Home Amines 58-33-3
58-33-3,MFCD00012652
Catalog No.:AA003SHI

58-33-3 | N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride

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5g
98%(HPLC)
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10g
≥95%
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$46.00   $32.00
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25g
>98.0%(T)(HPLC)
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$68.00   $48.00
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50g
≥95%
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100g
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003SHI
Chemical Name:
N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride
CAS Number:
58-33-3
Molecular Formula:
C17H21ClN2S
Molecular Weight:
320.8800
MDL Number:
MFCD00012652
SMILES:
CN(C(CN1c2ccccc2Sc2c1cccc2)C)C.Cl
Properties
Properties
 
Form:
Solid  
MP:
230-232°C  
Storage:
Light sensitive;Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
298  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  

Downstream Synthesis Route

[1]Bornschein;Wuenschmann;Kraft;Pfeifer[Pharmazie,1972,vol.27,#9,p.555-560]

[2]CurrentPatentAssignee:NEKTARTHERAPEUTICS-JP5828587,2015,B2

[1]Nakagawa;Chikuma;Li;Yamada;Kawazura[ChemicalandPharmaceuticalBulletin,1993,vol.41,#10,p.1691-1694]

[2]DesMarteau,DarrylD.;Petrov,ViacheslavA.;Montanari,Vittorio;Pregnolato,Massimo;Resnati,Giuseppe[JournalofOrganicChemistry,1994,vol.59,#10,p.2762-2765]

[1]Bosch,Eric;Kochi,JayK.[JournaloftheChemicalSociety.PerkintransactionsI,1995,#8,p.1057-1064]

[2]Upadhyay,Kanchan;Asthana,Anupama;Tamrakar,RaunakKumar[ResearchonChemicalIntermediates,2015,vol.41,#10,p.7481-7495]

[1]CurrentPatentAssignee:NEKTARTHERAPEUTICS-JP5828587,2015,B2Locationinpatent:Paragraph0189

[2]CurrentPatentAssignee:THEUNIVERSITYOFTEXASSYSTEM-WO2003/105811,2003,A2Locationinpatent:Page26

[1]CurrentPatentAssignee:PFIZERINC-US4097596,1978,A

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Title: Rapid tranquillisation in psychiatric emergency settings in Brazil: pragmatic randomised controlled trial of intramuscular haloperidol versus intramuscular haloperidol plus promethazine.

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Title: Beliefs and social norms about codeine and promethazine hydrochloride cough syrup (CPHCS) use and addiction among multi-ethnic college students.

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Journal: Aviation, space, and environmental medicine 20070401

Title: Acute urinary retention among astronauts.

Journal: Aviation, space, and environmental medicine 20070401

Title: Development and in vitro characterization of chitosan-based microspheres for nasal delivery of promethazine.

Journal: Drug development and industrial pharmacy 20070401

Title: Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives.

Journal: Bioorganic & medicinal chemistry letters 20070301

Title: A comparison of ondansetron with promethazine for treating postoperative nausea and vomiting in patients who received prophylaxis with ondansetron: a retrospective database analysis.

Journal: Anesthesia and analgesia 20070301

Title: Microcapsule-gel formulation of promethazine HCl for controlled nasal delivery: a motion sickness medication.

Journal: Journal of microencapsulation 20070301

Title: Influence of electrolytes/non-electrolytes on the cloud point phenomenon of the aqueous promethazine hydrochloride drug solution.

Journal: Journal of colloid and interface science 20070201

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Title: Premedication for coronary angiography: effects on anxiety and hemodynamic status.

Journal: Indian heart journal 20070101

Title: Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia.

Journal: European journal of clinical pharmacology 20061201

Title: Reduced interference by phenothiazines in amphetamine drug of abuse immunoassays.

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Title: Promethazine and sudden infant death.

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Title: Vanished behind the counter. Starting this week, you'll need help buying your claritin and nyquil.

Journal: U.S. news & world report 20061002

Title: The effects of alpha1-acid glycoprotein on the reversal of chloroquine resistance in Plasmodium falciparum.

Journal: Annals of tropical medicine and parasitology 20061001

Title: [Treatment of sleep disorders during pregnancy and breast feeding].

