[1]JournalofMedicinalChemistry,1984,vol.27,#12,p.1621-1629
[1]Patent:US3940394,1976,A,
[1]JournalofMedicinalChemistry,1984,vol.27,#12,p.1621-1629
[1]JournalofMedicinalChemistry,1984,vol.27,#12,p.1621-1629
[1]BioorganicandMedicinalChemistryLetters,2010,vol.20,#8,p.2469-2473
Title: Expression of cytochrome P450 epoxygenases and soluble epoxide hydrolase is regulated by hypolipidemic drugs in dose-dependent manner.
Journal: Toxicology and applied pharmacology 20180915
Title: PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling.
Journal: Toxicology 20170715
Title: The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARα down-regulation.
Journal: Toxicology 20170615
Title: Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.
Journal: Archives of toxicology 20170501
Title: Antidiabetic effect of SN158 through PPARα/γ dual activation in ob/ob mice.
Journal: Chemico-biological interactions 20170425
Title: Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis.
Journal: Toxicology 20170301
Title: Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.
Journal: Toxicology and applied pharmacology 20170301
Title: Activation of the Constitutive Androstane Receptor by Monophthalates.
Journal: Chemical research in toxicology 20161017
Title: Activation of peroxisome proliferator-activated receptor α ameliorates perfluorododecanoic acid-induced production of reactive oxygen species in rat liver.
Journal: Archives of toxicology 20160601
Title: Effects of Crude Oil/Dispersant Mixture and Dispersant Components on PPARγ Activity in Vitro and in Vivo: Identification of Dioctyl Sodium Sulfosuccinate (DOSS; CAS #577-11-7) as a Probable Obesogen.
Journal: Environmental health perspectives 20160101
Title: Transcriptome analyses demonstrate that Peroxisome Proliferator-Activated Receptor α (PPARα) activity of an ultraviolet absorber, 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole, as possible mechanism of their toxicity and the gender differences.
Journal: The Journal of toxicological sciences 20160101
Title: A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.
Journal: Archives of toxicology 20151201
Title: Activation of sterol regulatory element-binding proteins in mice exposed to perfluorooctanoic acid for 28 days.
Journal: Archives of toxicology 20150901
Title: Oxidative Stress Mechanisms Do Not Discriminate between Genotoxic and Nongenotoxic Liver Carcinogens.
Journal: Chemical research in toxicology 20150817
Title: Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150501
Title: Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium.
Journal: PloS one 20150101
Title: Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium.
Journal: Nuclear receptor signaling 20150101
Title: Role of the ubiquitin-proteasome system in cardiac dysfunction of adipose triglyceride lipase-deficient mice.
Journal: Journal of molecular and cellular cardiology 20141201
Title: Fish oil and fenofibrate prevented phosphorylation-dependent hepatic sortilin 1 degradation in Western diet-fed mice.
Journal: The Journal of biological chemistry 20140808
Title: Sargahydroquinoic acid inhibits TNFα-induced AP-1 and NF-κB signaling in HaCaT cells through PPARα activation.
Journal: Biochemical and biophysical research communications 20140808
Title: Resveratrol and its metabolites bind to PPARs.
Journal: Chembiochem : a European journal of chemical biology 20140526
Title: Evaluating the additivity of perfluoroalkyl acids in binary combinations on peroxisome proliferator-activated receptor-α activation.
Journal: Toxicology 20140227
Title: Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action.
Journal: PloS one 20140101
Title: PPARα-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons.
Journal: The Journal of steroid biochemistry and molecular biology 20131101
Title: Normalization strategies for gene expression studies by real-time PCR in a marine fish species, Scophthalmus maximus.
Journal: Marine genomics 20130601
Title: Identification of transcription factors and coactivators affected by dibutylphthalate interactions in fetal rat testes.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20130401
Title: Detection of genotoxic and non-genotoxic carcinogens in Xpc(-/-)p53(+/-) mice.
Journal: Toxicology and applied pharmacology 20130115
Title: Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.
Journal: PloS one 20130101
Title: Perfluorooctanoic acid induced-developmental cardiotoxicity: are peroxisome proliferator activated receptor α (PPARα) and bone morphorgenic protein 2 (BMP2) pathways involved?
Journal: Journal of toxicology and environmental health. Part A 20130101
Title: Wy14643 improves vascular function in the aorta of the spontaneously hypertensive rat mainly by activating peroxisome proliferator-activated receptors alpha.
Journal: European journal of pharmacology 20121205
Title: APOA5 gene expression in the human intestinal tissue and its response to in vitro exposure to fatty acid and fibrate.
Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD 20120901
Title: Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver.
Journal: Archives of toxicology 20120901
Title: Assessment of possible carcinogenicity of oxyfluorfen to humans using mode of action analysis of rodent liver effects.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120801
Title: PPAR-alpha activation as a preconditioning-like intervention in rats in vivo confers myocardial protection against acute ischaemia-reperfusion injury: involvement of PI3K-Akt.
Journal: Canadian journal of physiology and pharmacology 20120801
Title: Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells.
Journal: Cell death and differentiation 20120701
Title: Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity.
Journal: Hepatology (Baltimore, Md.) 20120701
Title: Topical application of PPARα (but not β/δ or γ) suppresses atopic dermatitis in NC/Nga mice.
Journal: Allergy 20120701
Title: Total synthesis and dual PPARα/γ agonist effects of amorphastilbol and its synthetic derivatives.
Journal: Bioorganic & medicinal chemistry letters 20120615
Title: Cytokine production by infrapatellar fat pad can be stimulated by interleukin 1β and inhibited by peroxisome proliferator activated receptor α agonist.
Journal: Annals of the rheumatic diseases 20120601
Title: Co-treatment with retinyl retinoate and a PPARα agonist reduces retinoid dermatitis.
Journal: International journal of dermatology 20120601
Title: Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart.
Journal: Physiological genomics 20120319
Title: Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists.
Journal: Bioorganic & medicinal chemistry 20120315
Title: Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARα and CAR/PXR.
Journal: Toxicology 20120311
Title: PPARα and PPARγ regulate the nucleoside transporter hENT1.
Journal: Biochemical and biophysical research communications 20120309
Title: Peroxisome proliferator-activated receptor-α agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis.
Journal: Journal of gastroenterology and hepatology 20120201
Title: Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120201
Title: Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer.
Journal: PLoS computational biology 20120201
Title: Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.
Journal: Journal of medicinal chemistry 20120112
Title: Cardiac dysfunction in adipose triglyceride lipase deficiency: treatment with a PPARα agonist.
Journal: British journal of pharmacology 20120101
Title: Fine metabolic regulation in ruminants via nutrient-gene interactions: saturated long-chain fatty acids increase expression of genes involved in lipid metabolism and immune response partly through PPAR-α activation.
Journal: The British journal of nutrition 20120101
Title: Fenofibrate down-regulates renal OCT2-mediated organic cation transport via PPARα-independent pathways.
Journal: Drug metabolism and pharmacokinetics 20120101
Title: Combining ZHENG Theory and High-Throughput Expression Data to Predict New Effects of Chinese Herbal Formulae.
Journal: Evidence-based complementary and alternative medicine : eCAM 20120101
Title: Organotypic modeling of human keratinocyte response to peroxisome proliferators.
Journal: Cells, tissues, organs 20120101
Title: Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction.
Journal: PloS one 20120101
Title: In Vitro and In Vivo Characterizations of Chiglitazar, a Newly Identified PPAR Pan-Agonist.
Journal: PPAR research 20120101
Title: Tertiary alkylamines as nucleophiles in substitution reactions at heteroaromatic halide during the synthesis of the highly potent pirinixic acid derivative 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS-121).
Journal: Molecules (Basel, Switzerland) 20111205
Title: Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20111201
Title: Adiponectin reduces connective tissue growth factor in human hepatocytes which is already induced in non-fibrotic non-alcoholic steatohepatitis.
Journal: Experimental and molecular pathology 20111201
Title: Efficacy of combined peroxisome proliferator-activated receptor-α ligand and glucocorticoid therapy in a murine model of atopic dermatitis.
Journal: The Journal of investigative dermatology 20110901
Title: PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation.
Journal: Biochimica et biophysica acta 20110801
Title: A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm.
