Title: Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid.
Journal: Chemical research in toxicology 20140421
Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Journal: Bioorganic & medicinal chemistry 20121115
Title: Synthesis and structure-activity relationships of lapacho analogues. 1. Suppression of human keratinocyte hyperproliferation by 2-substituted naphtho[2,3-b]furan-4,9-diones, activation by enzymatic one- and two-electron reduction, and intracellular generation of superoxide.
Journal: Journal of medicinal chemistry 20120823
Title: New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms.
Journal: Bioorganic & medicinal chemistry 20120815
Title: β-Lapachone analogs with enhanced antiproliferative activity.
Journal: European journal of medicinal chemistry 20120701
Title: An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis.
Journal: Cancer research 20120615
Title: On the search for potential anti-Trypanosoma cruzi drugs: synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions.
Journal: European journal of medicinal chemistry 20120601
Title: Screening of anti-cancer agent using zebrafish: comparison with the MTT assay.
Journal: Biochemical and biophysical research communications 20120525
Title: NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones.
Journal: Biochemical pharmacology 20120415
Title: Prevention of salt-induced renal injury by activation of NAD(P)H:quinone oxidoreductase 1, associated with NADPH oxidase.
Journal: Free radical biology & medicine 20120301
Title: Temperature-sensitive gels for intratumoral delivery of β-lapachone: effect of cyclodextrins and ethanol.
Journal: TheScientificWorldJournal 20120101
Title: No role of homologous recombination in dealing with β-lapachone cytotoxicity in yeast.
Journal: Chemical research in toxicology 20111219
Title: Preclinical genotoxicology of nor-β-lapachone in human cultured lymphocytes and Chinese hamster lung fibroblasts.
Journal: Chemical research in toxicology 20110919
Title: Corpus cavernosal smooth muscle relaxation effect of a novel AMPK activator, beta-lapachone.
Journal: The journal of sexual medicine 20110801
Title: Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity.
Journal: Cardiovascular research 20110801
Title: Synthesis and anti-Trypanosoma cruzi activity of β-lapachone analogues.
Journal: European journal of medicinal chemistry 20110701
Title: β-lapachone accelerates the recovery of burn-wound skin.
Journal: Histology and histopathology 20110701
Title: Identification of nor-β-lapachone derivatives as potential antibacterial compounds against Enterococcus faecalis clinical strain.
Journal: Current microbiology 20110201
Title: β-Lapachone-induced reactive oxygen species (ROS) generation mediates autophagic cell death in glioma U87 MG cells.
Journal: Chemico-biological interactions 20110115
Title: Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110115
Title: Trypanosoma cruzi: insights into naphthoquinone effects on growth and proteinase activity.
Journal: Experimental parasitology 20110101
Title: Hyperthermia enhances the effect of β-lapachone to cause γH2AX formations and cell death in human osteosarcoma cells.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20110101
Title: Synthesis and evaluation of quinonoid compounds against tumor cell lines.
Journal: European journal of medicinal chemistry 20110101
Title: Synthesis of biologically active (-)-dehydroiso-β-lapachone and the determination of its absolute configuration.
Journal: Chemical & pharmaceutical bulletin 20110101
Title: Endoplasmic reticulum stress-induced JNK activation is a critical event leading to mitochondria-mediated cell death caused by β-lapachone treatment.
Journal: PloS one 20110101
Title: β-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryos.
Journal: Journal of biomedical science 20110101
Title: β-lapachone significantly increases the effect of ionizing radiation to cause mitochondrial apoptosis via JNK activation in cancer cells.
Journal: PloS one 20110101
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation.
Journal: Cancer research 20101015
Title: Activity of β-lapachone derivatives against rifampicin-susceptible and -resistant strains of Mycobacterium tuberculosis.
Journal: Tuberculosis (Edinburgh, Scotland) 20100901
Title: Synthesis of naturally occurring naphthoquinone epoxides and application in the synthesis of beta-lapachone.
Journal: Organic & biomolecular chemistry 20100821
Title: Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaB.
Journal: Experimental & molecular medicine 20100531
Title: Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy.
Journal: Cancer research 20100515
Title: A naphthoquinone derivative can induce anemia through phosphatidylserine exposure-mediated erythrophagocytosis.
