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53233-89-9,MFCD00023474
Catalog No.:AA003MM2

53233-89-9 | 5-Chloro-2,3-dihydroxypyridine

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Purity
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250mg
95+%
in stock  
$46.00   $32.00
- +
1g
95%
in stock  
$70.00   $49.00
- +
5g
95%
in stock  
$261.00   $183.00
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50g
≥98%
in stock  
$1,838.00   $1,287.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003MM2
Chemical Name:
5-Chloro-2,3-dihydroxypyridine
CAS Number:
53233-89-9
Molecular Formula:
C5H4ClNO2
Molecular Weight:
145.5438
MDL Number:
MFCD00023474
SMILES:
Clc1cnc(c(c1)O)O
NSC Number:
137836
Properties
Properties
 
BP:
297.6°C at 760 mmHg  
Form:
Solid  
MP:
295 °C (dec.);(lit.);  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
207  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
XLogP3:
0.4  

Downstream Synthesis Route
53233-89-9    74-97-5   
5-chloro-1,3-benzodioxole 

[1]Patent:WO2004/41829,2004,A1.Locationinpatent:Page64

[2]Patent:WO2004/69249,2004,A1.Locationinpatent:Page/Pagecolumn57

53233-89-9    77-78-1   
5-chloro-3-methoxy-1-methyl-1H-pyridin-2-one 

[1]Patent:WO2003/103668,2003,A1.Locationinpatent:Page23

53233-89-9    35654-56-9   
4-(5-chloro-2-hydroxy-pyridin-3-yloxy)-6,7-dimethoxy-quinoline 

[1]Patent:EP1548008,2005,A1.Locationinpatent:Page/Pagecolumn121

53233-89-9    52462-29-0   
(p-cymene)Ru(5-chloro-2,3-dioxopyridine))3 

[1]InorganicChemistry,2003,vol.42,p.3576-3581

Literature

Title: Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase.

Journal: European journal of medicinal chemistry 20120801

Title: Proteomic differential display analysis for TS-1-resistant and -sensitive pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry.

Journal: Anticancer research 20110601

Title: Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl].

Journal: Bioinorganic chemistry and applications 20100101

Title: Experimental study of combination therapy with S-1 against pancreatic cancer.

Journal: Cancer chemotherapy and pharmacology 20091101

Title: Synthesis, Spectroscopic, and Anticancerous Properties of Mixed Ligand Palladium(II) and Silver(I) Complexes with 4,6-Diamino-5-hydroxy-2-mercaptopyrimidine and 2,2'-Bipyridyl.

Journal: Metal-based drugs 20080101

Title: Synergistic antitumor effect of combined 5-fluorouracil (5-FU) with 5-chloro-2,4-dihydroxypyridine on 5-FU-resistant gastric cancer cells: possible role of a dihydropyrimidine dehydrogenase-independent mechanism.

Journal: Journal of gastroenterology 20071001

Title: Role of dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine against non-small cell lung cancer--in correlation with the tumoral expression of thymidylate synthase and dihydropyrimidine dehydrogenase.

Journal: Lung cancer (Amsterdam, Netherlands) 20050701

Title: Phase I and pharmacokinetic study of the oral fluoropyrimidine S-1 on a once-daily-for-28-day schedule in patients with advanced malignancies.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040801

Title: The effect of food on the pharmacokinetics of S-1 after single oral administration to patients with solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040615

Title: Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors.

Journal: Cancer chemotherapy and pharmacology 20030701

Title: [Concentration of FT and CDHP and 5-FU in the ascites fluid of patient with peritoneal carcinomatosis after new anti-cancer drug TS-1 oral administration].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20020701

Title: Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells.

Journal: European journal of cancer (Oxford, England : 1990) 20020601

Title: Increased intestinal permeability correlates with gastrointestinal toxicity among formulations of the fluorouracil analogue tegafur in rats.

Journal: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20020101

Title: Fluorouracil (5FU) pharmacokinetics in 5FU prodrug formulations with a dihydropyrimidine dehydrogenase inhibitor.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20011115

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