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486-21-5,MFCD00221757
Catalog No.:AA0038ZF

486-21-5 | Isofraxidin

Pack Size
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5mg
95%
in stock  
$81.00   $57.00
- +
10mg
98% by HPLC
in stock  
$116.00   $81.00
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25mg
98% by HPLC
in stock  
$174.00   $122.00
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50mg
98% by HPLC
in stock  
$250.00   $175.00
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100mg
98% by HPLC
in stock  
$386.00   $270.00
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250mg
95%
in stock  
$808.00   $565.00
- +
500mg
98% by HPLC
in stock  
$1,103.00   $772.00
- +
1000mg
98% by HPLC
in stock  
$1,726.00   $1,208.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0038ZF
Chemical Name:
Isofraxidin
CAS Number:
486-21-5
Molecular Formula:
C11H10O5
Molecular Weight:
222.1941
MDL Number:
MFCD00221757
SMILES:
COc1c(O)c(OC)cc2c1oc(=O)cc2
NSC Number:
324637
Properties
Computed Properties
 
Complexity:
301  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
1.5  

Downstream Synthesis Route

[1]Spaeth;Jerzmanowska-Sienkiewiczowa[ChemischeBerichte,1937,vol.70,p.1672,1676]

[1]Janotetal.[BulletindelaSocietedeChimieBiologique,1955,vol.37,p.361,364]Spaeth;Jerzmanowska-Sienkiewiczowa[ChemischeBerichte,1937,vol.70,p.1019]Narantuyaa,S.;Batsuren,D.;Batirov,E.Kh.;Malikov,V.M.[ChemistryofNaturalCompounds,1986,vol.22,#2,p.228-229][KhimiyaPrirodnykhSoedinenii,1986,#2,p.243-244]

[2]Tsukamoto;Hisada;Nishibe[ChemicalandPharmaceuticalBulletin,1985,vol.33,#9,p.4069-4073]

[3]Bhandari,Prabha;Tandon,Sheela;Rastogi,R.P.[Phytochemistry,1980,vol.19,p.1554-1555]

[1]Ahluwaliaetal.[Tetrahedron,1959,vol.5,p.90]

[1]Janotetal.[BulletindelaSocietedeChimieBiologique,1955,vol.37,p.361,364]

Coniferin 
  486-21-5 

[1]Kozawa;Matsuyama;Fukumoto;Baba[ChemicalandPharmaceuticalBulletin,1983,vol.31,#1,p.64-69]

[2]Malmberg,A.;Theander,O.[Phytochemistry,1980,vol.19,p.1739]

Literature

Title: Isofraxidin exhibited anti-inflammatory effects in vivo and inhibited TNF-α production in LPS-induced mouse peritoneal macrophages in vitro via the MAPK pathway.

Journal: International immunopharmacology 20121001

Title: Simultaneous quantification of five bioactive components of Acanthopanax senticosus and its extract by ultra performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry.

Journal: Molecules (Basel, Switzerland) 20120629

Title: Enrichment and purification of syringin, eleutheroside E and isofraxidin from Acanthopanax senticosus by macroporous resin.

Journal: International journal of molecular sciences 20120101

Title: Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons.

Journal: Journal of natural medicines 20110701

Title: Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells.

Journal: Biological & pharmaceutical bulletin 20100101

Title: [Studies on flavonoid glycosides of Sarcandra glabra].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080701

Title: Authentication of the traditional medicinal plant Eleutherococcus senticosus by DNA and chemical analyses.

Journal: Planta medica 20080601

Title: (+)-Syringaresinol-di-O-beta-D-glucoside, a phenolic compound from Acanthopanax senticosus Harms, suppresses proinflammatory mediators in SW982 human synovial sarcoma cells by inhibiting activating protein-1 and/or nuclear factor-kappaB activities.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20071201

Title: A rapid and sensitive UPLC-ESI MS method for analysis of isofraxidin, a natural antistress compound, and its metabolites in rat plasma.

Journal: Journal of separation science 20071201

Title: HPLC method for preliminary analysis of constituents in rat blood after oral administration of the extract of Acanthopanax senticosus.

Journal: Journal of separation science 20071201

Title: Pharmacokinetics of isofraxidin in rat plasma after oral administration of the extract of Acanthopanax senticosus using HPLC with solid phase extraction method.

Journal: Chemical & pharmaceutical bulletin 20070901

Title: Identification of herb Acanthopanax senticosus (Rupr. Et Maxim.) harms by capillary electrophoresis with electrochemical detection.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20070601

Title: Method development for the determination of coumarin compounds by capillary electrophoresis with indirect laser-induced fluorescence detection.

Journal: Journal of chromatography. A 20070427

Title: [High-performance liquid chromatography-electrospray ionization/tandem mass spectrometry of isofraxidin in Sarcandra glabra].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20061201

Title: Simultaneous determination of protocatechuic acid, syringin, chlorogenic acid, caffeic acid, liriodendrin and isofraxidin in Acanthopanax senticosus Harms by HPLC-DAD.

Journal: Biological & pharmaceutical bulletin 20060301

Title: [Study on the extraction process for free isofraxidin and hydrolytic condition of combined isofraxidin in Ciwujia with orthogonal design].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040301

Title: Constituents and pharmacological effects of Eucommia and Siberian ginseng.

Journal: Acta pharmacologica Sinica 20011201

Title: Four new coumarin derivatives from Artemisia keiskeana.

Journal: Journal of natural products 20010801

Title: Yamazaki T, et al. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells.Biol Pharm Bull. 2010;33(10):1716-22.

Title: Jin J , et al. Isofraxidin targets the TLR4/MD-2 axis to prevent osteoarthritis development.Food Funct. 2018 Nov 14;9(11):5641-5652.

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