Journal: Lakartidningen 20061001

Title: Effects of ethanol and promethazine on awareness of errors and judgements of performance.

Journal: Journal of psychopharmacology (Oxford, England) 20060901

Title: Influence of simulated weightlessness on the intramuscular and oral pharmacokinetics of promethazine in 12 human volunteers.

Journal: Journal of clinical pharmacology 20060901

Title: Practical oral sedation in dentistry. Part II--Clinical application of various oral sedatives and discussion.

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Title: A late cutaneous response in actively sensitized rats: a new method for evaluating the efficacy of antiallergic drugs.

Journal: Journal of pharmacological sciences 20060801

Title: Use of promethazine in infants in primary care.

Journal: International journal of clinical pharmacology and therapeutics 20060801

Title: Fasting duration influences the inhibition of food intake by histamine in chickens.

Journal: Physiology & behavior 20060730

Title: Differences of promethazine and terfenadine on ion channels in guinea pig ventricular myocytes.

Journal: Chinese medical journal 20060605

Title: Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus.

Journal: British journal of anaesthesia 20060601

Title: Accidental intra-arterial injection: a case report, new treatment modalities, and a review of the literature.

Journal: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20060601

Title: [Use of promethazine in pediatric asthmatic disorders].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20060601

Title: Akathisia with combined use of midodrine and promethazine.

Journal: JAMA 20060503

Title: Triage test and HPLC assay for analysis of vegetamin, an antipsychotic agent, using gastric contents and blood specimens.

Journal: Legal medicine (Tokyo, Japan) 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: The human Ca2+-activated K+ channel, IK, can be blocked by the tricyclic antihistamine promethazine.

Journal: Neuropharmacology 20060301

Title: Hydroxyzine, promethazine and thioridazine interaction with phospholipid monomolecular layers at the air-water interface.

Journal: Biophysical chemistry 20060201

Title: Selective inhibition of brain Na,K-ATPase by drugs.

Journal: Physiological research 20060101

Title: No more than necessary: safety and efficacy of low-dose promethazine.

Journal: The Annals of pharmacotherapy 20060101

Title: Case report of unrecognized akathisia resulting in an emergency landing and RSI during air medical transport.

Journal: Air medical journal 20060101

Title: Characterizing bitterness: identification of key structural features and development of a classification model.

Journal: Journal of chemical information and modeling 20060101

Title: Synergistic interaction between proton pump inhibitors and resistance modifiers: promoting effects of antibiotics and plasmid curing.

Journal: In vivo (Athens, Greece) 20060101

Title: Promethazine protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.

Journal: Neurobiology of disease 20051201

Title: Multivariate optimization approach for chiral resolution of drugs using human serum albumin in affinity electrokinetic chromatography-partial filling technique.

Journal: Electrophoresis 20051101

Title: An informal discussion of emergency nurses' current clinical practice: what's new and what works. Danger with use of intravenous promethazine in the emergency department.

Journal: Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association 20051001

Title: Determination of promethazine hydrochloride in pharmaceuticals by capillary isotachophoresis.

Journal: Methods and findings in experimental and clinical pharmacology 20051001

Title: Determination of promethazine hydrochloride and its preparations by highly accurate nephelometric titration.

Journal: International journal of pharmaceutics 20050930

Title: Inappropriate drug prescribing in older adults: the updated 2002 Beers criteria--a population-based cohort study.

Journal: British journal of clinical pharmacology 20050801

Title: Limitations of rapid tranquillisation trial.

Journal: The British journal of psychiatry : the journal of mental science 20050801

Title: Drug combinations for rapid tranquillisation.

Journal: The British journal of psychiatry : the journal of mental science 20050801

Title: An unexpected cause of an acute hypersensitivity reaction during recovery from anaesthesia.

Journal: Anaesthesia and intensive care 20050801

Title: 2-O-(2-hydroxybutyl)-beta-cyclodextrin as a chiral selector for the capillary electrophoretic separation of chiral drugs.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20050801

Title: Sedation.

Journal: Pediatric annals 20050801

Title: Pain, inflammation and a nodule after IV medication.

Journal: Advance for nurse practitioners 20050701

Title: [An answer to the question: can promethazine be routinely used in asthmatic disease in childhood?].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20050701

Title: Boxed warning added to promethazine labeling for pediatric use.

