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499-80-9,MFCD00149413
Catalog No.:AA00I8TS

499-80-9 | 2,4-Pyridinedicarboxylic acid

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5g
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10g
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25g
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50g
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100g
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500g
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I8TS
Chemical Name:
2,4-Pyridinedicarboxylic acid
CAS Number:
499-80-9
Molecular Formula:
C7H5NO4
Molecular Weight:
167.1189
MDL Number:
MFCD00149413
SMILES:
OC(=O)c1ccnc(c1)C(=O)O
NSC Number:
403248
Properties
Properties
 
BP:
574.8°C at 760 mmHg  
Form:
Solid  
MP:
243-246 °C  
Refractive Index:
1.6280 (estimate)  
Solubility:
2.49g/l  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
204  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
0.2  

Literature

Title: Selective stabilization of HIF-1α in renal tubular cells by 2-oxoglutarate analogues.

Journal: The American journal of pathology 20121101

Title: α-Ketoglutarate-related inhibitors of HIF prolyl hydroxylases are substrates of renal organic anion transporters 1 (OAT1) and 4 (OAT4).

Journal: Pflugers Archiv : European journal of physiology 20121001

Title: Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C).

Journal: Bioorganic & medicinal chemistry letters 20120915

Title: The synthesis, spectroscopic, X-ray characterization and in vitro cytotoxic testing results of activity of five new trans-platinum(IV) complexes with functionalized pyridines.

Journal: European journal of medicinal chemistry 20120901

Title: Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.

Journal: The FEBS journal 20120601

Title: Picolinate ruthenium(II)-arene complex with in vitro antiproliferative and antimetastatic properties: comparison to a series of ruthenium(II)-arene complexes with similar structure.

Journal: Journal of inorganic biochemistry 20120301

Title: Enabling lead discovery for histone lysine demethylases by high-throughput RapidFire mass spectrometry.

Journal: Journal of biomolecular screening 20120101

Title: Poly[[hexa-aqua-(μ(2)-oxalato-κO,O:O,O)bis(μ(3)-pyridine-2,4-dicarboxyl-ato-κN,O:O:O)dicerium(III)] monohydrate].

Journal: Acta crystallographica. Section E, Structure reports online 20120101

Title: Biapenem inactivation by B2 metallo β-lactamases: energy landscape of the post-hydrolysis reactions.

Journal: PloS one 20120101

Title: Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.

Journal: The Journal of biological chemistry 20111202

Title: Poly[[hexa-aqua-(μ(2)-oxalato-κO,O:O,O)bis-(μ(3)-pyridine-2,4-dicarboxyl-ato-κN,O:O:O)dilanthanum(III)] monohydrate].

Journal: Acta crystallographica. Section E, Structure reports online 20111201

Title: Poly[tri-μ(2)-aqua-(μ(3)-pyridine-2,4-dicarboxyl-ato-κN,O:O:O)barium].

Journal: Acta crystallographica. Section E, Structure reports online 20110701

Title: Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: towards understanding selectivity of inhibitors targeting oncogenic histone demethylases.

Journal: FEBS letters 20110623

Title: Bis(1-methyl-4-oxoimidazolidin-2-iminium) diaqua-bis-(pyridine-2,4-dicarboxyl-ato-κN,O)zincate(II) dihydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20110401

Title: Bis(4-carb-oxy-pyridine-2-carboxyl-ato-κN,O)copper(II) dimethyl sulfoxide disolvate.

Journal: Acta crystallographica. Section E, Structure reports online 20110201

Title: Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α).

Journal: PloS one 20110101

Title: Chemical biology of lysine demethylases.

Journal: Current chemical genomics 20110101

Title: Methods for Activity Analysis of the Proteins that Regulate Histone Methylation.

Journal: Current chemical genomics 20110101

Title: Quantitative proteomic approaches to studying histone modifications.

Journal: Current chemical genomics 20110101

Title: Poly[hexa-aqua-hexa-kis-(μ-pyridine-2,4-dicarboxyl-ato)tricopper(II)dieuropium(III)].

Journal: Acta crystallographica. Section E, Structure reports online 20101201

Title: Mechanism for the formation of substituted manganese(V) cyanidonitrido complexes: crystallographic and kinetic study of the substitution reactions of trans-[MnN(H2O)(CN)4]2- with monodentate pyridine and bidentate pyridine-carboxylate ligands.

Journal: Inorganic chemistry 20101018

Title: Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.

Journal: Bioorganic & medicinal chemistry letters 20101015

Title: Characterization of two carnation petal prolyl 4 hydroxylases.

Journal: Physiologia plantarum 20101001

Title: A red zwitterionic co-crystal of acetaminophen and 2,4-pyridinedicarboxylic acid.

Journal: Journal of pharmaceutical sciences 20100901

Title: Bis(μ-pyridine-2,4-dicarboxyl-ato)-κN,O:O;κO:N,O-bis-[triaqua-magnesium(II)].

Journal: Acta crystallographica. Section E, Structure reports online 20100901

Title: Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.

Journal: Journal of medicinal chemistry 20100812

Title: Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry.

