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502487-67-4,MFCD11046358
Catalog No.:AA00DB4S

502487-67-4 | SQ109

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100mg
95%
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$385.00   $270.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DB4S
Chemical Name:
SQ109
CAS Number:
502487-67-4
Molecular Formula:
C22H38N2
Molecular Weight:
330.5505
MDL Number:
MFCD11046358
SMILES:
CC(=CCNCCNC1C2CC3CC1CC(C2)C3)CCC=C(C)C
Properties
Computed Properties
 
Complexity:
431  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
9  
XLogP3:
5.1  

Literature

Title: Head-to-head prenyl tranferases: anti-infective drug targets.

Journal: Journal of medicinal chemistry 20120510

Title: SQ109 and PNU-100480 interact to kill Mycobacterium tuberculosis in vitro.

Journal: The Journal of antimicrobial chemotherapy 20120501

Title: Tuberculosis: the drug development pipeline at a glance.

Journal: European journal of medicinal chemistry 20120501

Title: Synthesis and in vitro antimycobacterial activity of compounds derived from (R)- and (S)-2-amino-1-butanol - The crucial role of the configuration.

Journal: European journal of medicinal chemistry 20120201

Title: Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide.

Journal: PloS one 20120101

Title: Design, synthesis, and biological evaluation of novel fluorinated ethanolamines.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20111223

Title: Novel linear diamine disubstituted polycyclic 'cage' derivatives as potential antimycobacterial candidates.

Journal: Chemical biology & drug design 20111201

Title: The many faces of the adamantyl group in drug design.

Journal: European journal of medicinal chemistry 20110601

Title: [Present and future in the use of anti-tubercular drugs].

Journal: Pneumologia (Bucharest, Romania) 20110101

Title: Drugs in development for tuberculosis.

Journal: Drugs 20101203

Title: In vitro interactions between new antitubercular drug candidates SQ109 and TMC207.

Journal: Antimicrobial agents and chemotherapy 20100701

Title: Current development and future prospects in chemotherapy of tuberculosis.

Journal: Respirology (Carlton, Vic.) 20100701

Title: Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates.

Journal: European journal of medicinal chemistry 20100501

Title: Pentacyclo-undecane derived cyclic tetra-amines: synthesis and evaluation as potent anti-tuberculosis agents.

Journal: European journal of medicinal chemistry 20091101

Title: Synthesis and evaluation of carbamate prodrugs of SQ109 as antituberculosis agents.

Journal: Bioorganic & medicinal chemistry letters 20090515

Title: SQ109.

Journal: Tuberculosis (Edinburgh, Scotland) 20080301

Title: New anti-tuberculosis drugs with novel mechanisms of action.

Journal: Current medicinal chemistry 20080101

Title: Advances in the treatment of tuberculosis.

Journal: Clinical pharmacology and therapeutics 20071101

Title: New tuberculosis therapeutics: a growing pipeline.

Journal: The Journal of infectious diseases 20070815

Title: Drug therapy of experimental tuberculosis (TB): improved outcome by combining SQ109, a new diamine antibiotic, with existing TB drugs.

Journal: Antimicrobial agents and chemotherapy 20070401

Title: Novel agents in the management of Mycobacterium tuberculosis disease.

Journal: Current medicinal chemistry 20070101

Title: Synergistic interactions of SQ109, a new ethylene diamine, with front-line antitubercular drugs in vitro.

Journal: The Journal of antimicrobial chemotherapy 20060801

Title: Interspecies pharmacokinetics and in vitro metabolism of SQ109.

Journal: British journal of pharmacology 20060301

Title: Pharmacoproteomic effects of isoniazid, ethambutol, and N-geranyl-N'-(2-adamantyl)ethane-1,2-diamine (SQ109) on Mycobacterium tuberculosis H37Rv.

Journal: The Journal of pharmacology and experimental therapeutics 20051101

Title: Veiga-Santos P, et al. SQ109, a new drug lead for Chagas disease. Antimicrob Agents Chemother. 2015 Apr;59(4):1950-61.

Title: Jia L, et al. Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug. Br J Pharmacol. 2005 Jan;144(1):80-7

Title: Jia L, et al. Interspecies pharmacokinetics and in vitro metabolism of SQ109. Br J Pharmacol. 2006 Mar;147(5):476-85.

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