Title: Antitumor effects of deguelin on H460 human lung cancer cells in vitro and in vivo: Roles of apoptotic cell death and H460 tumor xenografts model.
Journal: Environmental toxicology 20170101
Title: Protective role of hypoxia-inducible factor-1α-dependent CD39 and CD73 in fulminant acute liver failure.
Journal: Toxicology and applied pharmacology 20170101
Title: Synthesis and Evaluation of a Novel Deguelin Derivative, L80, which Disrupts ATP Binding to the C-terminal Domain of Heat Shock Protein 90.
Journal: Molecular pharmacology 20150801
Title: Deguelin, a selective silencer of the NPM1 mutant, potentiates apoptosis and induces differentiation in AML cells carrying the NPM1 mutation.
Journal: Annals of hematology 20150201
Title: Deguelin inhibits the migration and invasion of lung cancer A549 and H460 cells via regulating actin cytoskeleton rearrangement.
Journal: International journal of clinical and experimental pathology 20150101
Title: Deguelin inhibits the migration and invasion of U-2 OS human osteosarcoma cells via the inhibition of matrix metalloproteinase-2/-9 in vitro.
Journal: Molecules (Basel, Switzerland) 20141015
Title: Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model.
Journal: Oncogene 20130822
Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Journal: Bioorganic & medicinal chemistry 20121115
Title: Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice.
Journal: Digestive diseases and sciences 20121101
Title: Delivering instilled hydrophobic drug to the bladder by a cationic nanoparticle and thermo-sensitive hydrogel composite system.
Journal: Nanoscale 20121021
Title: Distinct chemotypes of Tephrosia vogelii and implications for their use in pest control and soil enrichment.
Journal: Phytochemistry 20120601
Title: Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells.
Journal: Oncology reports 20120401
Title: The greening of pesticide-environment interactions: some personal observations.
Journal: Environmental health perspectives 20120401
Title: Comparison of several extraction procedures for the determination of biopesticides in soil samples by ultrahigh pressure LC-MS/MS.
Journal: Journal of separation science 20120401
Title: Synthesis of deguelin-biotin conjugates and investigation into deguelin's interactions.
Journal: Bioorganic & medicinal chemistry 20120115
Title: A new prenylated flavanone from Derris trifoliata Lour.
Journal: Molecules (Basel, Switzerland) 20120111
Title: Chronic Akt blockade aggravates pathological hypertrophy and inhibits physiological hypertrophy.
Journal: American journal of physiology. Heart and circulatory physiology 20120101
Title: Wnt signaling pathways in urological cancers: past decades and still growing.
Journal: Molecular cancer 20120101
Title: Multi-level targeting of the phosphatidylinositol-3-kinase pathway in non-small cell lung cancer cells.
Journal: PloS one 20120101
Title: Mitochondrial electron transport chain in heavy metal-induced neurotoxicity: effects of cadmium, mercury, and copper.
Journal: TheScientificWorldJournal 20120101
Title: Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma.
Journal: Journal of oncology 20120101
Title: Radiation, inflammation, and immune responses in cancer.
Journal: Frontiers in oncology 20120101
Title: Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat.
Journal: PloS one 20120101
Title: Anticancer efficacy of deguelin in human prostate cancer cells targeting glycogen synthase kinase-3 β/β-catenin pathway.
Journal: International journal of cancer 20111215
Title: Exploring the boundaries of additivity: mixtures of NADH: quinone oxidoreductase inhibitors.
Journal: Chemical research in toxicology 20110815
Title: Role for pAKT in rat urinary bladder with cyclophosphamide (CYP)-induced cystitis.
Journal: American journal of physiology. Renal physiology 20110801
Title: Radish (Raphanus sativus L. leaf) ethanol extract inhibits protein and mRNA expression of ErbB(2) and ErbB(3) in MDA-MB-231 human breast cancer cells.
Journal: Nutrition research and practice 20110801
Title: [Effects of deguelin on proliferation and apoptosis of MCF-7 breast cancer cells by phosphatidylinositol 3-kinase/Akt signaling pathway].
Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20110501
Title: Activation of STAT1 is required for interferon-alpha-mediated cell death.
Journal: Experimental cell research 20110101
Title: NNK-Induced Lung Tumors: A Review of Animal Model.
Journal: Journal of oncology 20110101
Title: X-linked inhibitor of apoptosis positive nuclear labeling: a new independent prognostic biomarker of breast invasive ductal carcinoma.
Journal: Diagnostic pathology 20110101
Title: SRC-3 has a role in cancer other than as a nuclear receptor coactivator.
Journal: International journal of biological sciences 20110101
Title: Deguelin--an inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor-D in lung tumor model.
Journal: International journal of cancer 20101115
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer.
Journal: Oncology reports 20101001
Title: Inhibition of Cell Proliferation and MAP Kinase and Akt Pathways in Oral Squamous cell Carcinoma by Genistein and Biochanin A.
Journal: Evidence-based complementary and alternative medicine : eCAM 20100901
Title: Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20100823
Title: [Separation and preparation of two rotenoids from the roots of Derris by high-speed counter-current chromatography].