Journal: British journal of pharmacology 20110801
Title: Peroxisome proliferator activated receptor alpha activation decreases inflammatory and destructive responses in osteoarthritic cartilage.
Journal: Osteoarthritis and cartilage 20110701
Title: Differential regulation of bovine pyruvate carboxylase promoters by fatty acids and peroxisome proliferator-activated receptor-α agonist.
Journal: Journal of dairy science 20110701
Title: Effects of chronic systemic treatment with peroxisome proliferator-activated receptor α activators on neuroinflammation induced by intracerebral injection of lipopolysaccharide in adult mice.
Journal: Neuroscience research 20110601
Title: 20-Hydroxyeicosatetraenoic acid inhibits ATP-induced COX-2 expression via peroxisome proliferator activator receptor-α in vascular smooth muscle cells.
Journal: British journal of pharmacology 20110601
Title: Revisiting glitazars: thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse effects in rodents.
Journal: Bioorganic & medicinal chemistry letters 20110515
Title: Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E₂ synthase-1 (mPGES-1).
Journal: Journal of medicinal chemistry 20110512
Title: A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver.
Journal: Biochimie 20110501
Title: Lack of PPARα exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative/nitrosative stress.
Journal: Toxicology letters 20110410
Title: PPARα agonist prevented the apoptosis induced by glucose and fatty acid in neonatal cardiomyocytes.
Journal: Journal of endocrinological investigation 20110401
Title: Fenofibrate suppresses microvascular inflammation and apoptosis through adenosine monophosphate-activated protein kinase activation.
Journal: Metabolism: clinical and experimental 20110401
Title: Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors.
Journal: Biological psychiatry 20110401
Title: A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold.
Journal: Bioorganic & medicinal chemistry letters 20110301
Title: Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists.
Journal: Bioorganic & medicinal chemistry 20110115
Title: 26-Week carcinogenicity study of di-isodecyl phthalate by dietary administration to CB6F1-rasH2 transgenic mice.
Journal: Archives of toxicology 20110101
Title: Activation of peroxisome proliferator-activated receptor α in megakaryocytes reduces platelet-derived growth factor-BB in platelets.
Journal: Journal of atherosclerosis and thrombosis 20110101
Title: Peroxisome proliferator-activated receptor activators protect sebocytes from apoptosis: a new treatment modality for acne?
Journal: The British journal of dermatology 20110101
Title: The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats.
Journal: BMC endocrine disorders 20110101
Title: Clofibrate relaxes the longitudinal smooth muscle of the mouse distal colon through calcium-mediated desensitisation of contractile machinery.
Journal: Pharmacology 20110101
Title: Two thiophenes compounds are partial peroxisome proliferator-activated receptor α/γ dual agonists.
Journal: Biological & pharmaceutical bulletin 20110101
Title: Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice.
Journal: Lipids in health and disease 20110101
Title: Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity.
Journal: Toxicology and applied pharmacology 20101215
Title: PPARalpha-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20101201
Title: Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20101201
Title: Fenofibrate but not fenofibric acid inhibits 11beta-hydroxysteroid dehydrogenase 1 in C2C12 myotubes.
Journal: Molecular and cellular biochemistry 20101101
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Functionalization of fatty acid mimetics for solid-phase coupling and subsequent target identification.
Journal: Archiv der Pharmazie 20101101
Title: Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR.
Journal: Archives of toxicology 20101001
Title: PPARα contributes to colonic protection in mice with DSS-induced colitis.
Journal: International immunopharmacology 20101001
Title: Adiponectin-mediated heme oxygenase-1 induction protects against iron-induced liver injury via a PPARα dependent mechanism.
Journal: The American journal of pathology 20101001
Title: Effect of prenatal peroxisome proliferator-activated receptor alpha (PPARalpha) agonism on postnatal development.
Journal: Toxicology 20100930
Title: Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans.
Journal: Diabetologia 20100901
Title: Peroxisome proliferation activation receptor alpha modulation of Ca2+-regulated exocytosis via arachidonic acid in guinea-pig antral mucous cells.
Journal: Experimental physiology 20100801
Title: Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNFalpha/NF-kappaB signaling axis.
Journal: Leukemia 20100801
Title: Pravastatin attenuates carboplatin-induced nephrotoxicity in rodents via peroxisome proliferator-activated receptor alpha-regulated heme oxygenase-1.
Journal: Molecular pharmacology 20100701
Title: Evaluation of in vivo liver genotoxic potential of Wy-14,643 and piperonyl butoxide in rats subjected to two-week repeated oral administration.
Journal: Archives of toxicology 20100601
Title: Deciphering diseases and biological targets for environmental chemicals using toxicogenomics networks.
Journal: PLoS computational biology 20100501
Title: The effects of a PPARalpha agonist on myocardial damage in obese diabetic mice with heart failure.
Journal: International heart journal 20100501
Title: Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator.
Journal: Bioorganic & medicinal chemistry letters 20100415
Title: Validation of an in vitro screening test for predicting the tumor promoting potential of chemicals based on gene expression.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100401
Title: Control of steroid 21-oic acid synthesis by peroxisome proliferator-activated receptor alpha and role of the hypothalamic-pituitary-adrenal axis.
Journal: The Journal of biological chemistry 20100305
Title: The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Journal: The Journal of pharmacology and experimental therapeutics 20100301
Title: Impacts of different promoters on the mammalian one-hybrid assay for detecting nuclear receptor agonists.
Journal: Analytical and bioanalytical chemistry 20100301
Title: Short-term therapy with peroxisome proliferation-activator receptor-alpha agonist Wy-14,643 protects murine fatty liver against ischemia-reperfusion injury.
Journal: Hepatology (Baltimore, Md.) 20100301
Title: Enantiomer separation and indirect chromatographic absolute configuration prediction of chiral pirinixic acid derivatives: Limitations of polysaccharide-type chiral stationary phases in comparison to chiral anion-exchangers.
Journal: Journal of chromatography. A 20100212
Title: Design, synthesis, and docking studies of novel benzimidazoles for the treatment of metabolic syndrome.
Journal: Journal of medicinal chemistry 20100211
Title: Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse.
Journal: Carcinogenesis 20100201
Title: The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms.
Journal: Environmental health perspectives 20100201
Title: Induction of RIP-2 kinase by proinflammatory cytokines is mediated via NF-kappaB signaling pathways and involves a novel feed-forward regulatory mechanism.
Journal: Molecular and cellular biochemistry 20100101
Title: Glucans from the Caripia montagnei mushroom present anti-inflammatory activity.
Journal: International immunopharmacology 20100101
Title: Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100101
Title: Iridoids from Fraxinus excelsior with adipocyte differentiation-inhibitory and PPARalpha activation activity.
Journal: Journal of natural products 20100101
Title: Analysis of the heat shock response in mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha).
Journal: BMC genomics 20100101
Title: Peroxisome proliferator-activated receptor alpha (PPARalpha) agonists induce constitutive androstane receptor (CAR) and cytochrome P450 2B in rat primary hepatocytes.
Journal: Drug metabolism and pharmacokinetics 20100101
Title: PPARα in Obesity: Sex Difference and Estrogen Involvement.
Journal: PPAR research 20100101
Title: WY-14 643, a selective PPAR{alpha} agonist, induces proinflammatory and proangiogenic responses in human ocular cells.
Journal: International journal of toxicology 20100101
Title: PRIC295, a Nuclear Receptor Coactivator, Identified from PPARα-Interacting Cofactor Complex.
Journal: PPAR research 20100101
Title: Gene Expression Profiling in Wild-Type and PPARα-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPARα-Independent Effects.
Journal: PPAR research 20100101
Title: Effects of the PPARα Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism.
Journal: PPAR research 20100101
Title: Regulation of Proteome Maintenance Gene Expression by Activators of Peroxisome Proliferator-Activated Receptor α.
Journal: PPAR research 20100101
Title: Role of the nuclear receptors HNF4 alpha, PPAR alpha, and LXRs in the TNF alpha-mediated inhibition of human apolipoprotein A-I gene expression in HepG2 cells.
