Home Other Building Blocks 469-59-0
469-59-0,MFCD01684066
Catalog No.:AA00D9OS

469-59-0 | Jervine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
95%
in stock  
$113.00   $79.00
- +
25mg
95%
in stock  
$196.00   $137.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00D9OS
Chemical Name:
Jervine
CAS Number:
469-59-0
Molecular Formula:
C27H39NO3
Molecular Weight:
425.6035
MDL Number:
MFCD01684066
SMILES:
O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2C(=O)C2=C(C)[C@]4(CC[C@@H]32)O[C@H]2[C@H]([C@H]4C)NC[C@H](C2)C)C1)C
Properties
Properties
 
BP:
592°C at 760 mmHg  
Form:
Solid  
MP:
242- 244°C  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
876  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
XLogP3:
2.9  

Literature

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: ABCG2 is required to control the sonic hedgehog pathway in side population cells with stem-like properties.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20110901

Title: FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size.

Journal: PLoS genetics 20110601

Title: Characterization and identification of steroidal alkaloids in Fritillaria species using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.

Journal: Journal of chromatography. A 20101105

Title: Modulators of the hedgehog signaling pathway.

Journal: Bioorganic & medicinal chemistry 20100915

Title: Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum.

Journal: Phytotherapy research : PTR 20100601

Title: Ingestion of false hellebore plants can cross-react with a digoxin clinical chemistry assay.

Journal: Clinical toxicology (Philadelphia, Pa.) 20100601

Title: Hedgehog signaling is required at multiple stages of zebrafish tooth development.

Journal: BMC developmental biology 20100101

Title: Synthesis of all diastereomers of the piperidine--alkaloid substructure of cyclopamine.

Journal: Organic letters 20091203

Title: Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.

Journal: PloS one 20090101

Title: Antitumor activity of extracts and compounds from the rhizomes of Veratrum dahuricum.

Journal: Phytotherapy research : PTR 20080801

Title: [Determination of jervine and veratramine in Veratrum plants using high performance liquid chromatography coupled with evaporative light scattering detection].

Journal: Se pu = Chinese journal of chromatography 20080101

Title: Isolation, purification, and full NMR assignments of cyclopamine from Veratrum californicum.

Journal: Chemistry Central journal 20080101

Title: A study on the chemical constituents of Veratrum nigrum L. processed by rice vinegar.

Journal: Journal of Asian natural products research 20080101

Title: Accidental intoxication with Veratrum album.

Journal: Journal of analytical toxicology 20080101

Title: Factors that regulate embryonic gustatory development.

Journal: BMC neuroscience 20070101

Title: Critical time window of hedgehog-dependent angiogenesis in murine yolk sac.

Journal: Microvascular research 20060301

Title: Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening.

Journal: Journal of medicinal chemistry 20050728

Title: Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development.

Journal: Developmental biology 20041215

Title: Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells.

Journal: Journal of agricultural and food chemistry 20040519

Title: Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium.

Journal: Developmental biology 20030201

Title: Development of an enzyme-linked immunosorbent assay for the veratrum plant teratogens: cyclopamine and jervine.

Journal: Journal of agricultural and food chemistry 20030129

Title: Roughing up Smoothened: chemical modulators of hedgehog signaling.

Journal: Journal of biology 20020101

Title: Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

Journal: Journal of biology 20020101

Title: Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis.

Journal: Development (Cambridge, England) 20010801

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:469-59-0 Molecular Formula|469-59-0 MDL|469-59-0 SMILES|469-59-0 Jervine