Journal: Se pu = Chinese journal of chromatography 20100801
Title: Natural toxins for use in pest management.
Journal: Toxins 20100801
Title: IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter.
Journal: Cell death & disease 20100601
Title: Deguelin suppresses cell proliferation via the inhibition of survivin expression and STAT3 phosphorylation in HTLV-1-transformed T cells.
Journal: Leukemia research 20100301
Title: Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention.
Journal: Journal of the National Cancer Institute 20100106
Title: A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate.
Journal: British journal of cancer 20100105
Title: The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100101
Title: Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols.
Journal: Molecular cancer 20100101
Title: A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses.
Journal: PloS one 20100101
Title: Suppression of lung tumorigenesis by leucine zipper/EF hand-containing transmembrane-1.
Journal: PloS one 20100101
Title: Parkinson's disease: is it a toxic syndrome?
Journal: Neurology research international 20100101
Title: 1-Nitropyrene stabilizes the mRNA of cytochrome P450 1a1, a carcinogen-metabolizing enzyme, via the Akt pathway.
Journal: Chemical research in toxicology 20091201
Title: Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway.
Journal: Cancer prevention research (Philadelphia, Pa.) 20091101
Title: A novel look into estrogen receptor-negative breast cancer prevention with the natural, multifunctional signal transduction inhibitor deguelin.
Journal: Cancer prevention research (Philadelphia, Pa.) 20091101
Title: Optimising resolution for a preparative separation of Chinese herbal medicine using a surrogate model sample system.
Journal: Journal of chromatography. A 20090626
Title: Nitric oxide inhibitory principles from Derris trifoliata stems.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20090601
Title: Involvement of SRC-3 in deguelin-induced apoptosis in Jurkat cells.
Journal: International journal of hematology 20090601
Title: Deguelin blocks cells survival signal pathways and induces apoptosis of HL-60 cells in vitro.
Journal: International journal of hematology 20090601
Title: Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation.
Journal: Nature chemical biology 20090401
Title: Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis.
Journal: Cancer prevention research (Philadelphia, Pa.) 20090401
Title: Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells.
Journal: Journal of veterinary science 20090301
Title: Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1alpha.
Journal: Cancer research 20090215
Title: A novel flow cytometric high throughput assay for a systematic study on molecular mechanisms underlying T cell receptor-mediated integrin activation.
Journal: PloS one 20090101
Title: Acute inhibition of selected membrane-proximal mouse T cell receptor signaling by mitochondrial antagonists.
Journal: PloS one 20090101
Title: Angiogenesis in pre-malignant conditions.
Journal: British journal of cancer 20081209
Title: Simultaneous blockade of AP-1 and phosphatidylinositol 3-kinase pathway in non-small cell lung cancer cells.
Journal: British journal of cancer 20081209
Title: Deguelin inhibits retinal neovascularization by down-regulation of HIF-1alpha in oxygen-induced retinopathy.
Journal: Journal of cellular and molecular medicine 20081201
Title: A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy.
Journal: Cancer prevention research (Philadelphia, Pa.) 20081201
Title: Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils.
Journal: Journal of natural products 20081001
Title: Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.
Journal: Journal of natural products 20081001
Title: Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis.
Journal: Oncology reports 20080701
Title: Enhancement radiosensitization of breast cancer cells by deguelin.
Journal: Cancer biotherapy & radiopharmaceuticals 20080601
Title: Antiangiogenic effect of deguelin on choroidal neovascularization.
Journal: The Journal of pharmacology and experimental therapeutics 20080201
Title: Preparative isolation and purification of three rotenoids and one isoflavone from the seeds of Millettia pachycarpa Benth by high-speed counter-current chromatography.
Journal: Journal of chromatography. A 20080118
Title: Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha.
Journal: International journal of cancer 20080101
Title: Deguelin represses both the expression of nucleophosmin and some nucleoporins: Nup88 and Nup214 in Jurkat cells.
Journal: Biological & pharmaceutical bulletin 20080101
Title: Studies on cellular resilience and adaptation following acute and repetitive exposure to ozone in cultured human epithelial (HeLa) cells.
Journal: Redox report : communications in free radical research 20080101
Title: Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin.
Journal: Cancer research 20071215
Title: Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo.
Journal: Biology of reproduction 20071101
Title: Deguelin inhibits expression of IkappaBalpha protein and induces apoptosis of B-CLL cells in vitro.
Journal: Leukemia 20070801
Title: The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.
Journal: Current genomics 20070801
Title: Structural basis for depletion of heat shock protein 90 client proteins by deguelin.
Journal: Journal of the National Cancer Institute 20070620
Title: Anti-cancer effects of deguelin on human leukemia K562 and K562/ADM cells In Vitro.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20070401
Title: AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro.
Journal: The Journal of biological chemistry 20070309
Title: [Effect of deguelin on proliferation and apoptosis of lymphoma Daudi cells and its mechanism].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20070301
Title: The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-kappaB pathway.
Journal: Carcinogenesis 20070201
Title: Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa.
