Home Thiazoles 5317-37-3
5317-37-3,MFCD01706819
Catalog No.:AA0037NG

5317-37-3 | 10-[3-(4-Methyl-1-piperazinyl)propyl]-10H-phenothiazine dihydrochloride

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Purity
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10mg
3 weeks  
$503.00   $352.00
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100mg
3 weeks  
$2,686.00   $1,880.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0037NG
Chemical Name:
10-[3-(4-Methyl-1-piperazinyl)propyl]-10H-phenothiazine dihydrochloride
CAS Number:
5317-37-3
Molecular Formula:
C20H27Cl2N3S
Molecular Weight:
412.4195
MDL Number:
MFCD01706819
SMILES:
CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cccc2.Cl.Cl
Properties
Properties
 
Form:
Solid  
MP:
229-231°C (dec.)  
Storage:
Keep in dry area;-20 ℃;Inert atmosphere;  

Computed Properties
 
Complexity:
374  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  

Literature

Title: Attentional and emotional functioning in schizophrenia patients treated with conventional and atypical antipsychotic drugs.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20120101

Title: Some dopaminergic genes polymorphisms are not associated with response to antipsychotic drugs in schizophrenic patients.

Journal: Pharmacological reports : PR 20120101

Title: Management of marked liver enzyme increase during olanzapine treatment: a case report and review of the literature.

Journal: Psychiatria Danubina 20110901

Title: The role of CYP2D6 and TaqI A polymorphisms in malignant neuroleptic syndrome: two case reports with three episodes.

Journal: Psychiatria Danubina 20100301

Title: [Perazine in the treatment of psychotic disorders--research review].

Journal: Psychiatria polska 20100101

Title: Perazine elevates clozapine serum levels by inhibiting hepatic metabolism.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20090801

Title: Validation of derivative spectrophotometry method for determination of active ingredients from neuroleptics in pharmaceutical preparations.

Journal: Acta poloniae pharmaceutica 20090101

Title: [Drug-induced agranulocytosis--case reports and literature review].

Journal: Przeglad lekarski 20090101

Title: Perazine at therapeutic drug concentrations inhibits human cytochrome P450 isoenzyme 1A2 (CYP1A2) and caffeine metabolism--an in vitro study.

Journal: Pharmacological reports : PR 20090101

Title: [Antipsychotics in clinical practice. Treatment of the first schizophrenic episode].

Journal: Psychiatria polska 20080101

Title: [Ischemic colitis without atherosclerosis?].

Journal: Deutsche medizinische Wochenschrift (1946) 20070330

Title: Perazine and carbamazepine in comparison to olanzapine in schizophrenia.

Journal: Neuropsychobiology 20070101

Title: Perazine for schizophrenia.

Journal: The Cochrane database of systematic reviews 20060419

Title: Effect of chronic treatment with perazine on lipopolysaccharide-induced interleukin-1 beta levels in the rat brain.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20060401

Title: Automated analysis of quetiapine and other antipsychotic drugs in human blood by high performance-liquid chromatography with column-switching and spectrophotometric detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060118

Title: Acute psychosis with a mediastinal carcinoma metastasis.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20050101

Title: Direct effects of neuroleptics on the activity of CYP2A in the liver of rats.

Journal: Pharmacological reports : PR 20050101

Title: Schizophrenia.

Journal: Clinical evidence 20041201

Title: The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20040501

Title: Schizophrenia.

Journal: Clinical evidence 20031201

Title: Antipsychotic efficacy of the antidepressant trimipramine: a randomized, double-blind comparison with the phenothiazine perazine.

Journal: Pharmacopsychiatry 20030101

Title: Effects of cytochrome P-450 inducers on the perazine metabolism in a primary culture of human hepatocytes.

Journal: Polish journal of pharmacology 20030101

Title: The contribution of cytochrome P-450 isoenzymes to the metabolism of phenothiazine neuroleptics.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20021001

Title: Switching to amisulpride due to hepatic complications.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20020501

Title: Perazine for schizophrenia.

Journal: The Cochrane database of systematic reviews 20020101

Title: Perazine as a potent inhibitor of human CYP1A2 but not CYP3A4.

Journal: Polish journal of pharmacology 20020101

Title: Intracellular distribution of psychotropic drugs in the grey and white matter of the brain: the role of lysosomal trapping.

Journal: British journal of pharmacology 20011001

Title: Neuroleptics normalize increased release of interleukin- 1 beta and tumor necrosis factor-alpha from monocytes in schizophrenia.

Journal: Schizophrenia research 20010701

Title: Relevance of liver enzyme elevations with four different neuroleptics: a retrospective review of 7,263 treatment courses.

Journal: Journal of clinical psychopharmacology 20010401

Title: The effect of selective serotonin reuptake inhibitors (SSRIs) on the pharmacokinetics and metabolism of perazine in the rat.

Journal: The Journal of pharmacy and pharmacology 20010401

Title: [Neuroleptic malignant syndrome--case report].

Journal: Przeglad lekarski 20010101

Title: Examination of iron (III) and hexacyanoferrate (III) ions as reagents for the spectrophotometric determination of promazine and perazine.

Journal: Acta poloniae pharmaceutica 20010101

Title: Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro.

Journal: Psychopharmacology 20000901

Title: [Psychotic episode caused by prevention of malaria with mefloquine. A case report].

Journal: Der Nervenarzt 19920501

Title: [Electroconvulsive therapy in treatment of acute life threatening catatonia in toxic epidermal necrolysis (Lyell syndrome)].

Journal: Der Nervenarzt 19920501

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Tags:5317-37-3 Molecular Formula|5317-37-3 MDL|5317-37-3 SMILES|5317-37-3 10-[3-(4-Methyl-1-piperazinyl)propyl]-10H-phenothiazine dihydrochloride