Journal: The New England journal of medicine 20050623

Title: Promethazine for the treatment of agitation after electroconvulsive therapy: a case series.

Journal: The journal of ECT 20050601

Title: Multiple fixed drug eruption due to drug combination.

Journal: Contact dermatitis 20050601

Title: Motion-sickness medications for aircrew: impact on psychomotor performance.

Journal: Aviation, space, and environmental medicine 20050601

Title: Neuroleptic malignant syndrome with promethazine.

Journal: The Australian and New Zealand journal of psychiatry 20050401

Title: Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus.

Journal: Toxicon : official journal of the International Society on Toxinology 20050401

Title: Interaction of surface-active drugs in rabbits.

Journal: Biomedical chromatography : BMC 20050301

Title: Promethazine adverse events after implementation of a medication shortage interchange.

Journal: The Annals of pharmacotherapy 20050201

Title: The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report.

Journal: Journal of clinical anesthesia 20050201

Title: Haloperidol plus promethazine for psychosis induced aggression.

Journal: The Cochrane database of systematic reviews 20050125

Title: Neuroleptic malignant syndrome with promethazine.

Journal: The Australian and New Zealand journal of psychiatry 20050101

Title: Systematic delivery of chloroquine and promethazine using pH-sensitive polymers.

Journal: Drug delivery 20050101

Title: Comment: Promethazine adverse events after implementation of a medication shortage interchange.

Journal: The Annals of pharmacotherapy 20050101

Title: Rapid accurate mass desorption electrospray ionisation tandem mass spectrometry of pharmaceutical samples.

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: Conscious sedation and special needs patients.

Journal: Journal of dentistry for children (Chicago, Ill.) 20050101

Title: Endogenous opioids, mu-opiate receptors and chloroquine-induced pruritus: a double-blind comparison of naltrexone and promethazine in patients with malaria fever who have an established history of generalized chloroquine-induced itching.

Journal: International journal of dermatology 20041201

Title: Prescription of codeine in young infants.

Journal: Hong Kong medical journal = Xianggang yi xue za zhi 20041201

Title: Patient Notes: motion sickness.

Journal: Postgraduate medicine 20041001

Title: Perioperative management of pacemaker implantation for congenital complete heart block.

Journal: Journal of cardiothoracic and vascular anesthesia 20041001

Title: Bead injection spectroscopy-flow injection analysis (BIS-FIA): an interesting tool applicable to pharmaceutical analysis. Determination of promethazine and trifluoperazine.

Journal: Journal of pharmaceutical and biomedical analysis 20040903

Title: A randomized clinical trial to assess the efficacy of the Epley maneuver in the treatment of acute benign positional vertigo.

Journal: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 20040901

Title: Stimulation of the semicircular canals via the rotary chair as a means to test pharmacologic countermeasures for space motion sickness.

Journal: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20040901

Title: In vivo visualization of Tradescantia leaf tissue and monitoring the physiological and morphological states under different water supply conditions using optical coherence tomography.

Journal: Planta 20040801

Title: Rapid tranquillisation of violent or agitated patients in a psychiatric emergency setting. Pragmatic randomised trial of intramuscular lorazepam v. haloperidol plus promethazine.

Journal: The British journal of psychiatry : the journal of mental science 20040701

Title: [A study of the stability of dioxopromethazine in aqueous solutions and ophthalmic instillation].

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20040701

Title: A forensic toxicological dilemma: the interpretation of post-mortem concentrations of central acting analgesics.

Journal: Forensic science international 20040610

Title: The effect of dexamethasone and promethazine in combination with buparvaquone in the management of East Coast fever.

Journal: The Onderstepoort journal of veterinary research 20040601

Title: The effect of promethazine on postoperative pain: a comparison of preoperative, postoperative, and placebo administration in patients following total abdominal hysterectomy.

Journal: Acta anaesthesiologica Scandinavica 20040501

Title: Influence of histamine and H1-receptor antagonists on ejaculated human spermatozoa: role of intrasperm Ca2+.

Journal: Indian journal of experimental biology 20040501

Title: The efficacy low dose of prednisolone in the treatment of hyperemesis gravidarum.

