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489-32-7,MFCD00210516
Catalog No.:AA00DL7E

489-32-7 | Icariin

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250mg
98%
in stock  
$13.00   $9.00
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1g
95%
in stock  
$45.00   $32.00
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5g
95%
in stock  
$145.00   $102.00
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10g
95%
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$245.00   $171.00
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25g
95%
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$477.00   $334.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DL7E
Chemical Name:
Icariin
CAS Number:
489-32-7
Molecular Formula:
C33H40O15
Molecular Weight:
676.6617
MDL Number:
MFCD00210516
SMILES:
COc1ccc(cc1)c1oc2c(CC=C(C)C)c(O[C@@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O)cc(c2c(=O)c1O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O)O
Properties
Computed Properties
 
Complexity:
1170  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Heavy Atom Count:
48  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
9  
XLogP3:
1.7  

Literature

Title: Icariin protects against intestinal ischemia-reperfusion injury.

Journal: The Journal of surgical research 20150301

Title: Protective effects of icariin-mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion-induced acute lung injury.

Journal: Molecular medicine reports 20150101

Title: Interaction of the bioactive flavonol, icariin, with the essential human solute carrier transporters.

Journal: Journal of biochemical and molecular toxicology 20140201

Title: Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice.

Journal: Toxicology and applied pharmacology 20131115

Title: Herba epimedii flavonoids suppress osteoclastic differentiation and bone resorption by inducing G2/M arrest and apoptosis.

Journal: Biochimie 20121201

Title: Icariin: a potential promoting compound for cartilage tissue engineering.

Journal: Osteoarthritis and cartilage 20121201

Title: Icariin inhibits corticosterone-induced apoptosis in hypothalamic neurons via the PI3-K/Akt signaling pathway.

Journal: Molecular medicine reports 20121101

Title: Enhancement of epimedium fried with suet oil based on in vivo formation of self-assembled flavonoid compound nanomicelles.

Journal: Molecules (Basel, Switzerland) 20121101

Title: Icariin promotes extracellular matrix synthesis and gene expression of chondrocytes in vitro.

Journal: Phytotherapy research : PTR 20120901

Title: Immunoadjuvant activity of icariin that induces Th1-type antibody in mice.

Journal: Archives of pharmacal research 20120901

Title: Icariin enhances the healing of rapid palatal expansion induced root resorption in rats.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120815

Title: Estrogenic/antiestrogenic activities of a Epimedium koreanum extract and its major components: in vitro and in vivo studies.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120801

Title: Icariin improves cognitive deficits and activates quiescent neural stem cells in aging rats.

Journal: Journal of ethnopharmacology 20120801

Title: Metabolite profiles of icariin in rat plasma by ultra-fast liquid chromatography coupled to triple-quadrupole/time-of-flight mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20120701

Title: The beneficial effect of Icariin on bone is diminished in osteoprotegerin-deficient mice.

Journal: Bone 20120701

Title: [Phenotype-based primary screening for drugs promoting neuronal subtype differentiation in embryonic stem cells with light microscope].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20120701

Title: [Variation of icariin and total flavonoid of Epimedium acuminatum in different parts and habitats].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120701

Title: Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13.

Journal: Bioorganic & medicinal chemistry letters 20120615

Title: Icarisid II, a PDE5 inhibitor from Epimedium wanshanense, increases cellular cGMP by enhancing NOS in diabetic ED rats corpus cavernosum tissue.

Journal: Andrologia 20120501

Title: Icariin associated with exercise therapy is an effective treatment for postmenopausal osteoporosis.

Journal: Chinese medical journal 20120501

Title: Effects of natural products on the function of human organic anion transporting polypeptide 1B1.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20120401

Title: [Comparative study on chemical quality of main species of epimedium].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120401

Title: Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120315

Title: Icariin stimulates MC3T3-E1 cell proliferation and differentiation through up-regulation of bone morphogenetic protein-2.

Journal: International journal of molecular medicine 20120301

Title: [Research on the preparative method of Arctigenin].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20120301

Title: A combined chitosan/nano-size hydroxyapatite system for the controlled release of icariin.

Journal: Journal of materials science. Materials in medicine 20120201

Title: Pharmacokinetics and tissue distribution profile of icariin propylene glycol-liposome intraperitoneal injection in mice.

Journal: The Journal of pharmacy and pharmacology 20120201

Title: Metabolite profiling of four major flavonoids of Herba Epimedii in zebrafish.