Journal: The Journal of pharmacology and experimental therapeutics 20100501
Title: The evaluation of quinonoid compounds against Trypanosoma cruzi: synthesis of imidazolic anthraquinones, nor-beta-lapachone derivatives and beta-lapachone-based 1,2,3-triazoles.
Journal: Bioorganic & medicinal chemistry 20100501
Title: Antifungal activity of the naphthoquinone beta-lapachone against disseminated infection with Cryptococcus neoformans var. neoformans in dexamethasone-immunosuppressed Swiss mice.
Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20100401
Title: Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol.
Journal: Bioorganic & medicinal chemistry 20100401
Title: Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt.
Journal: Journal of cellular physiology 20100201
Title: Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20091201
Title: The trypanocidal activity of naphthoquinones: a review.
Journal: Molecules (Basel, Switzerland) 20091110
Title: Cisplatin enhances the anticancer effect of beta-lapachone by upregulating NQO1.
Journal: Anti-cancer drugs 20091101
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Journal: Nature chemical biology 20091001
Title: Toxicological assessment of beta-lapachone on organs from pregnant and non-pregnant rats.
Journal: Phytotherapy research : PTR 20090901
Title: Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae.
Journal: Bioorganic & medicinal chemistry 20090901
Title: In vitro synergic effect of beta-lapachone and isoniazid on the growth of Mycobacterium fortuitum and Mycobacterium smegmatis.
Journal: Memorias do Instituto Oswaldo Cruz 20090701
Title: Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation.
Journal: Circulation research 20090410
Title: Restenosis revisited.
Journal: Circulation research 20090410
Title: Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice.
Journal: Diabetes 20090401
Title: Ex vivo activities of beta-lapachone and alpha-lapachone on macrophages: a quantitative pharmacological analysis based on amperometric monitoring of oxidative bursts by single cells.
Journal: Chembiochem : a European journal of chemical biology 20090213
Title: Photosensitizing properties of triplet beta-lapachones in acetonitrile solution.
Journal: Photochemistry and photobiology 20090101
Title: In vitro metabolism of beta-lapachone (ARQ 501) in mammalian hepatocytes and cultured human cells.
Journal: Rapid communications in mass spectrometry : RCM 20090101
Title: Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independent.
Journal: BMC cell biology 20090101
Title: Heat shock increases expression of NAD(P)H:quinone oxidoreductase (NQO1), mediator of beta-lapachone cytotoxicity, by increasing NQO1 gene activity and via Hsp70-mediated stabilisation of NQO1 protein.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20090101
Title: Modulatory effects of Tabebuia impetiginosa (Lamiales, Bignoniaceae) on doxorubicin-induced somatic mutation and recombination in Drosophila melanogaster.
Journal: Genetics and molecular biology 20090101
Title: Involvement of endoplasmic reticulum stress and activation of MAP kinases in beta-lapachone-induced human prostate cancer cell apoptosis.
Journal: Histology and histopathology 20081101
Title: Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol.
Journal: Bioorganic & medicinal chemistry letters 20081015
Title: Inner reorganization during the radical-biradical transition in a nor-beta-lapachone derivative possessing two redox centers.
Journal: Organic & biomolecular chemistry 20080921
Title: Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of ARQ 501 (beta-lapachone) in plasma and tumors from nu/nu mouse xenografts.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080901
Title: Inactivation of the SMN complex by oxidative stress.
Journal: Molecular cell 20080725
Title: Identification of the in vitro metabolites of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (ARQ 501; beta-lapachone) in whole blood.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080401
Title: Identification of a novel glucosylsulfate conjugate as a metabolite of 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione (ARQ 501, beta-lapachone) in mammals.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080401
Title: Laser flash photolysis study of the triplet reactivity of beta-lapachones.
Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20080401
Title: Beta-lapachone inhibits proliferation and induces apoptosis in retinoblastoma cell lines.
Journal: Eye (London, England) 20080301
Title: Anti-cancer effect of bio-reductive drug beta-lapachon is enhanced by activating NQO1 with heat shock.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20080301
Title: Topoisomerase inhibitors as anti-arthritic agents.
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Title: Trypanosoma cruzi: activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms.