Journal: Acta obstetricia et gynecologica Scandinavica 20040301

Title: MI: did nurse's administration of drug injure pt.?: failure to meet 'more probable than not' test.

Journal: Nursing law's Regan report 20040301

Title: [Simultaneous isotachophoresis determination of dioxopromethazine and phenylephrine in eye drops].

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20040301

Title: Plasmodium berghei: efficacy and safety of combinations of chloroquine and promethazine in chloroquine resistant infections in gravid mice.

Journal: African journal of medicine and medical sciences 20040301

Title: Promethazine-induced psychosis in a 16-year-old girl.

Journal: Psychosomatics 20040101

Title: Postoperative nausea and vomiting in the plastic surgery patient.

Journal: Aesthetic plastic surgery 20040101

Title: An evaluation of the care provided to patients prescribed controlled substances for chronic nonmalignant pain at an academic family medicine center.

Journal: Family medicine 20040101

Title: Effects of drug countermeasures for space motion sickness on working memory in humans.

Journal: Neurotoxicology and teratology 20040101

Title: Promethazine: a novel application as a neuroprotectant that reduces ischemia-mediated injury by inhibiting mitochondrial dysfunction.

Journal: Clinical neurosurgery 20040101

Title: Corticotropin-releasing hormone causes vasodilation in human skin via mast cell-dependent pathways.

Journal: The Journal of clinical endocrinology and metabolism 20031101

Title: The use of simple ketamine anaesthesia for day-case diagnostic laparoscopy.

Journal: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20031101

Title: Comparison of three outpatient regimens in the management of nausea and vomiting in pregnancy.

Journal: Journal of perinatology : official journal of the California Perinatal Association 20031001

Title: The critical role of velocity storage in production of motion sickness.

Journal: Annals of the New York Academy of Sciences 20031001

Title: Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine.

Journal: BMJ (Clinical research ed.) 20030927

Title: Chiral separation of dioxopromethazine in eye drops by CZE with charged cyclodextrin.

Journal: Journal of pharmaceutical and biomedical analysis 20030919

Title: Antiplasmid effect of promethazine in mixed bacterial cultures.

Journal: International journal of antimicrobial agents 20030901

Title: Enhancement of plasmid curing by 9-aminoacridine and two phenothiazines in the presence of proton pump inhibitor 1-(2-benzoxazolyl)-3,3,3-trifluoro-2-propanone.

Journal: International journal of antimicrobial agents 20030901

Title: Influence of pH on electrophoretic behavior of phenothiazines and determination of pKa values by capillary zone electrophoresis.

Journal: Electrophoresis 20030901

Title: Mixed drug intoxication involving zaleplon ('Sonata').

Journal: Forensic science international 20030708

Title: The relation of motion sickness to the spatial-temporal properties of velocity storage.

Journal: Experimental brain research 20030701

Title: Effect of combining naloxone and morphine for intravenous patient-controlled analgesia.

Journal: Anesthesiology 20030701

Title: Treatment of the common cold.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20030601

Title: Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol.

Journal: Therapeutic drug monitoring 20030401

Title: The effects of acute doses of fexofenadine, promethazine, and placebo on cognitive and psychomotor function in healthy Japanese volunteers.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20030401

Title: Clinical practice. Vestibular neuritis.

Journal: The New England journal of medicine 20030313

Title: Interaction of carbamazepine and promethazine in rabbits.

Journal: Biomedical chromatography : BMC 20030101

Title: Promethazine treatment of steroid-induced psychosis in a child.

Journal: The Annals of pharmacotherapy 20030101

Title: [Immediate and generalized reaction to Montenegro skin test].

Journal: Revista da Sociedade Brasileira de Medicina Tropical 20030101

Title: Comparison of the effect of orally versus submucosally administered meperidine on the behavior of pediatric dental patients: a retrospective study.

Journal: Anesthesia progress 20030101

Title: Magnesium sulphate versus phenytoin for eclampsia.

Journal: The Cochrane database of systematic reviews 20030101

Title: Beliefs and social norms about codeine and promethazine hydrochloride cough syrup (CPHCS) onset and perceived addiction among urban Houstonian adolescents: an addiction trend in the city of lean.