Journal: Molecules (Basel, Switzerland) 20120104

Title: Attenuation of LPS-induced inflammation by ICT, a derivate of icariin, via inhibition of the CD14/TLR4 signaling pathway in human monocytes.

Journal: International immunopharmacology 20120101

Title: Different molecular targets of Icariin on bMSCs in CORT and OVX -rats.

Journal: Frontiers in bioscience (Elite edition) 20120101

Title: Icariin ameliorates streptozotocin-induced diabetic retinopathy in vitro and in vivo.

Journal: International journal of molecular sciences 20120101

Title: Effects of icariside II on improving erectile function in rats with streptozotocin-induced diabetes.

Journal: Journal of andrology 20120101

Title: Effects of H(2)O(2), paraquat, and ethephon on herbal drug quality of Schiandra chinensis based on reactive oxygen species system.

Journal: Pharmacognosy magazine 20120101

Title: Effectiveness of the Novel Herbal Medicine, KIOM-MA, and Its Bioconversion Product, KIOM-MA128, on the Treatment of Atopic Dermatitis.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Icariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signaling.

Journal: PloS one 20120101

Title: Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.

Journal: Frontiers in microbiology 20120101

Title: Locating the binding sites of Pb(II) ion with human and bovine serum albumins.

Journal: PloS one 20120101

Title: Role of STAT3 in Transformation and Drug Resistance in CML.

Journal: Frontiers in oncology 20120101

Title: High-performance liquid chromatography-based multivariate analysis to predict the estrogenic activity of an Epimedium koreanum extract.

Journal: Bioscience, biotechnology, and biochemistry 20120101

Title: Changes in the intestinal absorption mechanism of icariin in the nanocavities of cyclodextrins.

Journal: International journal of nanomedicine 20120101

Title: Epimedium koreanum Extract and Its Constituent Icariin Improve Motor Dysfunction in Spinal Cord Injury.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Drug-Drug Interactions Potential of Icariin and Its Intestinal Metabolites via Inhibition of Intestinal UDP-Glucuronosyltransferases.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Protective effect of Icariin on the early stage of experimental diabetic nephropathy induced by streptozotocin via modulating transforming growth factor β1 and type IV collagen expression in rats.

Journal: Journal of ethnopharmacology 20111208

Title: The dose-effect of icariin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cells.

Journal: Molecules (Basel, Switzerland) 20111206

Title: Synergistic or antagonistic effect of MTE plus TF or icariin from Epimedium koreanum on the proliferation and differentiation of primary osteoblasts in vitro.

Journal: Biological trace element research 20111201

Title: Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.

Journal: Molecular and cellular biochemistry 20111201

Title: Rise of herbal and traditional medicine in erectile dysfunction management.

Journal: Current urology reports 20111201

Title: [Immunoregulatory mechanisms of an optimal Chinese herbal monomer compound in mice with allergic rhinitis].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20111201

Title: cGMP Signaling, Phosphodiesterases and Major Depressive Disorder.

Journal: Current neuropharmacology 20111201

Title: Icariin induces the expression of toll-like receptor 9 in ana-1 murine macrophages.

Journal: Phytotherapy research : PTR 20111101

Title: Involvement of ubiquitin-proteasome system in icariin-induced cardiomyocyte differentiation of embryonic stem cells using two-dimensional gel electrophoresis.

Journal: Journal of cellular biochemistry 20111101

Title: [Icariin and its pharmaceutical efficacy: research progress of molecular mechanism].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20111101

Title: Icariin induces apoptosis in mouse MLTC-10 Leydig tumor cells through activation of the mitochondrial pathway and down-regulation of the expression of piwil4.

Journal: International journal of oncology 20111001

Title: Effects of icariin on improving erectile function in streptozotocin-induced diabetic rats.

Journal: The journal of sexual medicine 20111001

Title: [Comparative study on absorption kinetics in intestines of rats of epimedii foliunm of Xianlinggubao capsules prepared by different processes].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111001

Title: [Study on extraction process for the icariin of hugu capsule with ultrasonic technology].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20111001

Title: [Effects of icariin on Bcl-2 and Bax protein expressions and eosinophils apoptosis in bronchial asthmatic mice].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20110901

Title: Molecular mechanism of icariin on rat asthmatic model.

Journal: Chinese medical journal 20110901

Title: [Preparation of flavonol glycoside reference standard series from Epimedium brevicornum Maxim using pilot-scale preparative high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20110901

Title: [Effects of icariin and icariside II on eNOS expression and NOS activity in porcine aorta endothelial cells].

Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20110818

Title: [Study of molecular mechanisms of fuyuan capsule, icariin and arasaponin R1 in treatment of osteoarthritis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801

Title: [Comparative study on effect of icariin and genistein on proliferation and mineralization of osteoblasts in vitro].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801

Title: Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions.

Journal: International immunopharmacology 20110701

Title: Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae.

Journal: Molecular bioSystems 20110701

Title: [Experimental study on the mechanism of icariin improving human osteoblasts proliferation and the expression of OPG protein].

Journal: Zhongguo gu shang = China journal of orthopaedics and traumatology 20110701

Title: [Effects of icariin on the proliferation, differentiation and maturation of rat calvarial osteoblasts in vitro].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110601

Title: [Icariin reduces mitochondrial oxidative stress injury in diabetic rat hearts].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601

Title: Simultaneous quantification of Panax and Epimedium species using Rapid Resolution Liquid Chromatography (RRLC).

Journal: Natural product communications 20110501

Title: Effect of icariin on bone formation during distraction osteogenesis in the rabbit mandible.

Journal: International journal of oral and maxillofacial surgery 20110401

Title: Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice.

Journal: Pharmacology, biochemistry, and behavior 20110401

Title: Icariin attenuates cardiac remodelling through down-regulating myocardial apoptosis and matrix metalloproteinase activity in rats with congestive heart failure.

Journal: The Journal of pharmacy and pharmacology 20110401

Title: A novel approach to simultaneous screening and confirmation of regulated pharmaceutical compounds in dietary supplements by LC/MS/MS with an information-dependent acquisition method.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20110401

Title: Icariin inhibits hydrogen peroxide-induced toxicity through inhibition of phosphorylation of JNK/p38 MAPK and p53 activity.

Journal: Mutation research 20110315

Title: In vivo and in vitro anti-inflammatory effects of a novel derivative of icariin.

Journal: Immunopharmacology and immunotoxicology 20110301

Title: Icariin induces mouse embryonic stem cell differentiation into beating functional cardiomyocytes.

Journal: Molecular and cellular biochemistry 20110301

Title: Icariin is more potent than genistein in promoting osteoblast differentiation and mineralization in vitro.

Journal: Journal of cellular biochemistry 20110301

Title: Neuroprotective effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons.

Journal: Brain research 20110223

Title: The effect of loading icariin on biocompatibility and bioactivity of porous β-TCP ceramic.

Journal: Journal of materials science. Materials in medicine 20110201

Title: Role of intestinal hydrolase in the absorption of prenylated flavonoids present in Yinyanghuo.

Journal: Molecules (Basel, Switzerland) 20110201

Title: [Effects of active ingredients in three kidney-tonifying Chinese herbal drugs on gene expression profile of bone marrow stromal cells from a rat model of corticosterone-induced osteoporosis].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20110201

Title: Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs/NF-κB regulated HIF-1α and PGE(2) synthesis.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20110115

Title: Simultaneous determination of seven flavonoids in dog plasma by ultra-performance liquid chromatography-tandem mass spectrometry and its application to a bioequivalence study of bioactive components in Herba Epimedii and Er-Xian Decoction.

Journal: Journal of pharmaceutical and biomedical analysis 20110105

Title: Schwann Cell Migration Induced by Earthworm Extract via Activation of PAs and MMP2/9 Mediated through ERK1/2 and p38.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Icaritin causes sustained ERK1/2 activation and induces apoptosis in human endometrial cancer cells.

Journal: PloS one 20110101

Title: Dilong: role in peripheral nerve regeneration.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings.

Journal: PloS one 20110101

Title: Calorie restriction and stroke.

Journal: Experimental & translational stroke medicine 20110101

Title: Treatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury.

Journal: Journal of neuroinflammation 20110101

Title: Effect of Cistanches Herba aqueous extract on bone loss in ovariectomized rat.

Journal: International journal of molecular sciences 20110101

Title: Pu-Erh tea and GABA attenuates oxidative stress in kainic acid-induced status epilepticus.

Journal: Journal of biomedical science 20110101

Title: Effects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopause.

Journal: Chinese medicine 20110101

Title: Neuroinflammation and cerebrovascular disease in old age: a translational medicine perspective.

Journal: Journal of aging research 20110101

Title: Chinese herb mix Tiáo-Gēng-Tāng possesses antiaging and antioxidative effects and upregulates expression of estrogen receptors alpha and beta in ovariectomized rats.

Journal: BMC complementary and alternative medicine 20110101

Title: Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans.

