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464-74-4,MFCD01740820
Catalog No.:AA00DB5C

464-74-4 | arenobufagin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$89.00   $62.00
- +
5mg
≥95%
in stock  
$238.00   $166.00
- +
25mg
95%
in stock  
$368.00   $258.00
- +
100mg
95%
in stock  
$1,157.00   $810.00
- +
250mg
95%
in stock  
$1,839.00   $1,288.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DB5C
Chemical Name:
arenobufagin
CAS Number:
464-74-4
Molecular Formula:
C24H32O6
Molecular Weight:
416.5073
MDL Number:
MFCD01740820
SMILES:
O[C@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2[C@H](O)C(=O)[C@]2([C@]1(O)CC[C@@H]2c1ccc(=O)oc1)C)C
Properties
Computed Properties
 
Complexity:
847  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
1  
XLogP3:
1.7  

Literature

Title: Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway.

Journal: Biochemical pharmacology 20120501

Title: [Analysis on competitive interaction between arenobufagin and verapamil hydrochloride with serum albumin].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20110701

Title: [Anti-angiogenetic effect of arenobufagin in vitro and in vivo].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20110501

Title: Zhang DM, et al. Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Carcinogenesis. 2013 Jun;34(6):1331-42.

Title: Li M, et al. Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway. Biochem Pharmacol. 2012 May 1;83(9):1251-60.

Title: Cruz Jdos S, et al. Arenobufagin, a compound in toad venom, blocks Na(+)-K+ pump current in cardiac myocytes. Eur J Pharmacol. 1993 Aug 3;239(1-3):223-6.

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SDS
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