Journal: Journal of proteome research 20100806

Title: Poly[μ(6)-pyridine-2,4-dicarboxyl-ato-barium].

Journal: Acta crystallographica. Section E, Structure reports online 20100701

Title: (2S*)-2-Ammonio-3-(1H-indol-3-yl)propionate pyridine-2,4-dicarboxylic acid ethanol solvate.

Journal: Acta crystallographica. Section E, Structure reports online 20100501

Title: Ruthenium(II)-arene complexes with functionalized pyridines: synthesis, characterization and cytotoxic activity.

Journal: European journal of medicinal chemistry 20100301

Title: Dimethyl-ammonium diaqua-(pyridine-2,4-dicarboxyl-ato-κN,O)cuprate(II).

Journal: Acta crystallographica. Section E, Structure reports online 20100201

Title: Pyridine-2,4-dicarboxylate: a versatile building block for the preparation of functional coordination polymers.

Journal: Journal of nanoscience and nanotechnology 20100101

Title: Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

Journal: PloS one 20100101

Title: catena-Poly[diammonium [diaqua-bis(pyridine-2,4-dicarboxyl-ato-κN,O)cuprate(II)] [[diaqua-copper(II)]-μ-pyridine-2,4-dicarboxyl-ato-κN,O:O-[tetra-aqua-cadmium(II)]-μ-pyridine-2,4-dicarboxyl-ato-κO:N,O] hexa-hydrate].

Journal: Acta crystallographica. Section E, Structure reports online 20091201

Title: Poly[μ(2)-aqua-aqua-μ(4)-pyridine-2,4-dicarboxyl-ato-strontium].

Journal: Acta crystallographica. Section E, Structure reports online 20090801

Title: Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.

Journal: Journal of medicinal chemistry 20090514

Title: Direct and continuous assay for prolyl 4-hydroxylase.

Journal: Analytical biochemistry 20090315

Title: Pharmacologically induced angiogenesis in transgenic zebrafish.

Journal: Biochemical and biophysical research communications 20090123

Title: Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis state of the art.

Journal: Fibrogenesis & tissue repair 20090101

Title: Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.

Journal: Journal of medicinal chemistry 20081127

Title: Synthesis, characterization and fluorescence properties of novel pyridine dicarboxylic acid derivatives and corresponding Tb(III) complexes.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081101

Title: Aqua-tricarbon-yl(4-carboxy-pyridine-2-carboxyl-ato-κN,O)rhenium(I).

Journal: Acta crystallographica. Section E, Structure reports online 20081001

Title: A cocrystal of pyridine-2,4-dicarboxylic acid and serine.

Journal: Acta crystallographica. Section E, Structure reports online 20080101

Title: The active site of an algal prolyl 4-hydroxylase has a large structural plasticity.

Journal: The Journal of biological chemistry 20071221

Title: Competitive inhibition of glutamate dehydrogenase reaction.

Journal: FEBS letters 20070612

Title: Cell-specific and nuclear targeting with [M(CO)(3)](+) (M=(99m)Tc, Re)-based complexes conjugated to acridine orange and bombesin.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

Title: Synthesis, structure and fluorescent studies of novel uranium coordination polymers in the pyridinedicarboxylic acid system.

Journal: Dalton transactions (Cambridge, England : 2003) 20061021

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Allosteric NADP-glutamate dehydrogenase from aspergilli: purification, characterization and implications for metabolic regulation at the carbon-nitrogen interface.

Journal: Microbiology (Reading, England) 20050501

Title: X-ray structure characterization of palladium(II) ternary complexes of pyridinedicarboxylic and phthalic acid with phenanthroline and bipyridine.

Journal: Chemical & pharmaceutical bulletin 20050401

Title: Characterization of a second Arabidopsis thaliana prolyl 4-hydroxylase with distinct substrate specificity.

Journal: The Journal of biological chemistry 20050114

Title: Framework control by a metalloligand having multicoordination ability: new synthetic approach for crystal structures and magnetic properties.

Journal: Inorganic chemistry 20050110

Title: A new [2 + 1] mixed ligand concept based on [99(m)Tc(OH2)3(CO)3]+: a basic study.

Journal: Dalton transactions (Cambridge, England : 2003) 20040507

Title: Reactions of the dirhenium(II) complex Re2Cl4(mu-dppm)2 with pyridinecarboxylic acids. Examples of bidentate O,O versus N,O coordination and tridentate O,N,O coordination and structural isomers that contain the pyridine-2,6-dicarboxylate ligand.

Journal: Inorganic chemistry 20030922

Title: Regioselective hydroxylation of quinolinic acid, lutidinic acid and isocinchomeronic acid by resting cells of pyridine dicarboxylic acid-degrading microorganisms.

Journal: Applied microbiology and biotechnology 20030901

Title: Self-referencing intensity measurements based on square-wave gated phase-modulation fluorimetry.

Journal: Applied spectroscopy 20030501

Title: New microporous coordination polymer affording guest-coordination sites at channel walls.

Journal: Chemical communications (Cambridge, England) 20020207

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Tags:499-80-9 Molecular Formula|499-80-9 MDL|499-80-9 SMILES|499-80-9 2,4-Pyridinedicarboxylic acid