Indole-3-carboxaldehyde is a versatile compound with diverse applications in organic synthesis and medicinal chemistry. It serves as a crucial building block for the preparation of various indole derivatives, including complex molecules with significant biological activities. One notable application of indole-3-carboxaldehyde is its involvement in Schiff base condensation reactions, leading to the formation of multifunctional silica nano-vehicles and magnetic nanoparticles. These nanostructures hold promise in various fields, including drug delivery and catalysis. In organic synthesis, indole-3-carboxaldehyde is utilized as a starting material for the synthesis of several higher-order indoles, such as isoindolo[2,1-a]indoles, aplysinopsins, and 4-substituted-tetrahydrobenz[cd]indoles. These compounds exhibit diverse pharmacological properties and find applications in drug discovery and development.

Title: Synthesis and antimycobacterial activity of novel thiadiazolylhydrazones of 1-substituted indole-3-carboxaldehydes.

Journal: Chemical biology & drug design20140201

Title: Indiacens A and B: prenyl indoles from the myxobacterium Sandaracinus amylolyticus.

Journal: Journal of natural products20121026

Title: Antitrypanosomal alkaloids from the marine bacterium Bacillus pumilus.

Journal: Molecules (Basel, Switzerland)20120918

Title: Synthesis and characterization of some new complexes of Cu(II), Ni(II) and V(IV) with Schiff base derived from indole-3-carboxaldehyde. Biological activity on prokaryotes and eukaryotes.

Journal: European journal of medicinal chemistry20120701

Title: A new sesquiterpene from an endophytic Aspergillus versicolor strain.

Journal: Natural product communications20120701

Title: Alkaloids from the root of Isatis indigotica.

Journal: Journal of natural products20120622

Title: Synthesis and cytotoxicity of novel 2,2'-bis- and 2,2',2″-tris-indolylmethanes-based bengacarboline analogs.

Journal: Archives of pharmacal research20120601

Title: Synthesis of 5-alkylated barbituric acids and 3-alkylated indoles via microwave-assisted three-component reactions in solvent-free conditions using Hantzsch 1,4-dihydropyridines as reducing agents.

Journal: Molecular diversity20120501

Title: Translatome and metabolome effects triggered by gibberellins during rosette growth in Arabidopsis.

Journal: Journal of experimental botany20120401

Title: Update of spectroscopic data for 4-hydroxydictyolactone and dictyol E isolated from a Halimeda stuposa - Dictyota sp. assemblage.

Journal: Molecules (Basel, Switzerland)20120308

Title: (Z)-3-(1H-Indol-3-yl)-2-(3,4,5-tri-methoxy-phen-yl)acrylonitrile.

Journal: Acta crystallographica. Section E, Structure reports online20120301

Title: Novel bis(indolyl)hydrazide-hydrazones as potent cytotoxic agents.

Journal: Bioorganic & medicinal chemistry letters20120101

Title: Conjugation of a 3-(1H-phenanthro[9,10-d]imidazol-2-yl)-1H-indole intercalator to a triplex oligonucleotide and to a three-way junction.

Journal: Bioorganic & medicinal chemistry20120101

Title: 5',11'-Dihydro-dispiro-[cyclo-hexane-1,6'-indolo[3,2-b]carbazole-12',1''-cyclo-hexa-ne].

Journal: Acta crystallographica. Section E, Structure reports online20120101

Title: Interaction of cruciferous phytoanticipins with plant fungal pathogens: indole glucosinolates are not metabolized but the corresponding desulfo-derivatives and nitriles are.

Journal: Phytochemistry20111201

Title: Solvent-free, microwave assisted Knoevenagel condensation of novel 2,5-disubstituted indole analogues and their biological evaluation.

Journal: European journal of medicinal chemistry20111201

Title: Trichoderma-induced plant immunity likely involves both hormonal- and camalexin-dependent mechanisms in Arabidopsis thaliana and confers resistance against necrotrophic fungi Botrytis cinerea.

Journal: Plant signaling & behavior20111001

Title: The Arabidopsis phi class glutathione transferase AtGSTF2: binding and regulation by biologically active heterocyclic ligands.

Journal: The Biochemical journal20110815

Title: LC-MS/MS quantification of sulforaphane and indole-3-carbinol metabolites in human plasma and urine after dietary intake of selenium-fortified broccoli.

Journal: Journal of agricultural and food chemistry20110810

Title: Motile zoospores of Batrachochytrium dendrobatidis move away from antifungal metabolites produced by amphibian skin bacteria.

Journal: EcoHealth20110301

Title: Brassinin oxidase mediated transformation of the phytoalexin brassinin: structure of the elusive co-product, deuterium isotope effect and stereoselectivity.