Journal: PloS one 20110101

Title: DNA Interaction and DNA Cleavage Studies of a New Platinum(II) Complex Containing Aliphatic and Aromatic Dinitrogen Ligands.

Journal: Bioinorganic chemistry and applications 20110101

Title: Flavonoids, apigenin and icariin exert potent melanogenic activities in murine B16 melanoma cells.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20101215

Title: Icariin, a natural flavonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway.

Journal: Cancer letters 20101208

Title: [Icariin promotes osteogenic differentiation of rat bone marrow stromal cells in vitro].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101201

Title: [Simultaneous assay of epimedin A epimedin B, epimedin C and icariin in herba epimedii by QAMS].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101201

Title: [Comparative study on the osteogenic differentiation of rat bone marrow stromal cells effected by icariin and icariside II].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20101201

Title: Icariin inhibits hydrogen peroxide-mediated cytotoxicity by up-regulating sirtuin type 1-dependent catalase and peroxiredoxin.

Journal: Basic & clinical pharmacology & toxicology 20101101

Title: Icariin-mediated differentiation of mouse adipose-derived stem cells into cardiomyocytes.

Journal: Molecular and cellular biochemistry 20101101

Title: Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells.

Journal: Neuropharmacology 20101101

Title: Icariin improves memory impairment in Alzheimer's disease model mice (5xFAD) and attenuates amyloid β-induced neurite atrophy.

Journal: Phytotherapy research : PTR 20101101

Title: Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20101001

Title: [Total flavonoids and icariin contents of Epimedium pubescens in different types of communities and their relationships with soil factors].

Journal: Ying yong sheng tai xue bao = The journal of applied ecology 20101001

Title: Analysis of biliary excretion of icariin in rats.

Journal: Journal of agricultural and food chemistry 20100922

Title: Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway.

Journal: European journal of pharmacology 20100910

Title: Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats.

Journal: Pharmacology, biochemistry, and behavior 20100901

Title: Chemical pattern-aided classification to simplify the intricacy of morphological taxonomy of Epimedium species using chromatographic fingerprinting.

Journal: Journal of pharmaceutical and biomedical analysis 20100801

Title: Preparation of icariside II from icariin by enzymatic hydrolysis method.

Journal: Fitoterapia 20100701

Title: Icariin exterts negative effects on human gastric cancer cell invasion and migration by vasodilator-stimulated phosphoprotein via Rac1 pathway.

Journal: European journal of pharmacology 20100610

Title: Involvement of androgen receptor in nitric oxide production induced by icariin in human umbilical vein endothelial cells.

Journal: FEBS letters 20100603

Title: Neuroprotective effects of icariin on memory impairment and neurochemical deficits in senescence-accelerated mouse prone 8 (SAMP8) mice.

Journal: Brain research 20100602

Title: Icariin attenuates lipopolysaccharide-induced microglial activation and resultant death of neurons by inhibiting TAK1/IKK/NF-kappaB and JNK/p38 MAPK pathways.

Journal: International immunopharmacology 20100601

Title: [Optimal combination of baicalin, icariin and Astragalus saponin I from a Chinese herbal compound Biminne].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20100601

Title: [Quality research on Epimedium cut crude drug processed with oil].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100601

Title: Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100501

Title: Liquid chromatography-tandem mass spectrometry analysis of metabolites in rats after administration of prenylflavonoids from Epimediums.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100501

Title: [Chinese medicinal monomer and compound for 60Co-gamma-induced spermatogenic disturbance in mice].

Journal: Zhonghua nan ke xue = National journal of andrology 20100501

Title: Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo.

Journal: The journal of sexual medicine 20100401

Title: [Study on preparation of icaritin by enzymolysis of icariin with snail hydrolase].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100401

Title: [Experimental study of icariin in inducing bone marrow mesenchymal stem cell differentiation].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100401

Title: Chuanxiongzine relaxes isolated corpus cavernosum strips and raises intracavernous pressure in rabbits.

Journal: International journal of impotence research 20100301

Title: Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats.

Journal: Psychoneuroendocrinology 20100201

Title: Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells.

Journal: British journal of pharmacology 20100201

Title: Icariin inhibits beta-amyloid peptide segment 25-35 induced expression of beta-secretase in rat hippocampus.

Journal: European journal of pharmacology 20100125

Title: Icariin: a potential osteoinductive compound for bone tissue engineering.

Journal: Tissue engineering. Part A 20100101

Title: An in vitro study on neuroprotective effects of serum containing Gengnianchun decoction and its main monomers against amyloid beta protein-induced cellular toxicity.