Journal: Biochemistry 20091222
Title: The absence of a functional peroxisome proliferator-activated receptor-alpha gene in mice enhances motor sensitizing effects of morphine, but not cocaine.
Journal: Neuroscience 20091201
Title: Organic cation/carnitine transporter OCTN3 is present in astrocytes and is up-regulated by peroxisome proliferators-activator receptor agonist.
Journal: The international journal of biochemistry & cell biology 20091201
Title: Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver.
Journal: Molecular and cellular biology 20091201
Title: 7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.
Journal: Journal of medicinal chemistry 20091112
Title: PPARalpha ligand WY14643 reduced acute rejection after rat lung transplantation with the upregulation of IL-4, IL-10 and TGFbeta mRNA expression.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20091101
Title: Studies on induction of lamotrigine metabolism in transgenic UGT1 mice.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20091101
Title: A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants.
Journal: Environmental health perspectives 20091101
Title: Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice.
Journal: Chemico-biological interactions 20091030
Title: New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.
Journal: Journal of medicinal chemistry 20091022
Title: Chronic treatment with the peroxisome proliferator-activated receptor alpha agonist Wy-14,643 attenuates myocardial respiratory capacity and contractile function.
Journal: Molecular and cellular biochemistry 20091001
Title: Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells.
Journal: Biochimica et biophysica acta 20091001
Title: Synergistic acceleration of thyroid hormone degradation by phenobarbital and the PPAR alpha agonist WY14643 in rat hepatocytes.
Journal: Toxicology and applied pharmacology 20091001
Title: Regulation of CYP4A expression by bezafibrate in primary culture of rat and human hepatocytes: interspecies difference and influence of N-acetylcysteine.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20091001
Title: Interference of alpha-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways.
Journal: European journal of pharmacology 20091001
Title: PPARalpha ligands cause lymphocyte depletion and cell cycle block and this is associated with augmented TRB3 and reduced Cyclin B1 expression.
Journal: Molecular immunology 20091001
Title: Glucose deprivation, oxidative stress and peroxisome proliferator-activated receptor-alpha (PPARA) cause peroxisome proliferation in preimplantation mouse embryos.
Journal: Reproduction (Cambridge, England) 20090901
Title: Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner.
Journal: Hepatology (Baltimore, Md.) 20090901
Title: Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells.
Journal: Anticancer research 20090901
Title: Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor alpha activity.
Journal: Journal of lipid research 20090801
Title: Oleoylethanolamide, a natural ligand for PPAR-alpha, inhibits insulin receptor signalling in HTC rat hepatoma cells.
Journal: Biochimica et biophysica acta 20090801
Title: Differential hepatic effects of perfluorobutyrate mediated by mouse and human PPAR-alpha.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090701
Title: Cyanide-induced death of dopaminergic cells is mediated by uncoupling protein-2 up-regulation and reduced Bcl-2 expression.
Journal: Toxicology and applied pharmacology 20090701
Title: PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle.
Journal: American journal of physiology. Endocrinology and metabolism 20090701
Title: Effects of WY-14643 on peroxisomal enzyme activity and hormone secretion in immortalized human trophoblast cells.
Journal: Biological & pharmaceutical bulletin 20090701
Title: Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species.
Journal: Reproductive toxicology (Elmsford, N.Y.) 20090601
Title: The IkappaBalpha gene is a peroxisome proliferator-activated receptor cardiac target gene.
Journal: The FEBS journal 20090601
Title: Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine.
Journal: European journal of gastroenterology & hepatology 20090601
Title: Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy.
Journal: The Journal of toxicological sciences 20090601
Title: Peroxisome proliferator-activated receptor alpha activation induces unfavourable changes in fatty acid composition of myocardial phospholipids.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090601
Title: 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibits fibrogenic response in human hepatoma cells.
Journal: Toxicology letters 20090522
Title: Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase.
Journal: Archives of biochemistry and biophysics 20090501
Title: Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors.
Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20090501
Title: Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis.
Journal: The Journal of biological chemistry 20090403
Title: Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium.
Journal: Toxicology and applied pharmacology 20090401
Title: Cancer biomarker AKR1B10 and carbonyl metabolism.
Journal: Chemico-biological interactions 20090316
Title: Regulation of peroxisome proliferator-activated receptor-alpha by MDM2.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090301
Title: Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver.
Journal: Toxicology and applied pharmacology 20090301
Title: PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway.
Journal: American journal of physiology. Heart and circulatory physiology 20090301
Title: Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1.
Journal: European journal of pharmacology 20090301
Title: Differential effects of in vivo PPAR alpha and gamma activation on fatty acid transport proteins expression and lipid content in rat liver.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090301
Title: Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification.
Journal: The Journal of investigative dermatology 20090201
Title: Rapid non-genomic regulation of Ca2+ signals and insulin secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans.
Journal: The Journal of endocrinology 20090201
Title: Optimization of an enzyme-linked immunosorbent assay to screen ligand of Peroxisome proliferator-activated receptor alpha.
Journal: Immunopharmacology and immunotoxicology 20090101
Title: Chronic, in vivo, PPARalpha activation prevents lipid overload in rat liver induced by high fat feeding.
Journal: Advances in medical sciences 20090101
Title: Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human.
Journal: PloS one 20090101
Title: Modulation of the hepatic fatty acid pool in peroxisomal 3-ketoacyl-CoA thiolase B-null mice exposed to the selective PPARalpha agonist Wy14,643.
Journal: Biochimie 20090101
Title: Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.
Journal: PloS one 20090101
Title: Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Journal: Journal of medicinal chemistry 20081225
Title: Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design.
Journal: Journal of medicinal chemistry 20081225
Title: Effects of Wy14643 on hepatic ischemia reperfusion injury in rats.
Journal: World journal of gastroenterology 20081207
Title: PPARalpha activation and increased dietary lipid oppose thyroid hormone signaling and rescue impaired glucose-stimulated insulin secretion in hyperthyroidism.
Journal: American journal of physiology. Endocrinology and metabolism 20081201
Title: Synthesis and evaluation of a series of benzopyran derivatives as PPAR alpha/gamma agonists.
Journal: European journal of medicinal chemistry 20081101
Title: A PPARs cross-talk concertedly commits C6 glioma cells to oligodendrocytes and induces enzymes involved in myelin synthesis.
Journal: Journal of cellular physiology 20081101
Title: Peroxisome proliferator-activated receptor-alpha reduces inflammation and vascular leakage in a murine model of acute lung injury.
Journal: The European respiratory journal 20081101
Title: Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20081101
Title: Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity.
Journal: Bioorganic & medicinal chemistry 20081101
Title: Inflammatory pathways are activated during cardiomyocyte hypertrophy and attenuated by peroxisome proliferator-activated receptors PPARalpha and PPARdelta.
Journal: The Journal of biological chemistry 20081024
Title: Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.
Journal: Bioorganic & medicinal chemistry letters 20081015
Title: PPAR alpha, more than PPAR delta, mediates the hepatic and skeletal muscle alterations induced by the PPAR agonist GW0742.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20081001
Title: Effects of peroxisome proliferator-activated receptor alpha (PPARalpha) agonists on leucine-induced phosphorylation of translational targets in C2C12 cells.
Journal: Biochimica et biophysica acta 20081001
Title: Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.
Journal: Mutation research 20080926
Title: Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.
Journal: Journal of medicinal chemistry 20080911
Title: Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice.
Journal: Journal of hepatology 20080901
Title: A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats.
Journal: Toxicology 20080819
Title: Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.
Journal: Diabetes 20080801
Title: Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists.
Journal: Bioorganic & medicinal chemistry 20080801
Title: Characterization of Madin-Darby bovine kidney cell line for peroxisome proliferator-activated receptors: temporal response and sensitivity to fatty acids.
Journal: Journal of dairy science 20080701
Title: The in vivo gene expression signature of oxidative stress.
Journal: Physiological genomics 20080612
Title: Effect of peroxisome proliferator-activated receptor-alpha ligands in the interaction between adipocytes and macrophages in obese adipose tissue.
Journal: Obesity (Silver Spring, Md.) 20080601
Title: Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha.
Journal: Biochimica et biophysica acta 20080601
Title: Gene profiling in the livers of wild-type and PPARalpha-null mice exposed to perfluorooctanoic acid.