Journal: Bioorganic & medicinal chemistry20110215

Title: Bis{benzyl 3-[(1H-indol-3-yl)methyl-idene]dithio-carbazato-κN,S}palladium(II) pyridine disolvate.

Journal: Acta crystallographica. Section E, Structure reports online20110201

Title: Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.

Journal: Journal of medicinal chemistry20110113

Title: 3-indolylacetonitrile decreases Escherichia coli O157:H7 biofilm formation and Pseudomonas aeruginosa virulence.

Journal: Environmental microbiology20110101

Title: The synthesis and spectral properties of a stimuli-responsive D-π-A charge transfer dye.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20110101

Title: Indole and 3-indolylacetonitrile inhibit spore maturation in Paenibacillus alvei.

Journal: BMC microbiology20110101

Title: Differential expression of cysteine desulfurases in soybean.

Journal: BMC plant biology20110101

Title: Production of bioactive secondary metabolites by marine vibrionaceae.

Journal: Marine drugs20110101

Title: Advancement into the Arctic region for bioactive sponge secondary metabolites.

Journal: Marine drugs20110101

Title: Structure and biological evaluation of novel cytotoxic sterol glycosides from the marine red alga Peyssonnelia sp.

Journal: Bioorganic & medicinal chemistry20101201

Title: 2-Hy-droxy-5-[(E)-(1H-indol-3-yl-methyl-idene)aza-nium-yl]benzoate.

Journal: Acta crystallographica. Section E, Structure reports online20101201

Title: Synthesis and biological activities of new furo[3,4-b]carbazoles: potential topoisomerase II inhibitors.

Journal: European journal of medicinal chemistry20101101

Title: The activity pattern and gene expression profile of aldehyde oxidase during the development of Pisum sativum seeds.

Journal: Plant science : an international journal of experimental plant biology20101101

Title: Aniline-induced tryptophan production and identification of indole derivatives from three purple bacteria.

Journal: Current microbiology20101001

Title: (E)-1-Diphenyl-methyl-idene-2-[(1H-indol-3-yl)methyl-idene]hydrazine.

Journal: Acta crystallographica. Section E, Structure reports online20100701

Title: Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: indolenyl sulfonamide derivatives.

Journal: European journal of medicinal chemistry20100301

Title: A novel role for Arabidopsis mitochondrial ABC transporter ATM3 in molybdenum cofactor biosynthesis.

Journal: The Plant cell20100201

Title: Metabolomic, transcriptional, hormonal, and signaling cross-talk in superroot2.

Journal: Molecular plant20100101

Title: Secondary metabolites of Volvariella bombycina and their inhibitory effects on melanogenesis.

Journal: Journal of microbiology and biotechnology20100101

Title: Cutaneous bacteria of the redback salamander prevent morbidity associated with a lethal disease.

Journal: PloS one20100101

Title: The effect of tegaserod on symptoms and quality of life in korean women with irritable bowel syndrome with constipation.

Journal: Journal of neurogastroenterology and motility20100101

Title: [Approaches to raising efficacy of treatment of patients with chronic prostatitis associated with intracellular infections].

Journal: Urologiia (Moscow, Russia : 1999)20100101

Title: 3,4,5-Trihydr-oxy-N'-(1H-indol-2-ylmethyl-idene)benzohydrazide-1H-indole-2-carbaldehyde azine-methanol (2/1/2).

Journal: Acta crystallographica. Section E, Structure reports online20100101

Title: Formyl- and acetylindols: vibrational spectroscopy of an expectably pharmacologically active compound family.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20091201

Title: An efficient one-step synthesis of heterobiaryl pyrazolo[3,4-b]pyridines via indole ring opening.

Journal: Organic letters20091119

Title: An expeditious I2-catalyzed entry into 6H-indolo[2,3-b]quinoline system of cryptotackieine.

Journal: The Journal of organic chemistry20091106

Title: Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities.

Journal: European journal of medicinal chemistry20091101

Title: Discovery of novel antileishmanial agents in an attempt to synthesize pentamidine-aplysinopsin hybrid molecule.

Journal: Journal of medicinal chemistry20091008

Title: Biochemical characterization and substrate specificity of the gene cluster for biosyntheses of K-252a and its analogs by in vitro heterologous expression system of Escherichia coli.

Journal: Molecular bioSystems20091001

Title: A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.

Journal: Bioorganic & medicinal chemistry letters20090901

Title: Ethyl 1-acetyl-1H-indole-3-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online20090801

Title: N'-[(E)-3-Indol-3-ylmethyl-ene]isonicotino-hydrazide monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online20090801

Title: The multifunctional enzyme CYP71B15 (PHYTOALEXIN DEFICIENT3) converts cysteine-indole-3-acetonitrile to camalexin in the indole-3-acetonitrile metabolic network of Arabidopsis thaliana.

