Home Amines 515-94-6
515-94-6,MFCD00044531
Catalog No.:AA00I94Z

515-94-6 | 2,3-Diaminopropionic acid

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1g
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$70.00   $49.00
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5g
96%
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$236.00   $166.00
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25g
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$809.00   $567.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00I94Z
Chemical Name:
2,3-Diaminopropionic acid
CAS Number:
515-94-6
Molecular Formula:
C3H8N2O2
Molecular Weight:
104.1078
MDL Number:
MFCD00044531
SMILES:
NC(C(=O)O)CN
NSC Number:
115849
Properties
Properties
 
BP:
325.6°C at 760 mmHg  
Form:
Solid  
MP:
110°C  
Refractive Index:
1.4715 (estimate)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
73.3  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
7  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-4.3  

Literature

Title: Cyclic RGD peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120514

Title: Inactivation of glucosamine-6-phosphate synthase by N3-oxoacyl derivatives of L-2,3-diaminopropanoic acid.

Journal: Chembiochem : a European journal of chemical biology 20120102

Title: Capreomycin--a polypeptide antitubercular antibiotic with unusual binding properties toward copper(II).

Journal: Journal of inorganic biochemistry 20120101

Title: Formation of ion-selective channel using cyclic tetrapeptides.

Journal: Bioorganic & medicinal chemistry 20120101

Title: Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems.

Journal: Oxidative medicine and cellular longevity 20120101

Title: Is neurodegenerative disease a long-latency response to early-life genotoxin exposure?

Journal: International journal of environmental research and public health 20111001

Title: Does α-amino-β-methylaminopropionic acid (BMAA) play a role in neurodegeneration?

Journal: International journal of environmental research and public health 20110901

Title: Structure-activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists.

Journal: Bioorganic & medicinal chemistry letters 20110101

Title: Mutation of L-2,3-diaminopropionic acid synthase genes blocks staphyloferrin B synthesis in Staphylococcus aureus.

Journal: BMC microbiology 20110101

Title: The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis.

Journal: Journal of the American Chemical Society 20101110

Title: Syntheses of bifunctional 2,3-diamino propionic acid-based chelators as small and strong tripod ligands for the labelling of biomolecules with (99m)Tc.

Journal: Organic & biomolecular chemistry 20100621

Title: Incorporation of 2,3-diaminopropionic acid into linear cationic amphipathic peptides produces pH-sensitive vectors.

Journal: Chembiochem : a European journal of chemical biology 20100614

Title: Soluble monometallic salen complexes derived from O-functionalised diamines as metalloligands for the synthesis of heterobimetallic complexes.

Journal: Dalton transactions (Cambridge, England : 2003) 20100507

Title: Structure and binding of peptide-dendrimer ligands to vitamin B12.

Journal: Chembiochem : a European journal of chemical biology 20100215

Title: Evaluation of [99mTc-(CO)3-X-Y-Bombesin(7-14)NH2] conjugates for targeting gastrin-releasing peptide receptors overexpressed on breast carcinoma.

Journal: Anticancer research 20100101

Title: Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus.

Journal: Molecular microbiology 20091101

Title: Highly enantioselective synthesis of (S)-alpha-alkyl-alpha,beta-diaminopropionic acids via asymmetric phase-transfer catalytic alkylation of 2-phenyl-2-imidazoline-4-carboxylic acid tert-butyl esters.

Journal: Organic letters 20090820

Title: Beta-N-methylaminoalanine (BMAA): metabolism and metabolic effects in model systems and in neural and other tissues of the rat in vitro.

Journal: Toxicon : official journal of the International Society on Toxinology 20090801

Title: Proteolysis of peptide dendrimers.

Journal: Chembiochem : a European journal of chemical biology 20090615

Title: N-Terminal 2,3-diaminopropionic acid (Dap) peptides as efficient methylglyoxal scavengers to inhibit advanced glycation endproduct (AGE) formation.

Journal: Bioorganic & medicinal chemistry 20090315

Title: Investigations into viomycin biosynthesis by using heterologous production in Streptomyces lividans.