Journal: Toxicologic pathology 20080601
Title: Comparative hepatic effects of perfluorooctanoic acid and WY 14,643 in PPAR-alpha knockout and wild-type mice.
Journal: Toxicologic pathology 20080601
Title: 1Alpha,25-dihydroxyvitamin D3 attenuates cyanide-induced neurotoxicity by inhibiting uncoupling protein-2 up-regulation.
Journal: Journal of neuroscience research 20080501
Title: Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080501
Title: In vivo imaging reveals selective peroxisome proliferator activated receptor modulator activity of the synthetic ligand 3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid (MK-886).
Journal: Molecular pharmacology 20080501
Title: Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers.
Journal: European journal of pharmacology 20080428
Title: PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators.
Journal: Toxicology 20080403
Title: Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis.
Journal: The Journal of allergy and clinical immunology 20080401
Title: Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine.
Journal: Biochimica et biophysica acta 20080401
Title: Nuclear receptor agonists improve insulin responsiveness in cultured cardiomyocytes through enhanced signaling and preserved cytoskeletal architecture.
Journal: Endocrinology 20080301
Title: Modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor alpha by dehydroepiandrosterone and other peroxisome proliferators.
Journal: Molecular pharmacology 20080301
Title: Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.
Journal: Bioorganic & medicinal chemistry 20080301
Title: Alpha-alkyl substituted pirinixic acid derivatives as potent dual agonists of the peroxisome proliferator activated receptor alpha and gamma.
Journal: Archiv der Pharmazie 20080301
Title: Peroxisome proliferator-activated receptor alpha activation attenuated angiotensin type 1-mediated but enhanced angiotensin type 2-mediated hemodynamic effects to angiotensin II in the rat.
Journal: Journal of hypertension 20080301
Title: Down-regulation of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase by polyunsaturated fatty acids in hepatocytes is not mediated by PPARalpha.
Journal: European journal of nutrition 20080301
Title: The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080101
Title: Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive oxygen species-dependent mechanism.
Journal: Stem cells (Dayton, Ohio) 20080101
Title: Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies.
Journal: Environmental health perspectives 20080101
Title: Placental implications of peroxisome proliferator-activated receptors in gestation and parturition.
Journal: PPAR research 20080101
Title: Effect of synthetic dietary triglycerides: a novel research paradigm for nutrigenomics.
Journal: PloS one 20080101
Title: PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression.
Journal: BMC genomics 20080101
Title: Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response.
Journal: BMC genomics 20080101
Title: Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders.
Journal: PPAR research 20080101
Title: PPARalpha- and DEHP-Induced Cancers.
Journal: PPAR research 20080101
Title: Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain.
Journal: Pain 20071215
Title: Time course investigation of PPARalpha- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression.
Journal: Toxicology and applied pharmacology 20071215
Title: Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver.
Journal: The Journal of biological chemistry 20071214
Title: PPARalpha-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: potential role in starvation adaptation.
Journal: FEBS letters 20071211
Title: Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha.
Journal: Mutation research 20071201
Title: Inactivation of peroxisome proliferator-activated receptor isoforms alpha, beta/delta, and gamma mediate distinct facets of hypertrophic transformation of adult cardiac myocytes.
Journal: Pflugers Archiv : European journal of physiology 20071201
Title: PPARalpha and PP2A are involved in the proapoptotic effect of conjugated linoleic acid on human hepatoma cell line SK-HEP-1.
Journal: International journal of cancer 20071201
Title: PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.
Journal: British journal of pharmacology 20071201
Title: Hepatic PGC-1beta overexpression induces combined hyperlipidemia and modulates the response to PPARalpha activation.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20071201
Title: Peroxisome proliferator-activated receptor-alpha is required for the neurotrophic effect of oleic acid in neurons.
Journal: Journal of neurochemistry 20071101
Title: Norepinephrine and rosiglitazone synergistically induce Elovl3 expression in brown adipocytes.
Journal: American journal of physiology. Endocrinology and metabolism 20071101
Title: WY14,643, a PPARalpha ligand, attenuates expression of anti-glomerular basement membrane disease.
Journal: Clinical and experimental immunology 20071101
Title: Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells.
Journal: European journal of pharmacology 20071001
Title: Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
Journal: Circulation 20070918
Title: Peroxisome proliferator-activated receptor alpha is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro.
Journal: Cell biology international 20070901
Title: Cytotoxicity of peroxisome proliferator-activated receptor alpha and gamma agonists in renal proximal tubular cell lines.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20070901
Title: The putative tumor suppressor Tsc-22 is downregulated early in chemically induced hepatocarcinogenesis and may be a suppressor of Gadd45b.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070901
Title: Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation.
Journal: Molecular endocrinology (Baltimore, Md.) 20070901
Title: Different mechanisms of modulation of gap junction communication by non-genotoxic carcinogens in rat liver in vivo.
Journal: Toxicology 20070816
Title: Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARalpha activation and oxidative stress.
Journal: Toxicology and applied pharmacology 20070815
Title: WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070801
Title: The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter.
Journal: Journal of lipid research 20070801
Title: A role of liver fatty acid-binding protein in cisplatin-induced acute renal failure.
Journal: Kidney international 20070801
Title: Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists.
Journal: Bioorganic & medicinal chemistry letters 20070801
Title: Activation of PPARdelta inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts.
Journal: Cardiovascular research 20070801
Title: Genome-wide analysis of PPARalpha activation in murine small intestine.
Journal: Physiological genomics 20070718
Title: Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070701
Title: Quinoline-based derivatives of pirinixic acid as dual PPAR alpha/gamma agonists.
Journal: Archiv der Pharmazie 20070701
Title: Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis.
Journal: The Journal of biological chemistry 20070615
Title: Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.
Journal: European journal of pharmacology 20070601
Title: PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes.
Journal: Diabetes 20070601
Title: Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070601
Title: The peroxisome proliferator WY-14,643 promotes hepatocarcinogenesis caused by endogenously generated oxidative DNA base modifications in repair-deficient Csbm/m/Ogg1-/- mice.
Journal: Cancer research 20070601
Title: The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.
Journal: Journal of hepatology 20070501
Title: Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors.
Journal: Cellular and molecular life sciences : CMLS 20070501
Title: Beyond lipids, pharmacological PPARalpha activation has important effects on amino acid metabolism as studied in the rat.
Journal: American journal of physiology. Endocrinology and metabolism 20070401
Title: Synthesis and evaluation of N-acetyl-L-tyrosine based compounds as PPARalpha selective activators.
Journal: European journal of medicinal chemistry 20070401
Title: Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20070401
Title: PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle.
Journal: Biochemical and biophysical research communications 20070323
Title: Immunoselection and characterization of a human genomic PPAR binding fragment located within POTE genes.
Journal: Biochimie 20070301
Title: Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070301
Title: Tetradecylselenoacetic acid, a PPAR ligand with antioxidant, antiinflammatory, and hypolipidemic properties.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070301
Title: PPARalpha agonist induces the accumulation of ceramide in the heart of rats fed high-fat diet.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070301
Title: Activation of PPARalpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2.
Journal: Biochemical pharmacology 20070215
Title: Peroxisome proliferator-activated receptor alpha-independent effects of peroxisome proliferators on cysteinyl leukotriene production in mast cells.
Journal: European journal of pharmacology 20070205
Title: The dominant negative thyroid hormone receptor beta-mutant {Delta}337T alters PPAR{alpha} signaling in heart.
Journal: American journal of physiology. Endocrinology and metabolism 20070201
Title: Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidase.
Journal: Free radical biology & medicine 20070201
Title: Activation of peroxisome proliferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism.
Journal: The American journal of pathology 20070201
Title: Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation.
Journal: Journal of medicinal chemistry 20070125
Title: Metabolism of phytol to phytanic acid in the mouse, and the role of PPARalpha in its regulation.
Journal: Journal of lipid research 20070101
Title: Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells.
Journal: Toxicology and applied pharmacology 20070101
Title: Cardiovascular actions of the peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist Wy14,643.
Journal: Cardiovascular drug reviews 20070101
Title: In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma and quantitative analysis of in vivo induction pathway.
Journal: Toxicology and applied pharmacology 20061215
Title: Wy-14,643 and fenofibrate inhibit mitochondrial respiration in isolated rat cardiac mitochondria.
Journal: Mitochondrion 20061201
Title: Peroxisome proliferator-activated receptor-alpha and glucocorticoids interactively regulate insulin secretion during pregnancy.
Journal: Diabetes 20061201
Title: Profiling of gene expression in rat liver and rat primary cultured hepatocytes treated with peroxisome proliferators.
Journal: The Journal of toxicological sciences 20061201
Title: Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor alpha.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20061101
Title: Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver.
Journal: Hepatology (Baltimore, Md.) 20061101
Title: Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha.
Journal: Molecular pharmacology 20061001
Title: Peroxisome proliferator-activated receptor alpha activation during pregnancy severely impairs mammary lobuloalveolar development in mice.
Journal: Endocrinology 20061001
Title: WY 14,643 inhibits human aldose reductase activity.
Journal: Journal of enzyme inhibition and medicinal chemistry 20061001
Title: Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain.
Journal: Endocrinology 20060901
Title: PPARalpha-mediated upregulation of uncoupling protein-2 switches cyanide-induced apoptosis to necrosis in primary cortical cells.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060901
Title: Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity.
Journal: Journal of lipid research 20060901
Title: Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth.
Journal: Pharmacogenetics and genomics 20060901
Title: Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators.
Journal: Shock (Augusta, Ga.) 20060901
Title: Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity.
Journal: Environmental health perspectives 20060901
Title: Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: effects of the PPAR-alpha agonist WY14643.
Journal: Free radical biology & medicine 20060815
Title: Activation of peroxisome proliferator-activated receptor alpha enhances apoptosis in the mouse liver.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060801
Title: Agonists of the peroxisome proliferator-activated receptor alpha induce a fiber-type-selective transcriptional response in rat skeletal muscle.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060801
Title: [Influence and mechanism of peroxisome proliferation activated receptor-alpha expression induced by WY14643 in rat lung with acute lung injury].
Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20060801
Title: PPARalpha and PPARgamma regulation of liver and adipose proteins in obese and dyslipidemic rodents.
Journal: Journal of proteome research 20060801
Title: Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist.
Journal: The Journal of biological chemistry 20060707
Title: The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats.
Journal: British journal of pharmacology 20060701
Title: Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast.
Journal: Toxicology letters 20060601
Title: Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.
Journal: The Journal of clinical investigation 20060601
Title: Differential effects of contraction and PPAR agonists on the expression of fatty acid transporters in rat skeletal muscle.
Journal: The Journal of physiology 20060515
Title: Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis.
Journal: Carcinogenesis 20060501
Title: Protection against myocardial ischaemia/reperfusion injury by PPAR-alpha activation is related to production of nitric oxide and endothelin-1.
Journal: Basic research in cardiology 20060501
Title: PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver.
Journal: Journal of lipid research 20060501
Title: Synthesis and anti-diabetic activity of (RS)-2-ethoxy-3-{4-[2-(4-trifluoro-methanesulfonyloxy-phenyl)-ethoxy]-phenyl}-propionic acid.
Journal: Acta pharmacologica Sinica 20060501
Title: Inhibition of hepatocarcinogenesis by the deletion of the p50 subunit of NF-kappaB in mice administered the peroxisome proliferator Wy-14,643.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060401
Title: Fenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC.
Journal: Biochemical and biophysical research communications 20060324
Title: Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression.
Journal: Endocrinology 20060301
Title: Effects of fatty acids on skeletal muscle cell differentiation in vitro.
Journal: The British journal of nutrition 20060301
Title: Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways.
Journal: Biochemical pharmacology 20060227
Title: PPARalpha activation increases triglyceride mass and adipose differentiation-related protein in hepatocytes.
Journal: Journal of lipid research 20060201
Title: Ginsenoside Rf, a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha.
Journal: Biochemical and biophysical research communications 20060106
Title: Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060101
Title: Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060101
Title: Gene expression profiles in rat liver slices exposed to hepatocarcinogenic enzyme inducers, peroxisome proliferators, and 17alpha-ethinylestradiol.
Journal: International journal of toxicology 20060101
Title: Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists.
Journal: BMC bioinformatics 20060101
Title: Hepatocellular proliferation in response to agonists of peroxisome proliferator-activated receptor alpha: a role for Kupffer cells?
Journal: Journal of carcinogenesis 20060101
Title: PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism.
Journal: Biochemical and biophysical research communications 20051230
Title: PPARalpha activation potentiates AhR-induced CYP1A1 expression.
Journal: Toxicology 20051215
Title: Peroxisomal proliferation protects from beta-amyloid neurodegeneration.
Journal: The Journal of biological chemistry 20051209
Title: Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination.
Journal: Diabetes 20051201
Title: Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levels.
Journal: Diabetes 20051201
Title: ROLE OF ENDOGENOUS AND EXOGENOUS LIGANDS FOR THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR alpha IN THE DEVELOPMENT OF BLEOMYCIN-INDUCED LUNG INJURY.
Journal: Shock (Augusta, Ga.) 20051201
Title: The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes.
Journal: The Journal of biological chemistry 20051118
Title: Statins and PPARalpha agonists induce myotoxicity in differentiated rat skeletal muscle cultures but do not exhibit synergy with co-treatment.
Journal: Toxicology and applied pharmacology 20051101
Title: Synthesis of new carbo- and heterocyclic analogues of 8-HETE and evaluation of their activity towards the PPARs.
Journal: Bioorganic & medicinal chemistry letters 20051015
Title: Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
Journal: Clinical chemistry 20051001
Title: Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050901
Title: A teleost in vitro reporter gene assay to screen for agonists of the peroxisome proliferator-activated receptors.
Journal: Environmental toxicology and chemistry 20050901
Title: Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.
Journal: Journal of medicinal chemistry 20050825
Title: Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver.
Journal: Mutation research 20050804
Title: Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C.
Journal: Biochemistry 20050802
Title: Anti-inflammatory effect of fibrate protects from cisplatin-induced ARF.
Journal: American journal of physiology. Renal physiology 20050801
Title: Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells.
Journal: Endocrinology 20050801
Title: Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia.
Journal: Journal of neuroscience research 20050801
Title: A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver.
Journal: The Biochemical journal 20050715
Title: Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells.
Journal: Life sciences 20050715
Title: Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors.
Journal: The Journal of pharmacology and experimental therapeutics 20050701
Title: Adiponectin receptor gene expression in human skeletal muscle cells is not regulated by fibrates and thiazolidinediones.
Journal: International journal of obesity (2005) 20050701
Title: Peroxisome proliferator-activated receptor alpha and its response element are required but not sufficient for transcriptional activation of the mouse heart-type fatty acid binding protein gene.
Journal: The international journal of biochemistry & cell biology 20050701
Title: A new retinoid-like compound that activates peroxisome proliferator-activated receptors and lowers blood glucose in diabetic mice.
Journal: Biological & pharmaceutical bulletin 20050701
Title: Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats.
Journal: Neuropharmacology 20050601
Title: Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition.
Journal: Cancer research 20050515
Title: Peroxisome proliferator-activated receptor alpha physically interacts with CCAAT/enhancer binding protein (C/EBPbeta) to inhibit C/EBPbeta-responsive alpha1-acid glycoprotein gene expression.
Journal: Molecular endocrinology (Baltimore, Md.) 20050501
Title: Conditional regulation of the human CYP4X1 and CYP4Z1 genes.
Journal: Archives of biochemistry and biophysics 20050415
Title: Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor.
Journal: Molecular pharmacology 20050401
Title: Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases.
Journal: Journal of lipid research 20050401
Title: Future strategies in the treatment of acute renal failure: growth factors, stem cells, and other novel therapies.
Journal: Current opinion in pediatrics 20050401
Title: Unique patterns of gene expression changes in liver after treatment of mice for 2 weeks with different known carcinogens and non-carcinogens.
Journal: Carcinogenesis 20050301
Title: Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.
Journal: Archives of biochemistry and biophysics 20050201
Title: Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists.
Journal: The Journal of biological chemistry 20050128
Title: Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liver.
Journal: The Journal of biological chemistry 20050114
Title: Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis.
Journal: Carcinogenesis 20050101
Title: The peroxisome proliferator-activated receptor alpha activator, Wy14,643, is anti-inflammatory in vivo.
Journal: Inflammopharmacology 20050101
Title: Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.
Journal: Journal of biochemical and molecular toxicology 20050101
Title: The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes.
Journal: The Journal of biological chemistry 20041210
Title: Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation properties.
Journal: Circulation research 20041210
Title: Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver.
Journal: Molecular pharmacology 20041201
Title: Peroxisome proliferator-activated receptor alpha regulates B lymphocyte development via an indirect pathway in mice.
Journal: Biochemical pharmacology 20041201
Title: PPARalpha ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats.
Journal: Biochemical and biophysical research communications 20041112
Title: Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle.
Journal: American journal of physiology. Endocrinology and metabolism 20041101
Title: alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers.
Journal: The American journal of pathology 20041101
Title: Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.
Journal: Gastroenterology 20041101
Title: Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.
Journal: The Journal of biological chemistry 20041029
Title: Statin induction of liver fatty acid-binding protein (L-FABP) gene expression is peroxisome proliferator-activated receptor-alpha-dependent.
Journal: The Journal of biological chemistry 20041029
Title: PPARalpha activators down-regulate CYP2C7, a retinoic acid and testosterone hydroxylase.
Journal: Toxicology 20041015
Title: Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver.
Journal: Toxicology 20041015
Title: Integrated genomic and proteomic analyses of gene expression in Mammalian cells.
Journal: Molecular & cellular proteomics : MCP 20041001
Title: WY 14643, a potent exogenous PPAR-alpha ligand, reduces intestinal injury associated with splanchnic artery occlusion shock.
Journal: Shock (Augusta, Ga.) 20041001
Title: Enhancement of insulin signaling through inhibition of tissue lipid accumulation by activation of peroxisome proliferator-activated receptor (PPAR) alpha in obese mice.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20041001
Title: 17beta-hydroxysteroid dehydrogenase type 11 is a major peroxisome proliferator-activated receptor alpha-regulated gene in mouse intestine.
Journal: European journal of biochemistry 20041001
Title: Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro.
Journal: The British journal of dermatology 20041001
Title: Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats.
Journal: American journal of hypertension 20040901
Title: PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.
Journal: Regulatory peptides 20040815
Title: Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha.
Journal: Alcohol (Fayetteville, N.Y.) 20040801
Title: Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons.
Journal: Journal of neuroscience research 20040715
Title: Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators.
Journal: Bioorganic & medicinal chemistry letters 20040705
Title: Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes.
Journal: Biochimica et biophysica acta 20040705
Title: Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha).
Journal: The Journal of biological chemistry 20040702
Title: Dissociation of oxidant production by peroxisome proliferator-activated receptor ligands from cell death in human cell lines.
Journal: Free radical biology & medicine 20040701
Title: Protein profiling of mouse livers with peroxisome proliferator-activated receptor alpha activation.
Journal: Molecular and cellular biology 20040701
Title: WY-14643 and 9- cis-retinoic acid induce IRS-2/PI 3-kinase signalling pathway and increase glucose transport in human skeletal muscle cells: differential effect in myotubes from healthy subjects and Type 2 diabetic patients.
Journal: Diabetologia 20040701
Title: Different ways to regulate the PPARalpha stability.
Journal: Biochemical and biophysical research communications 20040625
Title: Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver.
Journal: The Journal of biological chemistry 20040604
Title: Coadministration of a liver X receptor agonist and a peroxisome proliferator activator receptor-alpha agonist in Mice: effects of nuclear receptor interplay on high-density lipoprotein and triglyceride metabolism in vivo.
Journal: The Journal of pharmacology and experimental therapeutics 20040601
Title: Differential regulation of cytosolic and peroxisomal bile acid amidation by PPAR alpha activation favors the formation of unconjugated bile acids.
Journal: Journal of lipid research 20040601
Title: Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha.
Journal: Cancer research 20040601
Title: The human semaphorin 6B gene is down regulated by PPARs.
Journal: Genomics 20040601
Title: Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases.
Journal: The Journal of biological chemistry 20040521
Title: Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.
Journal: The Journal of biological chemistry 20040521
Title: Modulation of PPARalpha expression and inflammatory interleukin-6 production by chronic glucose increases monocyte/endothelial adhesion.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20040501
Title: Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice.
Journal: Hepatology (Baltimore, Md.) 20040501
Title: Cardiovascular drugs inhibit MMP-9 activity from human THP-1 macrophages.
Journal: DNA and cell biology 20040501
Title: Peroxisome proliferator-activated receptor-alpha regulates postischemic liver injury.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20040401
Title: Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20040401
Title: Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040401
Title: Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level.
Journal: The Biochemical journal 20040315
Title: PPAR alpha ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity.
Journal: American journal of physiology. Renal physiology 20040301
Title: Reduction of palmitate-induced cardiac apoptosis by fenofibrate.
Journal: Molecular and cellular biochemistry 20040301
Title: PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation.
Journal: Circulation research 20040220
Title: Catalase transgenic mice: characterization and sensitivity to oxidative stress.
Journal: Archives of biochemistry and biophysics 20040215
Title: Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators.
Journal: Cancer research 20040201
Title: Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells.
Journal: Immunity 20040201
Title: 15-Deoxy-delta(12,14)-prostaglandin J2 inhibits the IL-1beta-induced expression of granulocyte-macrophage colony-stimulating factor in BEAS-2B bronchial epithelial cells.
Journal: The Tohoku journal of experimental medicine 20040201
Title: Hepatocarcinogenesis by peroxisome proliferators.
Journal: The Journal of toxicological sciences 20040201
Title: Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR.
Journal: Biochemical and biophysical research communications 20040130
Title: Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes.
Journal: Biochemical and biophysical research communications 20040109
Title: Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth.
Journal: Biochemical pharmacology 20040101
Title: Relationship between PPARalpha activation and NO on proximal tubular Na+ transport in the rat.
Journal: BMC pharmacology 20040101
Title: Peroxisome proliferator-activated receptor agonists inhibit interleukin-1beta-mediated nitric oxide production in cultured lacrimal gland acinar cells.
Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201
Title: Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice.
Journal: Journal of lipid research 20031101
Title: Induction of plasminogen activator inhibitor I by the PPARalpha ligand, Wy-14,643, is dependent on ERK1/2 signaling pathway.
Journal: Thrombosis and haemostasis 20031001
Title: WY-14,643-mediated promotion of hepatocarcinogenesis in connexin32-wild-type and connexin32-null mice.
Journal: Carcinogenesis 20030901
Title: Assessment of hepatocytes and liver slices as in vitro test systems to predict in vivo gene expression.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030901
Title: Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes.
Journal: Endocrinology 20030901
Title: Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme.
Journal: The Journal of biological chemistry 20030829
Title: Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice.
Journal: The Journal of biological chemistry 20030725
Title: Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice.
Journal: American journal of physiology. Heart and circulatory physiology 20030701
Title: Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.
Journal: Molecular endocrinology (Baltimore, Md.) 20030701
Title: Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis.
Journal: Diabetes 20030701
Title: Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice.
Journal: Hepatology (Baltimore, Md.) 20030701
Title: Bezafibrate is a dual ligand for PPARalpha and PPARbeta: studies using null mice.
Journal: Biochimica et biophysica acta 20030610
Title: Identification of hepatic transcriptional changes in insulin-resistant rats treated with peroxisome proliferator activated receptor-alpha agonists.
Journal: Journal of molecular endocrinology 20030601
Title: Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators.
Journal: The Journal of biological chemistry 20030516
Title: Increased expression of the lipocalin 24p3 as an apoptotic mechanism for MK886.
Journal: The Biochemical journal 20030515
Title: Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis.
Journal: Journal of leukocyte biology 20030501
Title: Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643.
Journal: Toxicology and applied pharmacology 20030501
Title: Acute (24 h) activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) reverses high-fat feeding-induced insulin hypersecretion in vivo and in perifused pancreatic islets.
Journal: The Journal of endocrinology 20030501
Title: Dysregulation of DNA repair pathways in a transforming growth factor alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis.
Journal: Laboratory investigation; a journal of technical methods and pathology 20030501
Title: Hepatic protein expression of lean mice and obese diabetic mice treated with peroxisome proliferator-activated receptor activators.
Journal: Proteomics 20030401
Title: Protein expression changes in the Sprague Dawley rat liver proteome following administration of peroxisome proliferator activated receptor alpha and gamma ligands.
Journal: Proteomics 20030401
Title: Peroxisome proliferator-activated receptor alpha is involved in the regulation of lipid metabolism by ginseng.
Journal: British journal of pharmacology 20030401
Title: Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643.
Journal: Carcinogenesis 20030401
Title: Activation of peroxisome proliferator-activated receptors alpha and gamma1 inhibits human smooth muscle cell proliferation.
Journal: Molecular and cellular biochemistry 20030401
Title: 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism.
Journal: Biochemical and biophysical research communications 20030307
Title: PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly.
Journal: American journal of physiology. Endocrinology and metabolism 20030301
Title: Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20030301
Title: PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway.
Journal: Journal of the American Society of Nephrology : JASN 20030301
Title: Age-dependent effects of nongenotoxic hepatocarcinogens on liver apoptosis in vivo.
Journal: Mechanisms of ageing and development 20030301
Title: Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages.
Journal: Circulation research 20030207
Title: Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice.
Journal: The Biochemical journal 20030201
Title: Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone.
Journal: The Biochemical journal 20030201
Title: Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes.
Journal: Journal of dermatological science 20030201
Title: Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes.
Journal: The Journal of biological chemistry 20030103
Title: Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone.
Journal: Archives of biochemistry and biophysics 20030101
Title: Peroxisome proliferator-activated receptor-alpha activation during pregnancy attenuates glucose-stimulated insulin hypersecretion in vivo by increasing insulin sensitivity, without impairing pregnancy-induced increases in beta-cell glucose sensing and responsiveness.
Journal: Endocrinology 20030101
Title: Delayed induction of delta-6 and delta-5 desaturases by a peroxisome proliferator.
Journal: Biochemical and biophysical research communications 20021220
Title: WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20021215
Title: Non-genotoxic carcinogens: early effects on gap junctions, cell proliferation and apoptosis in the rat.
Journal: Toxicology 20021202
Title: Peroxisome proliferator-activated receptor activators inhibit oxidized low-density lipoprotein-induced endothelin-1 secretion in endothelial cells.
Journal: Journal of cardiovascular pharmacology 20021201
Title: Agonists of peroxisome-proliferator activated receptor-alpha (clofibrate and WY14643) reduce renal ischemia/reperfusion injury in the rat.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20021201
Title: Hepatic expression of polymerase beta, Ref-1, PCNA, and Bax in WY 14,643-exposed rats and hamsters.
Journal: Experimental and molecular pathology 20021201
Title: PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cells.
Journal: Antioxidants & redox signaling 20021201
Title: PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4.
Journal: Circulation research 20021129
Title: Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms.
Journal: Archives of biochemistry and biophysics 20021115
Title: AZ 242, a novel PPARalpha/gamma agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats.
Journal: Journal of lipid research 20021101
Title: A metabolic switching hypothesis for the first step in the hypolipidemic effects of fibrates.
Journal: Biological & pharmaceutical bulletin 20021101
Title: PPAR alpha stimulates the rat gastrin-producing cell.
Journal: Molecular and cellular endocrinology 20020930
Title: Peroxisome proliferator-activated receptor ligands negatively regulate the expression of the high-affinity IgE receptor Fc epsilon RI in human basophilic KU812 cells.
Journal: Biochemical and biophysical research communications 20020920
Title: Inhibition of cytokine-induced matrix metalloproteinase 9 expression by peroxisome proliferator-activated receptor alpha agonists is indirect and due to a NO-mediated reduction of mRNA stability.
Journal: The Journal of biological chemistry 20020906
Title: PPAR agonists amplify iNOS expression while inhibiting NF-kappaB: implications for mesangial cell activation by cytokines.
Journal: Journal of the American Society of Nephrology : JASN 20020901
Title: Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20020901
Title: Effects of the rat hepatic peroxisome proliferator, Wyeth 14,643, on the lactating goat.
Journal: Drug and chemical toxicology 20020801
Title: Peroxisome proliferator-activated receptor alpha in the human breast cancer cell lines MCF-7 and MDA-MB-231.
Journal: Molecular carcinogenesis 20020801
Title: Interactions of fluorochemicals with rat liver fatty acid-binding protein.
Journal: Toxicology 20020715
Title: WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice.
Journal: The Journal of biological chemistry 20020705
Title: Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020701
Title: Ligands of the peroxisome proliferator-activated receptor-PPAR-a reduce myocardial infarct size.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20020701
Title: Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts.
Journal: Toxicology and applied pharmacology 20020701
Title: Advantages of glutamate dehydrogenase as a blood biomarker of acute hepatic injury in rats.
Journal: Laboratory animals 20020701
Title: Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48.
Journal: The Journal of biological chemistry 20020621
Title: Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2.
Journal: Brain research 20020621
Title: Gene expression analysis reveals chemical-specific profiles.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20020601
Title: Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma.
Journal: Journal of neurochemistry 20020601
Title: Peroxisome proliferator-activated receptor agonists inhibit inflammatory edema and hyperalgesia.
Journal: Inflammation 20020601
Title: PPAR activators inhibit endothelial cell migration by targeting Akt.
Journal: Biochemical and biophysical research communications 20020524
Title: Involvement of the peroxisome proliferator-activated receptor alpha in the immunomodulation caused by peroxisome proliferators in mice.
Journal: Biochemical pharmacology 20020515
Title: Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells.
Journal: Atherosclerosis 20020501
Title: Selective inhibition of cyclooxygenase-2 expression by 15-deoxy-Delta(12,14)(12,14)-prostaglandin J(2) in activated human astrocytes, but not in human brain macrophages.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20020501
Title: Comparative effects of phthalate monoesters on gap junctional intercellular communication and peroxisome proliferation in rodent and primate hepatocytes.
Journal: Journal of toxicology and environmental health. Part A 20020426
Title: PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis.
Journal: Circulation research 20020405
Title: Peroxisome proliferators activate growth regulatory pathways largely via peroxisome proliferator-activated receptor alpha-independent mechanisms.
Journal: Cellular signalling 20020401
Title: Mechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes.
Journal: The Journal of biological chemistry 20020315
Title: Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20020315
Title: Potentiation of TNF-alpha-stimulated group IIA phospholipase A(2) expression by peroxisome proliferator-activated receptor alpha activators in rat mesangial cells.
Journal: Journal of the American Society of Nephrology : JASN 20020301
Title: Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.
Journal: Journal of medicinal chemistry 20020214
Title: The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020201
Title: Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin.
Journal: Diabetes 20020201
Title: Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism.
Journal: Arthritis and rheumatism 20020201
Title: Characterization of the adipose tissue atrophy induced by peroxisome proliferators in mice.
Journal: Lipids 20020201
Title: Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator- activated receptor alpha agonists.
Journal: Biochemical and biophysical research communications 20020125
Title: PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells.
Journal: European journal of pharmacology 20020125
Title: Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism.
Journal: The Journal of biological chemistry 20020111
Title: Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models.
Journal: The Journal of investigative dermatology 20020101
Title: Effect of peroxisome proliferators on the methylation and protein level of the c-myc protooncogene in B6C3F1 mice liver.
Journal: Journal of biochemical and molecular toxicology 20020101
Title: Profiling of acyl-CoA oxidase-deficient and peroxisome proliferator Wy14,643-treated mouse liver protein by surface-enhanced laser desorption/ionization ProteinChip Biology System.
Journal: Gene expression 20020101
Title: The transcription of the peroxisome proliferator-activated receptor alpha gene is regulated by protein kinase C.
Journal: Toxicology letters 20011215
Title: Antagonism of the actions of peroxisome proliferator-activated receptor-alpha by bile acids.
Journal: The Journal of biological chemistry 20011214
Title: Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion.
Journal: Diabetes 20011201
Title: Peroxisome proliferator-activated receptor alpha (PPAR alpha) agonist, WY-14,643, increased transcription of myosin light chain-2 in cardiomyocytes.
Journal: The Journal of toxicological sciences 20011201
Title: Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light-induced inflammation.
Journal: The Journal of investigative dermatology 20011201
Title: Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart.
Journal: The Journal of biological chemistry 20011130
Title: Human peroxisome proliferator-activated receptor alpha (PPARalpha) supports the induction of peroxisome proliferation in PPARalpha-deficient mouse liver.
Journal: The Journal of biological chemistry 20011109
Title: Hepatocellular proliferation in response to a peroxisome proliferator does not require TNFalpha signaling.
Journal: Carcinogenesis 20011101
Title: Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20011101
Title: Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development.
Journal: Molecular genetics and metabolism 20011101
Title: Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines.
Journal: The Journal of biological chemistry 20011019
Title: Stabilization of peroxisome proliferator-activated receptor alpha by the ligand.
Journal: Biochemical and biophysical research communications 20011019
Title: Activation of the peroxisome proliferator-activated receptor-alpha enhances cell death in cultured cerebellar granule cells.
Journal: Journal of neuroscience research 20011015
Title: Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha.
Journal: Biochemical and biophysical research communications 20010921
Title: Comparison of the mutant frequencies and mutation spectra of three non-genotoxic carcinogens, oxazepam, phenobarbital, and Wyeth 14,643, at the lambdacII locus in Big Blue transgenic mice.
Journal: Biochemical pharmacology 20010915
Title: Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta.
Journal: The Journal of biological chemistry 20010907
Title: Phenobarbital, oxazepam and Wyeth 14,643 cause DNA damage as measured by the Comet assay.
Journal: Mutagenesis 20010901
Title: Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice.
Journal: Biochemical and biophysical research communications 20010831
Title: Effects of bezafibrate on beta-cell function of rat pancreatic islets.
Journal: European journal of pharmacology 20010831
Title: Altered expression of the carboxylesterases ES-4 and ES-10 by peroxisome proliferator chemicals.
Journal: Toxicology 20010828
Title: Regulation of p85alpha phosphatidylinositol-3-kinase expression by peroxisome proliferator-activated receptors (PPARs) in human muscle cells.
Journal: FEBS letters 20010803
Title: (-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity.
Journal: Journal of medicinal chemistry 20010802
Title: Peroxisome proliferator-activated receptor-alpha ligands inhibit cardiac lipoprotein lipase activity.
Journal: American journal of physiology. Heart and circulatory physiology 20010801
Title: PPARalpha-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator.
Journal: Endocrinology 20010801
Title: Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells.
Journal: The Journal of biological chemistry 20010727
Title: Identification of a peroxisome-proliferator-activated-receptor response element in the apolipoprotein E gene control region.
Journal: The Biochemical journal 20010715
Title: Inhibitors of arachidonic acid metabolism potentiate tumour necrosis factor-alpha-induced apoptosis in HL-60 cells.
Journal: European journal of pharmacology 20010713
Title: Differential activation of hepatic NF-kappaB in rats and hamsters by the peroxisome proliferators Wy-14,643, gemfibrozil, and dibutyl phthalate.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010701
Title: Wy-14,643-induced hypomethylation of the c-myc gene in mouse liver.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010701
Title: Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells.
Journal: Experimental cell research 20010701
Title: Cloning of the human cholesteryl ester hydrolase promoter: identification of functional peroxisomal proliferator-activated receptor responsive elements.
Journal: Biochemical and biophysical research communications 20010622
Title: Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20010615
Title: Evidence that reduction of hepatocyte growth factor (HGF) is not required for peroxisome proliferator-induced hepatocyte proliferation.
Journal: Carcinogenesis 20010601
Title: The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor alpha-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal beta-oxidation enzymes acyl-CoA oxidase and hydratase-dehydrogenase.
Journal: Molecular and cellular endocrinology 20010515
Title: Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells.
Journal: Toxicology and applied pharmacology 20010501
Title: PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice.
Journal: The Journal of clinical investigation 20010415
Title: Effects of peroxisome proliferators on antioxidant enzymes and antioxidant vitamins in rats and hamsters.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010401
Title: Differential regulation of expression of genes encoding uncoupling proteins 2 and 3 in brown adipose tissue during lactation in mice.
Journal: The Biochemical journal 20010401
Title: The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis.
Journal: European journal of immunology 20010401
Title: WY-14,643 and other agonists of the peroxisome proliferator-activated receptor reveal a new mode of action for salicylic acid in soybean disease resistance.
Journal: Planta 20010401
Title: Peroxisome proliferators and fatty acids negatively regulate liver X receptor-mediated activity and sterol biosynthesis.
Journal: The Journal of steroid biochemistry and molecular biology 20010401
Title: Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids.
Journal: American journal of physiology. Endocrinology and metabolism 20010301
Title: Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010301
Title: Tumor necrosis factor alpha is not required for WY14,643-induced cell proliferation.
Journal: Carcinogenesis 20010301
Title: Peroxisome proliferators do not increase DNA synthesis in purified rat hepatocytes.
Journal: Carcinogenesis 20010301
Title: Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010301
Title: Effects of peroxisome proliferators on glutathione and glutathione-related enzymes in rats and hamsters.
Journal: Toxicology and applied pharmacology 20010215
Title: Delayed activation of PPARgamma by LPS and IFN-gamma attenuates the oxidative burst in macrophages.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010201
Title: PPARalpha agonists inhibit tissue factor expression in human monocytes and macrophages.
Journal: Circulation 20010116
Title: PPARalpha activators inhibit tissue factor expression and activity in human monocytes.
Journal: Circulation 20010116
Title: Fatty-acyl-CoA thioesters inhibit recruitment of steroid receptor co-activator 1 to alpha and gamma isoforms of peroxisome-proliferator-activated receptors by competing with agonists.
Journal: The Biochemical journal 20010115
Title: Dexamethasone selectively inhibits WY14,643-induced cell proliferation and not peroxisome proliferation in mice.
Journal: Toxicology and applied pharmacology 20010115
Title: Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates.
Journal: Biochimica et biophysica acta 20010115
Title: Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell.
Journal: The Journal of biological chemistry 20010112
Title: The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver.
Journal: The Journal of biological chemistry 20010105
Title: Expression of the mRNA encoding truncated PPAR alpha does not correlate with hepatic insensitivity to peroxisome proliferators.
Journal: Molecular and cellular biochemistry 20010101
Title: Therapeutic treatment of DMBA-induced mammary tumors with PPAR ligands.
Journal: Anticancer research 20010101
Title: Unique renal tubule changes induced in rats and mice by the peroxisome proliferators 2,4-dichlorophenoxyacetic acid (2,4-D) and WY-14643.
Journal: Toxicologic pathology 20010101
Title: Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis.
Journal: Gene expression 20010101
Title: 15-Deoxy-Delta(12,14)-prostaglandin J(2) facilitates thyroglobulin production by cultured human thyrocytes.
Journal: American journal of physiology. Cell physiology 20001201
Title: Down-regulation of uncoupling protein-3 and -2 by thiazolidinediones in C2C12 myotubes.
Journal: FEBS letters 20001027
Title: Keratinocyte differentiation in hyperproliferative epidermis: topical application of PPARalpha activators restores tissue homeostasis.
Journal: The Journal of investigative dermatology 20000901
Title: Peroxisome proliferator-activated receptor alpha (PPARalpha) activators, bezafibrate and Wy-14,643, increase uncoupling protein-3 mRNA levels without modifying the mitochondrial membrane potential in primary culture of rat preadipocytes.
Journal: Archives of biochemistry and biophysics 20000815
Title: Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene.
Journal: Diabetes 20000701
Title: Evidence against the peroxisome proliferator-activated receptor alpha (PPARalpha) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription.
Journal: Journal of lipid research 20000501
Title: The PPARs: from orphan receptors to drug discovery.
Journal: Journal of medicinal chemistry 20000224
Title: The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes.
Journal: Cell biology and toxicology 20000101
Title: trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals.
Journal: Toxicology and applied pharmacology 19991201
Title: PPARalpha activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARgamma-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes.
Journal: Biochemical and biophysical research communications 19991022
Title: Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice.
Journal: Carcinogenesis 19990801
Title: Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha.
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