cytokine production in rat mixed glial cells.
Journal: Journal of neuroimmunology 20050901
Title: Overexpression of regucalcin suppresses cell proliferation in cloned rat hepatoma H4-II-E cells: involvement of intracellular signaling factors and cell cycle-related genes.
Journal: Journal of cellular biochemistry 20050815
Title: Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif.
Journal: The Journal of biological chemistry 20050805
Title: Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells.
Journal: Molecular cancer therapeutics 20050801
Title: Phytochemicals in broccoli transcriptionally induce thioredoxin reductase.
Journal: Journal of agricultural and food chemistry 20050713
Title: Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.
Journal: Oncogene 20050630
Title: Nrf2 as a novel molecular target for chemoprevention.
Journal: Cancer letters 20050628
Title: A mutated p53 status did not prevent the induction of apoptosis by sulforaphane, a promising anti-cancer drug.
Journal: Investigational new drugs 20050601
Title: Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells.
Journal: Biochemical pharmacology 20050601
Title: Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.
Journal: The Journal of biological chemistry 20050520
Title: Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.
Journal: Biochemistry 20050510
Title: Overexpression of regucalcin suppresses apoptotic cell death in the cloned rat hepatoma H4-II-E cells induced by a naturally occurring isothiocyanate sulforaphane.
Journal: International journal of molecular medicine 20050501
Title: Direct antioxidant activity of purified glucoerucin, the dietary secondary metabolite contained in rocket (Eruca sativa Mill.) seeds and sprouts.
Journal: Journal of agricultural and food chemistry 20050406
Title: Micronucleus formation and induction of apoptosis by different isothiocyanates and a mixture of isothiocyanates in human lymphocyte cultures.
Journal: Mutation research 20050404
Title: Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations.
Journal: Oncology reports 20050401
Title: Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pylori.
Journal: Planta medica 20050401
Title: Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.
Journal: Journal of biochemistry and molecular biology 20050331
Title: [Induction of uridine 5'-diphosphate-glucuronosyltransferase gene expression by sulforaphane and its mechanism: experimental study in human colon cancel cells].
Journal: Zhonghua yi xue za zhi 20050330
Title: Sulforaphane, erucin, and iberin up-regulate thioredoxin reductase 1 expression in human MCF-7 cells.
Journal: Journal of agricultural and food chemistry 20050309
Title: Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice.
Journal: Investigative ophthalmology & visual science 20050301
Title: Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent.
Journal: Cancer research 20050301
Title: Induction of phase I, II and III drug metabolism/transport by xenobiotics.
Journal: Archives of pharmacal research 20050301
Title: Effects of dietary chemopreventive phytochemicals on P-glycoprotein function.
Journal: Biochemical and biophysical research communications 20050218
Title: Red maca (Lepidium meyenii) reduced prostate size in rats.
Journal: Reproductive biology and endocrinology : RB&E 20050101
Title: Animal models and analytical approaches for understanding the relationships between wine and cancer.
Journal: Drugs under experimental and clinical research 20050101
Title: Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines.
Journal: Anticancer research 20050101
Title: Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells.
Journal: Journal of medicinal food 20050101
Title: Cultivation conditions and selenium fertilization alter the phenolic profile, glucosinolate, and sulforaphane content of broccoli.
Journal: Journal of medicinal food 20050101
Title: Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells.
Journal: Nutrition and cancer 20050101
Title: Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress.
Journal: Inflammopharmacology 20050101
Title: Time-dependent modulation of thioredoxin reductase activity might contribute to sulforaphane-mediated inhibition of NF-kappaB binding to DNA.
Journal: Antioxidants & redox signaling 20050101
Title: Oltipraz, 3H-1,2-dithiole-3-thione, and sulforaphane induce overlapping and protective antioxidant responses in murine microglial cells.
Journal: Toxicology letters 20041128
Title: Ebselen augments its peroxidase activity by inducing nrf-2-dependent transcription.
Journal: Archives of biochemistry and biophysics 20041115
Title: Phase II enzyme inducer, sulforaphane, inhibits UVB-induced AP-1 activation in human keratinocytes by a novel mechanism.
Journal: Molecular carcinogenesis 20041101
Title: Sulforaphane halts breast cancer cell growth.
Journal: Drug discovery today 20041101
Title: Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo.
Journal: British journal of cancer 20041018
Title: The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.
Journal: Molecular cancer therapeutics 20041001
Title: Isothiocyanates as novel cytotoxic and cytostatic agents: molecular pathway on human transformed and non-transformed cells.
Journal: Biochemical pharmacology 20040915
Title: Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells.
Journal: Carcinogenesis 20040901
Title: Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines.
Journal: Experimental biology and medicine (Maywood, N.J.) 20040901
Title: A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.
Journal: Cancer research 20040815
Title: Oral broccoli sprouts for the treatment of Helicobacter pylori infection: a preliminary report.
Journal: Digestive diseases and sciences 20040801
Title: In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat.
Journal: The Journal of pharmacology and experimental therapeutics 20040701
Title: Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040701
Title: Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.
Journal: The Journal of biological chemistry 20040611
Title: Broccoli consumption and chronic atrophic gastritis among Japanese males: an epidemiological investigation.
Journal: Acta medica Okayama 20040601
Title: Heating decreases epithiospecifier protein activity and increases sulforaphane formation in broccoli.
Journal: Phytochemistry 20040501
Title: Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds.
Journal: Journal of agricultural and food chemistry 20040407
Title: Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line.
Journal: Pharmaceutical research 20040401
Title: Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway.
Journal: Pharmaceutical research 20040401
Title: Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium.
Journal: Integrative cancer therapies 20040301
Title: Glucoraphanin and 4-hydroxyglucobrassicin contents in seeds of 59 cultivars of broccoli, raab, kohlrabi, radish, cauliflower, brussels sprouts, kale, and cabbage.
Journal: Journal of agricultural and food chemistry 20040225
Title: Cellular accumulation of dietary anticarcinogenic isothiocyanates is followed by transporter-mediated export as dithiocarbamates.
Journal: Cancer letters 20040210
Title: Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040204
Title: Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization.
Journal: Carcinogenesis 20040201
Title: Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables.
Journal: Cancer letters 20040108
Title: Induction of cytochrome P450, generation of oxidative stress and in vitro cell-transforming and DNA-damaging activities by glucoraphanin, the bioprecursor of the chemopreventive agent sulforaphane found in broccoli.
Journal: Carcinogenesis 20040101
Title: Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo.
Journal: Carcinogenesis 20040101
Title: Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention.
Journal: International journal of oncology 20040101
Title: Sulforaphane inhibits growth of a colon cancer cell line.
Journal: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20040101
Title: Effects of different processing methods on induction of quinone reductase by dietary broccoli in rats.
Journal: Journal of medicinal food 20040101
Title: Effects of dietary anticarcinogens and nonsteroidal anti-inflammatory drugs on rat gastrointestinal UDP-glucuronosyltransferases.
Journal: Anticancer research 20040101
Title: Inhibition by allyl sulfides and phenethyl isothiocyanate of methyl-n-pentylnitrosamine depentylation by rat esophageal microsomes, human and rat CYP2E1, and Rat CYP2A3.
Journal: Nutrition and cancer 20040101
Title: Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells.
Journal: Nutrition and cancer 20040101
Title: Sulforaphane-mediated induction of a phase 2 detoxifying enzyme NAD(P)H:quinone reductase and apoptosis in human lymphoblastoid cells.
Journal: Acta biochimica Polonica 20040101
Title: Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk.
Journal: Nutrition and cancer 20040101
Title: Application of sulforaphane--does it lead to improvement of islet graft survival after warm and/or cold ischemia.
Journal: Annals of transplantation 20040101
Title: Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes.
Journal: Carcinogenesis 20031201
Title: Sulforaphane modulates cell cycle and apoptosis in transformed and non-transformed human T lymphocytes.
Journal: Annals of the New York Academy of Sciences 20031201
Title: Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element.
Journal: Molecular pharmacology 20031101
Title: Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane.
Journal: Cancer research 20031101
Title: Selected isothiocyanates rapidly induce growth inhibition of cancer cells.
Journal: Molecular cancer therapeutics 20031001
Title: Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence.
Journal: The Biochemical journal 20030901
Title: Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element.
Journal: The Journal of nutrition 20030901
Title: Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria.
Journal: Journal of natural products 20030901
Title: Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase.
Journal: Journal of natural products 20030901
Title: Voltammetric and electrochemical quartz crystal microbalance studies of sulforaphane and its Zn(II) complexes.
Journal: Journal of pharmaceutical and biomedical analysis 20030808
Title: Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora.
Journal: Journal of natural products 20030801
Title: Naturally occurring Phe151Leu substitution near a conserved folding module lowers stability of glutathione transferase P1-1.
Journal: Biochimica et biophysica acta 20030626
Title: Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.
Journal: The Journal of biological chemistry 20030613
Title: Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030601
Title: Food matrix effects on bioactivity of broccoli-derived sulforaphane in liver and colon of F344 rats.
Journal: Journal of agricultural and food chemistry 20030521
Title: Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean).
Journal: Journal of natural products 20030501
Title: Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers.
Journal: Life sciences 20030404
Title: The effect of indole-3-carbinol and sulforaphane on a prostate cancer cell line.
Journal: ANZ journal of surgery 20030301
Title: Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation.
Journal: Carcinogenesis 20030301
Title: Inhibition of mutagenicity of food-derived heterocyclic amines by sulforaphane--a constituent of broccoli.