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20100101

Title: Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradation.

Journal: Nutrition research (New York, N.Y.) 20100101

Title: Icariin inhibits the increased inward calcium currents induced by amyloid-beta(25-35) peptide in CA1 pyramidal neurons of neonatal rat hippocampal slice.

Journal: The American journal of Chinese medicine 20100101

Title: Development of a EST dataset and characterization of EST-SSRs in a traditional Chinese medicinal plant, Epimedium sagittatum (Sieb. Et Zucc.) Maxim.

Journal: BMC genomics 20100101

Title: Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke.

Journal: Neuropharmacology 20100101

Title: Icariin derivative inhibits inflammation through suppression of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Anti-oxidative effects of the biennial flower of Panax notoginseng against H2O2-induced cytotoxicity in cultured PC12 cells.

Journal: Chinese medicine 20100101

Title: Interaction of bioactive coomassie brilliant blue g with protein: insights from spectroscopic methods.

Journal: Scientia pharmaceutica 20100101

Title: [Effect of icariin on the mRNA expressions of Cbfalpha1, BMP2, BMP4 in rat osteoblasts].

Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20091218

Title: Icariin inhibits neurotoxicity of beta-amyloid by upregulating cocaine-regulated and amphetamine-regulated transcripts.

Journal: Neuroreport 20091125

Title: [Research on variation regularity of five main flavonoids contents in Epimedium and processed Epimedium].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091101

Title: [Absorption and metabolism of flavonoids in Herba Epimedii via rat intestinal perfusion model].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091101

Title: Pharmacokinetics of prenylflavonoids and correlations with the dynamics of estrogen action in sera following ingestion of a standardized Epimedium extract.

Journal: Journal of pharmaceutical and biomedical analysis 20090908

Title: Protective effects of icariin on cognitive deficits induced by chronic cerebral hypoperfusion in rats.

Journal: Clinical and experimental pharmacology & physiology 20090801

Title: Synthesis and antimultidrug resistance evaluation of icariin and its derivatives.

Journal: Bioorganic & medicinal chemistry letters 20090801

Title: [Effects of icariin on expression of glucose regulated protein 78 in vascular smooth muscle cell induced by homocysteine].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090801

Title: In vivo pharmacokinetics comparisons of icariin, emodin and psoralen from gan-kang granules and extracts of herba Epimedii, Nepal dock root, Ficus hirta yahl.

Journal: Journal of ethnopharmacology 20090730

Title: Simultaneous determination of notoginsenoside R1, ginsenoside Rg1, Re, Rb1 and icariin in rat plasma by ultra-performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090715

Title: [Identifying the characteristics of FTIR spectra of herba epimedii icariin via wavelet analysis and RBF neural network].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20090701

Title: Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1.

Journal: European journal of pharmacology 20090501

Title: Antiosteoporotic activity of icariin in ovariectomized rats.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20090401

Title: [Effects of icariin on inflammation model stimulated by lipopolysaccharide in vitro and in vivo].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20090401

Title: [Sampling in quality control of medicinal materials-A case of Epimedium].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090401

Title: Simple and sensitive liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of five Epimedium prenylflavonoids in rat sera.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090101

Title: Effect of stability of internal standard on quantification of 15 flavonoids in Epimedium using CZE.

Journal: Journal of separation science 20090101

Title: [Study on the interaction of hesperidin or icariin with lysozyme by fluorescence spectroscopy].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20090101

Title: Separation and purification of epimedin A, B, C, and icariin from the medicinal herb Epimedium brevicornum maxim by dual-mode HSCCC.

Journal: Journal of chromatographic science 20090101

Title: Significant differences in alkaloid content of Coptis chinensis (Huanglian), from its related American species.

Journal: Chinese medicine 20090101

Title: Anti-proliferative efficacy of icariin on HepG2 hepatoma and its possible mechanism of action.

Journal: The American journal of Chinese medicine 20090101

Title: [Progress of pharmacological research on icariin].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081201

Title: Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells.

Journal: Biochemical and biophysical research communications 20081114

Title: [Effect of icariin on intermediate and advanced activation of murine T lymphocytes in vitro].

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20081101

Title: Intestinal absorption mechanisms of prenylated flavonoids present in the heat-processed Epimedium koreanum Nakai (Yin Yanghuo).

Journal: Pharmaceutical research 20080901

Title: Potent inhibition of human phosphodiesterase-5 by icariin derivatives.

