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Home Other Building Blocks 473278-54-5
473278-54-5,MFCD02682962
Catalog No.:AA00DFD8

473278-54-5 | 2'-O-(2-Methoxyethyl)-guanosine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
97%
in stock  
$24.00   $17.00
- +
250mg
97%
in stock  
$36.00   $25.00
- +
1g
97%
in stock  
$91.00   $64.00
- +
5g
97%
in stock  
$212.00   $149.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DFD8
Chemical Name:
2'-O-(2-Methoxyethyl)-guanosine
CAS Number:
473278-54-5
Molecular Formula:
C13H19N5O6
Molecular Weight:
341.3199
MDL Number:
MFCD02682962
SMILES:
COCCO[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1nc(N)[nH]c2=O)CO
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
505  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  
XLogP3:
-1.5  

Upstream Synthesis Route

[1]Nucleosides,nucleotidesandnucleicacids,2003,vol.22,#5-8,p.583-587

[2]TheJournaloforganicchemistry,2002,vol.67,#22,p.7887-7889

[3]Patent:US2003/225262,2003,A1,.Locationinpatent:Pagecolumn34-35

[1]Patent:US2008/234475,2008,A1,.Locationinpatent:Page/Pagecolumn8

[2]Patent:US2008/234475,2008,A1,.Locationinpatent:Page/Pagecolumn8

[1]Nucleosides,NucleotidesandNucleicAcids,2008,vol.27,#9,p.1024-1033

[1]Nucleosides,NucleotidesandNucleicAcids,2003,vol.22,#5-8,p.1327-1330

[1]Nucleosides,nucleotidesandnucleicacids,2003,vol.22,#5-8,p.583-587

Literature

Title: Process research on the preparation of DMT protected 2'-O-methoxyethylguanosine for oligonucleotide synthesis in therapeutic applications.

Journal: Nucleosides, nucleotides & nucleic acids 20080901

Title: Synthesis of 2'-O-methoxyethylguanosine using a novel silicon-based protecting group.

Journal: The Journal of organic chemistry 20021101

Title: McPherson AK, et, al. An Improved Process for the Manufacture of 5′-O-(4,4′-Dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine. Org. Process Res. Dev. 2020, 24, 11, 2583-2590.

Title: Saleh AF, et, al. 2'-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells. Toxicol Sci. 2018 May 1;163(1):70-78.

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SDS
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