Journal: Bioorganic & medicinal chemistry 20070201
Title: [Effect of deguelin on expression of nup98 in K562 cells].
Journal: Zhongguo shi yan xue ye xue za zhi 20070201
Title: [Deguelin regulates cell cycle and nuclear pore complex protein Nup98 and Nup88 in U937 cells in vitro].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20070201
Title: Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells.
Journal: Molecular pharmacology 20070101
Title: Soluble Fas ligand inhibits angiogenesis in rheumatoid arthritis.
Journal: Arthritis research & therapy 20070101
Title: Mechanism of uptake and retention of F-18 BMS-747158-02 in cardiomyocytes: a novel PET myocardial imaging agent.
Journal: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20070101
Title: Structures of new flavonoids, erycibenins D, E, and F, and NO production inhibitors from Erycibe expansa originating in Thailand.
Journal: Chemical & pharmaceutical bulletin 20061101
Title: Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20061015
Title: Deguelin inhibits expression of IkappaBalpha protein in Raji and U937 cells.
Journal: Acta pharmacologica Sinica 20060401
Title: Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.
Journal: Journal of cellular biochemistry 20060201
Title: Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice.
Journal: Neoplasia (New York, N.Y.) 20051201
Title: Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens.
Journal: Journal of the National Cancer Institute 20051116
Title: Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis.
Journal: Journal of the National Cancer Institute 20051116
Title: Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588.
Journal: The Journal of biological chemistry 20051111
Title: Fast and versatile multiresidue method for the analysis of botanical insecticides on fruits and vegetables by HPLC/DAD/MS.
Journal: Journal of agricultural and food chemistry 20051102
Title: Deguelin regulates nuclear pore complex proteins Nup98 and Nup88 in U937 cells in vitro.
Journal: Acta pharmacologica Sinica 20051001
Title: Regulating expressions of cyclin D1, pRb, and anti-cancer effects of deguelin on human Burkitt's lymphoma Daudi cells in vitro.
Journal: Acta pharmacologica Sinica 20050701
Title: Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway.
Journal: British journal of haematology 20050601
Title: Effect of deguelin on UVB-induced skin carcinogenesis.
Journal: Journal of chemotherapy (Florence, Italy) 20050601
Title: Mechanisms of interleukin-4 effects on calcium signaling in airway smooth muscle cells.
Journal: The Journal of pharmacology and experimental therapeutics 20050401
Title: Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo.
Journal: The Journal of biological chemistry 20050318
Title: 7a-O-methyldeguelol, a modified rotenoid with an open ring-C, from the roots of Derris trifoliata.
Journal: Phytochemistry 20050301
Title: Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease.
Journal: Chemical research in toxicology 20041101
Title: Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells.
Journal: Biochemical pharmacology 20040915
Title: Natural inhibitors of carcinogenesis.
Journal: Planta medica 20040801
Title: Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics.
Journal: Apoptosis : an international journal on programmed cell death 20040701
Title: Cancer chemopreventive activity of rotenoids from Derris trifoliata.
Journal: Planta medica 20040601
Title: Co-targeting IGF-1R and c-kit: synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells.
Journal: British journal of cancer 20040504
Title: Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040201
Title: Rotenone and rotenoids in cubè resins, formulations, and residues on olives.
Journal: Journal of agricultural and food chemistry 20040128
Title: Cancer chemopreventive activity of rotenoids from Derris trifoliata.
Journal: Planta medica 20040101
Title: Concise synthesis of the chemopreventitive agent (+/-)-deguelin via a key 6-endo hydroarylation.
Journal: Organic letters 20031030
Title: Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti.
Journal: Pest management science 20031001
Title: Deguelin suppresses the formation of carcinogen-induced aberrant crypt foci in the colon of CF-1 mice.
Journal: International journal of cancer 20030310
Title: AKT and the phosphatidylinositol 3-kinase/AKT pathway: important molecular targets for lung cancer prevention and treatment.
Journal: Journal of the National Cancer Institute 20030219
Title: Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells.
Journal: Journal of the National Cancer Institute 20030219
Title: Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest.
Journal: European journal of cancer (Oxford, England : 1990) 20021201
Title: Discovery of cancer preventive agents from natural products: from plants to prevention.
Journal: Current oncology reports 20021101
Title: [Modification of the analytical method for rotenoids in plants].
Journal: Se pu = Chinese journal of chromatography 20020301
Title: Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats.
Journal: Cancer chemotherapy and pharmacology 20010301
Title: Review article number 135 biosynthesis in the rotenoid group of natural products: applications of isotope methodology.
Journal: Phytochemistry 19981120
Title: NADH: ubiquinone oxidoreductase inhibitors block induction of ornithine decarboxylase activity in MCF-7 human breast cancer cells.
Journal: Pharmacology & toxicology 19981101
Title: Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent.
Journal: Cancer research 19970815
Title: Anomalous structure-activity relationships of 13-homo-13-oxarotenoids and 13-homo-13-oxadehyrorotenoids.
Journal: Chemical research in toxicology 19970801
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