Journal: The Plant cell20090601

Title: Aplysinopsins--marine indole alkaloids: chemistry, bioactivity and ecological significance.

Journal: Marine drugs20090601

Title: 5-Hydr-oxy-1,7-bis-(1H-indol-3-yl)hepta-1,4,6-trien-3-one hemihydrate.

Journal: Acta crystallographica. Section E, Structure reports online20090601

Title: 2-[(E)-2-(1H-Indol-3-yl)ethen-yl]-1-methyl-pyridinium 4-bromo-benzene-sulfonate.

Journal: Acta crystallographica. Section E, Structure reports online20090501

Title: Synthesis and assessment of 99mTc chelate-conjugated alendronate for development of specific radiopharmaceuticals.

Journal: Cancer biotherapy & radiopharmaceuticals20090401

Title: A combined experimental and theoretical study of the polar [3 + 2] cycloaddition of electrophilically activated carbonyl ylides with aldehydes and imines.

Journal: The Journal of organic chemistry20090306

Title: Bis{4-[(E)-2-(1H-indol-3-yl)ethen-yl]-1-methyl-pyridinium} 4-fluoro-benzene-sulfonate nitrate 0.25-hydrate.

Journal: Acta crystallographica. Section E, Structure reports online20090201

Title: Investigation of antimicrobial activities of indole-3-aldehyde hydrazide/hydrazone derivatives.

Journal: Chemotherapy20090101

Title: Synthesis, spectroscopic, and antimicrobial studies on bivalent zinc and mercury complexes of 2-formylpyridine thiosemicarbazone.

Journal: Bioinorganic chemistry and applications20090101

Title: A chromanone alkaloid from Derris ovalifolia stem.

Journal: Natural product research20090101

Title: [Production of biologically active substances of indol nature by bacteria of Azotobacter genus].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 )20090101

Title: Synthesis, Antiinflammatory and Antibacterial Activity of Novel Indolyl-isoxazoles.

Journal: Indian journal of pharmaceutical sciences20090101

Title: N-[1-(2-Hydroxy-phen-yl)ethyl-idene]-N-(1H-indol-3-ylmethyl-ene)carbonic dihydrazide.

Journal: Acta crystallographica. Section E, Structure reports online20081201

Title: Amphibian chemical defense: antifungal metabolites of the microsymbiont Janthinobacterium lividum on the salamander Plethodon cinereus.

Journal: Journal of chemical ecology20081101

Title: New Pd(II) complexes of the synthesized 1-N-substituted thiosemicarbazones of 3-indole carboxaldehyde: characterization and antiamoebic assessment against E. histolytica.

Journal: European journal of medicinal chemistry20080901

Title: AhR ligands, malassezin, and indolo[3,2-b]carbazole are selectively produced by Malassezia furfur strains isolated from seborrheic dermatitis.

Journal: The Journal of investigative dermatology20080701

Title: 1H-Indole-3-carbaldehyde thio-semi-carbazone.

Journal: Acta crystallographica. Section E, Structure reports online20080501

Title: 1H-Indole-3-carbaldehyde azine.

Journal: Acta crystallographica. Section E, Structure reports online20080301

Title: Synthesis, characterization and biological activity of Schiff base analogues of indole-3-carboxaldehyde.

Journal: European journal of medicinal chemistry20080101

Title: Highly sensitive feature detection for high resolution LC/MS.

Journal: BMC bioinformatics20080101

Title: Synthesis of novel indolyl-pyrimidine antiinflammatory, antioxidant and antibacterial agents.

Journal: Indian journal of pharmaceutical sciences20080101

Title: Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells.

Journal: Carcinogenesis20071201

Title: Inhibition of amyloid fibrillation of lysozyme by indole derivatives--possible mechanism of action.

Journal: The FEBS journal20071201

Title: [Studies on chemical constituents of Laurencia tristicha ( II )].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20071201

Title: Benhamycin, novel alkaloid from terrestrial Streptomyces sp.

Journal: Natural product research20071101

Title: Synthesis, characterization and antiamoebic activity of new indole-3-carboxaldehyde thiosemicarbazones and their Pd(II) complexes.

Journal: European journal of medicinal chemistry20071001

Title: Synthesis and novel fluorescence phenomenon of terbium complex with a new Schiff base ligand derived from condensation of triaminotriethylamine and 3-indolemethanal.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20070601

Title: Monoindole alkaloids from a marine sponge Spongosorites sp.

Journal: Marine drugs20070601

Title: Anticancer activity evaluation of kuanoniamines A and C isolated from the marine sponge Oceanapia sagittaria, collected from the Gulf of Thailand.