Journal: Journal of drug education 20030101

Title: Acute allergic reaction following contact with a spider.

Journal: Toxicon : official journal of the International Society on Toxinology 20021001

Title: [Landau-Kleffner and autistic regression: the importance of differential diagnosis].

Journal: Arquivos de neuro-psiquiatria 20020901

Title: Recovery, enrichment and selectivity in liquid-phase microextraction comparison with conventional liquid-liquid extraction.

Journal: Journal of chromatography. A 20020719

Title: Central effects of cinnarizine: restricted use in aircrew.

Journal: Aviation, space, and environmental medicine 20020601

Title: Anxiolytic premedication reduces preoperative anxiety and pain during oocyte retrieval. A randomized double-blinded placebo-controlled trial.

Journal: Human reproduction (Oxford, England) 20020501

Title: Liquid-phase microextraction of protein-bound drugs under non-equilibrium conditions.

Journal: The Analyst 20020501

Title: Study of the stability of promethazine enantiomers by liquid chromatography using a vancomycin-bonded chiral stationary phase.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020425

Title: Toxicity of ethacrynic acid in isolated rat hepatocytes.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20020401

Title: Investigation of the effect of tablet surface area/volume on drug release from hydroxypropylmethylcellulose controlled-release matrix tablets.

Journal: Drug development and industrial pharmacy 20020401

Title: Nanoparticles in plant extracts: influence of drugs on the formation of nanoparticles and precipitates in black tea infusions.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020301

Title: The effect of meperidine and promethazine on fetal heart rate indices during the active phase of labor.

Journal: The Israel Medical Association journal : IMAJ 20020301

Title: [Validation of the HPLC method in the determination of dioxopromethazine and phenylephrine in eye drops].

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20020301

Title: Cold temperatures reduce the sensitivity of stored platelets to disaggregating agents.

Journal: Platelets 20020201

Title: Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes.

Journal: European journal of clinical pharmacology 20020201

Title: Extractive-spectrophotometric determination of some phenothiazines with dipicrylamine and picric acid.

Journal: Journal of pharmaceutical and biomedical analysis 20020101

Title: Current practices in managing acutely disturbed patients at three hospitals in Rio de Janeiro-Brazil: a prevalence study.

Journal: BMC psychiatry 20020101

Title: A comparative evaluation of oral midazolam with other sedatives as premedication in pediatric dentistry.

Journal: The Journal of clinical pediatric dentistry 20020101

Title: Antihistamine antinociception is mediated by Gi-protein activation.

Journal: Neuroscience 20020101

Title: An evaluation of the effects of high-dose fexofenadine on the central nervous system: a double-blind, placebo-controlled study in healthy volunteers.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20020101

Title: Investigation of interaction of promethazine with cyclodextrins.

Journal: Acta poloniae pharmaceutica 20020101

Title: Simultaneous determination of promethazine, chlorpromazine, and perphenazine by multivariate calibration methods and derivative spectrophotometry.

Journal: Journal of AOAC International 20020101

Title: [Suicidal attempts with old (currently unused) drug].

Journal: Przeglad lekarski 20020101

Title: Project USAP 2000--use of sedative agents by pediatric dentists: a 15-year follow-up survey.

Journal: Pediatric dentistry 20020101

Title: TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243].

Journal: BMC psychiatry 20020101

Title: Interaction between various resistance modifiers and apoptosis inducer 12H-benzo[alpha]phenothiazine.

Journal: Anticancer research 20020101

Title: [The activity of enzymes and free radical oxidation in acute and chronic fetal hypoxia in general anesthesia during cesarean section].

Journal: Akusherstvo i ginekologiia 20020101

Title: A comparison study between ketamine and ketamine-promethazine combination for oral sedation in pediatric dental patients.

Journal: Anesthesia progress 20020101

Title: [Evaluation and treatment of hyperemesis gravidarum].

Journal: Minerva ginecologica 20011201

Title: Different job demands of nightshifts in hospitals.

Journal: Journal of human ergology 20011201

Title: Quantitation of promethazine and metabolites in urine samples using on-line solid-phase extraction and column-switching.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20011105

Title: Standard treatment: the role of antihistamines.