Journal: Chembiochem : a European journal of chemical biology 20090126

Title: Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20090120

Title: Molecular cloning, sequencing, and expression of a L -glutamine D-fructose 6-phosphate amidotransferase gene from Volvariella volvacea.

Journal: The protein journal 20090101

Title: Identification of catalytic Peptide dendrimers by 'off-bead' in silica high-throughput screening of combinatorial libraries.

Journal: Journal of combinatorial chemistry 20090101

Title: L-2,3-diaminopropionate: one of the building blocks for the biosynthesis of Zwittermicin A in Bacillus thuringiensis subsp. kurstaki strain YBT-1520.

Journal: FEBS letters 20080903

Title: Terpene conjugates of diaminedichloridoplatinum(II) complexes: antiproliferative effects in HL-60 leukemia, 518A2 melanoma, and HT-29 colon cancer cells.

Journal: Chemistry & biodiversity 20080801

Title: Identification of a novel beta-replacement reaction in the biosynthesis of 2,3-diaminobutyric acid in peptidylnucleoside mureidomycin A.

Journal: Organic & biomolecular chemistry 20080607

Title: A convenient route to enantiopure 3-aryl-2,3-diaminopropanoic acids by diastereoselective Mannich reaction of camphor-based tricyclic iminolactone with imines.

Journal: The Journal of organic chemistry 20080502

Title: Synthesis and conformational studies of peptidomimetics containing a new bifunctional diketopiperazine scaffold acting as a beta-hairpin inducer.

Journal: The Journal of organic chemistry 20080118

Title: Small molecule inhibitors of integrin alpha2beta1.

Journal: Journal of medicinal chemistry 20071101

Title: Asymmetric synthesis of beta2-amino acids: 2-substituted-3-aminopropanoic acids from N-acryloyl SuperQuat derivatives.

Journal: Organic & biomolecular chemistry 20070907

Title: Variable stability heterodimeric coiled-coils from manipulation of electrostatic interface residue chain length.

Journal: Journal of the American Chemical Society 20070822

Title: Chiroptical properties of diamino carboxylic acids.

Journal: Chirality 20070701

Title: Identification of three Zwittermicin A biosynthesis-related genes from Bacillus thuringiensis subsp. kurstaki strain YBT-1520.

Journal: Archives of microbiology 20070401

Title: Structure activity relationship studies on the antimicrobial activity of novel edeine A and D analogues.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20061001

Title: Aziridinium from N,N-dibenzyl serine methyl ester: synthesis of enantiomerically pure beta-amino and alpha,beta-diamino esters.

Journal: Organic letters 20060511

Title: Electron capture dissociation mass spectrometry of peptide cations containing a lysine homologue: a mobile proton model for explaining the observation of b-type product ions.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Synthesis, anti-inflammatory and analgesic activities evaluation of some mono, bi and tricyclic pyrimidine derivatives.

Journal: Bioorganic & medicinal chemistry 20051115

Title: Novel parent structures for inhibitors of the murine GABA transporters mGAT3 and mGAT4.

Journal: European journal of pharmacology 20050905

Title: Antibiotics GE23077, novel inhibitors of bacterial RNA polymerase. Part 3: Chemical derivatization.

Journal: Bioorganic & medicinal chemistry letters 20050815

Title: [Nalpha-benzylTyr1,cyclo(D-Asp5,Dap8)]- dynorphin A-(1-11)NH2 cyclized in the 'address' domain is a novel kappa-opioid receptor antagonist.

Journal: Journal of medicinal chemistry 20050714

Title: Inhibition of mitosis by glycopeptide dendrimer conjugates of colchicine.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20050620

Title: Soluble MHC-peptide complexes induce rapid death of CD8+ CTL.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20050601

Title: Hydrolytically stable, diaminocarboxylic acid-based membranes buffering in the pH range from 6 to 8.5 for isoelectric trapping separations.

Journal: Electrophoresis 20050601

Title: Antibiotics GE23077, novel inhibitors of bacterial RNA polymerase. II. Structure elucidation.

Journal: The Journal of antibiotics 20050401

Title: A rat model of neurolathyrism: repeated injection of L: -beta-ODAP induces the paraparesis of the hind legs.

Journal: Amino acids 20050301

Title: Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation.