Journal: Marine drugs20070601

Title: [Chemical constituents from aerial parts of Plumbago zeylanica Linn].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20070501

Title: [Studies on chemical constituents in root of Isatis indigotica].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20070401

Title: Lagaspholones A and B: two new jatropholane-type diterpenes from Euphorbia lagascae.

Journal: Organic letters20070201

Title: Amorphane sesquiterpenes from a marine Streptomyces sp.

Journal: Journal of natural products20070201

Title: Toward the control of Leptosphaeria maculans: design, syntheses, biological activity, and metabolism of potential detoxification inhibitors of the crucifer phytoalexin brassinin.

Journal: Bioorganic & medicinal chemistry20060715

Title: Synthesis, anti-inflammatory and analgesic activity evaluation of some amidine and hydrazone derivatives.

Journal: Bioorganic & medicinal chemistry20060701

Title: Low molecular weight indole fragments as IMPDH inhibitors.

Journal: Bioorganic & medicinal chemistry letters20060501

Title: Enantioselective total syntheses of welwitindolinone A and fischerindoles I and G.

Journal: Journal of the American Chemical Society20051109

Title: Copper complexes of imidazole-2-, pyrrole-2- and indol-3-carbaldehyde thiosemicarbazones: inhibitory activity against fungi and bacteria.

Journal: Journal of inorganic biochemistry20051101

Title: Molecular characterization of the gallate dioxygenase from Pseudomonas putida KT2440. The prototype of a new subgroup of extradiol dioxygenases.

Journal: The Journal of biological chemistry20051021

Title: Characterization of the oxidase activity in mammalian catalase.

Journal: The Journal of biological chemistry20051021

Title: Isolation of three new naturally occurring compounds from the culture of Micromonospora sp. P1068.

Journal: Natural product research20051001

Title: Rapid access to the Welwitindolinone alkaloid skeleton by cyclization of indolecarboxaldehyde substituted cyclohexanones.

Journal: Organic letters20050915

Title: Aldehyde oxidase (AO) in the root nodules of Lupinus albus and Medicago truncatula: identification of AO in meristematic and infection zones.

Journal: Molecular plant-microbe interactions : MPMI20050501

Title: (Z)-3-(1H-Indol-3-yl)-2-(3-thienyl)acrylonitrile and (Z)-3-[1-(4-tert-butylbenzyl)-1H-indol-3-yl]-2-(3-thienyl)acrylonitrile.

Journal: Acta crystallographica. Section C, Crystal structure communications20050201

Title: Hymeniacidon perleve associated bioactive bacterium pseudomonas sp. NJ6-3-1.

Journal: Prikladnaia biokhimiia i mikrobiologiia20050101

Title: Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040801

Title: Alkaloids from the fungus Lactarius subplinthogalus.

Journal: Natural product research20040401

Title: [Synthesis of 1-indole substituted beta-carboline alkaloid and its derivatives and evaluation of their preliminary antitumor activities].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20040401

Title: Universally occurring phenylpropanoid and species-specific indolic metabolites in infected and uninfected Arabidopsis thaliana roots and leaves.

Journal: Phytochemistry20040301

Title: Complete and remarkable reversal of chemoselectivity in [4 + 2] cycloadditions involving electron-poor indoles as dienophiles. Diels-Alder versus hetero-Diels-Alder processes.

Journal: The Journal of organic chemistry20031017

Title: Three new jatrophane-type diterpenes from Euphorbia pubescens.

Journal: Planta medica20030401

Title: Isolation and identification of lateral bud growth inhibitor, indole-3-aldehyde, involved in apical dominance of pea seedlings.

Journal: Phytochemistry20021201

Title: Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva.

Journal: Planta medica20021201

Title: Peroxynitrite scavenging activities of aromatic compounds isolated from Konnyaku, Amorphophallus konjac K.Koch.

Journal: Bioscience, biotechnology, and biochemistry20020601

Title: 1,2-bis(1H-indol-3-yl)ethane-1,2-dione, an indole alkaloid from the marine sponge Smenospongia sp.

Journal: Journal of natural products20020401

Title: Chemical defenses of crucifers: elicitation and metabolism of phytoalexins and indole-3-acetonitrile in brown mustard and turnip.

Journal: Phytochemistry20020301

Title: Fate of indole-3-carbinol in cultured human breast tumor cells.

Journal: Chemical research in toxicology20020201

Title: Metabolism of tyrosine and tryptophan--new genes for old pathways.

Journal: Current opinion in plant biology20010601

Title: Structure-activity relationship for bromoindole carbaldehydes: effects on the sea urchin embryo cell cycle.

Journal: Environmental toxicology and chemistry20010301

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487-89-8 | 1H-Indole-3-carbaldehyde