Journal: The journal of investigative dermatology. Symposium proceedings 20011101

Title: The use of on-line and off-line chromatographic extraction techniques coupled with mass spectrometry for support of in vivo and in vitro assays in drug discovery.

Journal: Current topics in medicinal chemistry 20011101

Title: Iatrogenic cardiopulmonary arrest during pediatric sedation with meperidine, promethazine, and chlorpromazine.

Journal: Pediatric emergency care 20011001

Title: Eye exposure to squashed spiders.

Journal: The Medical journal of Australia 20011001

Title: Codeine ingestion and apparent life-threatening event in a neonate.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20011001

Title: Treating dyspnea in a patient with advanced chronic obstructive pulmonary disease.

Journal: The Western journal of medicine 20010901

Title: Preinsertion local anesthesia at the trocar site improves perioperative pain and decreases costs of laparoscopic cholecystectomy.

Journal: Surgical endoscopy 20010901

Title: Antimicrobial activity of trifluoromethyl ketones and their synergism with promethazine.

Journal: International journal of antimicrobial agents 20010801

Title: Airway protection following simulated gastro-oesophageal reflux in sedated and sleeping neonatal piglets during active sleep.

Journal: Clinical and experimental pharmacology & physiology 20010701

Title: [Work time distribution in night shift: are clinics facing a adjustment boom?].

Journal: Pflege Zeitschrift 20010701

Title: Mechanistic appraisal of the charge-transfer complexes of promethazine with chloranil: a modelling approach.

Journal: Chemical & pharmaceutical bulletin 20010601

Title: Glutaric acidemia, type I, missed by newborn screening in an infant with dystonia following promethazine administration.

Journal: Pediatrics 20010501

Title: Neuroleptic malignant syndrome precipitated by promethazine and lorazepam.

Journal: The Australian and New Zealand journal of psychiatry 20010401

Title: Angle closure risk from proprietary medicines.

Journal: Eye (London, England) 20010401

Title: Enhancement of antibiotic activity against poly-drug resistant Mycobacterium tuberculosis by phenothiazines.

Journal: International journal of antimicrobial agents 20010301

Title: An investigation into the effects of cetirizine on cognitive function and psychomotor performance in healthy volunteers.

Journal: European journal of clinical pharmacology 20010301

Title: A liquid chromatographic method for the simultaneous determination of promethazine and three of its metabolites in plasma using electrochemical and UV detectors.

Journal: Journal of chromatographic science 20010201

Title: Magnesium sulphate versus lytic cocktail for eclampsia.

Journal: The Cochrane database of systematic reviews 20010101

Title: Prolonged inhibition of presynaptic catecholamine synthesis with alpha-methyl-para-tyrosine attenuates the circadian rhythm of human TSH secretion.

Journal: Journal of the Society for Gynecologic Investigation 20010101

Title: A new goldfish model to evaluate pharmacokinetic and pharmacodynamic effects of drugs used for motion sickness in different gravity loads.

Journal: Acta astronautica 20010101

Title: Comparing the safety, efficacy and recovery of intranasal midazolam vs. oral chloral hydrate and promethazine.

Journal: Pediatric dentistry 20010101

Title: Adverse reactions related to phenergan.

Journal: Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates 20010101

Title: The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare.

Journal: Current medical research and opinion 20010101

Title: Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.

Journal: Journal of child and adolescent psychopharmacology 20000101

Title: Neuroleptic malignant syndrome due to promethazine.

Journal: Southern medical journal 19991001

Title: The effect of therapeutic drugs and other pharmacologic agents on activity of porphobilinogen deaminase, the enzyme that is deficient in intermittent acute porphyria.

Journal: Life sciences 19990101

Title: Complications following sedation of paediatric oncology patients undergoing radiotherapy.

Journal: West African journal of medicine 19980101

Title: Evaluation of the safety and efficacy of deep sedation for electrophysiology procedures administered in the absence of an anesthetist.

Journal: Pacing and clinical electrophysiology : PACE 19970701

Title: Comparison of oral transmucosal fentanyl citrate and intramuscular meperidine, promethazine, and chlorpromazine for conscious sedation of children undergoing laceration repair.

