Catalog No.:AA01EFED

532959-63-0 | N-[4-(4-Amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]-methylesulfonamide

Name: Name:N-[4-(4-Amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]-methylesulfonamide
Brand: AABLOCKS
SKU: AA01EFED
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1mg

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5mg

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$213.00 $149.00

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10mg

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$399.00 $279.00

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25mg

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Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA01EFED

Chemical Name:

N-[4-(4-Amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]-methylesulfonamide

CAS Number:

532959-63-0

Molecular Formula:

C17H23N5O2S

Molecular Weight:

361.4618

MDL Number:

MFCD30533308

SMILES:

CCc1nc2c(n1CCCCNS(=O)(=O)C)c1ccccc1nc2N

Properties

Computed Properties

Complexity:

538

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

1.9

Downstream Synthesis Route

532959-63-0

541-41-3

ethyl2-ethyl-1-{4-(methylsulfonyl)aminobutyl}-1H-imidazo4,5-cquinolin-4-ylcarbamate

[1]Patent:WO2007/30777,2007,A2.Locationinpatent:Page/Pagecolumn20

532959-63-0

108-24-7

N-(2-ethyl-1-{4-(methylsulfonyl)aminobutyl}-1H-imidazo4,5-cquinolin-4-yl)acetamide

[1]Patent:WO2007/30777,2007,A2.Locationinpatent:Page/Pagecolumn18

532959-63-0

592-34-7

butyl2-ethyl-1-{4-(methylsulfonyl)aminobutyl}-1H-imidazo4,5-cquinolin-4-ylcarbamate

[1]Patent:WO2007/30777,2007,A2.Locationinpatent:Page/Pagecolumn24

532959-63-0

97-72-3

N-(2-ethyl-1-{4-(methylsulfonyl)aminobutyl}-1H-imidazo4,5-cquinolin-4-yl)-2-methylpropanamide

[1]Patent:WO2007/30777,2007,A2.Locationinpatent:Page/Pagecolumn21

Literature

Title: Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.

Journal: Bioorganic & medicinal chemistry letters 20130201

Title: Therapy with TLR7 agonists induces lymphopenia: correlating pharmacology to mechanism in a mouse model.

Journal: Journal of clinical immunology 20121001

Title: Prolonged subcutaneous administration of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced hematologic malignancies.

Journal: American journal of hematology 20121001

Title: Toll-like receptor-7 agonist administered subcutaneously in a prolonged dosing schedule in heavily pretreated recurrent breast, ovarian, and cervix cancers.

Journal: Cancer immunology, immunotherapy : CII 20101201

Title: TLR7 agonist 852A inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type I IFN.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20080401

Title: An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080201

Title: Comparison of human B cell activation by TLR7 and TLR9 agonists.

Journal: BMC immunology 20080101

Title: First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20071201

Title: Fidock MD, et al. The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691). Clin Pharmacol Ther. 2011 Jun;89(6):821-9.

Title: Horscroft NJ, et al. Antiviral applications of Toll-like receptor agonists. J Antimicrob Chemother. 2012 Apr;67(4):789-801.

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