Journal: Journal of natural products 20080901

Title: [Primary study on effect of various components of modified formula radix hedysari on peripheral nerve regeneration].

Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20080901

Title: Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitro.

Journal: Stem cells and development 20080801

Title: Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract in mice.

Journal: Indian journal of pharmacology 20080801

Title: Antiosteoporotic chemical constituents from Er-Xian Decoction, a traditional Chinese herbal formula.

Journal: Journal of ethnopharmacology 20080723

Title: Fast quality control of Herba Epimedii by using Fourier transform infrared spectroscopy.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080701

Title: Determination of icariin in rat plasma by reverse-phase high-performance liquid chromatography after oral administration of a lipid-based suspension of Epimedium koreanum extract.

Journal: Biomedical chromatography : BMC 20080601

Title: Involvement of NF-kappaB and AP-1 activation in icariin promoted cardiac differentiation of mouse embryonic stem cells.

Journal: European journal of pharmacology 20080531

Title: Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner.

Journal: Biochemical and biophysical research communications 20080502

Title: Effects of icariin combined with Panax notoginseng saponins on ischemia reperfusion-induced cognitive impairments related with oxidative stress and CA1 of hippocampal neurons in rat.

Journal: Phytotherapy research : PTR 20080501

Title: [Absorption mechanism of icariin across Caco-2 monolayer model].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501

Title: Simultaneous extraction of epimedin A, B, C and icariin from Herba Epimedii by ultrasonic technique.

Journal: Ultrasonics sonochemistry 20080401

Title: Reactive oxygen species involved in prenylflavonoids, icariin and icaritin, initiating cardiac differentiation of mouse embryonic stem cells.

Journal: Journal of cellular biochemistry 20080401

Title: Simultaneous determination of seven flavonoids in Epimedium using pressurized liquid extraction and capillary electrochromatography.

Journal: Journal of separation science 20080301

Title: A rapid method for simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and ultra-performance liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20080122

Title: Effects of total flavonoids and flavonol glycosides from Epimedium koreanum Nakai on the proliferation and differentiation of primary osteoblasts.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20080101

Title: Simultaneous quantitation of five flavonoid glycosides in Herba Epimedii by high-performance liquid chromatography-tandem mass spectrometry.

Journal: Phytochemical analysis : PCA 20080101

Title: Ethanol extract from Epimedium brevicornum attenuates left ventricular dysfunction and cardiac remodeling through down-regulating matrix metalloproteinase-2 and -9 activity and myocardial apoptosis in rats with congestive heart failure.

Journal: International journal of molecular medicine 20080101

Title: Statistically designed enzymatic hydrolysis for optimized production of icariside II as a novel melanogenesis inhibitor.

Journal: Journal of microbiology and biotechnology 20080101

Title: Chemical markers for the quality control of herbal medicines: an overview.

Journal: Chinese medicine 20080101

Title: Evidences for the Involvement of Monoaminergic and GABAergic Systems in Antidepressant-like Activity of Tinospora cordifolia in Mice.

Journal: Indian journal of pharmaceutical sciences 20080101

Title: Trace analysis of icariin in human serum with dansyl chloride derivatization after oral administration of Epimedium decoction by liquid chromatography tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071215

Title: Effect of lipid-based suspension of Epimedium koreanum Nakai extract on sexual behavior in rats.

Journal: Journal of ethnopharmacology 20071203

Title: Simultaneous determination of icariin, icariside II and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC-MS/MS.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071201

Title: Simultaneous determination of nine flavonoids and qualitative evaluation of Herba Epimedii by high performance liquid chromatography with ultraviolet detection.

Journal: Journal of separation science 20071201

Title: Protective effect of icariin on DNA against radical-induced oxidative damage.

Journal: The Journal of pharmacy and pharmacology 20071201

Title: LC-MS/MS method for the simultaneous determination of icariin and its major metabolites in rat plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20071130

Title: [Effects of Erxian Decoction and its separate prescriptions on the levels of luteinizing hormone and follicle-stimulating hormone in anterior pituitary cells from female rats].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20071101

Title: [Systematic studies on quality of main species of Herba epimedii].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071101

Title: Icariin promotes expression of PGC-1alpha, PPARalpha, and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro.

Journal: Acta pharmacologica Sinica 20071001

Title: Pharmacological activity of cardiovascular agents from herbal medicine.

Journal: Cardiovascular & hematological agents in medicinal chemistry 20071001

Title: Icariin enhances the osteogenic differentiation of bone marrow stromal cells but has no effects on the differentiation of newborn calvarial osteoblasts of rats.