Journal: Amino acids 20050201

Title: Local expression of matrix metalloproteinases, cathepsins, and their inhibitors during the development of murine antigen-induced arthritis.

Journal: Arthritis research & therapy 20050101

Title: A conventional route for the synthesis of new oxazolidin-2-one derivatives with beta-aminoalanines.

Journal: Chemical & pharmaceutical bulletin 20041001

Title: Effect of variations in the structure of a polyleucine-based alpha-helical transmembrane peptide on its interaction with phosphatidylglycerol bilayers.

Journal: Biochemistry 20040330

Title: Engineering charge selectivity in model ion channels.

Journal: Bioorganic & medicinal chemistry 20040315

Title: Synthesis of 9-membered dilactams derived from 1,3-diaminopropionic and glutamic acids.

Journal: The journal of peptide research : official journal of the American Peptide Society 20040301

Title: An efficient synthesis of a probe for protein function: 2,3-diaminopropionic acid with orthogonal protecting groups.

Journal: Organic letters 20040122

Title: Synthesis and opioid activity of side-chain-to-side-chain cyclic dynorphin A-(1-11) amide analogues cyclized between positions 2 and 5. 1. Substitutions in position 3.

Journal: Journal of medicinal chemistry 20040115

Title: Crystallization and preliminary X-ray diffraction studies on recombinant diaminopropionate ammonia lyase from Escherichia coli.

Journal: Acta crystallographica. Section D, Biological crystallography 20030901

Title: Platinum complexes of diaminocarboxylic acids and their ethyl ester derivatives: the effect of the chelate ring size on antitumor activity and interactions with GMP and DNA.

Journal: Journal of inorganic biochemistry 20030901

Title: Identification and cloning of genes encoding viomycin biosynthesis from Streptomyces vinaceus and evidence for involvement of a rare oxygenase.

Journal: Gene 20030717

Title: Radiochemical investigations of gastrin-releasing peptide receptor-specific [(99m)Tc(X)(CO)3-Dpr-Ser-Ser-Ser-Gln-Trp-Ala-Val-Gly-His-Leu-Met-(NH2)] in PC-3, tumor-bearing, rodent models: syntheses, radiolabeling, and in vitro/in vivo studies where Dpr = 2,3-diaminopropionic acid and X = H2O or P(CH2OH)3.

Journal: Cancer research 20030715

Title: Synthesis of metal-chelating lipids to sensitize lanthanide ions.

Journal: The Journal of organic chemistry 20030516

Title: Design, synthesis and in vitro cytotoxicity of a cis-dichloroplatinum (II) complex linked to the minor groove binder stallimycin.

Journal: Arzneimittel-Forschung 20030101

Title: Gene cloning, purification, and characterization of 2,3-diaminopropionate ammonia-lyase from Escherichia coli.

Journal: Bioscience, biotechnology, and biochemistry 20021201

Title: Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase.

Journal: Biochemistry 20021112

Title: Effect of variations in the structure of a polyleucine-based alpha-helical transmembrane peptide on its interaction with phosphatidylcholine bilayers.

Journal: Biochemistry 20020723

Title: Design and synthesis of carboxylate inhibitors for matrix metalloproteinases.

Journal: Chemical & pharmaceutical bulletin 20011001

Title: Does the activation of poly (ADP-ribose) synthetase mediate tissue injury in the sepsis induced by cecal ligation and puncture?

Journal: Shock (Augusta, Ga.) 20010801

Title: Beta D305A mutant of tryptophan synthase shows strongly perturbed allosteric regulation and substrate specificity.

Journal: Biochemistry 20010626

Title: Highly enantioselective synthesis of alpha,beta-diaminopropanoic acid derivatives using a catalytic asymmetric hydrogenation approach.

Journal: The Journal of organic chemistry 20010615

Title: Glucosamine-6-phosphate synthase from Escherichia coli: determination of the mechanism of inactivation by N3-fumaroyl-L-2,3-diaminopropionic derivatives.

Journal: Biochemistry 19900417

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Tags:515-94-6 Molecular Formula|515-94-6 MDL|515-94-6 SMILES|515-94-6 2,3-Diaminopropionic acid