Journal: Bioorganic & medicinal chemistry 20080115
Title: Compatibility of the antitumoral beta-lapachone with different solid dosage forms excipients.
Journal: Journal of pharmaceutical and biomedical analysis 20071130
Title: Beta-lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20071008
Title: Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells.
Journal: Bioscience, biotechnology, and biochemistry 20070901
Title: Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells.
Journal: Neoplasia (New York, N.Y.) 20070801
Title: Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
Journal: Cancer research 20070715
Title: Applications of counter-current chromatography in organic synthesis purification of heterocyclic derivatives of lapachol.
Journal: Journal of chromatography. A 20070601
Title: Involvement of NO/cGMP signaling in the apoptotic and anti-angiogenic effects of beta-lapachone on endothelial cells in vitro.
Journal: Journal of cellular physiology 20070501
Title: Anti-inflammatory effects of beta-lapachone in lipopolysaccharide-stimulated BV2 microglia.
Journal: International immunopharmacology 20070401
Title: Synthesis and pharmacophore modeling of naphthoquinone derivatives with cytotoxic activity in human promyelocytic leukemia HL-60 cell line.
Journal: Journal of medicinal chemistry 20070222
Title: Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair.
Journal: The Journal of biological chemistry 20061103
Title: Beta-lapachone activates a Mre11p-Tel1p G1/S checkpoint in budding yeast.
Journal: Cell cycle (Georgetown, Tex.) 20061101
Title: Modulating beta-lapachone release from polymer millirods through cyclodextrin complexation.
Journal: Journal of pharmaceutical sciences 20061001
Title: Oxyrane derivative of alpha-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms.
Journal: Parasitology research 20060901
Title: Synergistic effects of radiation and beta-lapachone in DU-145 human prostate cancer cells in vitro.
Journal: Radiation research 20060501
Title: Preparation of alpha-diazocarbonyl compounds from beta-lapachone derivatives and other 1,2-naphthoquinones: use of the 2D NMR 1H,15N and 1H,13C HMBC techniques in assigning regiochemistry.
Journal: Magnetic resonance in chemistry : MRC 20060401
Title: beta-lapachone induces growth inhibition and apoptosis in bladder cancer cells by modulation of Bcl-2 family and activation of caspases.
Journal: Experimental oncology 20060301
Title: Beta-lapachone, a quinone isolated from Tabebuia avellanedae, induces apoptosis in HepG2 hepatoma cell line through induction of Bax and activation of caspase.
Journal: Journal of medicinal food 20060101
Title: Heat-induced up-regulation of NAD(P)H:quinone oxidoreductase potentiates anticancer effects of beta-lapachone.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051215
Title: Effect of a beta-lapachone-derived naphthoimidazole on Trypanosoma cruzi: identification of target organelles.
Journal: The Journal of antimicrobial chemotherapy 20051201
Title: Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050415
Title: Growth inhibition of A549 human lung carcinoma cells by beta-lapachone through induction of apoptosis and inhibition of telomerase activity.
Journal: International journal of oncology 20050401
Title: Antiplasmodial activity of naphthoquinones related to lapachol and beta-lapachone.
Journal: Chemistry & biodiversity 20050201
Title: Susceptibility of cancer cells to beta-lapachone is enhanced by ionizing radiation.
Journal: International journal of radiation oncology, biology, physics 20050101
Title: Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1.
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Title: 2-Phenyl-beta-lapachone can affect mitochondrial function by redox cycling mediated oxidation.
Journal: Archives of biochemistry and biophysics 20041215
Title: Alkaline-earth cations enhance ortho-quinone-catalyzed ascorbate oxidation.
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Title: Effect of chemopreventive agents on glutathione S-transferase P1-1 gene expression mechanisms via activating protein 1 and nuclear factor kappaB inhibition.
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Title: Studies on the trypanocidal activity of semi-synthetic pyran[b-4,3]naphtho[1,2-d]imidazoles from beta-lapachone.
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Title: Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation.
Journal: The Journal of biological chemistry 20040604
Title: Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.
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Title: beta-Lapachone-induced apoptosis is associated with activation of caspase-3 and inactivation of NF-kappaB in human colon cancer HCT-116 cells.
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Title: Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells.
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