Journal: Die Pharmazie 20071001

Title: Simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and high-performance liquid chromatography.

Journal: Journal of chromatography. A 20070907

Title: [Research on quality of Epimedium extract in market].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901

Title: Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro.

Journal: Life sciences 20070816

Title: Protective effects of icariin against learning and memory deficits induced by aluminium in rats.

Journal: Clinical and experimental pharmacology & physiology 20070801

Title: Hypouricemic action of selected flavonoids in mice: structure-activity relationships.

Journal: Biological & pharmaceutical bulletin 20070801

Title: [HPLC-MS3 analysis of chemical constituents in Epimedium brevicornum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070801

Title: Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20070701

Title: Icariin enhances endothelial nitric-oxide synthase expression on human endothelial cells in vitro.

Journal: Vascular pharmacology 20070701

Title: A novel anticancer agent, icaritin, induced cell growth inhibition, G1 arrest and mitochondrial transmembrane potential drop in human prostate carcinoma PC-3 cells.

Journal: European journal of pharmacology 20070614

Title: Chemical constituents of roots of Epimedium wushanense and evaluation of their biological activities.

Journal: Natural product research 20070601

Title: HPLC analysis and pharmacokinetics of icariin in rats.

Journal: Journal of separation science 20070601

Title: Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species.

Journal: Phytochemistry 20070501

Title: Icariin from Epimedium brevicornum attenuates chronic mild stress-induced behavioral and neuroendocrinological alterations in male Wistar rats.

Journal: Pharmacology, biochemistry, and behavior 20070501

Title: Icariin inhibits the osteoclast formation induced by RANKL and macrophage-colony stimulating factor in mouse bone marrow culture.

Journal: Die Pharmazie 20070501

Title: Vasorelaxant effects of icariin on isolated canine coronary artery.

Journal: Journal of cardiovascular pharmacology 20070401

Title: [Comparison of antioxidative and antitumor activities of six flavonoids from Epimedium koreanum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401

Title: Comparison between HPLC and HPTLC densitometry for the determination of icariin from Epimedium koreanum extracts.

Journal: Journal of separation science 20070301

Title: [A review on research of raw material and cut crude drug of Herba epimedii in last ten years].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070301

Title: Icariine stimulates proliferation and differentiation of human osteoblasts by increasing production of bone morphogenetic protein 2.

Journal: Chinese medical journal 20070205

Title: Effects of icariin on hypothalamic-pituitary-adrenal axis action and cytokine levels in stressed Sprague-Dawley rats.

Journal: Biological & pharmaceutical bulletin 20061201

Title: Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells.

Journal: Urology 20061201

Title: [The effect of icariin and astragalosid I on the proliferation and differentiation of bone marrow stromal cells].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061001

Title: The testosterone mimetic properties of icariin.

Journal: Asian journal of andrology 20060901

Title: [Effect of er xian decoction and its subdivisions on granulosa cells secretory function in rats].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20060601

Title: Icariin: a special antioxidant to protect linoleic acid against free-radical-induced peroxidation in micelles.

Journal: The journal of physical chemistry. A 20060518

Title: Icariin-mediated expression of cardiac genes and modulation of nitric oxide signaling pathway during differentiation of mouse embryonic stem cells into cardiomyocytes in vitro.

Journal: Acta pharmacologica Sinica 20060301

Title: Regulation of Cbfa1 expression by total flavonoids of Herba epimedii.

Journal: Endocrine journal 20060201

Title: Optimization for quantitative determination of four flavonoids in Epimedium by capillary zone electrophoresis coupled with diode array detection using central composite design.

Journal: Journal of chromatography. A 20060127

Title: Effect of icariin on cyclic GMP levels and on the mRNA expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in penile cavernosum.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101

Title: Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats.

Journal: Asian journal of andrology 20051201

Title: Antidepressant-like effect of icariin and its possible mechanism in mice.

Journal: Pharmacology, biochemistry, and behavior 20051201

Title: Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells.

Journal: Die Pharmazie 20051201

Title: Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20051101

Title: Screening of active compounds as neuromedin U2 receptor agonist from natural products.

Journal: Bioorganic & medicinal chemistry letters 20051015

Title: Protective effects of icariin on neurons injured by cerebral ischemia/reperfusion.

Journal: Chinese medical journal 20051005

Title: The osteoprotective effect of Herba epimedii (HEP) extract in vivo and in vitro.

Journal: Evidence-based complementary and alternative medicine : eCAM 20050901

Title: Protective effects of icariin on human umbilical vein endothelial cell injury induced by H2O2 in vitro.