Journal: Annals of emergency medicine 19961001

Title: Phototoxic and photoprotective effects of topical isothipendyl.

Journal: Photodermatology, photoimmunology & photomedicine 19950401

Title: A randomized, double-blind, cross-over study comparing a levosulpiride-based and a metoclopramide-based combination in the prevention of ProMECE-CytaBOM-induced emesis.

Journal: Haematologica 19950101

Title: The serotonin syndrome associated with paroxetine, an over-the-counter cold remedy, and vascular disease.

Journal: The American journal of emergency medicine 19941101

Title: [A case of life-threatening ventricular arrhythmias probably due to psychotropic drugs].

Journal: Kokyu to junkan. Respiration & circulation 19931101

Title: [A case of neuroleptic malignant syndrome with acute renal failure].

Journal: Hinyokika kiyo. Acta urologica Japonica 19921101

Title: Investigation of anti-motion sickness drugs in the squirrel monkey.

Journal: Journal of clinical pharmacology 19920201

Title: [Histamine release during induction of combination anesthesia using nalbuphine or fentanyl. Modulation of the reaction by premedication with promethazine/pethidine].

Journal: Der Anaesthesist 19920101

Title: Phenothiazine-associated apnea in two siblings.

Journal: DICP : the annals of pharmacotherapy 19910301

Title: [Behavioral effects of a new antidepressant, setiptiline].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19910101

Title: Hallucinations and hyperthermia after promethazine ingestion.

Journal: Acta paediatrica Scandinavica 19890101

Title: Drug-induced hallucinations.

Journal: Journal of the American Academy of Child and Adolescent Psychiatry 19880101

Title: Promethazine-induced dystonic reaction.

Journal: Pediatric emergency care 19870601

Title: Amelioration of ergotamine withdrawal symptoms with naproxen.

Journal: Headache 19870301

Title: Pharmacologic analysis of LY188695 (KB-2413), 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole difumarate, a potent histamine1 receptor antagonist.

Journal: Agents and actions 19870201

Title: Difficulty reversing drug-induced coma in a patient with sleep apnea.

Journal: Anesthesia and analgesia 19861101

Title: Phenothiazine-induced sleep apneas in normal infants.

Journal: Pediatrics 19850501

Title: Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines).

Journal: Clinical pharmacokinetics 19850101

Title: Case vignettes of movement disorders.

Journal: Brain research bulletin 19830801

Title: Fetal distress due to intravenous administration of pethidine (meperidine) with promethazine during labour.

Journal: The Australian & New Zealand journal of obstetrics & gynaecology 19821101

Title: Decorticate posture following 'cardiac cocktail': a transient complication of sedation for catheterization.

Journal: Pediatric cardiology 19820101

Title: Possible role of phenothiazines in sudden infant death.

Journal: Lancet (London, England) 19790818

Title: Respiratory depression in a child following meperidine, promethazine, and chlorpromazine premedication: report of case.

Journal: ASDC journal of dentistry for children 19790101

Title: Studies on antituberculotic action of some phenothiazine derivatives in vitro.

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Title: On the anticataleptic action of cyproheptadine.

Journal: Pharmacology, biochemistry, and behavior 19760801

Title: Accidental subarachnoid injection of gallamine. A case report.

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Title: Tardive dyskinesia treated with pimozide.

Journal: Journal of the neurological sciences 19750401

Title: Metoclopramide and pimozide in Parkinson's disease and levodopa-induced dyskinesias.

Journal: Journal of neurology, neurosurgery, and psychiatry 19750401

Title: Effects of bradykinin and indomethacin on cyclic GMP and cyclic AMP in lung slices.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19731201

Title: A comparison of althesin and thiopentone in induction of anaesthesia.

Journal: British journal of anaesthesia 19730101

Title: Encephalitic reaction to promethazine.

Journal: The Journal of pediatrics 19720501

Title: Intramuscular sodium methohexital as a sole pediatric anesthetic-analgesic agent.

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Title: Postoperative headache after nitrous oxide-oxygen-halothane anaesthesia.

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Title: Epileptiform convulsions in children following premedication with Pamergan SP100.

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Tags:58-33-3 Molecular Formula|58-33-3 MDL|58-33-3 SMILES|58-33-3 N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride