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4494-26-2,MFCD01689820
Catalog No.:AA003MP4

4494-26-2 | 5-Formyl-2'-deoxyuridine

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250mg
95%
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$312.00   $218.00
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1g
95%
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$950.00   $665.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003MP4
Chemical Name:
5-Formyl-2'-deoxyuridine
CAS Number:
4494-26-2
Molecular Formula:
C10H12N2O6
Molecular Weight:
256.2121
MDL Number:
MFCD01689820
SMILES:
OC[C@H]1O[C@H](C[C@@H]1O)n1cc(C=O)c(=O)[nH]c1=O
Properties
Properties
 
Form:
Solid  
MP:
162 - 164°C  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
421  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
-1.9  

Literature

Title: Design and synthesis of 3-carbamoylbenzoic acid derivatives as inhibitors of human apurinic/apyrimidinic endonuclease 1 (APE1).

Journal: ChemMedChem 20121001

Title: Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines.

Journal: Bioorganic & medicinal chemistry 20120101

Title: ATP chemosensitivity testing of new antitumor duplex drugs linking 3`-C-ethynylycytidine (ECyd) and 2´-deoxy-5-fluorouridine (5-FdU) in comparison to standard cytostatica and combinations thereof.

Journal: Investigational new drugs 20110601

Title: Quantification of oxidative DNA lesions in tissues of Long-Evans Cinnamon rats by capillary high-performance liquid chromatography-tandem mass spectrometry coupled with stable isotope-dilution method.

Journal: Analytical chemistry 20110315

Title: Selective detection of 5-formyl-2'-deoxyuridine, an oxidative lesion of thymidine, in DNA by a fluorogenic reagent.

Journal: Angewandte Chemie (International ed. in English) 20101102

Title: Solvent-free synthesis of pyrimidine nucleoside-aminophosphonate hybrids and their biological activity evaluation.

Journal: Nucleosides, nucleotides & nucleic acids 20100801

Title: Synthesis and properties of new fluorescent nucleosides and oligodeoxynucleotides derived from 5-formyl-2'-deoxyuridine.

Journal: Nucleic acids symposium series (2004) 20090101

Title: Synthesis of 5-formyl-2'-deoxyuridine and its incorporation into oligodeoxynucleotides.

Journal: Current protocols in nucleic acid chemistry 20081201

Title: Novel enamine derivatives of 5,6-dihydro-2'-deoxyuridine formed in reductive amination of 5-formyl-2'-deoxyuridine.

Journal: Nucleosides, nucleotides & nucleic acids 20080901

Title: Development of a novel selective detection method for 5-formyl-2'-deoxyuridine by fluorescent derivatization.

Journal: Nucleic acids symposium series (2004) 20080101

Title: Derivatization with Girard reagent T combined with LC-MS/MS for the sensitive detection of 5-formyl-2'-deoxyuridine in cellular DNA.

Journal: Analytical chemistry 20070101

Title: Structurally diverse 5-substituted pyrimidine nucleosides as inhibitors of Leishmania donovani promastigotes in vitro.

Journal: Bioorganic & medicinal chemistry letters 20061001

Title: 5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity.

Journal: Journal of medicinal chemistry 20060601

Title: [Synthesis and antiviral activity of new 5-substituted 2'-deoxyuridine derivatives].

Journal: Bioorganicheskaia khimiia 20050101

Title: Aggregation of RecA-derived peptides on single-stranded oligonucleotides triggered by schiff base-mediated crosslinking.

Journal: Bioorganic & medicinal chemistry letters 20030901

Title: Water mediated Dickerson-Drew-type crystal of DNA dodecamer containing 2'-deoxy-5-formyluridine.

Journal: Biophysical chemistry 20020328

Title: Mutations induced by 5-formyl-2'-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine.

Journal: Mutation research 20010509

Title: 5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism.

Journal: Toxicology letters 20010203

Title: Crystallization and preliminary X-ray analysis of a DNA dodecamer containing 2'-deoxy-5-formyluridine; what is the role of magnesium cation in crystallization of Dickerson-type DNA dodecamers?

Journal: Acta crystallographica. Section D, Biological crystallography 20010201

Title: Chemical cross-linking of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine.

Journal: Nucleosides, nucleotides & nucleic acids 20010101

Title: Evidence for a Schiff base formation of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine.

Journal: Nucleic acids research. Supplement (2001) 20010101

Title: X-ray analyses of DNA dodecamers containing 2'-deoxy-5-formyluridine.

Journal: Nucleic acids research. Supplement (2001) 20010101

Title: Antiherpes activity of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil and some other 5-substituted uracil arabinosyl nucleosides in two different cell lines.

Journal: Antiviral research 19830901

Title: Efficiency and selectivity of (E)-5-(2-bromovinyl)-2'-deoxyuridine and some other 5-substituted 2'-deoxypyrimidine nucleosides as anti-herpes agents.

Journal: Antiviral research 19820501

Title: Antiviral activity of 5-methylthiomethyl-2'-deoxyuridine and other 5-substituted 2'-deoxyuridines.

Journal: Biochemical pharmacology 19791115

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Tags:4494-26-2 Molecular Formula|4494-26-2 MDL|4494-26-2 SMILES|4494-26-2 5-Formyl-2'-deoxyuridine