Journal: Pharmacological research 20050801

Title: [Effect of icariin on hypoxia induced vascular endothelial cells injury].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050601

Title: Icariin-mediated modulation of cell cycle and p53 during cardiomyocyte differentiation in embryonic stem cells.

Journal: European journal of pharmacology 20050509

Title: Inducible effects of icariin, icaritin, and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro.

Journal: Acta pharmacologica Sinica 20050401

Title: [Chemical constituents from herb of Epimedium brevicornum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050401

Title: [Species and geographic distribution of large-flowered taxa of Epimedium in China].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050401

Title: [Preparation of two derivatives from icariin and investigation of their estrogen-like effects].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20050301

Title: Osteoblastic proliferative activity of Epimedium brevicornum Maxim.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20050301

Title: [Effects of Icariin on ovariectomized osteoporotic rats].

Journal: Wei sheng yan jiu = Journal of hygiene research 20050301

Title: [Effects of Epimedium pubescens icariine on proliferation and differentiation of human osteoblasts].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050201

Title: Determination of rat urinary metabolites of icariin in vivo and estrogenic activities of its metabolites on MCF-7 cells.

Journal: Die Pharmazie 20050201

Title: Preparative isolation and purification of three flavonoids from the Chinese medicinal plant Epimedium koreamum Nakai by high-speed counter-current chromatography.

Journal: Journal of chromatography. A 20050128

Title: [Study on water extraction process of Herba epimedii with microwave technology].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050101

Title: Effects of Icariin on expression of OPN mRNA and type I collagen in rat osteoblasts in vitro.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

Title: The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis.

Journal: The Journal of pharmacy and pharmacology 20041201

Title: Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells.

Journal: European journal of pharmacology 20041119

Title: Quantitative and qualitative HPLC analysis of thermogenic weight loss products.

Journal: Die Pharmazie 20041101

Title: Determination of icariin and metabolites in rat serum by capillary zone electrophoresis: rat pharmacokinetic studies after administration of icariin.

Journal: Journal of pharmaceutical and biomedical analysis 20041029

Title: [Effects of icariin on the erectile function and expression of nitrogen oxide synthase isoforms in corpus cavernosum of arterigenic erectile dysfunction rat model].

Journal: Zhonghua yi xue za zhi 20040602

Title: [Effects of icariin on intracavernosal pressure and systematic arterial blood pressure of rat].

Journal: Zhonghua yi xue za zhi 20040117

Title: Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth.

Journal: Clinical and experimental pharmacology & physiology 20040101

Title: [Determination of epimedin C and icariin in Herba Epimedii by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031101

Title: [Comment on main species of herba epimedii].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030401

Title: [Studies on extraction factors of buxueyangyan mixture].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030401

Title: Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities.

Journal: Asian journal of andrology 20030301

Title: Chemical and pharmacological investigations of Epimedium species: a survey.

Journal: Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 20030101

Title: Purification of icariin from the extract of Epimedium segittatum using high-speed counter-current chromatography.

Journal: Journal of chromatography. A 20020712

Title: [Quantitative determination of icariin in 'tangzhi shuangjiang cha' by high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20010701

Title: [Advances in study on pharmacological effects of Epimedium].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010501

Title: [Studies on preparation of herba epimedii total flavonoids phytosomes and their pharmaceutics].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010201

Title: [Determination of the pKa value of icariin and its content in the Chinese herb medicine epimedium grandiflorum morr. by capillary electrophoresis].

Journal: Se pu = Chinese journal of chromatography 20010101

Title: Xin ZC, et al. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian J Androl. 2003 Mar;5(1):15-8.

Title: Lu YF, et al. Icariin is a PPARα activator inducing lipid metabolic gene expression in mice. Molecules. 2014 Nov 6;19(11):18179-91.

Title: Hu Y, et al. Effects and mechanisms of icariin on atherosclerosis. Int J Clin Exp Med. 2015 Mar 15;8(3):3585-9.

Title: Chen M, et al. Effects of icariin on reproductive functions in male rats. Molecules. 2014 Jul 3;19(7):9502-14.

Title: Liu D, et al. Icariin protects rabbit BMSCs against OGD-induced apoptosis by inhibiting ERs-mediated autophagy via MAPK signaling pathway. Life Sci. 2020 Apr 26:117730.

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Tags:489-32-7 Molecular Formula|489-32-7 MDL|489-32-7 SMILES|489-32-7 Icariin