Journal: Indian journal of experimental biology 20030301
Title: Chemoprevention of cancerogenesis--the role of sulforaphane.
Journal: Acta poloniae pharmaceutica 20030101
Title: [Herb honey containing sulforaphane-aglycone with potential use in cancer prophylaxis].
Journal: Roczniki Panstwowego Zakladu Higieny 20030101
Title: Sulforaphane and 2-oxohexyl isothiocyanate induce cell growth arrest and apoptosis in L-1210 leukemia and ME-18 melanoma cells.
Journal: Oncology reports 20030101
Title: Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung.
Journal: Cancer letters 20021210
Title: Plant-derived biomolecules in fermented cabbage.
Journal: Journal of agricultural and food chemistry 20021106
Title: Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase.
Journal: Journal of natural products 20021101
Title: Cyclin D3 and p53 mediate sulforaphane-induced cell cycle delay and apoptosis in non-transformed human T lymphocytes.
Journal: Cellular and molecular life sciences : CMLS 20021101
Title: Influence of temperature and ontogeny on the levels of glucosinolates in broccoli (Brassica oleracea Var. italica) sprouts and their effect on the induction of mammalian phase 2 enzymes.
Journal: Journal of agricultural and food chemistry 20021009
Title: Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes.
Journal: Current drug metabolism 20021001
Title: Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine.
Journal: Pharmaceutical research 20021001
Title: Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.
Journal: Cancer research 20020915
Title: Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi.
Journal: Journal of medicinal chemistry 20020829
Title: Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells.
Journal: Carcinogenesis 20020801
Title: Glucosinolates of seven medicinal plants from Thailand.
Journal: Fitoterapia 20020601
Title: Glucosinolate research in the Arabidopsis era.
Journal: Trends in plant science 20020601
Title: High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate.
Journal: The Biochemical journal 20020515
Title: Induction of quinone reductase by withanolides.
Journal: Journal of natural products 20020501
Title: Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane.
Journal: Carcinogenesis 20020401
Title: Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells.
Journal: International journal of oncology 20020301
Title: A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway.
Journal: The Journal of biological chemistry 20020201
Title: Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans.
Journal: Clinica chimica acta; international journal of clinical chemistry 20020201
Title: The drug efflux pump MRP2: regulation of expression in physiopathological situations and by endogenous and exogenous compounds.
Journal: Cell biology and toxicology 20020101
Title: The cruciferous nitrile crambene has bioactivity similar to sulforaphane when administered to Fischer 344 rats but is far less potent in cell culture.
Journal: Nutrition and cancer 20020101
Title: Micronutrients and the regulation of cancerous cell growth and death: effect of sulforaphane, an isothiocyanate from broccoli.
Journal: IARC scientific publications 20020101
Title: Botanicals in cancer chemoprevention.
Journal: Cancer metastasis reviews 20020101
Title: Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile.
Journal: Journal of agricultural and food chemistry 20011201
Title: Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of Phase 2 detoxification enzymes.
Journal: Carcinogenesis 20011201
Title: The impaired glutathione system and its up-regulation by sulforaphane in vascular smooth muscle cells from spontaneously hypertensive rats.
Journal: Journal of hypertension 20011001
Title: Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens.
Journal: Mutation research 20010901
Title: Potent induction of phase 2 enzymes in human prostate cells by sulforaphane.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010901
Title: Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes.
Journal: Chemical research in toxicology 20010901
Title: A review of cancer chemopreventive agents.
Journal: Current medicinal chemistry 20010901
Title: Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms.
Journal: The Journal of biological chemistry 20010824
Title: The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.
Journal: Cancer research 20010415
Title: Study of the role of antimicrobial glucosinolate-derived isothiocyanates in resistance of Arabidopsis to microbial pathogens.
Journal: Plant physiology 20010401
Title: Preparative HPLC method for the purification of sulforaphane and sulforaphane nitrile from Brassica oleracea.
Journal: Journal of agricultural and food chemistry 20010401
Title: Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane.
Journal: Biochemical and biophysical research communications 20010323
Title: Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanates.
Journal: Carcinogenesis 20010301
Title: The importance of using scientific principles in the development of medicinal agents from plants.
Journal: Academic medicine : journal of the Association of American Medical Colleges 20010301
Title: Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dioxygenases control glucosinolate biosynthesis in Arabidopsis.
Journal: The Plant cell 20010301
Title: Inhibition of CYP2E1 with natural agents may be a feasible strategy for minimizing the hepatotoxicity of ethanol.
Journal: Medical hypotheses 20010101
Title: Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).
Journal: Drug metabolism reviews 20010101
Title: Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane.
Journal: Chemical research in toxicology 20000401
Title: Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels.
Journal: Carcinogenesis 19981101
Title: Electrophile and antioxidant regulation of enzymes that detoxify carcinogens.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19950912
Title: Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases.
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Title: A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19920315
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